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Article
Local Expression of MMP-7 in Oral Cancer

Author: Manal A. Habib منال حبيب
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2011 Volume: 7 Issue: 1 Pages: 14-17
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Squamous cell carcinoma of the oralcavity (OSCC) is a highly invasive neoplasm. ManyMMPs play role in human cancer invasion andmetastases.Aim: Estimating The MMp-7 expression level inHPV-16 positive and HPV-16 negative OSCCparaffin embedded sections.Method: Biopsies from thirty three patients with oralsquamous cell carcinoma (OSCC) were obtained andinvestigated for the presence of HPV-16 RNA withthe application of ISH and the MMP-7 expressionlevel using IHC .Results: Expression level of MMP-7 found to be highin OSCC sections 29 (87.8%) cases with nosignificant difference in its expression level betweenHPV-16 positive and HPV-16 negative OSCC casesp= 1.00.Conclusion: MMp-7 found to be expressed in highlevel in OSCC with no significant relevance to HPV-16.


Article
The possible role of EBV in carcinogenesis of colorectal carcinoma

Author: Manal A. habib منال حبيب
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 2 Pages: 174-176
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Except for the tight correlation to nasopharyngeal carcinoma, accumulating evidences show that Epstein-Barr virus (EBV) is correlated to other carcinomas. This study was to investigate the association of EBV with colorectal tumors.Materials & methods: Forty paraffin embedded blocks of colorectal tumors (thirty were adenocarcinoma and ten were benign tumors) were all examined for the presence of EBV DNA with the application of In Situ hybridization.Results: In Situ EBV DNA signals was detected in 6 out of 30 (20%) of colorectal carcinoma with no observed signals in the sections from benign group.Conclusion: Our results showed that infection of EBV exists in human colorectal adenocarcinoma, which indicates that EBV may be involved in the carcinogenesis process.Key words: EBV, In Situ Hybridization, colorectal tumors.

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