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Article
Fibromyalgia Syndrome in Chronic Obstructive Pulmonary Disease

Authors: Ziad Sh. Al-Rawi --- Faiq I. Gorial --- Nizar A. Jassim
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2009 Volume: 51 Issue: 1 Pages: 31-33
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Fibromyalgia syndrome is a common rheumatological syndrome with multiple systemic manifestations & associated with many diseases. The aim of the study is to assess the possible association between fibromyalgia syndrome (FMS) & chronic obstructive pulmonary disease (COPD), and to correlate this association with patient's age, age group, sex, marital status, duration of the disease, & its severity. Patients and Methods: Fifty patients with COPD & 50 healthy controls were included in this study. Full history was taken & complete physical examination was done for all patients in both groups. Disease characteristics [age, age group, sex, marital status, duration of the disease, & severity of COPD) were also documented. Pulmonary function tests and chest-X-ray were evaluated for all patients. The American College of Rheumatology (ACR) 1990 Criteria for the classification of FMS were applied to all patients & controls included in this study for diagnosis of FMS.Results: Four (8%) patients with COPD have FMS compared with 3(6%) controls (p=0.695). Also FMS was reported in 3 (16.7%) female patients with COPD compared with 1 (3.1%) male patient with COPD (p=0.04). There was no statistical significant association between FMS and: patient's age, age group, marital status, duration of the disease, & disease severity (p=0.816, p=0.481, p=0.702, p=0.178, p=0.181) respectively.Conclusions: FMS is more common in COPD patients compared to controls, but no statistical significant association between them. There was a statistical significant association between FMS & patient's sex only.

Keywords

COPD --- FMS


Article
Contrast Enhanced Doppler Echocardiography in Chronic Obstructive Airway Disease to Assess Peak Pulmonary Artery Systolic Pressure
إستخدام محاليل الزرق الوريدي كأوساط كاشفة في فحوص الأيكو دوبلر الصدري في أمراضالشعب الهوائية الأنسدادية المزمنة لتقييم ضغط الدم الإنقباضي للشريان الرئوي

Author: Saad Eldin Majeed د. سعد الدين مجيد
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 1 Pages: 51-55
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract: Background: Evaluation of pulmonary artery pressure is essential in the management of chronic obstructive airway disease. Aim of the study: Evaluation of commonly used infusion fluids as contrast media to improve the attenuated transthoracic Doppler echocardiographic estimation of pulmonary artery systolic pressure in chronic obstructive airway disease patients with poor acoustic window.Methods: Peak pulmonary artery systolic pressure (PPASP) in 60 healthy adults detected by trans-thoracic Doppler/echo was compared with that of similar number of difficult to image chronic obstructive pulmonary disease (COPD) patients before and after a contrast enhancement of the acoustic signal using commonly available infusion fluids (5% Glucose water, 0.9% normal saline, and 20% albumin and 5% albumin solutions) prepared by hand agitation. Results: Contrast enhancement has significantly improved the color display and the spectral velocity envelope, and although albumin was the best contrast medium among the tested fluids, its diluted solution had reported the best profiles. Conclusion: Hand agitated diluted albumin as contrast agent provide safe, inexpensive mean of improving the limited capabilities of the conventional Doppler/echocardiographic estimation of PPASP in COPD patients with poor acoustic window. Key words: COPD, contrast echocardiography

الملخص:عند مقارنة النتائج المقروءة لضغط الدم للشريان الرئوي و المستحصلة بإستخدام تقنية الأيكو/دوبلر الصدري لدى (60) ستين من البالغين الأصحاء بمثيلاتها عند عدد مماثل من المصابين بألتهاب الشعب الهوائية الأنسدادي المزمن قبل و بعد إستخدام محاليل الزرق الوريدي كأوساط كاشفة، لوحظ تحسناً معتبراً في الأشارة الصوتية المعتمدة، و تفوق محلول الألبومين المخفف كوسط كاشف. توفر الدراسة حلاً آمناً و رخيصاً و تكميلياً لتجاوز قصور تقنية الأيكو/دوبلر الصدري في حساب ضغط الدم الرئوي لدى المصابين قيد البحث.


