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Article
The Role of Anticardiolipin and Anti-B2 Glycoprotein Antibodies in Clinical Complication of Lupus Nephritis

Author: Nawar Abass Abud Noor
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2008 Volume: 7 Issue: 1 Pages: 22-25
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Although there was confliction regarding the association of raised anticardiolipin antibodies (ACL)level with renal disease in systemic lupus erythematosus (SLE), the role of B2glycoprotein as acofactor for ACL binding is established.The presence of ACL &anti-B2GPІ may be directlyinvolved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetalloss, thrombocytopenia and thrombosis.AIM OF STUDY:To study the possible association between some auto antibodies with the most common clinicalcomplication of disease.PATIENTS AND METHODS:The study was conducted on 25 patients with lupus nephritis, attended the renal clinic inspecialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP.RESULT:Although there was no significant difference in mean concentrations of ACL and anti- B2GPbetween lupus nephritis and without nephritis (P>0.05), lupus nephritis patients were more likelypositive for ACL. Positivity of 100% For ACL & anti- B2GPwere detected in thromboticcomplication, in fetal loss complication patients more likely to be positive for ACL (75%), anti-B2GP (50%), in thrombocytopenia positivity of ACL &anti-B2GP (75%).CONCLUSION:There was no association between anti-B2GP and renal disease and presence of both ACL &anti-B2GP carry higher risk for thrombosis and recurrent fetal loss.


Article
The Role of Anticardiolipin and Antiphospholipid Antibodies in Pregnants with Chronic Periodontitis

Authors: Mahmoud Y Taha --- Heba F Hamodat
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2013 Volume: 13 Issue: 27 Pages: 461-465
Publisher: Mosul University جامعة الموصل

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The aim of the study is to measure immunological and biochemical changes in blood and saliva of pregnant women with history of abortion and having chronic periodontitis. Materials and Methods: The study group consisted of (50) pregnant women at different stages of pregnancy with ages between (17-40) years old with history of one or more consecutive unexplained abortion and having chronic periodontitis, while the control group consisted of (10) pregnant women of comparable age to the study group with no history of any abortion with healthy periodontal conditions. Oral examination and the following parameters were studied: plaque index (PI), periodontal pocket depth index (PPD), bleeding on probing index (BOP), and anticardiolipin value (IgG), antiphospholipid value (IgG), highly sensitivity CRP concentration, and peroxidase enzyme activity were evaluated. Results: The serological and biochemical changes showed that highly levels of ACLA (IgG) and APLA (IgG) in the study group compared to control group. hs- CRP concentration in study and control group was same, peroxidase enzyme activity was elevated in the study group compared to the control group. There was a positive correlation between serum ACLA, peroxidase enzyme activity and periodontal parameters, and also a positive correlation between hs-CRP and PI, while reverse correlation between hs-CRP and PPD and BOP. Conclusion: Detection of high level of anticardiolipin and antiphospholipid in the serum of study group with significant difference compared with control group. High level of hs-CRP found in both study and control group without significant difference. Detection of significantly high level of peroxidase enzyme activity with the study group compared to control group


Article
Enoxaparin and aspirin versus aspirin alone therapy for recurrent pregnancy loss due to anti-phospholipid syndrome (APS)

Author: RAGHAD KAMEL
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2016 Volume: 2 Issue: 2 Pages: 182-192
Publisher: Tikrit University جامعة تكريت

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Abstract


Article
STUDY OF AMERICAN COCKROACH ALLERGY DISTRIBUTION AND ITS ASSOCIATION WITH SOME HLA- DQ AND - DR ALLELES IN ATOPIC PATIENTS IN BASRAH PROVINCE / IRAQ
دراسة انتشار ارجية الصرصرالامريكي وارتباطها مع بعض الألائلHLA- DQ و – DRلمرضى الحساسية في محافظة البصرة / العراق

Author: Huda K. Kareem * Fawziah A. Abdullah ** Dhia K. Kareem
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2016 Volume: 15 Issue: 1 Pages: 209-227
Publisher: Basrah University جامعة البصرة

