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Synthesis and Charactrization of some Hetrocyclic Compounds from Ninhydrin and Study of its Effect on Amylase Enzyme in Serum

Author: Ibtihal Q. Abdalla ابتهال قحطان عبد الله
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2018 Volume: 6 Issue: 1 Pages: 44-51
Publisher: Tikrit University جامعة تكريت

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Abstract

Ninhydrin is a chemical compound that is commonly used in analytical chemistry. In this research, ninhydrin was utilized to prepare some heterocyclic derivatives. It was reacted with hydrazine to make compound (1), which was the starting material to synthesize other heterocyclic derivatives in this research. These compounds were characterized by (FT-IR) and (H-NMR) techniques. The biological effect of the prepared compounds were tested against the activity of amylase enzyme in serum. These compounds resulted in deactivating the amylase enzyme in a percentage rate of (11.43, 36.49) %, which proves their effectiveness against the enzyme.

Keywords

hetrocyclic --- ninhydrin --- amalysis --- enzyme

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