Article
Early Detection of Chronic Obstructive Pulmonary Disease in Asymptomatic High Risk Male Smoker

Author: Abdulhamza Rajooj Hmood
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2015 Volume: 8 Issue: 1 Pages: 2070-2076
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: COPD is responsible for permanent morbidity, premature mortality, and great burden to the healthcare system. The most commonly encountered risk factor is tobacco smoking. Without screening, patients usually overlook early symptoms of cough and wheezes but commonly seek medical advice when they become dyspnic on mild to moderate exertion. By that time, half of their ventilatory reserves are lost. Spirometry remains the gold standard for diagnosing COPD and monitoring its progression.Aim of study: since COPD is preventable condition, we tried to screen high risk individuals with the aim of early detection and preventionPatients and methods: consecutive asymptomatic male smokers (n=170) were selected by high risk population screening. Participants were eligible if they were ≥ 30 years of age, regular smokers, had smoking history of >10 pack years with no significant respiratory symptoms except for occasional cough and willing to undergo spirometry.Results: a total of 170 asymptomatic male smokers were screened by spirometry according to the American thoracic society and European respiratory society. Overall, airway obstruction was seen in 30 (17.6%) subjects. Mild obstruction was seen in 19 (63.3%) and moderate obstruction in 11 (36.7%) subjects.Discussion: Airway obstruction was linked with duration of smoking (P value <0.001) and number of pack years (P value <0.001).Conclusions and Recommendations: early detection of COPD by spirometry especially in smokers of more than 20 pack years is likely to reduce the overall burden of disease.


Article
Disease modifying effects of simvastatin &/or telmisartan on pulmonary function in patients with mild to moderate chronic obstructive pulmonary disease(COPD)
التأثيرات المحورة للمرض لعقار السمفاستاتين و/ او التلميسارتان على وظيفة الرئتين في مرضى التهاب الرئتين الانسدادي المزمن البسيط الو المتوسط

Author: Ali M.Hadi علي محمد هادي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2011 Volume: 53 Issue: 4 Pages: 456-460
Publisher: Baghdad University جامعة بغداد


Article
Prevalence of gastro-oesophageal reflux symptoms in patients with COPD

Authors: Mohammad K. Haj Hammo محمد خالد حاج حمو --- Dhia J. Al layla ضياء جبر الليلة --- Rami M. A. Al Hayali رامي محمد عادل الحيالي
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2006 Volume: 32 Issue: 1&2 Pages: 18-22
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To assess whether there is an increase in prevalence of gastro-esophageal reflux disease (GERD) in patients with chronic obstructive pulmonary disease (COPD), and the influence of reflux on the respiratory symptoms of these patients. Methods: A case control study that was conducted at the outpatient clinic of Ibn Sina Teaching Hospital in Mosul, and two private clinics, during the years 2002-2003. Sixty six patients with COPD and 50 sex- and age- matched controls were questioned about experiencing GERD symptoms, utilizing a modified questionnaire originally developed by Mayo clinic. COPD patients were asked whether they noticed an association between experiencing reflux episodes and worsening respiratory symptoms, and whether smoking a cigarette is associated with GERD symptoms. Results: COPD patients showed a significantly increased prevalence of GERD symptoms as compared with the control group (29(43.9%)vs. 11(22%), respectively), (p=0.014). COPD patients more frequently reported significant heartburn (43.9%vs. 20%; p=0.007), and regurgitation (25.8%vs. 6%; p=0.005).COPD patients who were still smoking were not statistically significant from those who have stopped smoking regarding experiencing GERD symptoms (46.7%vs. 30.8%; p=0.08). Fifty one percent (51.7%) of COPD patients noticed that their respiratory symptoms are worsened during episodes of heartburn or regurgitation. Conclusion: GER symptoms are more prevalent in patients with COPD, compared to control subjects.Keywords: COPD, gastro-oesophagael reflux disease.


