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Article
Mitotic activity of cultured human lymphocytes treated with gold nanoparticles

Authors: Sumaiah I. Hussein --- Yahya D. Saihood --- Ayda M. Majeed --- Heba F. Hassan --- et al.
Journal: Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية ISSN: 20786123 Year: 2017 Volume: 10 Issue: 2 Pages: 212-215
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Potential health and environmental effects of nanoparticles need to be thoroughly assessed before their widespread commercialization.The present investigation was planned with the aims to determine the effects of gold nanoparticles (GNPs) onblast (BI) and mitotic (MI) indices of cultured lymphocytes. The results revealed that BI (50.3 ± 2.3, 30.2 ± 1.9, 10.5 ± 0.7 and0.0%, respectively) and MI (70.1 ± 2.9, 20.4 ± 1.1, 5.3 ± 0.1 and 0.0%, respectively) showed a gradual decreased percentageas the concentration of GNPs was increased from 0.085 to 0.66 μg/mL, and the difference was significant compared to controlculture (81.6 ± 2.5 and 90.2 ± 3.7%, respectively). A maximum inhibition of BI and MI was occurred at the concentration 0.66μg/mL. In conclusion, GNPs can be considered as a growth inhibiting agent, but it is too early to reach a final conclusion inthis regard and further investigations are required to elucidate the biochemical mechanisms involved in inhibiting the mitoticactivity of lymphocytes.


Article
Demographic Factors Influencing Hepatitis B infection towards Bad Prognosis in a Sample of Iraqi Patients
العوامل الديموغرافية المؤثرة في مرض التهاب الكبد الفيروسي البائي باتجاه المآل السيئ في عينة من المرضى العراقيين

Authors: Maysaa K. AL-Malkey ميـساء كاظـم المالكي --- Lina Talal لينا طلال --- Istabreq Abudel Al-Hadi استبرق عبد الهادي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2008 Volume: 21 Issue: 1 Pages: 24-29
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: This study was design to identify the predisposing factors affecting patients with hepatitis B towards chronic infection and bad prognosis such as chronic liver disease, liver cirrhosis and death. Patients & Methods: Data were collected from records of Digestive System and Liver Diseases Teaching Hospital in Baghdad about patients infected with HBV as well as basic demographic data, statistical analysis was performed using Chi-square test.Results: The infection rate was increased from 3% in 2001 to 35% in 2004 but the case-fatality rate was decreased from 40% in 2001 to 22% in 2004. The chronic liver disease recorded 72.5% and the liver cirrhosis recorded 5.5%.Conclusion: The early diagnosis of the disease and presence of medical professionals (gastroenterologists and hematologists) lead to minimize further bad prognosis which result in minimizing the deaths of patients in spite of increasing the rate of the disease in the few past years. Key words: HBV, chronic liver disease, liver cirrhosis, bad prognosis

الهدف : تهدف الدراسة للتعرف على العوامل الديموغرافية المؤثرة على المرضى المصابين بالتهاب الكبد الفيروسي البائي باتجاه المآل السيئ نحو الإصابة بالتهاب الكبد المزمن وتشمع الكبد والموت.طريقة العمل : تم جمع البيانات الخاصة حول المرضى المصابين بالتهاب الكبد الفيروسي البائي من مستشفى الجهاز الهضمي وأمراض الكبد التعليمي في بغداد بالإضافة إلى جمع المعلومات السكانية وتم تحليل هذه البيانات إحصائيا باستخدام Chi - square test .النتائج : أن معدل الإصابة أزداد من 3% في سنة 2001 إلى 35% في سنة 2004 ولكن نسبة الوفيات سجلت انخفاضاً من 40% في سنة 2001 على 22% في سنة 2004. سجل مرض التهاب الكبد المزمن نسبة 72.5% وسجل مرض تشمع الكبد نسبة 5.5%. الاستنتاجات : أن التشخيص المبكر للمرض ووجود أطباء متخصصين قلل من المآل السيئ للمرض وبالتالي قلل نسبة الوفيات بالرغم من ازدياد المرض خلال السنوات الماضية.


Article
HUMAN PAPILLOMA VIRUS TYPES 16 AND 18 IN A SAMPLE OF IRAQIS PATIENTS PRESENTED WITH ORAL CANCER

Authors: Maysaa K Al-Malkey ميساء كاظم المالكي --- Ahmed A.H. Abbas احمد عبد الحسن عباس --- Nahi Y. Yaseen
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 2 Pages: 174-181
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Oral squamous cell carcinoma is the most common malignant neoplasm of oral mucosa. Human papilloma (HPV) virus cause a broad scope of diseases from benign to invasive tumors, types 16 and 18 classified as carcinogenic to humans.Objective:To assess the occurrence rate of human papilloma virus genotypes in oral cancer patients and their association with various risk factors. Methods:Fifty five (55) unstimulated whole saliva samples were collected from 35 histopathologically confirmed patients with oral cancer and 20 apparently healthy subjects were enrolled in this study. Genomic DNA was extracted from exfoliate cells to amplify HPV-DNA using HPV-L1 gene sequence primers by polymerase chain reaction method, the viral genotyping was performed using direct sequencing method. Results:The mean age of patients group was 52.23±13.73 years, while in healthy subjects group was (50.55±12.5) years. Risk of smoking was highly significant with odds ratio 60.79 and a 95% confidence interval of 3.40-1086.71. However, the risk of alcoholism was significant with odds ratio 27.77 and a 95% confidence interval of 1.51-511.27. Forty-six percent (16/35) of oral cancer patients were positive for detection of HPV-DNA (P < 0.0002). The most frequent HPV genotypes in patients group was HPV-18 accounting for (31%) of cases (P < 0.05). The rate of HPV was significantly higher among younger ages (< 50 years) with P = 0.042. In addition, the rate of HPV was higher with other variables (male, tongue tissue, grade I differentiation, squamous cell carcinoma) with no significant association (P = 0.273, P = 0.739, P = 0.173, and P = 0.700 respectively).Conclusion:Human papilloma virus types 16 and 18 may be a risk factor for oral cancer independent of alcohol and tobacco. Keywords: OC, HPV, OSCC, PCR, Direct sequencing

Keywords

OC --- HPV --- OSCC --- PCR --- Direct sequencing

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