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The antibacterial effect of Ellagic acid on Lacto bacillus acidophilus in comparison to Chlorhexidine

Author: Dr. Saadi Jawad Muslim ,B.D.S, MSc. د. سعدي جواد مسلم
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2015 Volume: 12 Issue: 1 Pages: 126-133
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Ellagic acid is a natural herb extract were prepared from flesh pomegranateextract. The preparation and experiments were done and conducted in a laboratory ofchemistry department of Ministry of Science and Technology. Biological activity ofEllagic acid to ward pathogenic bacteria (Lactobacillus acidophilus) was studied. Thepurpose of this study was to evaluate the antibacterial effect of prepared Ellagic acidwith different concentrations on growth of lacto bacillus acidophilus in comparisonwith Chlorhexidine gluconate 0.2% and deionized water. This in vitro bacteriologicalstudy was tested according to agar well diffusion technique. The results showed that ahighly significant increase in mean values of Ellagic acid compared to Chlorhexidineand deionized water. The concentration, 5 mg/ml and10 mg/ml of Ellagic acid showedstronger effects in inhibition of lactobacillus acidophilus, than Chlorhexidine 0.2%.Ellagic acid 5and10mg/ml has the ability to interfere with the adherence ofLactobacilli in vitro.Previous study showed that Ellagic acid had antibacterial effect on Streptococcusmutans , Ellagic acid could be used as antibacterial mouth washes to preventdental caries.Chlorhexidine.

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