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Article
The effectiveness of vaginal lisuride in the treatment of hyperprolactinemia

Author: Hind Abdul khaliq Nassir
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2015 Volume: 14 Issue: 1 Pages: 14-17
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: hyperprolactinemia is a disorder which may be represented clinically by one or more of the following: galactorrhea ,infertility , oligmenorrhea , amenorrhea, luteal phase defect and hirsutisim, lisuride drug was recently used vaginaly in the treatment of hyperprolactinemia to decrease the side effects by it's use orally .Patients & Methods: An interventional study conducted over a period of one year from October 2011 to October 2012 , in Al-Yarmok Teaching Hospital ,50 patients presented with one or more of the following symptoms, abnormal menstrual cycle(amenorrhea,oligmenorrhea), infertility(unovulatory), galactorrhea. All the 50 patients with elevated prolactin level were received lisuride (dopergin) 0.2 mg vaginally at bed time and continued for 12 weeks ,serum prolactin was measured at 8,12 weeks with monitoring of ovulation by serial U/S.Results: The study include fifty patients with mean age was 27.2years ±SD7.01 ,and there mean weight was 62.1kg ±SD9.08All 50 patients had elevated serum prolactin level with mean 66.1ng/ml ±SD 15.5,at the end of the treatment the range of serum prolactin level between 6-17ng/ml ± SD2.9 , which was significantly lower than pre treatment level P =0.0001 At the end of the treatment 86% achieved regular cycle , Ovulation occur in significant number of patients p value < 0.01, (37.5%) of them get pregnancy .less side effect compared to oral lisuridConclusion: Vaginal lisurid is an effective drug used for the treatment of hyperprolactinemia to avoid the discontinuation of the drug because of it's side effect, when given orally.


Article
The effect of pre-operative intravenous Cyklokapron on the amount of blood loss during and after caesarean section for anemic patients At Al Yarmouk teaching hospital in Baghdad.

Authors: Hind Abdul Khaliq --- Ban Hadi Hameed
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2016 Volume: 15 Issue: 3 Pages: 23-27
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Back ground: caesarean section carries significant morbidity and mortality over vaginal delivery. Anemia with hemorrhagic complications add significantly for this morbidity and mortality. Aim of the study: to assess the effectiveness of Cyklokapron in reducing the intra-operative blood loss at time of caesarean section and postpartum hemorrhage in anemic patients and to evaluate its safety when used prophylactically. Patients and method: A hundred pregnant women aged 19 - 41 years with term gestation were recruited in this randomized, case control, prospective therapeutic trial, which was conducted for a period of one year at Al Yarmouk teaching hospital Baghdad Iraq, the participants were admitted for caesarean section. They were divided randomly into two groups; the study group 50 patients received intravenous Cyklokapron pre-operatively and a control group matched for the indication of caesarean section, the intra-operative, post-operative blood loss and hematocrit were evaluated and compared for both groups. Results: The intra-operative blood loss was measured in both groups, the total loss was significantly lower in the study group (170.12 ± 68.4 ml) compared to the control group (420.39 ± 130.6 ml) as P value was 0.0001 Concerning the post-operative blood loss, it was comparable in both groups and blood transfusion was required for two patients in the control group because of severe anemia (hemoglobin less than 8 gmdl) with no transfusion in the study group and this difference was not significant statistically. The mean reduction in hematocrit was significantly lower in the study group compared to control group (1.52 ± 0.81%) versus (2.58±0.85%) respectively and P value was less than 0.05 Conclusion and recommendations: The current study revealed that Cyklokapron is significantly effective in reducing blood loss at time of caesarean section. We recommend further studies with higher doses and more patients to evaluate its effect in reducing the intra-operative loss and preventing postpartum hemorrhage.


Article
Predictors for Response to Letrozole as an Ovulation Induction in Anovulatory Infertile Polycystic Ovarian Syndrome Women

Authors: Fadia J Alizzi --- Hind Abdul Khaliq Showman --- Hayder A Fawzi
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2019 Volume: 9 Issue: 1 Pages: 89-110
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

To assess the predictive value of different clinical, laboratory, and ultrasound parameters in Letrozole when used as an ovulation induction in anovulatory infertile PCOS women. The current study was done in the secondary-referral infertility clinic in AL-Yarmouk teaching hospital, and Al-Mustansiriyah medical college. Sixty-seven anovulatory infertile women with the polycystic ovarian syndrome. Letrozole was given orally on day 2 or 3 of the menstrual cycle for five days and repeated for three consecutive cycles. The primary outcome measures were to evaluate the response rate in the form of successful ovulation and clinical pregnancy. The ovulation rate was (64.2%), with clomiphene naïve vs. previous clomiphene use; it was 87.5%, 51.2% respectively, while pregnancy rate was (32.8%), 41.6% with clomiphene naïve vs. 27.9% with previous clomiphene use. Clinical (age, BMI, Waist circumference, cycle length and days between cycle, infertility period and type, previous reproductive outcome, androgen symptom and m-FG score), laboratory (E2, FSH, LH, testosterone, FAI, FBS, fasting insulin, HOMA – IR, and AMH) and ultrasound (mean ovarian volume, mean AFC and antral follicular diameter) parameters were founded to affect ovulation and pregnancy in different extent. After putting all variables in a scoring system, it was found that if the patients had > 26 points for the score, it's more likely that the woman becomes pregnant. A predictive pregnancy score was developed from basic clinical, laboratory, and ultrasound parameters. It may help the clinician to individualized ovulation induction protocol in PCOS women; however, external validation of this system is recommended in a more extensive prospective study.

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