research centers


Search results: Found 6

Listing 1 - 6 of 6
Sort by

Article
Correlation of HER-2 Status with Estrogen, Progesterone Receptors and Histological Grading in 122 Invasive Breast Carcinomas
ارتباط حالة HER-2 مع هرمون الاستروجين ، مستقبلات البروجسترون والدرجات النسيجية في 122 سرطان الثدى الغازي

Author: Salah A. Ali
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2009 Volume: 13 Issue: 2 Pages: 1-7
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and Objectives: Many laboratory & clinical studies have suggested that there are important inverse relationships between expression of HER-2 oncoprotein and hormonal receptors(ER,PR),the prognosis & treatment are also greatly depend on hormonal receptor of neoplastic cells to define these relationships using standard immunohistochemistry for HER-2,ER and PR studies were performed in addition to routine histopahtological grading of carcinoma of the breast.Methods: Between January 2006 and December 2008 at histopathology lab of Rezgary hospital & private lab, (122) women who were operated on for diagnostic excisional biopsies of the breast cancers to allow analysis of routinely resected tissue. Quantitative expression of HER-2,ER and PR was measured on the resected samples of the breast cancers with cutoff points HER-2,ER and PR positivity were 10.6%,5.5%,5% respectively in addition to routine study of histopathology for grading of cancers according to Nottingham modified Bloom & Richardson criteria.Results: Immunohistochemical analysis for ER, PR, and HER-2 were performed. ER and PR expression were decreased significantly in HER-2 positive tumors compared with HER- 2 negative tumors (ER,15.57%,vs 41.8% vs. and PR, 13.11% vs. 37.70%;). Even among HER-2+ tumors, the rate of ER or PR expression in high-grade tumors was significantly decreased compared with intermediate grade tumors. HER-2 was positive in 73.3% of grade 2 and 66.6% of grade 3 ductal carcinomas and 6.89 in grade 1 ductal carcinomas. HER-2 expression essentially in grades 2 and 3 ductal carcinomas, very few cases in grade 1 and correlated inversely with ER or PR expression. Although ER or PR expression is decreased in HER-2+ tumors, a substantial proportion of them still express ER or PR.Conclusions: The results of this study are consistent with the indication of inverse relationships between HER-2 and ER,PR increased ER and PR levels in low grade neoplastic tissue ,the low grade neoplasms responding to hormonal therapy while high grade responding to hormonal therapy while high grage responding to herceptin

Keywords

HER-2 --- ER --- PR --- breast cancers


Article
A study of p53 expression in transitional cell carcinoma of urinary bladder in Erbil governorate
دراسة تعبير p53 في سرطان الخلايا الانتقالية للمثانة في محافظة أربيل

Authors: Bakir Sadeq --- Salah A. Ali
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 3 Pages: 248-255
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: This study aimed to evaluate p53 protein expression in both normal bladder epithelium and in cases of transitional cell carcinoma (TCC) of urinary blad-der by immunohistochemical study and to correlate p53 expression in urothelial cancer with other clinico-pathological parameters.Methods: This is a retrospective and prospective study for sample collection during the period from January 2006-May 2009. The samples studied included 105 formalin fixed, paraffin embedded urinary bladder tissue specimens; they consisted of the following diag-nostic categories: chronic non specific cystitis (n=5) and urothelial cancer (n=100). In this study the nuclear p53 protein expression was detected in tissue samples by Dako Cytoma-tion. LSAB + System-HRP staining protocol using monoclonal mouse anti human protein DO-7.Results: None of the chronic non specific cystitis cases showed p53 nuclear immunostain-ing, while 93% of urothelial cancer specimens examined showed immunopositivity for p53 protein. In this study, a statistically significant correlation was observed between p53 over-expression rate with the tumor grade (p= <0.001) and histological architecture (p= 0.023), but not with other clinico-pathological parameters like age and gender.Conclusion: Results of the present study showed the validity and simplicity of application of immunohistochemistry in determining the status of p53 protein expression. The results suggest that p53 overexpression is strongly associated with the aggressiveness of urothe-lial cancer.


Article
The role of FNA cytology of the testis in management of male infertility (in Iraq)
دور دراسة علم الخلايا بابرة دقيقة في الخصية في معالجة العقم عند الذكور (في العراق)

Authors: Suhel M. Alnajjar --- Salah A. Ali
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 3 Pages: 233-240
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objectives: Fine needle aspiration cytology of the testis is now well recognized in diagnosis of testicular diseases. Recently it has also gained popularity for its diagnostic and therapeutic role in male infertility. The purpose of this article is to put light on role of testicular fine needle testicular cytology in male infertility and provide brief information on method of testicular fine needle aspiration interpretation of testicular fine needle aspiration cytology for evaluation of spermatogenesis, its advantages, limitations and complications as compared to testicular biopsy, moreover to its coincidence with hormonal situation of the patient for diagnosis.Methods: This is a prospective study for sample collection during the period from January 2009-Dec 2010. The samples studied included 152 patients underwent FNA of testis for evaluation of spermatogenesis , spermiogenesis & the presence of active mature sperms in addition to hormonal assay for FSH, LH, testosterone and prolactine correlating with clinical findingsResults: : The majority of cases of infertility were due to secondary maturation arrest (94 cases 61.84%) (P=0.03) followed by obstructive orchiopathy (38case 25%) & then the minority of cases were due to untreatable conditions including primary maturation arrest & total testicular atrophyConclusion: FNAC is the dependent method of Azospermic patient evaluation despite of the presence of controversial ideas depending on that the FNAC size is not a suitable window to be able to represent whole testis in evaluation of azospermia.


