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Article
Erectile Dysfunction in Diabetic Patients in the Holy Kerbala/Iraq in 2018

Authors: rfooAl As .rD, Abdil Razak Mohamid --- Dr Al Mousawi, Ali
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2018 Issue: 15 Pages: 1-10
Publisher: Kerbala University جامعة كربلاء

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Abstract

BackgroundErectile dysfunction affects more than 50% of diabetic patients and results in miserablecouple’s life, especially for young adults. Possible predictors are proper therapy andpatient’s compliance with treatment, in addition to the warning signs and symptoms ofsensory neuron and motor deficits. Therefore, this study was conducted to determine theprevalence of Erectile dysfunction and its predictors among diabetic patients in Kerbala.Material and methodsThe study included a convenient sample of 61 patients with diabetes mellitus type I and II.They were chosen through a systematic sampling among patients at the diabetes mellitusclinic at Al Hussein Teaching Hospital in Holy Kerbala /Iraq in 2018. All participantswere interviewed using standard questionnaire. Analysis of data used descriptive andanalytic tools including t-test, chi-square test, logistic regression and structural Equationmodeling through the statistical Package of social sciences and Amos and Excel softwareat a significance level of <.05.ResultsThe mean age of patients was 53.5 ± 10.18 years and mean duration of disease was 10.9±6.90 years. One half of the participants complained of erectile dysfunction. Goodglycemic control may hinder this complication induction. Motor neuron changes,discovered on clinical examination, might be the earliest warning signs and sensorydeficits are also predictors of erectile dysfunction. Similarly, autonomic changesdiscovered through orthostatic hypotension might also represent its early sign.ConclusionsErectile dysfunction is a common complication of diabetes and health care providers needto investigate for early signs of this occurrence through sensory and motor neuronedeficits.


Article
Husbands Violence against Wives in Kerbala Governorate, Iraq in 2018

Authors: Jawad, Naba --- Al Mousawi, Ali --- Al Haydari, A
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2019 Volume: 12 Issue: 1 Pages: 4143-4153
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Husband violence is an international problematic behavior with grave abuse of civilian privileges that happens between all religious, cultural, economic and social groups. However, this problem is widely prevalent in under-developed countries with huge mass of media news and discussion about its great impact and sequel in these societies. It aims to identify the lifetime prevalence of husband among health center clients and to identify its relationship to socio-demographic variables.Methods: a survey was conducted among a cross sectional sample among 320 women (aged 15 to 65 years) attending primary health care centers in Kerbala governorate in Iraq in 2018. A female doctor measured husband violence and potential predictors through interview questionnaire dependent mainly on the World Health Organization questionnaire used in multi-country study questionnaire.Results: Tow thirds of the sample were exposed to husband violence. The verbal violence was the most common type of husband violence (27.5%) followed by sexual (21.6%) and physical violence (20.3%). Even pregnant women were not spared while all divorced women in the sample were abused. Low economic income significantly raised husband violence which was also associated with husband substance use (smoking, alcohol and other substances). Abused women welcomed any help even by health care personals (64%).Conclusions: Husband violence was very common problem among women in Karbala city and verbal violence was the most common type. The problem needs further large scale investigation and urgent preventive programs to be set through wide community efforts.


Article
Evaluation of Some Genetic Factors in Rheumatoid Arthritis patients in Iraq
تقييم بعض العوامل الوراثية في مرضى التهاب المفاصل الرثوي في العراق

Author: Israa K. Al –Yasiri Jaafar K. Al-Mousawi Ali M.Al- Mohana
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2014 Volume: 13 Issue: 2-2 Pages: 66-74
Publisher: Baghdad University جامعة بغداد

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Abstract

Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disease affecting the joints. With more sophisticated and effective therapies becoming available and with the understanding that early intervention is crucial in preventing irreversible joint damage. The main purpose of this observational study was to evaluate and detects a good genetic factors may be used in early detection of RA. A total of 40 patients with RA who were fulfilled four or more of the 1987 American College of Rheumatology (ACR), 20 patients with joints problems (JP), 20 RA patient relatives (PR) and 10 apparently healthy control individuals were included in this study. Human leukocyte antigen (HLA) genotyping was performed using Mr. Spot SSO system. The distribution of HLA class II genotypes in 20 RA patients and 30 control groups were studied. HLA-DRB1*04 was significantly most common genotypes in the RA patients (70%) compared to control groups (23.3%). While, the frequency of HLA-DRB1*11 was very high among controls (53.3%) compared to RA patients (25.0%), but the difference was not statistically significant. RA susceptibility in most Iraqi patients was associated with the HLA-DRB1*04 genotype. The HLA-DRB1*04 allele contributed significantly to the development of RA .HLA- Therefore, HLA-DRB1*04 allele appears to play an important pathogenic role in all subsets of RA.