Article
Chronic Obstructive Pulmonary Disease; an Pidemiological Prospective Study

Author: Muhammed .W.Al.Obaidy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: supplement Pages: 600-607
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: COPD is preventable and treatable disease state characterized by airflow limitation that is not fully reversible, The airflow limitation is usually progressive and is associated with an abnormal inflammatory response of the lung to noxious particle or gases. Primarily caused by cigarette smoking (1)..COPD is the fourth leading cause of death worldwide and estimated to be the third cause of death by 2020(5 ). OBJECTIVE : *To describe sample of COPD patients by important parameters recommended from GLOBAL INITIATIVE FOR COPD & COPD PROFESSIONAL ORGANIZATION, (wwwgoldcopd.com &www COPD professional .org). * To have an enough idea about the prevalence of disease in Iraqi patients, study risk factors, , methods of diagnosis & management . PATIENTS AND METHODS : A cross sectional study of 200 patients that were recruited from outpatients & inpatients at medical city Those patients diagnosed as COPD according to ; -Age more than 35 years History of cough or productive cough, or. history of shortness of breath with.FEV1/ FVC less than 0.7 & FEV1 is 80% of predicted (MILD COPD) by spirometry Exclude patients-Patients with mixed obstructive & restrictive ventilator defect byspirometry. The study conducted from March 2005- March 2006 (about 1 year). to evaluate & compare the different way of presentation ,diagnosis, management & therapeutic measures. A total number of 200 patients were seen, examine,A send for important (available) tests needed & their medical records . RESULTS: Diseases are more prevalent in male 162 patients (81%) than female 38 patients (19%) & M;F about (4/1).Also COPD are more common in those who lived in rural area 127 patients(63.5%)than those in urban area 73patients(36.5%). show smoking are the most important risk factor in COPD patients recruited in this study about 177 patients( 88.5%) are smokers than 23 patients (11.5%) are never smoke. smokers about 117 patients ( 58.5% ) are current smokers( 94 patients 47% male & 23 patients 11.5% female) than 36 patients (18%) are ex smokers ( 29 patients 14.5% male & 7 patients 3.5% female) than 17 patients(8.5%) are passive smokers ( 12 patients ( 6%) male & 5 patients 2.5% female, than 7 patients ( 3.5%) all of them male are pipe smokers, In analysis cough presentation, we noticed 20 patients (10%) have dry cough and 140 patients (70%) have had productive cough. In those complaints from productive cough show 34 patients (17%) are scanty amount of sputum than 27 patients (13.5%) have moderate, and 79 patients (39.5%) large amount. . CONCLUSION: Cough and age are the most important predictors of the disease..tobacco smoking is the most important risk factors for COPD&smoking cessation is the single most effective important preventive steps cost effective in COPD management... Air pollution either indoor or outdoor plays an important role in development of COPD


Article
Protective effects of simvastatin and/or telmisartan on cardiovascular system in patients with mild to moderate chronic obstructive pulmonary disease (COPD).

Authors: Ali, M. H علي محمد هادي --- Kasim, J. Al-Shamma قاسم الشماع --- Qais, A. H قيس
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2012 Volume: 12 Issue: 2 Pages: 161-170
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:The objective of this study is to evaluate the protective effects ofsimvastatin, telmisartan or their combination on cardiovascular system inpatients with COPD.Eighty patients with mild to moderate COPD were participated in thisstudy. They were recruited into four groups where the first group includes 20patients on an inhaled β2- agonist only (control), the second group includes 20patients on an inhaled β2- agonist plus 20mg/d simvastatin, the third groupincludes 20 patients on an inhaled β2- agonist plus 40mg/d telmisartan and thefourth group includes 20 patients on an inhaled β2- agonist plus combination ofboth simvastatin and telmisartan. Twenty apparently healthy subjects wereselected to be a normal group for comparison. Baseline, 3 and 6 months periodswere used to monitor patients. Assessing the plasma levels of hs-CRP, VCAM-1and lipid profile. ANOVA method for statistics were used to compare theresults.There was a great reduction in hs-CRP and VCAM-1 in addition tomodulation of lipid profile after the use of simvastatin 20mg/d, telmisartan40mg/d and their combination in COPD patients.Simvastatin 20mg/d, telmisartan 40mg/d and their combination exerted aprotective effect on the cardiovascular system in COPD patients after 3 and 6months of therapy by reducing hs-CRP, VCAM-1 and lipid profile.

