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Article
Potentiometric Study of Phenytoin – PVC Membrane Electrodes for Determination of Phenytoin in pharmaceutical preparations

Authors: Yehya K. Al-Bayati --- Raad R. Karabat
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2015 Volume: 18 Issue: 1 Pages: 79-87
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Ion selective electrodes for phenytoin were prepared using sodium tetraphenyl borate (NaTPB) ionophore and various plasticizers: di-n-butylphthalate (DBPH), tri-n-butylphosphate(TBP), o-nitrophenyloctyl ether (ONPOE) and di-octylphenylphosphonate (DOPH). The response characteristics of these electrodes, including slope of the calibration plot, the corresponding concentration range, detection limit, response time, life time, pH effect, and selectivity were studied. The experimental results showed that the best electrode was based on DOPH and DBPH as plasticizers, displaying a linear range from1.00×10−1 M to 1.00 × 10−5 M and 1.00×10−1 M to 2.00×10−5 with a Nernstian slope of 26.6 mV/decade and 26.2 mV/decade, correlation coefficient of 0.9993 and 0.9989, The detection limit was 6.00×10−6 M and 9.00×10−6, the lifetime was around 30 and 28 days respectively. The proposed electrodes were successfully applied to the determination of phenytoin in a pharmaceutical preparation.

الاقطاب الانتقائية لدواء الفينتون تم تحضيرها في هذا البحث من خلال استخدام الليكاند صوديوم تترا فنيل بوريت وتكوين معقد المزدوج الايوني (فينتون-تترافنيل بوريت) ومن ثم تحضير الاغشية البولميرية بوجود بولي فانيل كلورايد وبأستخدام الملدنات الاتية الاتيةdi-n-butylphthalate (DBPH-(1tri-n- butylphosphate(TBP)-2o- nitrophenyloctyl ether (ONPOE)-3di-octylphenylphosphonate (DOPH)-4على التواليوتم دراسة زمن الاستجابة وعمر القطب والدالة الحامضية ووجد ان الاقطاب المحضرة الحاوية على الملدنdi-n-butylphthalate (DBPH-( di-octylphenylphosphonate (DOPH)-تمتلك مى الخطيةfrom1.00×10−1 M to 1.00 × 10−5 M and 1.00×10−1 M to2.00×10−5على التوالي والميل 26.2 and 26.6 ملي فولت/حقبة وعمر القطب 30,28 يوم وعلى التوالي وتم تقدير الأدوية الصيدلانية باستخدام الاغشية المحضرة.


Article
Second Derivative Spectrophotometric Determination of Phenytoin in Pharmaceutical Preparations

Authors: Yehya K. Al-Bayati --- Raad R. Karabat
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2016 Volume: 19 Issue: 1 Pages: 36-42
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

A simple, rapid, accurate, precise, specific and economical spectrophotometric method was used for determination of phenytoin .In this study, a second derivative spectrophotometric method was used for the determination of phenytoin (PHT). This method obeys Beer’s law in the employed concentration ranges of 2-10 ppm for phenytoin. The UV derivative spectra 1D for (PHT) have (V) at 233.3 nm,2D spectra for (PHT) have (P) at 226.7 nm, 3D spectra for PHT) have (P) at 223.6 nm, and (V) at 230.4 nm4D spectra for (PHT) have (P) at 236.5 nm, and (V) at 228.5nm.thelinear concentration ranges (2-10) ppm with correlation coefficient (r) 0.9996, 0.9987, 0.9973, 0.9979. The second derivative D2 tech. at (226.7) nm successfully applied for determination the Phenytoin drug in pharmaceutical samples. Results of analysis were validated statistically and by recovery studies.

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