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The cytotoxic effect of different intracanal medicaments

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Abstract

Background: Different intracanal medicaments are being used in endodontics but little attention is paid to their cytotoxicity. The aim of this research was to assess the cytotoxic effect of the traditionally used intracanal medicaments and compare them with 2% acetic acid.Materials and Methods: Different intracanal medicaments and 2% acetic acid were inoculated in the tibia bone of white albino rabbits for 3, 7, 14 and 28 days. After the incubation time, the animals were sacrificed and the inoculated areas were assessed histopathologically.Results: Two percent acetic acid induced an inflammatory reaction comparable to that of normal saline, and calcium hydroxide that subsided after 14 days. The formaldehyde containing agents, and CMCP induced a more severe inflammatory reaction, with tricresol formalin showing a reaction even after 28 days.Conclusions: Two percent acetic acid was more biocompatible than the other tested root canal medicaments.


Article
Clinical evaluation of the antibacterial action of different root canal medicaments

Authors: Hussain F. Al-Huwaizi حسين فيصل الحويزي --- Aladin Al-Rubayi علاء الدين الربيعي --- Ammer Al-Najjar عامر النجار
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: special issue Pages: 15-18
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Different intracanal medicaments were evaluated in vivo for their antibacterial action.Materials and methods: A total of one hundred and twenty anterior opened necrotic teeth with no apicalradiolucencies were chosen for this study. Endodontic treatment procedures were performed to the teeth whichwere medicated between the appointments by different intracanal medicaments (Tricresol formalin, formocresol ,2% acetic acid, CMCP, calcium hydroxide, and normal saline as control). The elimination of the bacterial flora ofthese teeth was monitored during the treatment appointments by swabbing the root canals and culturing the swabson blood agar culture media.Results: The teeth medicated by tricresol formalin formocresol and 2% acetic acid experienced the most decrease inthe bacteria count and showed the highest negative cultures. CMCP was next, then calcium hydroxide and lastlynormal saline.Conclusion: The chemo mechanical debridement of the root canals was effective in eliminating most of thebacterial flora but not to the degree of sterility

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