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Stromal CD10 expression in invasive breast carcinoma
التعبير Stromal CD10 في سرطان الثدي الغازية

Authors: Wahda MT. Alnuaimy --- Ava T. Ismail --- Jalal A. Jalal --- Haval D. Ali
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 1 Pages: 41-48
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objective: This study aimed to assess the immunohistochemical expression of stromal CD10 in invasive breast carcinoma and determine its relationship with some clinicopathological parameters.Methods: A cross-sectional study was conducted on 91 female breast cancer cases collected from the archive of pathology department in Rizgary Teaching Hospital and some private labs during the period from January 2012 to August 2015. CD10 expression was detected by immunohistochemistry using labeled polymer and enhanced polymer systems (Dako EnVision™ Flex) Dakoprotocol. The scoring was based on the intensity and percentage of the stained stromal cells. Then CD10 immunoexpression was correlated with the age of patients, tumor size, histopathological types, tumor grade, lymphovascular invasion, lymph node status, and tumor stage.Results: Stromal CD10 expression was observed in 70.4% of the cases. A statistically significant positive correlation was seen between stromal CD10 and the tumor subtype (P = 0.02), tumor grade (P = 0.025), lymphovascular invasion (P = 0.002), and lymph node status (P = 0.047), however, no statistically significant association was identified between stromal CD10 expression and age, tumor size and tumor stage.Conclusion: Stromal CD10 is expressed in the majority of cases of invasive breast carcinoma and concerning the positive correlations between stromal CD10 expression and tumor grade, lymphovascular invasion, and lymph node status suggest a strong effect of stromal CD10 expression on aggressive behavior of breast carcinoma.


Article
Metabolic Syndrome and Serum Leptin Levels in Erbil Population
متلازمة التمثيل الغذائي ومستويات مصل اللبتين في أربيل

Authors: Shatha R. Mustaffa --- Ava T. Ismail --- Sanaa G. Hama AL-Mandalawi
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 76-84
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Metabolic syndrome is a potent risk factor for cardiovascu-lar diseases (CVDs), has not been adequately explored in Erbil individuals and its relation to leptin hormone. The present study aim to evaluate such a relationship between serum leptin and metabolic syndrome in Erbil individuals.Methods: Samples collection were carried out in Razgary teaching hospital, 45 cases with metabolic syndrome and 30 healthy control subjects, anthropometric variables measure-ments (blood pressure, body weight, body height, body mass index) and biochemical tests: fasting, serum glucose, serum triglycerides, high-density lipoprotein cholesterol and serum leptin were obtained from the study samples.Results: Serum leptin levels were significantly higher in females in comparison to the males in metabolic syndromes group (with median 53.6 Vs 23.8 ng/dl with P value < 0.05) with also present statistical significant difference in leptin between metabolic syndrome group and control group in both males and females. No important association between se-rum leptin and each of selected criteria of metabolic syndrome. The observed case-control difference in serum leptin is mainly attributed to gender and body mass index (BMI) differ-ences and not a function of metabolic syndrome itself.Conclusions: Among subjects with metabolic syndrome, only age , gender and body mass index were important in determining the magnitude of serum leptin among cases groups.

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