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Serum Lipoprotein (A) in Patients with Fibromyalgia Syndrome

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Abstract

Background: Fibromyalgia syndrome (FMS) is the most common rheumatic cause of diffuse pain and multiple regional musculoskeletal pain and disability. Objective: is to assess the contribution of serum lipoprotein (A) in the pathogenesis of FMS patients.Methods: One hundred twenty two FMS patients were compared with 60 healthy control individuals who were age and sex matched. All FMS features and criteria are applied for patients and controls; patients with secondary FMS were excluded. Serum Lipoprotein (A): [Lp(A)], body mass index (BMI), & s.lipid profile were determined for both groups.Results: There was a statistical significant difference between patients &controls in serum lipoprotein (A) (P=0.013). Also there was a statistical significant correlations between serum Lp(A) & FMS patients' age( r= 0.310, P=0.034 ); but not with: duration(r= -0.222, P=0.133) , BMI(r= 0.128,P=0.390) & s.lipid profile ( p> 0.05) of FMS patients.Conclusion: s.lipoprotein (A) may play an important role in pathogenesis of FMS patients.


Article
Carotid Intima-Media Thickness in Rheumatoid Arthritis Detected by Doppler Ultrasound

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Abstract

Background: The excess mortality associated with rheumatoid arthritis is largely due to cardiovascular disease. Rheumatoid arthritis is of primary importance in atherogenesis. The intima-media thickness of extracranial carotid arteries is a measurable index of the presence of atherosclerosis.Objective: To assess carotid intima-media thickness in rheumatoid arthritis by Doppler ultrasound.Methods: Fifty two Iraqi patients with rheumatoid arthritis were studied and compared with another fifty two, healthy individuals matched for age and sex as a control group. Full history was taken and complete clinical examination was done for all individuals in both groups. Rheumatoid arthritis diagnosis was based on The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Carotid intima-media thickness was measured by Doppler ultrasound.Results: There was a significant increase in the frequency of increased carotid intima-media thickness among individuals with rheumatoid arthritis (44.2%) compared to healthy control group (3.8%) (P=0.000001).Conclusion: Increased carotid intima-media thickness occurs in high frequency in rheumatoid arthritis.

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