التهاب المفاصل الرثوي هو من أمراض المناعة الذاتية المزمنة والمدمرة التي تؤثر على المفاصل بالعلاجِ المتطوّرِ والأكثرِ فعّالية الذي أصبح متوفرا وبالفَهْم بأنّ التدخّلِ المبكّرِ حاسمُ في مَنْع الضررِ المشتركِ الغير قابل للعكس فان من المهم والمهم جدا تشخيص التهاب المفاصل الرثوي في مرحلة مبكرة جدا ولتسهيل التشخيص في المراحل المبكرة من المرض، في كثير من الأحيان عندما لم يكن كل الأعراض السريرية واضحة للعيان، إن الغرض الرئيسي لهذه الدراسةِ هذه هو الكشف عن اختبار للعوامل الوراثية يمكن استخدامه في الكشف المبكر عن التهاب المفاصل الرثوي . شملت هذه الدراسة أربعين مريض يعانون من التهاب المفاصل الرثوي لديهم أربعة أو أكثر من العلامات المحددة من قبل الجمعية الأمريكية للروماتزم, 20 مريض يعانون من مشاكل في المفاصل، 20 شخص من أقارب المرضى الذين يعانون من التهاب المفاصل الرثوي و 10 أشخاص أصحاء كمجموعة سيطرة. كما تم استخدم تقنية مستر سبوت نظام SSO (التسلسل المتخصص أحادي النيوكليوتيدات) من أجل الكشف الوراثي عن مستضد كريات الدم البيض البشرية (HLA). تم دراسة التوزيع الوراثي لمستضد كريات الدم البيض البشرية (HLA) الصنف الثاني لعشرين من مرضى التهاب المفاصل الرثوي وثلاثين من مجاميع السيطرة، أثبتت هذه الدراسة أن HLA-DRB1 * 04 كان معنويا وأكثر شيوعا (70٪) بين المرضى بالمقارنة مع مجموعات السيطرة (23.3٪). في حين HLA-DRB1 * 11 كان موجودا في عدد صغير نسبيا من مرضى التهاب المفاصل الرثوي (25٪) بالمقارنة مع مجموعات السيطرة (53.3٪). ومع ذلك، لا توجد هنالك فروق معنوية. وجد ان الحساسية للإصابة بمرض التهاب المفاصل الرثوي في المرضى العراقيين مرتبط بوجود العامل الوراثي HLA-DRB1 04 * و أن أليل 04 * HLA-DRB1 ساهم بشكل كبير في تطوير التهاب المفاصل الرثوي، ولذلك، يبدو أن HLA-DRB1 * 04 أليل تلعب دورا هاما في التهاب المفاصل الرثوي.

Keywords

Rheumatoid arthritis --- HLA.


Article
Monotherapy or Combined therapy in non-responding Epilepsy, Which is best?

Authors: Dr. Al Asfoor, Abdil Razak Mohamid --- Dr. Al Mousawi, Ali --- Dr. Haloom, Amar
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2019 Issue: 16 Pages: 29-41
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Epilepsy is one of the most prevalent chronic diseases (4/1000 children and 7/1000 adult worldwide). It is also associated with significant increased risk of psychiatric disorder and family distress. Treatment consists of anticonvulsants medications, lifestyle modification and psycho education. The compliance of the patient with treatment is very important for the management of epilepsy however, the subject has not been widely investigated.Subjects and methods: A convenient cross-sectional study was conducted among 113 patients (62 females and 51 males) with uncontrolled epileptic in a tertiary care center in AL Hussieny Teaching hospital in Kerbala and the Medical City in Baghdad / Iraq and the later represents the main center dealing with non-responding patients referred from all over the country. A special survey questionnaire form was prepared for this purpose including demographic information in addition to family history, type of epilepsy and treatment. In addition the results of investigations performed were assessed including: Video Electro-Encephalogram (EEG,) and Magnetic Resonance Imaging (MRI).Results: The mean age of the sample was 25.27±15.14 year and no significant gender difference was discovered. The monotherapy group of patients were younger than combined therapy group however the difference in age was not significant (p=.275). Most patients (71%, 80 patients) were in the monotherapy group, while only 29% (33 patients) were in the Combined therapy group. Video EEG was abnormal in 69.9% of (79 patients) of the total sample, while it was positive in 36% in combined therapy patients vs. 27% in monotherapy patients. Similarly, MRI was abnormality was encountered more in the combined therapy group (21% vs.14%). The main finding for this study was that monptherapy type of treatment was better in controlling epilepsy with highly significant difference (61% vs. 28%, p<.001). Additionally, the significant predictors of epileptic fit were positive family history and duration of disease.Conclusions: Monotherapy was found to be significantly better than combined therapy in controlling fit among patients with uncontrolled epileptic in tertiary care centers in Iraq.


