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Article
Cytotoxicity of 1, 2-Dihydroxybenzene Towards Hep-2 and AMGM5 Cancer Cell Lines in Presence of SuperOxidase Dismutase and Peroxidase .

Author: Marwa I. Salman
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 2 Pages: 74-80
Publisher: Baghdad University جامعة بغداد

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Abstract

The cytotoxic effect of 1,2-Dihydroxybenzene(catechol) was studied in human cancer cell lines, Epidermoid larynx carcinoma (Hep-2) and Cerebral glioblastoma multiforme (AMGM5), catechol undergo autoxidizes in physiological buffer to quinones. The results showed that catechol has a fatal effect to these cells after 72h of exposure .This toxicity was connected to the creation of quinones. There was a noticeable defeat of cell viability in a dose reliant manner in both cell type. Cytotoxicity was vetoed by the adding of 100ul SOD, while the addion of 500 ul POD or SOD combined with POD did not upturn the inhibition encouraged by SOD alone in both cells type.

Keywords

AMGM5 --- Hep-2 --- SOD --- 1 --- 2-dihydroxybenzen.


Article
Cytotoxicity of Silver Nanoparticles Synthesized With the Assistant of Microwave
سمية جزيئات الفضة النانوية المصنعة باستخدام المايكرويف

Authors: Marwa I Salman Marwa_i_salman@yahoo.com --- Israa Al-Ogaidi Israaalizaidan@yahoo.com --- Maryam I Salman i_maryam15@yahoo.com
Journal: Journal of university of Anbar for Pure science مجلة جامعة الانبار للعلوم الصرفة ISSN: ISSN: 19918941 Year: 2018 Volume: 12 Issue: 2 Pages: 1-7
Publisher: University of Anbar جامعة الانبار

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Abstract

Silver nanoparticles (AgNPs) are broadly designed for various application. In the current research silver nanoparticles (AgNPs) have been examined for their poisonous outcome on human lymphocyte and chicken embryo fibroblast cell line. AgNPs were synthesized by a simple and easy method from AgNO3 solution with glucose exposed to microwave radiation. The typical size of AgNPs were 30 nm with spherical shape. The cells which cultured with diverse concentrations of silver were examined for their viability using MTT assess, a photometric technique to conclude cell metabolism. The results show that the cell viability of the both cell type were diminished significantly (P<0.05) in dosage dependent mode, and the silver nanoparticles presented higher cytotoxicity to CEF than to human lymphocyte at the same concentration and time point.

تستخدم جزيئات الفضة النانوية في تطبيقات عديدة تم دراسة التأثير السمي لجزيئات الفضة النانوية على نوعين من الخلايا الطبيعية وهي خلايا اللمفاوية للإنسان وخلايا جنين الدجاج المولدة للالياف. صنعت جزيئات الفضة النانوية بحجم 30 نانوميتر وبشكل كروي وبطريقة بسيطة باستعمال محلول من نترات الفضة والكلوكوز المعرض للمايكروويف. تم دراسة نسبة بقاء الخلايا المعاملة بتراكيز مختلفة من جزيئات االفضة النانوية باستخدام طريقة الــــ MTT وهي عبارة عن طريقة طيفية لقياس ايض الخلايا. اظهرت النتائج ان نسبة بقاء الخلايا لكلا النوعين تقل وبصورة معنوية كلما زاد تركيز جزيئات الفضة النانوية (P<0.05), كما اتضح ان التأثير السمي لجزيئات الفضة النانوية هو أعلى معنوياً (P<0.05) على خلايا المولدة للالياف لجنين الدجاج مقارنة بالخلايا اللمفاوية للانسان.

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