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Reporting Fine Needle Aspiration Cytopathology (FNAC) of Thyroid Lesion Per Guidelines of Recent Bethesda System For Reporting Thyroid Cytopathology Markedly Reduces Number of Un Necessary Thyroidectomies

Authors: Hussain Abady Aljebori --- Basim Shehab Ahmed --- Hiba Ahmed Gaidan
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 2 Pages: 309 -316
Publisher: Babylon University جامعة بابل

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Abstract

Estimation of accuracy of fine needle aspiration cytopathology (FNAC) of thyroid in diagnosis of different thyroid lesions, and evaluation of the value of reporting FNAC per guidelines of Bethesda system in reducing the number of un necessary thyroidectomies. This is a case control prospective study conducted on 221 patients with thyroid nodule[s]. Patient were recruited to Cytopathology Department, Al-Yarmouk Teaching Hospital in the period from January 2014 to March 2017. Results of FNAC were reported per recent Bethesda System for Reporting of Thyroid Cytopathology (TBSRTC). Final diagnoses were determined by histopathology of surgically removed thyroid tissues. Females were more than males with a ratio of 5.31/1, median age was 45.67±3.1 years. Twelve of cases (5.43%) categorized as nondiagnostic/ unsatisfactory samples, 128 (57.92%) as benign, and 29 (13.13%) as atypia of undetermined significance/atypical follicular lesion of undetermined significance (AUS/AFLUS), 34 (15.38%) as follicular neoplasm/suspected follicular neoplasm (FN/SFN), 5 (2.26%) as suspicious for malignancy, and 13 cases (5.88%) as malignant. Histopathology found 2 cases from cytopathological benign category, 7 from AUS/AFLUS, 11 from FN/SFN, 3 from SFM, and twelve from malignantcategory to be malignant. FNAC achieved a sensitivity of 85.71%, specificity of 99.21%, positive predictive value of 92.31%, negative predictive value of 98.44%, and total accuracy of 97.87%. Reporting thyroid cytopathology per Bethesda system increases sensitivity, specificity, accuracy of thyroid cytopathology, increases understanding of reporting system by clinician, improves management plans, and reducing number of un necessary thyroidectomies.


Article
Evaluation of Protective Activity of Curcumin in Reducing Methotrexate Induced Liver Cells Injury: An Experimental Study on Iraqi White Domestic Rabbits

Authors: Hussain Abady Aljebori --- Ali H Abady --- Isra’a Mahdi
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2018 Volume: 26 Issue: 5 Pages: 145-157
Publisher: Babylon University جامعة بابل

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Abstract

Background: Hepatotoxicity is a common problem in medical practice, most of the commonly used drugs are potentially hepatotoxic. Although Methotrexate is a hepa- toxic drug, it is widely used in the treatment of many cancerous and non-cancerous conditions because of its cytotoxic and immunosuppressant activity. Curcumin con- tains a variety of natural substances with antioxidant properties, it is widely used in folk medicine.Antioxidant activity of Curcumin can reduce liver cell injury induced by Methotrexateadministration.Objective: The research aims to study the methotrexate hepatoxicity on rabbits, and the hepatoprotective activity of Curcumin.Materials and Methods: Thirty white domestic rabbits were bought from animal market and grouped randomly into three groups; control group received intraperitoneal normal saline, methotrexate group received 6.5 mg/Kgm body weight intraperitoneal methotrexate, and curcumin group received oral Curcumin in addition to intraperitoneal methotrexate.Results: The study showed abnormal liver function tests, INR, liver tissues oxida- tive markers, and liver cell injury on histopathology in Methotrexate group, and normal findings in Curcumin groups.Conclusion: It is concluded that the Methotrexate is a hepatotoxic drug. The results also shoe that the concomitant administration of Curcumin reduced hepatotoxicity.Recommendation: It is recommended to use of Curcumin in clinical practice as a food supplement to patient receiving methotrexate to reduce hepatotoxicity.

