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Background:Both clomiphene citrate and tamoxiphene citrate, as an anti estrogen, is the mostcommon prescribed medication for male infertility.In humans, ant estrogens interferewith the normal negative feedback of sex steroids at the hypothalamus and pituitary,thereby increasing endogenous gonadotropin releasing hormone (GnRH) secretionfrom the hypothalamus and follicle stimulating hormone (FSH) and luteinizinghormone (LH) secretion directly from the pituitary.Objective:The objective of this study was to investigate the effect of clomiphene citrate (CC)and tamoxiphene citrate (TC) administered to male mice on quality of sperm motilityand activity.Materials and Methods:Ninety six male mice were divided into two major groups, and every one of thesegroups was subdivided into three minor groups involving control and two treatedgroups. In the CC study, 48 mice were administrated orally 0, 0.0125 mg and 0.025mg as control (G 1), low dose (G 2) and high dose (G 3) for 42 days. While, in theTC study, 48 mice were administrated orally 0, 0.01 mg and 0.02 mg as control (G1), low dose (G 2) and high dose (G 3) for 42 days. Then, the male mice weresacrificed, both vas deferens were collected and assessment sperm motility andactivity.Results: The results of present study appeared that the use high dose of CC or TCsignificantly increment (P<0.05) sperm motility and activity as compared to controlgroups.Conclusions:Based on the results of this study, it can be concluded that the administration of highdose of either CC or TC increases sperm motility and activity.

clomiphene citrate --- Tamoxiphene citrate --- mice sperm motility and activity.