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Correlation between Homocysteine and Insulin Resistance in women with Polycystic Ovarian Syndrome Referring to AL-Yarmook Teaching Hospital

Authors: Dhilal Q. Mohammed --- Hawaa AL-Dhahir --- Sabah M. Husein
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2014 Volume: 4 Issue: 2 Pages: 32-39
Publisher: Al-Nahrain University جامعة النهرين


Background:Polycystic ovarian syndrome (PCOS) is one of the most common endocrinedisorders among females in reproductive age. Women with PCOS have severalcardiovascular disease risk factors. Hyperinsulinemia and insulin resistance (IR)which is a known key factor in the development of type 2 diabetes (T2DM) mayassociate PCOS. Homocysteine, a sulfur-containing amino acid, is toxic to vascularendothelium, leads to early atherosclerosis. PCOS said to be associated with highplasma homocysteine.Objective:To determine the correlation between insulin resistance and homocysteine in PCOSpatients.Methods:Patients diagnosed as PCO according to Androgen Excess and PCOS Society/2009criteria were grouped into two groups: those with BMI less than 30kg/m2 and thosewith BMI 30kg/m2 and more. Blood was drawn for biochemical and hormonalassay. Information tabulated, means and percentages used, and the results wereanalyzed.Results: Homocysteine levels were significantly higher (P value < 0.05) in PCOSgroup (12.28±1.89 μmol/l) as compared to control (9.51±1.92 μmol/l).HOMA-IRwas significantly higher (P value < 0.05) in PCOS (4.15±2.54) as compared tocontrol (1.69±0.54) .There was no correlation between IR and homocysteine withinPCOS group.Conclusions:Polycystic ovarian patients have higher levels of homocysteine and IR compared tocontrol but there is no correlation between IR and homocysteine within PCOS group.

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