Article
Association between the Low Density Lipoprotein Receptor (A370T) Gene Polymorphism with Lipid Profile in Type 2 Diabetes Mellitus

Authors: Al Mousawi, Ali --- Reyad Henawa --- Mohannad Abdulameer Abdulrahman --- Al Asfoor, Abdul Razak Mohamad
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2020 Issue: 17 Pages: 43-56
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Brain natriuretic peptide was first isolated in 1988 from porcine brain, then a similar substance (hormone) was discovered to be secreted by the heart ventricles cardio myocytes in response to stretch. A lot of debate is running for decades regarding its functions as an indicator of the type of pathology or prognostic outcome in strokr patients.Patients and methods: Twenty four men and twenty four women with admitted at Al Husssieni Teaching hospital within 12 hours of cerebrovascular accidents were investigated to evaluate NT-pro-BNP and troponin levels estimation as indicator for determining pathology type and prognosis in stroke patients.Results : The maen age mean age of the patients was 50.77 ±12.98 year. Two thirds of the patients had cerebral ischemia, 29% had intracranial hemorrhage and only 6% had sub-arachnoid hemorrhage. There was no significant difference in the mean Pro-BNP level between these three types of stroke and the mean was 29.62±17.10 ng/dl, 143.25±38.29 ng/dl and 179.65±32.27 ng/dl for sub-arachnoid hemorrhage, intra-cranial hemorrhage and cerebral ischemia, respectively. Similarly no significant gender difference was detected (p=.167), nor there was a difference between those who deceased (20.8%) and those who discharged a live (p=.726). The highest fatality rate differ significantly among different types of stroke, and was highest among those with sub-arachnoid hemorrhage (100%), modest anong patients with intra-cranial hemorrhage (50%), while the least was among those with ischemia (no death). The cardiac complications after stroke were explored, but these did not affect NTproBNP level significantly. Conclusions: brain natriuretic peptide (BNP) level was found not to be significantly different across the thtree main types of stroke. Its level was not affected by gender and it provides no progmostic importance for the fate or oucome after stroke.

المقدمةة: تم عزل ، نايتروببتايدات الدماغ في عام 8811 من دماغ الخنزير ، ثم تم اكتشاف مادة مماثلة )هرمون(تفرزها عضلات القلب القلبية البطينية استجابةً لامتدا العضلاتد .ويدور الكثير من النقاش منذ عقود حول وظائفهكمؤشرمرضي أو النتائج التحذيرية له لدى مرضى السكتة الدماغية .المرضى وطرق البحث: تم فحص أربعة وعشرون رجلاً وأربعة وعشرون امرأة ممن تم ادخالهم في مستشفىالحسيني التعليمي في غضون 81 ساعة من السكتة الوعائية الدماغية لتقييم مستويات نايتروببتايدات الدماغالتروبونين كمؤشر لتحديد نوع المراض والتشخيص لدى مرضى السكتة الدماغية .81.81 سنة. يعاني ثلثا المرضى من نقص تروية دماغية ، و ± النتائج: كان متوسط عمر المريض هو 77.55٪18 مصابون بنزيف داخل الجمجمة و 6٪ فقط لديهم نزف تحت العنكبوتية. لم يكن هناك اختلاف كبير فيمستوى Pro-BNP المتوسط بين هذه الأنواع الثلاثة من السكتة الدماغية وكان متوسط نايتروببتايدات الدماغ41.15 نانوغرام ± 41.18 نانوغرام / ديسيلتر و 858.67 ± 85.87 نانوغرام / ديسيلتر ، 834.17 ± 18.61/ ديسيلتر للانواع الثلاثة المذكورة اعلاه ، على التوالي. وبالمثل ، لم يتم الكشف عن اختلاف كبير بين الجنسين)ع = . 865 ( ، ولم يكن هناك فرق بين أولئك الذين توفوا ) 17.1 ٪( وأولئك الذين خرجوا من العيش )ع =7.516 (. وظهر اختلاف كبير في معدل الوفاة بين ألانواع المختلفة من السكتة الدماغية ، وكان أعلاها بين، )٪ المصابين بنزف تحت العنكبوتية ) 877 ٪( ، ثم بين المرضى الذين يعانون من نزيف داخل الجمجمة ) 77بينما كان الأقل بين المصابين بنقص التروية الموت(. تم استكشاف مضاعفات القلب بعد السكتة الدماغية ، ولكنهذه لم تؤثر على مستوى ، نايتروببتايدات بشكل كبير . الدماغالاستنتاجات: تم قياس مستوى نايتروببتايدات الدماغ ووجد انه لا يختلف اختلافًا كبيرًا عبر الأنواع الرئيسية منالسكتة الدماغية.وكذلك لم يتأثر مستواه بالجنس ، ولا يقدم أي أهمية استباقية لمصيرالمريض )الوفاة( أو الخروجمن الستشفى بعد السكتة الدماغية .

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