Article
Fine Needle Aspiration Versus Open Biopsy for Testicular Sperm Recovery in Infertile Azoospermic Patients

Authors: Salah A Ali صلاح علي --- Suhel Al-Najjar سهيل النجار
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 5 Issue: 1 Pages: 23-28
Publisher: Diyala University جامعة ديالى

Loading...
Loading...
Abstract

Background and Objectives: This study aimed to develop a predictive model for sperm retrieval rate(SRR) sperm recovery by testicular fine-needle aspiration (TESA) & compare with (SRR) obtained by per cutanuose open biopsy sperm aspiration (PSA) correlating with hormonal parameters.Materials and Methods: This is a prospective study for sample obtained from 45 male patients during the period from January 2011-march2012.Clinical, paraclinical, and histological information of patients were gathered. All patients underwent both TESA and PSA in a single operation. Predictors of SRR by TESA were identified comparing with predictive outcome of PSA .Statistical Analysis Used: Categorical and continuous variables were compared using independent t test and -chi-square test. Logistic regression model was applied to develop a predictive model for SRR by TESA & PSA outcome.Results: Sperm retrieval rate for TESA and PSA was 42.2% and 48.8%, respectively (P = 0.03).Regarding age group is more common in 4th (50.3%), while 3rd & 5th dacedes each of them (20%). The duration of infertility were variable ranging from (10-20) years. Testis volume, luteinizing hormone, prolactin, and testosterone did not differ between patients.Conclusions: Serum FSH and testicular pathology were predictors of SRR by TESA. Patients with FSH < 23 IU/l and/or testicular pathology of hypospermatogenesis had comparable SRR by TESA versus PSA.


Article
Cell blocks histopathology versus FNA cytology in diagnosis of primary malignant lung mass: A comparative study
الكتل الخلوية لعلم الامراض والخلايا مقابل الخلايا بواسطة شفط الإبرة الدقيقة في تشخيص كتلة الرئة الخبيثة الأولية: دراسة مقارنة

Authors: Salah A. Ali --- Jawhar T. Omer --- Tenya T. Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 1 Pages: 1601-1607
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objective: Fine needle aspiration cytology with cell block preparation is widely used for preoperative confirmation of solitary lung mass and classification of the histologic types. This study aimed to highlight the importance of cell-block preparation in the diagnosis of primary malignant lung lesion by comparing cytomorphological preservation on paired cell block and conventional fine needle aspiration samples. Methods: During January 2012 to October 2015, a total of 100 cases with solitary lung mass were included, either visited Rizgary Teaching Hospital or Walfare private hospital. All the patients had undergone fine needle aspiration and cell block preparation under a CT-guide.Results: The samples were evaluated by the fine needle aspirations and cell blocks preparations from primary lung lesion under a CT-guide. 74% were male, and the majority of them were in the sixth and seventh decade. Squamous cell carcinoma was the most common histologic type consisting 42% of the studied cases, followed by adenocarconima (31%), small cell carcinoma (19%) and the remaining 8% were large cell carcinomas. In the assessment of agreement of cellularity between the two methods of sample preparation, cell block served better than fine needle aspiration (P = 0.715). However, this difference was statistically non-significant. A significant relation was found for morphology which was preserved in fine needle aspiration samples better than that in cell block samples (P <0.05). In contrast, all cell block samples displayed a statistically highly significant architectural preservation compared to fine needle aspiration samples (P <0.001). The sensitivity and specificity of the present study were 98.46%, 99.2% respectively. Conclusion: Direct fine needle aspiration smears and cell blocks complement each other, and our results indicate that both are needed in the diagnostic work-up of patients with a primary malignant lung mass.


Article
Multiple primaries of head and neck: Adeno cystic carcinoma of the larynx with follicular carcinoma of the thyroid gland Case Report
أوليات المتعددة للرأس والعنق: سرطان الغدة الكظرية في الحنجرة مع سرطان جريبي لسرطان الغدة الدرقية

Authors: Lana Sh. Dabbagh --- Salah A. Ali --- Arsalan A. M. Shem
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 1 Pages: 686-689
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Adeno cystic carcinoma of the larynx is very rare and concomitantly with the follicular thyroid carcinoma is not reported in the literature. This case was presented to our centre because of the stridor and small anterior neck mass. Evaluation of the case showed a subglottic mass with an enhanced right thyroid mass on the CT scan. The treatment was thyroidectomy followed by total laryngectomy and bilateral neck dissection. The histopathological study of the subglottic mass showed adeno cystic carcinoma and of the thyroid mass was follicular carcinoma. The adeno cystic carcinoma of the larynx is usually asymptomatic and it has the opportunity to invade deeply before the diagnosis. Proper evaluation of the head and neck is mandatory in any laryngeal lesion.

Keywords

Listing 1 - 6 of 6
Sort by
Narrow your search

Resource type

article (6)


Language

English (5)


Year
From To Submit

2017 (1)

2014 (1)

2013 (1)

2012 (2)

2009 (1)