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Molecular Detection of Some β-lactamases Genes in Uropathogenic Escherichia coli
التحري الجزيئي عن مورثات البيتالاكتاميز في الممرضة البولية ايشريكيا القولون

Authors: Ali H. Hammadi علي حسون حمادي --- Najlaa N. Yaseen نجلاء نبهان ياسين --- Harith J. F. Al-Mathkhury حارث جبار فهد المذخوري
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 3A Pages: 1925-1931
Publisher: Baghdad University جامعة بغداد

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Abstract

Around fifty Escherichia coli isolates were isolated from sixty midstream urine specimens collected from patients visiting hospitals in Baghdad city. Approximately, 52% of all isolates were identified as extended spectrum beta lactamases (ESBL) producer. Results demonstrated that 92% of these isolates were sensitive to carbapenems. Only four β-lactamase coding genes were detected; blaTEM, blaPER, blaVIM and blaCTX-M-2. As a conclusion, this work revealed that local E. coli isolates harboured ESBL coding genes which may contribute in its pathogenicity.

عزلت خمسون عزلة من الايشريكية القولونية من ستين عينة ادرار وسط المجرى جمعت من مرضى يزورون مستشفيات مدينة بغداد. شخص ما نسبته 52% من العزلات على انها منتجة لانزيمات بيتا- لاكتاميز موسعة الطيف. كما اظهرت النتائج ان 92% من هذه العزلات كان حساسا لمضادات الكاربابينيمات. تم التعرف على اربعة مورثات من مورثات البيتالاكتاميز و هي blaTEM و blaPER و blaVIM و blaCTX-M-2. و يمكن ان نخلص الى ان عزلات الايشريكية القولونية المحلية تحمل جينات البيتالاكتاميز موسعة الطيف.


Article
Detection of blaNDM -Metallo-β-Lactamase Genes in Klebsiella pneumonia Strains Isolated From Burn Patients in Baghdad Hospitals

Authors: Abbas Atyia Hammoudi --- Azhar Noori Hussein --- Mohammed Shamkhi Jebur
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 4 Pages: 904 -913
Publisher: Babylon University جامعة بابل

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Abstract

From the period from March to August 2016, 210 swabs were collected from the burn patients hospitalized in different hospitals in Baghdad City: Al-Karama Teaching Hospital, Special Burn Hospital, Central Teaching Laboratories, Child protection Teaching Hospital, Imam Ali Hospital. Out of 210 clinical isolates, 42 (37.5 %) had been shown a single isolated of pathogenic bacteria K. pneumoniae and the others were belonged to other bacteria and mixed growth isolates. Identification of all isolates were carried out depending on macroscopic, microscopic characterizations, conventional biochemical tests and Api 20E system.Metallo-β lactamase (MBL) enzymes were screen by two phenotypic methods(Meropenem-EDTA double disks method and Modified Hodg test). Susceptibility testing were used with The following antibiotic disks:Imipenem,Meropenem,Ceftazidime,Cefotaxime,Pipracillin,Gentamicin,Amikacin andCiprofloxacin.The percentage of resistance isolates were as followed:Imipenem (21.42%),Meropenem (19.04%),Ceftazidime(69.04%), Cefotaxime (85.71%), Pipracillin(85.71%), Gentamicin (26.19%), Amikacin (19.04 %) andCiprofloxacin(59.52%).The percentage of the prevalence of blaNDM-1 and blaNDM-2 genes in K. pneumoniae isolates from burn patients in Baghdad hospitals were as followed:20(100 %) forblaNDM-1 genes and 6 (30 %) for blaNDM-2 genes.

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