الخلاصة:إن مرض التهاب الرئتین ألانسدادي المزمن، تلك الحالة المرضیة التي تتمیز بقصور والتهابالمجرى الهوائي وهبوط وظیفة الرئتین لأمد طویل، هو أحد أهم الأسباب التي تنتهي بالوفاة في كل أنحاءالعالم. لقد بینت العدید من الدراسات الوبائیة بان الأشخاص المصابین بمرض التهاب الرئتین ألانسداديالمزمن تكون لدیهم خطورة الإصابة بأمراض الجهاز القلبي الوعائي ثلاثة مرات أعلى من جمهورالأصحاء.ان الهدف من هذه الدراسة هو لتقییم التأثیرات الوقائیة لعقار السمفاستاتین و/أو التلمیسارتان علىالجهاز القلبي الوعائي لمرضى التهاب الرئتین ألانسدادي المزمن البسیط أو المتوسط.تم مشاركة 80 مریضا مصابین بالتهاب الرئتین ألانسدادي المزمن في هذه الدراسة وتم توزیعهمعلى أربعة مجموعات تضمنت المجموعة الأولى 20 مریضا یستخدمون منشقة السالبیوتامول فقط(كمجموعة مقارنة)، المجموعة الثانیة تضمنت 20 مریضا یستخدمون منشقة السالبیوتامول مع عقارالسمفاستاتین 20 ملغ یومیا، المجموعة الثالثة تضمنت 20 مریضا یستخدمون منشقة السالبیوتامول مععقار التلمیسارتان 40 ملغ یومیا وتضمنت المجوعة الرابعة 20 مریضا یستخدمون منشقة السالبیوتامولمع خلیط العقارین معا. تم اختیار 20 شخصا من الأصحاء ظاهریا كمجموعة طبیعیة للمقارنة أیضا. لقدتم مراقبة المرضى عند بدء الدراسة، بعد 3 و 6 أشهر من العلاج. تم قیاس البروتین النشط عاليالحساسیة، جزیئة الالتصاق الوعائیة ومستوى الدهون في الدم.لقد بینت النتائج أن هناك انخفاضا شدیدا في المستویات الدمویة للبروتین النشط عالي الحساسیة،جزیئة الالتصاق الوعائیة ومستوى الدهون في الدم بعد استخدام عقار السمفاستاتین أو التلمیسارتان أوكلیهما.یمكن الاستنتاج بان استخدام عقار السمفاستاتین 20 ملغ یومیا أو التلمیسارتان 40 ملغ یومیا أوكلیهما لمدة 3 و 6 أشهر له تأثیر وقائي على الجهاز القلبي الوعائي لمرضى التهاب الرئتین ألانسداديالمزمن البسیط أو المتوسط.


Article
Chronic Obstructive Pulmonary Disease: Impact Of Hypoxia

Author: Amjed Hassan Abbas
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2014 Volume: 7 Issue: 2 Pages: 1971-1979
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Chronic obstructive lung disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. Many people suffer from this disease for years and die prematurely from it or its complications.Objective: This study was aimed to:1.Study and compare some demographic and physiological changes in hypoxic and non-hypoxic groups of patients with COPD. 2. Assessment of effect of smoking in both groups. 3. Correlate these findings with severity of the COPD.Patients and method: The study was performed in Merjan Teaching Hospital in Babylon Province in the period from November 2012 to October 2013, the study included one hundred eighty two (182) patients with history of COPD who were studied clinically and each patient was submitted for spirometry, pulse oximetry, chest x-ray and electrocardiography. According to the results of oximeter, patients were divided into two groups, hypoxic and non-hypoxic group, hypoxic group included 96 patients ( mean age was 57.14±11.24, 66% were males) while the non-hypoxic group included 86 patients (mean age was 54.42±12.75, 62% were males).Results & Discussion: Study showed that the mean pack years of tobacco use in hypoxic group was 42.83±47.95 pack years while in non-hypoxic group the mean duration was 24.91±32.84 and there was significant differences between groups (P=0.000),it also revealed that pack year was significantly correlated with the severity of obstruction in hypoxic group (P value= 0.000) in contrast to non-hypoxic group (P value= 0.2).The study also showed significant negative linear relation between degree of dyspnea (functional state) and oxygen saturation (SpO2) (r=-0.2, p=0.04) in reverse to non-hypoxic group (r=-0.11, p=0.3). Furthermore, the study clarified that most patients in both groups had normal ECG changes (73% in hypoxic group and 90% in non-hypoxic group) and the most common ECG finding in both groups was P pulmonale (11% in hypoxic group and 6% in non-hypoxic group).When linear regression analysis of the results of this study was considered, there was significant positive linear correlation between oxygen saturation (SpO2) and severity of obstruction in hypoxic group while non-significant linear correlation between SpO2 and severity of obstruction in non-hypoxic group.Conclusion: From the results of this study, we conclude that lung hypoxia has a relation with severity of obstruction, pack years, functional state and ECG changes. Females were more sensitive to the effects of smoking than males.

