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Article
MicroRNA 210 expression profile from human placentas of preeclamptic

Author: Miami A. Ali FICOG
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 2 Pages: 29-33
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Pre-eclampsia (PE) is a common pregnancy specificsyndrome that is characterized by hypertension and proteinuria.Evidence shows that pre-eclampsia is associated with alterations inplacental microRNA expression. Aims: The purpose of this study was tocompare the expression of the microRNA 210 in placentas from preeclampticpregnancies versus normal placentas.Patients and Methods: The study was carried out in the department ofGynecology and Obstetrics at Al-Yarmouk Teaching Hospital for theperiod from December 2009 to December 2010. Hundred pregnantwomen of age ranging from fifteen to forty years old, their gestationalage ranging between twenty nine to forty weeks were divided into threegroups: first group: mild Pre-eclampsia (twenty), second group: severepre-eclampsia (thirty) & third group (fifty) normotensive pregnantwomen of comparable gestation were taken as a control . After deliverythe Placentas from all patients (the study and the control groups) wereobtained and studied for the microRNA 210 expression which wasassessed by microRNA microarray and real-time reverse transcriptasepolymerasechain reaction analysis.Results: MicroRNA 210 was over expressed in the placentas of preeclampticpregnancies compared with normal placentas. In mild preeclampsiagroup the mean micro RNA-210 activity was 1.68±0.25, insevere pre-eclampsia group the mean microRNA-210 activity was1.89±0.13 and for the control group the mean microRNA-210 activity was0.99±015. There was highly statistical significance in microRNA-210activity of the studied groups since the P value for the mild preeclampsiaversus the control was 0.0001. For the severe pre-eclampsiaversus the control it was 0.0001 and for the severe pre-eclampsia versusmild pre-eclampsia was 0.0001.Conclusions: The results showed that microRNA 210 was over expressedin pre-eclamptic pregnancies (mild and severe), which suggests itsinvolvement in the pathogenesis of pre-eclampsia.

Keywords

MicroRNA --- Placenta --- Pre-eclampsia


Article
The Correlation Between Lipid Profiles and Macrosomia in Diabetic Pregnancies

Author: Miami A. Ali,
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2013 Volume: 12 Issue: 2 Pages: 40-44
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Maternal diabetes is an important risk factor for development of fetal macrosomia. Studies showed that elevated lipid profile levels in third trimester of the diabetic pregnant women may predict the macrosomia of the newborn babies. Objective: To assess the relationship of elevated lipid profile levels in third trimester with the occurrence of macrosomia in diabetic pregnant women. Study design: A case control study. Setting: Carried out at AL- Yarmouk Teaching Hospital/ Department of Obstetrics and Gynecology for one year from March 2011 to March 2012. Patients and Methods: A hundred pregnant women were enrolled in this study. Fifty women with diabetes mellitus (twenty six women with gestational diabetes mellitus, sixteen women had type 1diabetes mellitus, and eight women had type 2diabetes mellitus) and fifty healthy pregnant women taken as a control. Both groups were in the third trimester. The two groups were comparable for maternal age, gestational age, parity and body mass index. Blood samples were taken for measurement of serum lipid and sugar profile from both groups and correlated with the occurrence of macrosomia. Results: There were a significant and direct correlation between macrosomia and total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein cholesterols in diabetic groups (Gestational diabetes , type 1& type 2 DM ) in comparison to the control group (p=0.0275, 0.0001, 0.031, 0.0001). There was a significant inverse correlation between macrosomia and high density lipoprotein cholesterol in diabetic group in comparison to the control group (p=0.043). Conclusion: Macrosomia in newborns of diabetic pregnant women is associated significantly with maternal dyslipidemia during the third trimester of pregnancy


Article
Maternal &umbilical cord plasma homocysteine concentrations in pre-eclamptic pregnancy

Author: Miami A. Ali
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2014 Volume: 13 Issue: 1 Pages: 8-13
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Back ground: Serum concentrations of homocysteine decrease during normotensive pregnancy, but increases in pre-eclampsia like some other pregnancy complications. Hyperhomocysteinemia has been hypothesized to be associated with placental micro vascularization disease. Objectives: To evaluate the concentration of maternal &umbilical homocysteine in pre-eclamptic women in comparison with that of normotensive pregnant women. Study design: A case control study. Setting: Department of Gynecology and Obstetrics at Al-Yarmouk Teaching Hospital for a period of one year from April 2010 to April 2011. Patients & methods: Hundred singleton pregnant women with gestational age between 37 to 40 weeks were divided into two groups: (Study group): 50 pregnant patients with pre-eclampsia , 30 of them presented with severe pre-eclampsia and 20 presented with mild pre-eclampsia were compared to ( control group ) which include 50 normotensive pregnant patients. Bloods was collected from women in both groups, serum homocysteine and cord blood homocysteine were measured in patient with pre-eclampsia and were compared with that of normotensive patient. Results:Mean maternal serum homocysteine level in comparison between the study & the control groups was highly significant as the P value was (0.0001).Mean umbilical homocysteine level in comparison between the study & the control groups was highly significant as P value was (0.0001).Maternal homocysteine levels were found to have a significant strong direct correlation with the umbilical homocysteine in the severe pre-eclampsia since the r value was (0.808) while in the mild and the control groups, they were moderately correlated as the r value was (0.536,0.526) respectively. Conclusion :This study has shown a significant increase in homocystein concentration in maternal and umbilical cord blood of the fetuses in pre- eclamptic women compared with the values obtained from women of normal pregnancy.


