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Genotoxicity of aluminum chloride (AlCl3) on the al- and Medical bino rat Rattus norvegicus
السمية الخلوية الوراثية لمادة كلوريد الالمنيوم (AlCl3) على الجرذ الابيض Rattus norvegicus

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Abstract

Sixty males of the Albino rat Rattus norvegicus were used in this present study, and divided to four groups . Each group was contained fteen males. Three groups were injected intraperitoneal for 30 days with different of concentrations Aluminum Chloride AlCl3 and the fourth group was used as control. Animals were killed, and an autopsy was extracted micronuclei from its bone marrow in accordance with method of (Schmid,1975) [12] . And collected mitotic index through number of metaphase per 1000 lymphocyte was extracted from its bone marrow accordance with method of (Brusick,1980) [13].The results showed signi cant increased , of micronucleus (MN) in treated rats with increasing concentrations of AlCl3 , in comparison with the control group at (p<0.05) .As well was in the mitotic index (MI) in lymphocyte of bone marrow in com- parison with the control group at the level of signi cance (p<0.05).

الخ صه:استخدمت في الدراسة الحالية )60( ذكر من الجرذان المختبرية البيضاء نوع Rattu norvegicus والتي قسمت الى اربعة مجاميع احتوت كل مجموعة على )15( ذكر. حقنت ث ثة مجاميع عن طريق غشاء الخلب لمدة )30( يوم بتراكيز مختلفة من مادة كلوريد ا لمنيوم AlCl3 وحقنت المجموعة الرابعة بمادة السيطرة. قتلت الحيوانات، وتم تشريحها واستخرجت النوى الصغيرة من نخاع العظم وفقاً لطريقة)12[ )1975,Schmid[. كما حسب معامل ا نقسام الخلويمن خ ل عد الخ يا التي في الطور ا ستوائي الى 1000 خلية لمفاوية استخرجت من نخاع العظم وفقاً لطريقة )13[ )1980,Brusick[ . بينت النتائج زيادة معنوية في النوى الصغيرة للجرذان المعاملة بكلوريد ا لمنيوم AlCl3 ولجميع التراكيز مقارنة مع مجموعة السيطرة وعند مستوى معنوية.(p<0.05) كذلك انخفاض معامل ا نقسام الخلوي للخ يا اللمفاوية في نخاع العظم مقارنة مع مجموعة السيطرة وعند مستوى معنوية .(p<0.05)


Article
Ameliorative effect of black seed ( Nigella sativa L ) on the toxicity of aluminum in rabbits
التأثير الوقائي للحبة السوداء ( Nigella sativa L ) في التسمم بالألمنيوم في الأرانب

Author: Amira Kamil Mohammed اميرة كامل محمد
Journal: The Iraqi Journal of Veterinary Medicine المجلة الطبية البيطرية العراقية ISSN: 16095693 Year: 2010 Volume: 34 Issue: 2 Pages: 110-116
Publisher: Baghdad University جامعة بغداد

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Abstract

In the present study the biological activities of Nigella sativa on limitation and ameliorative detoxification of aluminum were investigated through evaluation of some hematological, biochemical parameters and histopathology. Eighteen mature rabbits were divided equally into three groups. Group 1 was served as a control group; group 2 was administrated orally with distill water both of AlCl3 ( sub lethal dose 200 mg / kg body weight ) and NS in dose of 10 g / liter; group 3 administrated NS only in same dose. The results are revealed significant elevation ( P<0.05 ) in RBCs count, Hb and PCV values in group 3 in comparison with groups 1 & 2; while the WBCs count decreased significantly in group 2 and increased significantly in group 3. serum ALT, AST, AP, creatinine, urea and uric acid concentration were increased significantly in group 2, while; the albumin concentration was decreased significantly in group 2, as well as histological changes in liver and kidney in group 2. These results indicate the protective effect of black seed against AlCl3 induced toxicity in rabbits.
Key words:AlCl3; black seeds; rabbits; toxicity

Keywords

:AlCl3 --- black seeds --- rabbits --- toxicity

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