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Article
Estimation of Aromatase Enzyme in Obese Infertile Men

Authors: Ula M. AL-Kawaz --- Nawal K. AL-Ani --- Hikmat F. Wassef
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2016 Volume: 6 Issue: 1 Pages: 22-31
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Male obesity is associated with physiological changes that can negatively affect male fertility. Obese men have demonstrated a 3-fold increase in the prevalence of oligozoospermia when compared with men with normal Body Mass Index (BMI). Objective: To estimate the role of aromatase enzyme in decreasing sperm parameters in obese infertile men. Subjects, Materials and Methods: Seventy obese infertile male (patients) and twenty obese fertile male (control) are enrolled in this study. Seminal fluid analysis done according to criteria of WHO (2010). Results: A significant negative correlation was found between human cytochrome enzyme and sperm concentration, progressively motile sperm, non-progressively motile sperm, immotile sperm and normal morphology.Conclusion:The present study showed clearly that male obesity negatively impacts fertilitythrough direct association between increased (BMI) and semen parameters. Theresults suggest that increased estrogen as a result of aromatization in the fattytissue, reflected through the increase in human cytochrome enzyme (aromatase),may be an important mechanism for the hypoandrogenemia and altered spermparameters


Article
Estimation of Aromatase Enzyme in Obese Infertile Men in Correlation with Sex Hormones and BMI

Authors: Hikmat F. Wassef --- Nawal K. AL-Ani --- Ula M. AL-Kawaz
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2017 Volume: 7 Issue: 1 Pages: 62-70
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Male obesity is associated with physiological changes that can negatively affect male fertility. Obese men have demonstrated a 3-fold increase in the prevalence of oligozoospermia when compared with men with normal Body Mass Index (BMI).


Article
Effect of Adenosine Triphosphate on in vitro Fertilization in Mice as a model for Human Being

Authors: Muhannad A. Mashkor Muhammad-Baqir M-R. Fakhrildin --- Muhammad –Baqir M-R Fakhrildin --- Nawal K. Al-Ani
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2015 Volume: 5 Issue: 1 Pages: 24-29
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Back ground:Optimal IVF and embryo culture conditions depend on the composition of culture media being the most important determinants of successful in vitro interaction of the gametes and subsequent embryo development. ATP is fundamental factor to maintain the life, by providing energy, and controlling the cell function and metabolism.Objective:To investigate the effect ATP supplied to culture medium on fertilization rate and in mice as model for human being.Materials and Methods:The female mice (90) were superovulated using superovulation program (SOP) to produce large number of oocyte were divided into three groups, G1 inseminated with vassal sperm in vitro alone (control) , G2 inseminated with vassal sperm in vitro using SMART enriched with ATP(1.25mM). While, G3 inseminated with vassal sperm in vitro using SMART medium enriched with ATP (2.5mM). Mouse spermatozoa were collected from both vas deferens. Then sperm parameters were assessed after 30 min. IVF technique was performed for 3 groups.Results: The results of the present study appear, significantly increment (P<0.05) in the IVF (%) was observed when using 2.5 mM ATP as compared to 1.25 mM ATP and control group.Conclusions: The result showed that addition of high ATP concentration (2.5 mM) enriched to the culture medium improved percentage of in vitro fertilization.

Keywords

ATP --- in vitro fertilization --- mice.

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