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Article
Toxoplasmosis in Iraqi Women: a Retrospective Study

Author: Hayder A. L. Mossa
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 697-701
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Toxoplasmsosis is a relatively widespread parasitic infection,caused by the protozoan toxoplasma gondii, which can affect pregnancyadversely.Objectives: To identify the cases of toxoplasmosis among pregnant women and toidentify its relation to the outcome of pregnancy.Materials and Methods: The present descriptive study of 54 female patients withtoxoplasmosis, their age ranged between 16-45 years old in the period between 2006-2007 in AL-Kadhimia Teaching hospital & IVF Institute of Embryo Researches &Infertility Treatment-AL-Nahrain University –Baghdad.Results: Pregnant woman with positive IgG and/or IgM anti-toxoplasma wasconsidered as a seropositive case. IgG have done to all women in the study, 51(94%)were positive and only 3(6%) were negative. IgM was performed to 27(50%) women,9(33%) were positive, 18(67%) were negative. Only (18%) of the positive IgG hadhistory of animal contact. IgG test was positive in 82% of women with a history ofabortion. IgG test was positive in 18% of women with a history of stillbirth.Conclusions: in conclusion the presence of IgG in the blood of women in this study isnot associated with abortion or stillbirth.

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Article
The Effect of Seasonal, Age ,Smoking and Occupational exposure status on semen parameters in Iraqi Subjects

Author: Hayder A. L. Mossa
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2010 Volume: 21 Issue: 7 Pages: 12-18
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The present descriptive study of 60 male subjects involved in this study their age ranged between 22-48 years old through the period between June 2008 till June 2009. Semen Samples were collected from the subjects in Institute of Embryo Researches & Infertility Treatment-AL-Nahrain University –Baghdad in different seasons of the year depending on their attendance to the institute, in addition to other factors involved in this study as age ,smoking status and occupational exposure.Except of the mentioned above all the factors that might be involved in the variation of the seminal fluid were excluded from this study.The study showed that the seasonal variations have an impact on the male semen parameters, the smoking & occupational exposure status have some impacts on the male semen parameters, while it did not find any relationship between age and semen parameters .

تمت دراسة 60 شخصا حضروا لمعهد أبحاث الأجنة وعلاج العقم تتراوح أعمارهم ما بين 22-48 سنة للفترة ما بين حزيران 2008- وأيار 2009 , الدراسة كانت بطريقة وصفية. جمعت عينات السائل المنوي من الأشخاص المشمولين بالدراسة وفي مختلف فصول السنة عدا الأشخاص الذين لديهم عوامل ذات صلة باختلاف عوامل السائل المنوي حيث استثنوا من هذه الدراسة . بينت الدراسة التأثير الكبير للعوامل المناخية على عوامل السائل المنوي.أما تأثير عوامل التدخين ومخاطر المهنة ,حيث أظهرت الدراسة حدوث انخفاض في نسبة الحيوانات المنوية الطبيعية وحصول تشوهات في شكل الحيوانات المنوية لدى الأشخاص الذين يمتازون بوجود هذين العاملين في هذه الدراسة,في حين لم تظهر الدراسة علاقة تقدم العمر بعوامل السائل المنوي.

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Article
A New Sperm Preparation Technique by Glass Wool Filtration Combined with Pentoxifylline Techniques versus Glass Wool Filtration alone for Infertile and Fertile Men

Authors: Ali A. Kadhim --- Hayder A. L. Mossa --- Mohammad O. Selman
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2017 Volume: 7 Issue: 1 Pages: 28-36
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

The procedures of assisted reproductive technologies have been developed during recent years and have been revealed the need for new suitable and effective techniques of sperm treatment in the laboratory.


Article
Evaluation of Anti-sperm Antibodies in Relevance to Testosterone Levels in Serum and Seminal Plasma in Infertile Men

Authors: Mohammad O. Selman --- Hayder A. L. Mossa --- Maryam H. Khaleefah
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2018 Volume: 8 Issue: 1 Pages: 22-28
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Immunological infertility is expected to be the reason of infertilityin 9-36% of the concerned twosomes. The major cause of immunologicalinfertility is the creation of anti-sperm antibodies (ASA), which influence thecapability of insemination of spermatozoa. It has been detected that anti-spermantibodies (ASA) are present either systemically in blood or locally in seminalplasma of approximately 10% of infertile male patients. Immunity to sperm cancause infertility; humoral antibodies directed against sperm did not necessarilyimpair fertility unless the circulating antibodies are also present within the reproductivetract and on the living sperm surface. Hormonal imbalance and spermautoimmunity have been considered as two systems that play in near associationand affect each other. Testosterone is the Steroid hormone necessary for the developmentand maintenance of secondary sexual characteristics as well as initiationand maintenance of Spermatogenesis .It was known that males with abnormalseminal fluids have lower concentrations of the testosterone hormone.Objectives: To study the serum & seminal plasma antisperm antibodies levels in relevance tolevels of testosterone in serum and seminal plasma accordingly to sperm function parametersin different groups of infertile patients.Subjects,Materials and Methods: Blood and semen samples were collected from (80) subjects(60) infertile patients (20Asthenozoospermic, 20 Oligozoospermic,20Azoospermic) and 20Normozoospermic subjects .The anti-sperm antibody and testosterone levels were measuredby using Enzyme Linked Immunosorbent Assay (ELISA).Results: The Antisperm antibodies were positive in serum of normozoospermic, asthenozoospermic,oligozoospermic and azoospermic men respectively are about 10%, 5%, 20%,5%and in the total group was 10% positive. The ASA in seminal plasma of normozoospermicmen, asthenozoospermic men, oligozoospermic men and azoospermic men respectively are0%, 0%, 5%, 5% and in the total groups 2.5%.These findings lead to no possibility to makeclear correlations with the studied hormones. There was significant increase (P<0.05) in thelevels of testosterone in serum and seminal plasma in comparison between normozoospermicand infertile men subgroups. There was significant decrease (P<0.05) in the levels of progesteronein serum and seminal plasma in comparison between normozoospermic men andinfertile men subgroups, the highest levels were observed in asthenozoospermic subgroup.The study showed that 10 patients (12.5%) out of 80 patients showed a positive ASA positivein serum or seminal plasma of all groups. The result was considered positive if the value was≥60 RU / ml .On these basis and regarding that screening criteria the positive ASA groupshowed the association with the low levels of testosterone in both types of the samples(serumand seminal plasma), these results was exhibited a high significant difference when comparedwith negative ASA group.Conclusion: Determination of the relevance of the levels of testosterone and anti-sperm antibodiesin the serum and seminal plasma, which in turn is important to determine the type ofinfertility especially the immunological type.