Keywords

COPD --- hypoxia --- pack year --- obstruction.


Article
FREQUENCY OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
تواتر ضعف البطين الأيسر الأنقباضي المزمن عند مرضى انسداد مجرى المسالك التنفسية المزمن

Authors: SABAH H. IBRAHIM صباح ابراهيم --- HUSSEIN M. JUMAAH حسين جمعة --- DHAHER J. AL-HABBO ظاهؤ الحبو --- FAKHIR Y. HUSSEIN فخري حسين
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2011 Volume: 5 Issue: 2 Pages: 51-59
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background and objectives To determine the frequency of left ventricular systolic dysfunction in chronic obstructive airway disease patients and its relation to age, gender, duration of smoking and other factors.Methods A case series study of forty two chronic obstructive airway disease patients (mean age 63.64±10.21 years) were studied for assessment of left ventricular systolic dysfunction using 2D and M-mode echocardiography with assessment of ejection fraction for all patients.Assessment of clinical parameters and biochemical parameters. The age and gender of the patients were assessed. Duration of smoking and the number of pack per year were also calculated. The study was carried out in the respiratory care unit and general medical units of Ibn-Sina Teaching Hospital.Results Forty two chronic obstructive airway disease patients 36 males (85.7%) and 6 (14.3%) females (mean age 63.64±10.21 years), were studied for assessment of left ventricular ejection fraction. Among the 42 patients only 9 (21.4%) had left ventricular ejection fraction with 2(22.2%) among females and 7 (77.8%) among males, (p= 0.382), The Mean age of left ventricular ejection fraction group was found to have no significant correlation at (p=0.442). Age compared with the groups of left ventricular ejection fraction, this correlation was not significant ( p=0.267). The mean duration of smoking and pack years showed no significant association with left ventricular ejection fraction (p=0.618 and p=0.348 respectively). Patients characteristics show no sensible statistical correlation to LVSF (p =0.338), (p =0.42, p =0.26), (p=0.163, p=0.288, p=0.463) in sequence.Conclusions The frequency of left ventricular systolic dysfunction in chronic obstructive airway disease patients was 21.4 %. Age, duration of smoking and pack years in addition to other patient’s characteristics didn't demonstrate a significant relation to left ventricular systolic function in chronic obstructive airway disease patient. More sophisticated tools should be used for evolution of left ventricular systolic dysfunction in chronic obstructive airway disease patients.