المقدمة: إصابات خلايا الكبد والخلل في وظائفةمنالمشاكل الشائعة في الممارسات الطبية. معظم العقاقير شائعة الاستخدام من الممكن ان تؤدي الى التهاب الكبد او خلل في وظائفة، مثلا المضادات الحيوية، مسكنات الالم مثل الباراسيتامول وغيرة، الأدوية المضادة للسرطان، تناول الكحول، والمواد الكيميائية السامة الأخرى المستخدمة في الصناعة. على الرغم من أن الميثوتريكسيت هو عامل فعال مضاد للسرطان، فهو كذلك يستخدم على نطاق واسع في علاج العديد من الحالات غير السرطانية كالأمراض الجلدية والروماتيزملانة مضاد للمناعة. الكركميحتوي على مجموعة متنوعة من المواد الطبيعية مع خصائص مضادة للأكسدة قوية وفعالة في مكافحة الإجهاد التأكسدي الناجم عن تناول الميثوتريكسيت. الهدف من الدراسة: أولا لمعرفة تأثير دواء الميثوتريكست على انسجة الكبد، وثانيا دراسة النشاط الوقائي لمادة الكركم في الحد من تاثير هذا الدواء على انسجة الكبد.المواد والطرق: تمت الدراسة على الارانب البيضاء العراقية وقد تم فصل الحيوانات عشوائيا إلى ثلاث مجموعات. مجموعة السيطرة، مجموعة ميثوتريكسيت، ومجموعة الكركم.النتائج: أثبتت نتائج مستويات البيليروبينوإنزيمات الكبد في مصل الدم والفحوصات النسيجية على انسجة الكبد عن التهاب الكبد الحاد نتيجة تأثير علاج الميثوتريكسيت، وتشير البتائج عن توليد الأكسجين التفاعلي (روس)، ونقص في آليات الدفاع المضادللأكسدة.الاستنتاج: أثبتت الدراسة ان لمادة الكركم تأثير مضاد للاكسدة وباستطاعتة التقليل من التاثيرات الجانبية لدواء الميثوتريكسيت على انسجة الكبد.التوصية: توصي الدراسة باستخدام مادة الكركم في الممارسة السريرية وخاصة للمرض الذين يستخدمون العلاجات الكيمياويةكونة مكمل غذائي وكونةمادة طبيعية ومضاد قوي للاكسدة.


Article
Bronchial wash miR-21 as a potential biomarker for non-small cell lung cancer

Authors: Hussain Abady Aljebori --- Ban A. Abdulmajeed --- Adnan Aljubori
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 39-60
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Lung cancer is one of the major health problems all over the world. Most ofcases are discovered at advanced stages because of late appearance of symptoms and the lackof efficient and effective methods for early diagnosis and screening of high risk groups. ThemicroRNA-21(miR-21) was stably present and reliably measurable in all samples of bronchialwash whether positive or negative (control) for lung cancer.Objectives: to evaluate the expressions of the miRNA-21 as a minimally invasive diagnosticbiomarker for non-small cell lung cancer (NSCLC).Results: Relative quantification of miR-21 gene showed overexpression in samples positivefor NSCLC (non-small cell lung cancer) and ROC study yielding 85% sensitivity and 98%specificity in distinguishing NSCLC patients from controls with p-value < 0.05.Conclusion: altered expressions of the miR-21 in samples of bronchial wash may provide apotential biomarker for detection of non-small cell lung cancer.


Article
Accuracy of Perineal Percutaneous Fine Needle Aspiration Cytology (FNAC) of Prostate under Ultra- Sound in Comparism with Transrectal Aspiration in Diagnosis of Prostatic Cancer

Authors: Hussain Abady Aljebori --- Hiba Ahmed Gaidan --- Suhaila Sleem Kareem
Journal: Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية ISSN: 20786123 Year: 2017 Volume: 10 Issue: 2 Pages: 196-203
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Prostatic carcinoma is the commonest internal malignancy of adult males. Patients usually presenting withvoiding symptoms. Clinical suspicion of prostatic carcinoma depends on finding of one or more of the followings; hard prostaticnodule(s) on digital rectal examination (DRE), hypoechoic lesion on transrectal ultrasonography (TRUS), and/or highserum level of prostatic specific antigen (PSA). Final diagnosis depends on FNAC and/or histopathology. Objective: This is acase control prospective study designed to evaluate the usefulness of FNAC of prostate through perineal skin under ultrasoundinstead of transrectal aspiration in diagnosis of suspicious prostatic conditions.Patients and Methods: One hundred and ten males with voiding symptoms and clinical suspicion of prostatic carcinoma wereparticipated in the study. Their ages were between 45 and 92 years. The aspiration was carried out as outpatient procedure.Results: Cytopathological results were; 64 (58.18%) positive, 4 (3.64%) suspicious, and 40 (36.36%) negative for prostaticcancer. Two specimens (1.82%) were inadequate for proper cytopathology. Results of histopathological examination of resectedspecimens from the same patients was very close to that of cytopathology with only two false positive and one falsenegative results. There was no any mentioned complication following aspiration, and sensitivity, specificity, and accuracywere 98%, 95%, and 91.81% respectively, and all results were statistically significant with p-values <0.05.Conclusion: Percutaneous perineal FNAC of prostate under ultrasound is a safe, reliable, cost effective, and as accurate astransrectal FNAC in diagnosis of prostatic cancer.

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