Article
Advanced Stimulatory Method for Activation of Sperm Function Parameters by using TAD Glutathione in Iraqi Infertile Men

Authors: Azher S. Hindal --- Hayder A.L.Mossa --- Muayad S.Abood
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2018 Volume: 8 Issue: 1 Pages: 38-45
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: One of the major concerns among the male reproductive health isthe inability to achieve parenthood even after regular unprotected intercourse.The efficiency of the sperm selection techniques is expressed as the concentrationof spermatozoa with normal motility. Discontinuous density gradientcentrifugation (DGC) method widely used over the last decade due to effectivenessand reproducibility in recovering most motile sperm, which separatessperm based on their motility, size, and density differential. Glutathione act asan amino acid donor during spermatogenesis. If the levels of glutathione are toolow during spermatogenesis, the number of mature and morphologically normalspermatozoa generated will be decreased.Objectives:The aim of this study was to assess the beneficial role of TAD 600mgGlutathione combined with DGC technique for activation of human sperm ofasthenozoospermic, oligozoospermic and normozoospermic subjects comparedwith the DGC technique alone.Patients, Materials and Methods:Sixty males were involved in this study, dividedinto three groups, (twenty asthenozoospermic, Twenty oligozoospermicand twenty normozoospermic subjects)during their attendance to the InfertilityClinic at High Institute for Infertility Diagnosis and Assisted Reproductive Technologies;Al- Nahrain University. Semen samples were obtained, and seminalfluid analysis was assessed. Each semen sample was divided into three parts.The first part prepared as in vitro sperm characterization before activation, thesecond part using density gradient centrifugation technique, while the last partprepared using density gradient centrifugation combined with TAD 600mg Glutathione.Results: After in vitro sperm activation for asthenozoospermic, oligozoospermicand normozoospermic samples a significant increase was observed in the spermfunction parameters including sperm concentration, motility and morphologicallynormal sperm percentage as compared to pre-activation using combined techniques(density gradient centrifugation and TAD 600mg Glutathione) as comparedto DGC technique alone.Conclusions:TAD 600mg Glutathione combined to the DGC technique was foundto give higher significant results on sperm function parameters (sperm concentration,motility and morphology) when using a low quality of semen samplessuch as decreased sperm motility as compared with DGC technique alone.


Article
Relationship of Seminal plasma Total Antioxidant Capacity (TAC) with LH and FSH Levels in Serum with Sperm Function Parameters in Different Groups of Infertile Men

Authors: Fahad D. Oleiwi --- Hayder A. L. Mossa --- Mohammad O. Selman
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2018 Volume: 8 Issue: 1 Pages: 64-69
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Oxidative stress (OS) plays a vital role in human reproduction. Itrises as a consequence of excessive reactive oxygen species (ROS) productionand/or reduced total antioxidant capacity (TAC) protection. Oxidative stress mediateddamages to the plasma membrane of the spermatozoa may account for defectivespermatozoa function parameters that are observed in a high percentageof infertile patients.Objectives: This study aimed to evaluate the relationship between level of seminalplasma TAC in relevance to luteinizing hormone (LH) and follicle stimulatinghormone (FSH) in serum with the assessment of routine spermatozoaparameters in different groups of infertile men.Subjects,Materials and Methods: Blood and semen samples were collected fromthe infertile and fertile subjects. The total number of samples were (80), the infertilemen were divided into three groups (azoospermic, oligozoospermic andasthenozoospermic) each with (20) sample, and (20) as fertile men. Then the levelsof serum hormones and seminal plasma TAC were measured using EnzymeLinked Immunosorbent Assay (ELISA).Results: The results of hormonal levels in serum showed that there were highlysignificant difference (P<0.001) in the levels of FSH and LH between controlgroup and infertile groups. In this study its appear that there were a highly significant(p<0.001) difference in the level of TAC between study groups and controlgroup which were increased among normozoospermic men and decreased amonginfertile groups. The lower limit of TAC were seen in asthenozoospermic men.The results of this study also showed that there were a relationship between TACof seminal plasma and hormonal levels, it is appear that TAC are negatively correlatedwith LH and FSH.Conclusions: From the results obtained it could be concluded that; LH and FSHhave an effect on male fertility via regulation of seminal plasma TAC. On theother hand seminal plasma TAC are negatively correlated with the number of immotilespermatozoa and positively correlated with concentration, progressivelymotile and morphologically normal spermatozoa.

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