Article
The Corellation Between the Clinical Diagnosis & Histopathological Findings of Placental Abruption

Authors: Miami A. Ali, --- Thaeer Jawad
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 3 Pages: 329-334
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND:The diagnosis of placental abruption is mostly clinical, histopathological diagnosis is poorlysensitive. Acute and chronic inflammatory processes had been proposed to cause placentalabruption evidences that supports this remains sparse OBJECTIVE: To assess the correlation between the clinical diagnosis and histopathological findings ofplacental abruption and to examine the profile of chronic and acute histological lesions associatedwith clinical abruption. PATIENTS AND METHOD: The study included fifty singleton pregnant women with a suspected clinical diagnosis of placental abruption compared to fifty consecutive normal pregnancies ( control group), attendingAL -Yarmouk Teaching Hospital over a period of twelve months, from the first of April 2010 tothe end of march 2011 . Examination of the concordance between clinical indicators for placentalabruption with those of a histological diagnosis was done. The profile of acute and chroniclesions was also examined histopathologically. RESULTS: Among the fifty clinically diagnosed placental abruption cases , thirteen percent (fifteen patients)were confirmed as placental abruption based on gross and histological findings . The mostcommon indication leading to a clinical diagnosis of abruption was evidence of retroplacentalclot(s) or bleeding . Acute lesions that were associated with abruption with confirmed pathologyincluded chorioamnionitis , and chorionic villous hemorrhage . Among the chronic lesions,chronic deciduitis, decidul vasculopathy, & dysmaturation were associated with pathologicallyconfirmed placental abruption. CONCLUSION: The relation between clinical & histological diagnosis of placental abruption remains weak. Acute and chronic histological lesions were observed more frequently in placentas of pregnanciescomplicated by placental abruption than the control cases


Article
Comparison of Measurement of 24-Hour Urine Protein Excretion Versus Random Urine Protein-Creatinine Ratio in Pregnant Woman with Pre-eclampsia

Authors: Miami A. Ali --- Manal Madany A. Qader --- **, Manal Jasim
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 3 Pages: 313-319
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACK GROUND: Measurement of protein excretion in a 24-hour urine collection has been the long-standing gold-standard but time consuming test for the quantitative evaluation of proteinuria induced by preeclampsia. An alternative method is the measurement of protein- creatinine ratio in a spot urine sample, which provides a more convenient and rapid method to assess protein excretion.OBJECTIVE:To assess the correlation between the spot urine protein- creatinine ratio and 24-hour urine protein excretion in women with preeclampsia and to use the urine protein- creatinine ratio as alternative to time-consuming 24-hour urine protein collection. Study design: A cross sectional study.Setting: Department of Obstetrics and Gynecology at Al-Yarmouk Teaching Hospital for a period of one year from Jan. 2013 to Jan. 2014PATIENTSAND METHODS:Eighty three singleton pregnant women suffering from pre-eclampsia with gestational age between 28 to 39 weeks were selected to participate in the study. They were divided into two groups: 61pregnant women with mild to moderate pre-eclampsia and 22 with severe pre-eclampsia.These women were prospectively studied for proteinuria. Urine protein- creatinine ratio was determined in a spot mid-stream urine sample, and the amount of protein excretion was measured in 24-hour urine collected on the subsequent day. The correlation between the two tests was assessed.RESULTS : Diagnostic value of protein/creatinine ratio was expressed in terms of specificity and sensitivity.There was significant correlation between protein/ creatinine ratio in a single void urine with 24 hr. urine collection for protein as the P value was (0.0001), The ROC curve analysis showed an area under the curve of (0.879), indicating that the urine protein: creatinine ratio can detect severe proteinuria at a cutoff point of 4.2 with a sensitivity of (81.8%) and specificity of (85.2%). CONCLUSION: There is a significant correlation between the spot urine protein/ creatinine ratio and 24-hour urine protein excretion in women with preeclampsia.


Article
The prevalence of bacterial vaginosis among women with preterm labour

Authors: Miami A. Ali --- Zainab Abdulameer --- Isra S. Ibraheem
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2015 Volume: 14 Issue: 2 Pages: 49-53
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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