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Abstract

Ninety six for each healthy(n=96)and atopic,(n=96)individuals duals from the same geographical region, paired by sex and age, their sera specific IgE antibodies were estimated by enzyme linked immune sorbent assay test (ELISA) and genotyped by polymerase chain reaction based onHLA-DQB1*0602, HLA-DQB1*0604 andHLA-DRB1*12.The specific IgE based on ELISA results revealed that Out of 96 only59 (61.5%) of atopic patients were sensitive to CR allergen. The association between sensitivity to CR allergen and age was considered to be not statistically significant (P>0.05).However the higher rate of CR allergens sensitivity(62.9%) was observed in first age group(<45 year) of atopic patients. In contrast the effect of sex on sensitivity to CR allergens was considered to be statistically significant (p<0.05) and the higher rate of sensitivity(75.6%) was observed in atopic patients males.The overall differences in the HLA-DQB1*0602, HLA-DQB1*0604 and HLA- DRB1*12 alleles frequency between patients and controlswerestatistically (p<0.05).According to the results of risk factors statistical analysis values(p:value = 0.0001; OR:84.3481; CI 95%: 5.065- 1404.520) HLA-DQB1*0602 allele was associated with susceptibility of patients to the CR allergy.The overall differences in the HLA-DQB1*0602, HLA-DQB1*0604 and, HLA- DRB1*12 alleles distribution between atopic patients and controls were statistically highly significant (p<0.01) concerning the effect of the age and sex. In general the allele HLA- DRB1*12 was not observed in both atopic patients and controls in contrast HLA-DQB1*0602 was present in atopic patients only while HLA-DQB1*0604 appeared in both patients and controls with different frequencies The older atopic patients showed higher frequency (61.8% ) for the HLA- DQB1*0602 allele . In contrast higher frequency of HLA- DQB1*0604 allele occurred in younger patients(40.3%) . According to sex ,the higher frequency of HLA-QB1*0602allele was observed in males patients(31.7%)while the allele HLA-DQB1*0604 higher frequency(17.9 %)was observed in the females of the control group. The overall frequency of HLA-DQB1*0602(60.4%)orHLA- DQB1*0604(39.6%) as a single allele was observed in the seropositive or seronegative atopic patients. The seropositive showed higher frequency(35.6 and 15.3%) for HLA- DQB1*0602 and HLA- DQB1*0604 respectively

Keywords

ELISA --- IgE antibodies --- Allergy.


Article
Effect of plasmapheresis on panel reactive antibodies in kidney transplant candidates

Author: Sahban Al Mallah
Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2016 Volume: 3 Issue: 2 Pages: 94-106
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

Panel reactive antibody (PRA) is one of the tests used to assess the degree of sensitization before kidney transplant, and plasmapheresis is one of the measures used for desensitization. In this study we assessed the role of plasmapheresis as a desensitizing measure. This study was conducted in the medical city complex in Baghdad, Iraq; for the whole year 2012, enrolling patients attending the lab. of the nephrology and kidney transplant centre recording their PRA readings before and after plasmapheresis ( for those with PRA >=20%); in addition to date, age, sex, blood group and whether or not they had been previously transplanted. Data were analyzed using chi square and pair T-test. A 179 patients enrolled, 35 (19.6%) of them had positive PRA test, 12 reading were 20% or more; and were rechecked after plasmapheresis with no significant difference. A part from history of previous transplant; none of the other factors showed significant association with PRA levels In conclusion, no significant effect of plasmapheresis on the levels of PRA.


Article
THE PREVALENCE AND CLINICAL SIGNIFICANCE OF PERINUCLEAR ANTINEUTROPHIL CYTOPLASMIC ANTIBODY IN PATIENTS WITH INDETERMINATE COLITIS

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Background: Indeterminate colitis (IC), a term originated by pathologists to characterize confounding histopathlogic appearance of resected mucosa, has become catch phrase for cases in which diagnostic criteria at all levels elude classification as Crohn's disease (CD) or ulcerative colitis (UC).OBJECTIVES: evaluate the prevalence of pANCA expression in the sera and its isotypes. Patients and methods: PATIENTS GROUP consisted of 60 patients (40 males and 20 females) with indeterminate colitis and their age range was (19-84 years). CONTROL GROUP consisted of 30 (15 males and 15 females) healthy volunteers and their age range was (20- 66 years). Antineutrophil cytoplasmic ( pANCA and cANCA) testing was performed by an IIF technique on ethanol fixed human EOH granulocytes as substrate (EUROIMMUNE- Germany). Sigmoidoscope and colonoscope examination were done for the patients group and biopsies were taken from the patients for histopathological examination.Results:Serological results of ANCA showed a significant increased frequency of pANCA (63.3%) in indeterminate colitis patients as compared to controls (p=0.000). The highest percentage of this pANCA titer was 1:10 (p=0.000) then 1:100 (p=0.008) and most of them was IgG (53.3%) (p=0.000). Sensitivity of pANCA was 60%, specificity of pANCA was 40%, positive predictive value of pANCA was 61.1% and negative predictive value of pANCA was 66.6%. cANCA did not demonstrated in both groups. Conclusions : pANCA was more prevalent in indeterminate colitis and could be used as a predictive serological marker for the outcome of disease.