خلفية واهداف البحث: تحديد تواتر خلل البطين الأيسر الانقباضي في مرضى انسداد مجرى المسالك التنفسية المزمن، وعلاقته بالعمر والجنس للمرضى ودراسة تاثيرمدة التدخين وعوامل أخرى على هذا الفحص.طرق البحث: تم دراس ة 42 مريضا يعانون من مرض انسداد مجرى المسالك التنفسية المزمن ،متوسط أعمارهم مع تقييم معلمات (D2 and M Mode) 10.21 سنة)، لتقييم خلل البطين الأيسر الانقباضي، وذلك باستخدام ±63.64) الكيمياء الحيوية والفحوصات السريرية ومتغيرالعمر .جرى تقييم المرضى من الجنسين . وتم احساب تاثير مدة التدخين. أجريت الدراسة في وحدة العناية التنفسية والوحدات الطبية العامة لمستشفى ابن سينا،وقد تم احتساب تاثير هذه تم ( SPSS المتغييرات مع وظيفة البطين الأيسر الانقباضي . تم إجراء التحاليل الإحصائية بواسطة برنامج ( 16 ذات دلالة ( P < حسب الحاجة، وتعتبر قيمة ( 0.05 ANOVA استخدام اختبار كاي سكوير بالاضافة الى اختبار إحصائية معنوية.النتائج: تم دراسة اثنين وأربعين مريضا يعانون من مرض انسداد مجرى المسالك التنفسية المزمن. 36 ذكور 10.21 سنة. لتقييم خلل البطين الأيسر الانقباضي بين ± 14.3 %) إناث. متوسط اعمارهم 63.64 ) ٪85.7 ) و 6 ) 21.4 %) يعاني من خلل البطين الأيسر الانقباضي مع 2 ) المرضى بينت النتائج ان من بين 42 مريض سوى 9 متوسط اعمار . (P= 77.8 ) من بين الذكور وكانت قيمة الارتباط ( 0.382 %) ٪22.2 ) من بين الإناث و 7 ) العمرو مقارنة مع مجموعات .(P= مجموعة خلل البطين الأيسر الانقباضي ليست ذات ارتباط معنوي كبيرة ( 0.442 التدخين لم تظهر له أي .P= مرضى خلل البطين الأيسر الانقباضي ، ليست ذات ارتباط معنوي كبيرة 0.267 على التوالي . خصائص المرضى لم تظهر أي علاقة معنوية احصائية = (P= ارتباط معنوي ايظا مع ( 0.348على التوالي. (P = 0.463 ،P = 0.288 ، ع (= 0.163 ، ( P ، 0.26 = (ع = 0.42 ،(0.338 .٪ الاستنتاجات: تواتر خلل البطين الأيسر الانقباضي عند مرض انسداد مجرى المسالك التنفسية المزمن كان 21.4 من المرضى، مدة التدخين عمر المرضى بالاضافة الى عمر وجنس المرضى لم تثبت وجود علاقة معنوية كبيرة مع في LVSD عند مرضى انسداد مجرى المسالك التنفسية المزمن. وينبغي استخدام أدوات أكثر تطورا لفحص LVSF المرضى الذين يعانون من انسداد مجرى المسالك التنفسية المزمن.


Article
Impact Of Hypoxemia In Patient With Chronic Obstructive Pulmonary Disease On Renal Function Tests

Authors: Amjed Hassan Abbas --- Samir Sawadi Hammuod
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 140 -147
Publisher: Babylon University جامعة بابل

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Abstract

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases and is expected to be progressively increasing. There are many co-morbidities associated with it, but the relation between it and changes in renal function tests is still unclear. The aim of this work was to illustrate the extent of kidney dysfunction in patients who suffer from COPD. This study was performed in Merjan Medical City, the period of study was from November 2013 to June 2014, it included 86 patients with COPD and 70 control healthy subjects who completed medical questionnaires, pulmonary function tests and measurement of blood urea and serum creatinine. The data was statistically analyzed, the level of statistical significance that was depended for this study was P values ≤0.05. The results of this study revealed significant difference in the mean values of blood urea (Bur), serum creatinine (Scr), and creatinine clearance (Ccr) before and after treatment for all patients, Bur increased and Ccr decreased significantly in hypoxic group in comparison with non hypoxic group (P ˂ 0.05); while no significant changes in Scr (P = 0.1). In addition, the study showed a significant correlation between blood urea and creatinine clearance (Ccr) with SPO2 (before treatment) (p < 0.05), while non-significant negative correlation between serum creatinine and SPO2 (before treatment) (r = 0.1, P > 0.05).The results illustrated that the Bur and Scr increased; while Ccr decreased significantly in male group in comparison to female group (P˂0.05). Also there was no significant correlation between blood urea, serum creatinine, and creatinine clearance with forced expiratory volume in first second (FEV1) (before treatment) (P > 0.05). From this study, we conclude that abnormalities of renal function tests are common in patients with COPD at the first days of admission to hospital.

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