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P53 Expression in Endometrial Hyperplasia and Endometrial Carcinoma
التعبير P53 في فرط تنسج بطانة الرحم وسرطان بطانة الرحم

Authors: Rivan Hermiz Isaac --- Nadya Y. Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 28-34
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Mutations of the P53 tumor suppressor gene and altera-tions in its protein expression often occur in a variety of human malignant tumors, including endometrial carcinoma, but the practical implications of this phenomenon are yet to be fully exploited. This study was designed to evaluate P53 protein expression in normal, hyper-plastic and malignant endometrium by immunohistochemical study and to correlate P53 expression in endometrial carcinoma with other clinic-pathological prognostic parameters (age, histologic type, tumor grade, cervical & myometrial invasion, and tumor stage).Methods: The studied samples included 100 formalin fixed, paraffin embedded endo-metrial tissue specimens which were divided to the following diagnostic categories: - Pro-liferative endometrium (n=10); secretory endometrium (n=10); simple hyperplasia (n=10); complex hyperplasia without atypia (n=20); atypical complex hyperplasia (n=10) and endo-metrial carcinoma (n=40).Results: None of the normal endometrium, simple hyperplasia and complex hyperplasia without atypia showed P53 immunostaining, while 20% of atypical complex hyperplasia and 32.5% of endometrial carcinoma showed immunoreactivity for P53. In endometrial car-cinoma, significant correlation was observed between P53 expression and age at diagno-sis, histological grade,FIGO stage, myometrial invasion & cervical invasion ; but not with the histological type .Conclusions: The results indicated the validity & simplicity of the application of immuno-histochemistry in determining the status of P53 overexpresion which is strongly associated with endometrial carcinoma aggressiveness and high malignant potential.


Article
Accuracy of Modified Alvarado Scoring System in Early Diagnosis of Acute Appendicitis
دقة تعديل نظام تسجيل Alvarado في التشخيص المبكر لالتهاب الزائدة الدودية الحاد

Authors: Star S. Hussein --- Nadya Y. Ahmed --- Tayeb S. Kareem
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2009 Volume: 13 Issue: 2 Pages: 8-13
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Appendicitis is a common surgical emergency. The patients with equivocal signs can present a diagnostic challenge. Early diagnosis and intervention is mandatory for prevention of complications. On the other hand negative appendicectomy should be avoided as much as possible. The aim is to evaluate the role of the modified Alvarado scoring system in early diagnosis of acute appendicitis.Methods: During a period of 6 months from 1st February to 31st July 2008; 250 patients with right iliac fossa pain were admitted and observed in Emergency Hospital in Erbil. The age of the patients was ranged between 13-70 years (mean 22 years ). The male to female ratio was 3:2. They were prospectively evaluated on admission using modified Alvarado scoring system to determine whether or not they had acute appendicitis. The results were correlated with the operative and histopathological findings.Results: After first scoring; 179 (72%) patients were admitted and 71 (28%) patients were discharged. Rescoring by modified Alvarado scoring system was done after 6 hours from admission, only 162 (91%) patients were operated on , and the rest 17 (9%) patients were discharged. During operation we found that 142 cases (87.5%) had really acute appendicitis. Overall the modified Alvarado scoring system showed sensitivity of (93%) for [8-9] scores and (39%) for [1-7] scores. .Conclusions: The modified Alvarado scoring system is accurate in early diagnosis of acute appendicitis . Patients with 8-9 scores should be operated on immediately without hesitation. Patients with score 5-7 must be admitted and scored frequently. Score 1-4 can be discharged unless otherwise indicated.

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