Article
Incidence of Anticardiolipin Antibodies Level in Patients with Recurrent Abortion
تقييم مستوى الاجسام المضادة للكارديوليبين (IgG, IgM) لدى المريضات المبتليات بالاسقاط المتكرر

Author: Farhan A. Risan فرحان عبود رسن
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2011 Volume: 1 Issue: 1 Pages: 6-10
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Antiphospholipid syndrome is a major reproductive complication in women, that is characterized by recurrent abortion, thrombosis and thrombocytopenia in association with antiicardiolipin antibodies .Aims: To estimate the incidence of anticardiolipin (IgM & IgG) antibodies in pregnant women with the history of recurrent spontaneous abortion .Design of study Case and Control : Serological estimation by Enzyme Linked Immunosorbent assay (ELISA) was done for the following tests:1.Estimation of ACL IgM & IgG in (59) pregnant women.2.Estimation of ACL IgM & IgG in (20) non pregnant women.Methods & Materials: Fifty nine women with recurrent pregnancy loss in first and second trimester were selected and (20) non-pregnant women as control group. Anticardiolipin (IgM & IgG) antibodies were estimated in the sera by the enzyme linked immnnvsorbent assay method (ELISA)Results : The level of positive ACL IgM was 1.95 0.8, negative (0.62 0.3 and control group o.41 0.21, while the level of positive ACL IgG was 2.2 1.05, negative 0.54 0.28 and control 0.39 0.19 pg/mL.The results showed 2 of 59 IgM positive, while 7 of 59 IgG positive. Conclusion: Anticardiolipin antibodies in pregnant women are found to be the important factor for recurrent abortion especially in the first trimester of pregnancy.

تمهيد : تعد متلازمة مضادات الدهون المفسفرة من المضاعفات الرئيسة للجهاز التكاثري لدى النساء ، والذي يمتاز بالاسقاطات المتكررة والخثرة الدموية ، فضلاً عن نقص الاقراص الدموي والذي يرتبط بالاجسام المضادة للكارديوليبين (IgG, IgM).الهدف من الدراسة :تهدف الدراسة الى تقدير تواجد الاجسام المضادة للكارديوليبين Anticardiolipin (IgM & IgG) لدى النساء الحوامل اللواتي يعانين من حالات الاسقاط المتكررة .المواد وطرائق العمل :تسع وخمسون امرأة تعاني من حالات الاسقاط المتكرر ، لاسيما في الثلث الاول والثاني من الحمل تم اختيارهن للدراسة ، فضلاً عن عشرين امرأة سليمة كمجموعة سيطرة . تم قياس مستوى الاجسام المضادة (IgM , IgG) في مصول المريضات والسليمات بوساطة طريقة الانزيم المرتبط الممتز المناعية (ELISA) .النتائج :اظهرت الدراسة بأن مستوى الاجسام المضادة (IgM) الموجبة هو 1.95 0.81 والسالبة 0.62 0.31 والسيطرة 0.41 0.21 ، في حين مستوى الاجسام المضادة (IgG) الموجبة 2.2 1.05 والسالبة 0.54 0.28 والسيطرة 0.39 0.19.كما بينت النتائج بأن (2) من أصل (59) كان مستوى الاجسام المضادة (IgM) موجبة في حين (7) من أصل (59) كان مستوى الاجسام المضادة (IgG) موجبة .


Article
Hepatitis C Virus Infection Assessment Among Chronic Hemodialysis Patients in AL-Kadhmiya Teaching Hospital

Authors: Jawad K. Mnuti --- Fadhil A. AL- Abbudi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 460-464
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Hepatitis C virus (HCV) has been recognized as an emerging problem in dialysis patients, and viral hepatitis remains a major hazard for both patients and medical staff of hemodialysis (HD) units.The reported yearly incidence of anti-HCV antibody worldwide between HD patients ranges from 10.5% to 24%, while the prevalence of anti-HCV antibody among dialysis patients varies in different countries (5-85%) worldwide, and may exceed 95% in the Middle EastOBJECTIVE:To asses the prevalence of anti-hepatitis C virus (HCV) among the hemodialysis unit in AL-Kadhmiya Teaching Hospital and to identify the risk factors of infection in relation to age, sex, blood transfusions and duration of dialysisPATIENTS AND METHODS:Across-sectional study was conducted in AL-Nahrain College of Medicine in AL-Kadhmiya Teaching Hospital in dialysis unit during the period from April 2008 to December 2010. 100 patients(58 male and 42 female their ages ranged from (15—75). are known cases of end stage renal failure on regular haemodialysis. All patients underwent a history and physical examination at baseline and investigations include blood urea nitrogen, creatinine, serum calcium, phosphorus, liver function test and screen for hepatitis C virus antibodies were tested by using Murex anti-HCV ELISA , Positive cases were confirmed by polymerase chain reactionRESULTS:The prevalence of HCV infection in patients in the dialysis unit was 41%. This study showed that there was an association between the history of blood transfusions, duration of the dialysis and kidney transplantation and the prevalence of HCV infection,( P.value <0.001.)Although the levels of AST and ALT were higher in the positive HCV marker group, there was no statistically significant difference between them.CONCLUSION:HCV infection is high in hemodialysis unit in alkadhmiya teaching hospital, HCV-related liver disease in patients on long-term dialysis often appears clinically mild, with only modest elevations in AST and ALT levels but most of them asymptomatic. Observation of appropriate preventive measures in the hemodialysis center is highly recommended


