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CHROMIUM INHIBITS IN VITRO VIABILITY AND STEROIDOGENIC IN RAM LEYDIG CELLS

Author: Mohanad A. Al-Bayati
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2017 Volume: 16 Issue: 2 Pages: 1-25
Publisher: Basrah University جامعة البصرة

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Abstract

One of an ecological hazardous agent Chromium; Cr (VI), The present experimentin vitro design to examine the mechanism of Leydig cell functions of Cr (VI) in ramtestis, Cr (VI) treated groups demising cell growth behavior of exponential phase wasupset of feeding time to Leydig cell in a dose-dependent manner, and inducedmitochondria-dependent ATP depletion and subsequently apoptosis. Cr (VI) effectmay be attributed, at least in part to DNA fragmentation increase DNA tail numberand tail length of COMET as compared with control group. Furthermore, theproperties of cell-specific regulation of cell membrane integrity had reduced anddeterminant cell concentration drop an.d reflected on the testosterone concentrationwere decreased as concentration-dependent manner, In conclusion, our results displaythe Cr (VI) is cytotoxic and impairs both viability and steroidogenic functions ofLeydig cells in ram testis via actually different pathway direct affecting of viabilityand indirect on steroidogenic activity, succeeding in testicular performance. However,the definite modes of action of harmfulness are not evidently unknown and must berechecked and studied in a different aspect

Keywords

Chromium --- Leydig cell --- DNA.

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