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The role of Bcl-2 protein, Bax protein and there ratio in peripheral bloodlymphocytes of asthmatic patients

Authors: Haider S. Kadhim --- Musaab H Ali --- Israa F. Jaffar
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2008 Volume: 50 Issue: 2 Pages: 219-222
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Asthma is an inflammatory airway disease; this inflammatory response can
be attributed to reduced lymphocyte apoptosis in peripheral blood and in airway tissues.
The mechanism behind this could be attributed to decreased Bcl2 protein and increase
Bax protein in peripheral blood lymphocytes of asthmatic patients.
Aim: to explore the mechanism behind decreased lymphocyte apoptosis in peripheral
blood of asthmatic patients at cellular level.
Method: Ninety four subjects; (44) control and (50) patients were included in this study
during the period from (2003) to (2004). The aspirated lymphocytes for each individual
were prepared and stained by immunocytochemistry to study the percentage of anti-
apoptotic Bcl-2 protein, pro-apoptotic Bax protein and their ratio.
Results: Our results showed that the percentage of Bcl2 protein in peripheral blood
lymphocyte of asthmatic patients were significantly higher than control (33.23±11.56,
21.47±4.16)(P=<0.00001).
The percentage of Bax protein in peripheral blood lymphocyte in asthmatic patients was
significantly lower than the control (21.43±6.88, 24.89±4.8) (P-O.0323). Bcl2/Bax ratio
was positive in asthmatic patients there was significant difference in comparison with the
control (1.68±0.57, 0.87 ± 0.17) (P=<0.00001).
Conclusion: This study clarifies the role of these 2 proteins in the process of reduction of
apoptosis in peripheral blood lymphocytes of asthmatic patients.

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