Article
Hepatitis C Virus Infection Assessment Among Chronic Hemodialysis Patients in AL-Kadhmiya Teaching Hospital

Authors: Jawad K. mnuti --- Fadhil A. AL- Abbudi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 460-464
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Hepatitis C virus (HCV) has been recognized as an emerging problem in dialysis patients, and viralhepatitis remains a major hazard for both patients and medical staff of hemodialysis (HD) units.The reported yearly incidence of anti-HCV antibody worldwide between HD patients ranges from10.5% to 24%, while the prevalence of anti-HCV antibody among dialysis patients varies indifferent countries (5-85%) worldwide, and may exceed 95% in the Middle EastOBJECTIVE:To asses the prevalence of anti-hepatitis C virus (HCV) among the hemodialysis unit in ALKadhmiyaTeaching Hospital and to identify the risk factors of infection in relation to age, sex, bloodtransfusions and duration of dialysisPATIENTS AND METHODS:Across-sectional study was conducted in AL-Nahrain College of Medicine in AL-KadhmiyaTeaching Hospital in dialysis unit during the period from April 2008 to December 2010. 100patients(58 male and 42 female their ages ranged from (15—75). are known cases of end stage renalfailure on regular haemodialysis. All patients underwent a history and physical examination atbaseline and investigations include blood urea nitrogen, creatinine, serum calcium, phosphorus, liverfunction test and screen for hepatitis C virus antibodies were tested by using Murex anti-HCVELISA , Positive cases were confirmed by polymerase chain reactionRESULTS:The prevalence of HCV infection in patients in the dialysis unit was 41%. This study showed thatthere was an association between the history of blood transfusions, duration of the dialysis andkidney transplantation and the prevalence of HCV infection,( P.value <0.001.)Although the levels of AST and ALT were higher in the positive HCV marker group, there was nostatistically significant difference between them.CONCLUSION:HCV infection is high in hemodialysis unit in alkadhmiya teaching hospital, HCV-related liverdisease in patients on long-term dialysis often appears clinically mild, with only modest elevations inAST and ALT levels but most of them asymptomatic. Observation of appropriate preventivemeasures in the hemodialysis center is highly recommended.


Article
Seroepidemiological study of mumps in Mosul

Author: Tariq M. Quasim طارق
Journal: Iraqi Journal of Pharmacy المجلة العراقية للصيدلة ISSN: 16802594 Year: 2010 Volume: 9 & 10 Issue: 1 Pages: 70-74
Publisher: Mosul University جامعة الموصل

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Abstract

Objectives: to evaluate the prevalence of mumps specific IgG antibodies in sera of different age groups and sexes of Mosul population.Methods: 440 sera of different age groups and sexes were collected and tested by ELISA test.Results: Seropositivity against mumps virus among different age groups was 68% (males 36% and females 32%, the difference was not significant). However, significant differences (p< 0.05) were seen among males and females at different age groups.Conclusion: Seropositivity in age group 0-9 years which was within the introduction of MMR was the lowest. indicating that the level of immunity developed by MMR vaccine was below the herd immunity threshold.

هدف الدراسة: تقييم نسبة انتشار الاجسام المضادة نوع ج ضد فايروس النكاف في مصول الفئات العمرية المختلفة لاشخاص من مدينة الموصل.طرق العمل: تم جمع 440 عينة من مختلف الفئات العمرية في الموصل وتم فحصها بطريقة الاليزا.النتائج: ايجابية المصول للفئات العمرية المختلفة كانت 68% (36% ذكور و 32% إناث ولا يوجد بينها فروقات معنوية) بينما هنالك فروقات معنوية للفئات العمرية لكل من الذكور والإناث. الاستنتاج: إن ايجابية الموصول لفايروس النكاف في الفئة العمرية 0-9 سنة والتي كانت ضمن خطة التلقيح باللقاح الثلاثي (MMR) كانت أقل ما يمكن والتي توضح أن مستوى المناعة المتولدة لهذا اللقاح كانت أدنى مستوى المناعة الثابتة .

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