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Article
Combination of atorvastatin and fenofibrate altered androgenic activities of male rats

Authors: Kawa F. Dizaye --- Sundus Rashad Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2019 Volume: 23 Issue: 2 Pages: 273-282
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Many drugs and chemical substances may induce sexual dysfunction and have a negative impact on male fertility. Lipid-lowering agents like statins and fibrates are usually recommended for cardiovascular diseases prevention. However, the combination of atorvastatin and fenofibrate is the subject of questions concerning their effect on androgenic activities in this study. This study was designed to evaluate the efficacy and toxicity of atorvastatin, fenofibrate, and their combination on sperm parameters, sexual hormones, and histopathology of the testis. Methods: Twenty-four male rats were divided into four groups, each of six. The first group served as a control. The second, third, and fourth groups received atorvastatin, fenofibrate, and their combination, respectively. After 28 days, blood samples were collected for hormones and other parameters evaluations. Testis and epididymis were taken for histopathology studies and sperm parameters assessments.Results: Fenofibrate showed a significant reduction in sperm viability and serum levels of luteinizing and estradiol hormones. The combination of both drugs significantly reduced the sperm count and viability in normal male rats. Both atorvastatin and its combination mildly changed the histological structures of the testis, reduced number of spermatozoa, and arrested spermatogenesis.Conclusion: The findings from this prospective study suggested that there was no harmful effect of atorvastatin usage on conventional sperm parameters and sexual hormones. Fenofibrate usage was not adversely associated with sperm parameters other than sperm viability. The combination of atorvastatin and fenofibrate significantly reduced the sperm count and viability. No deleterious effects of the drugs were seen on the testosterone, which was the essential hormone for all stages of spermatogenesis, sperm production, maturation, and transport.


Article
Effects of Olanazapine and Haloperidol on Serum Malondialdehyde, Prolactin Level, Blood Glucose and Lipid Profile in Schizophrenic Patients
آثار أولانازابين وهالوبيريدول على مصل Malondialdehyde ، مستوى البرولاكتين ، نسبة الجلوكوز في الدم والدهون في مرضى الفصام

Authors: Sirwan Kamil Ali --- Muhammad A. Hassan --- Kawa F. Dizaye
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 13-21
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: The association of the atypical antipsychotics with hypergly-cemia, elevated lipids, and weight gain was recognized soon after the introduction of clozapine and has become of increased concern as the use and uses of atypical antipsy-chotics have been expanded. The aim of the present study was to investigate the preva-lence of diabetes, dyslipidaemia, lipid peroxidation and hyperprolactinemia in Olanzepine treated patients in comparison with patients treated with haloperidol.Methods: Fifty patients were selected randomly from psychiatric inpatient clinic in Erbil city in Iraqi Kurdistan Region between November 2007 and June 2008.All patients were diagnosed as schizophrenia, and none of them were in acute severe state. Thirty Schizophrenic patients received Haloperidol orally as typical antipsychotic and 20 patients received Olanazapine orally as atypical antipsychotic for a minimum of one month. Fasting blood samples for the assessment of serum malondialdehyde (MDA), lipid profile, fasting blood glucose (FBG) and prolactin levels were obtained after one month of the drug prescribing time. From those fifty patients, 16 patients were selected to follow them prospectively over a mean period of time of 112 days for olanzapine and 75 days for haloperidol. The prospective study includes FBG, lipid profile, BMI and serum MDA.Results: The prevalence of hyperprolactinaemia and lipid peroxidation was higher in Haloperidol treated patients. Whereas, the prevalence of diabetes and dyslipidaemia were higher in Olanazapine treated patients, The mean level of BMI of the Olanazapine group was significantly higher than BMI of the Haloperidol group. There was 6.66 % prevalence of DM in Olanazapine treated patients, but there was no prevalence of DM in Haloperidol treated patients. There was no incidence of diabetes mellitus in the prospective study for both Haloperidol and Olanazapine treated patients.Conclusions:No absolute evidence indicates that the atypical antipsychotic Olanazapine is the cause of diabetes, since the glucose levels of all patients were within normal range and there was no incidence of diabetes in the prospective study in spite of their higher weight and body mass index.


Article
Cardiovascular effects of vitexin isolated from Prosopis farcta

Authors: Dr. All Al-jeboory علي الجبوري --- Dr. Kawa F. Dizaye كاوة
Journal: Iraqi Journal of Pharmacy المجلة العراقية للصيدلة ISSN: 16802594 Year: 2006 Volume: 6 Issue: 1 Pages: 14-19
Publisher: Mosul University جامعة الموصل

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Abstract

Vitexin was isolated and identified from fruit of Prosopis farcta (Iraqi indigenous). Cardiovascular actions of vitexin were studied in vitro and in vivo. Vitexin produced a positive inotropic effect on isolated atrium of the rabbit which was not related to Beta 1 adrenergic receptor activation. Vitexin had no vasodilator activity nor it could reverse the vasoconstrictor responses of the isolated pulmonary artery of the rabbit to potassium chloride and phenylephrine.vitexin has produced a significant increase in urine flow and urinary sodium and potassium excretions in healthy and mild hypertensive volunteers and in rabbit. Moreover, vitexin significantly reduced mean arterial blood pressure of the mild hypertensive volunteers and rabbits. This hypotensive effect of vitexin is not related to a direct vasodilatation or to blocking alpha and Beta adrenergic receptors. The most likely mechanism of action of vitexin as a hypotensive compound is through its diuretic effects.

استخلصت وعينت هوية مادة الفتكسن(vitexin) من ثمرة نبات prosopis facta (عراقية المنشا) . ولقد درست التاثيرات القلبية الوعائية لهذه المادة في الزجاج وفي الجسم الحي . وكان تاثير مادة الفتكسين ايجابيا على انقباض عضلة القلب . وهذا التاثير ليس له علاقة بتحفيز مستقبل بتا 1 (B1) الادريناليني ولم يكن هناك تاثير موسع للشريان التنفسي لمادة الفتكسين ولم تعكس مادة الفتكسين الاستجابة الانقباضية للشريان التنفسي لكل من مادة كلوريد البوتاسيوم ومادة الفنيسل فرين . سببت مادة الفنتكسين زيادة في سرعة جريان البول وطرح الصوديوم والبوتاسيوم في المتطوعين الاصحاء والمرضى المصابين بفرط الدمالشرياني وكذلك في الارانب . قد يكون سبب هذه التاثيرات هو تثبيط نقل الصوديوم والبوتاسيوم في القنوات القاصية في الكلية . بالاضافة الى ذلك , قللت مادة الفتكسين معنويا ضغط الدم في المرضى المصابين بفرط الدم الشرياني المتوسط كذلك في الارانب ولم يكن التاثير المنخفض لفرط الدم الشرياني بسبب التاثير المباشر على الاوعية الدموية او نتيجة غلق مستقبلالت الفا (a) او بيتا والاكثر احتمالية كان التاثير المنخفض لفرط الدم الشرياني من خلال التاثير المدرر .

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