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COLORIMETRIC ASSAY OF ASPIRIN USING MODIFIED METHOD

Authors: Amera Abbas --- May Mohammed Jawad Al-Mudhafar --- Maadh Qusay Abdulkadir
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2009 Volume: 12 Issue: 3 Pages: 1-7
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Abstract
In this research, we did this qualitative and quantitative study in order to improve the assay of
aspirin colorimetrically using visible spectrophotometer. This method depends on aqueous
hydrolysis of aspirin and then treating it with the ferric chloride acidic solution to give violet
colored complex with salicylic acid, as a result of aspirin hydrolysis, which has a maximum
absorption at 530nm. This procedure was applied to determine the purity of aspirin powder and
tablet. The results were approximately comparative so that the linearity was observed in the high
value of both correlation coefficient (R = 0.998) and Determination Coefficient or Linearity (R2 =
0.996) while the molar absorpitivity was 1.3´103 mole-1.L.cm-1. This improvement cancelled the
acid or base aided hydrolysis which is widely used during aspirin assay. This method could be also
applied to salicylic acid.

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