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Article
Formulation of Econazole Nitrate as an Ophthalmic Ointment
صياغة نترات الإيونازول كمرهم للعين

Author: Heba Antwan Fatohy
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2009 Volume: 13 Issue: 2 Pages: 73-78
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Keratomycosis is an important cause of ocular morbidity and can lead to blindness due to lack of ocular antifungal agents. The goal of this study is to formulate a stable effective formula of econazole nitrate ophthalmic ointment.Econazole nitrate has an advantage over other antifungal agents in treatment of mixed infection since it is active against both dermatophytes and candida, and also it is effective in the treatment offilamentous fungi. .Methods: Econazole nitrate ophthalmic ointment of different strength were formulated and compared for their in vitro activity.The effect of different factors (light and type of container) and calculating the expiration date of the selected formula were studied.Results: Formula A (1gm Econazole nitrate in 100 gm ophthalmic ointment base) and formula B (2gm Econazole nitrate in 100gm ophthalmic ointment base) had good in vitro antifungal activity because both formula A and B inhibit the growth of the fungi used, but formula A was selected because it has the lowest concentration and the same activity. Also the results indicated that the selected formula A was affected by light and its % remaining was (96.7%), while there was no effect of the type of container used to store Econazole nitrate ophthalmic ointment.The expiration date of formula A was calculated to be (2.19) years.Conclusions: 1% Econazole nitrate ophthalmic ointment appears to be effective in vitro and should be stored in dark container.


Article
Development and in vitro Evaluation of Bioadhesive Vaginal Tabletusing Econazole Nitrate as a Model Drug

Author: Dina W. Ameen دينا وديع امين
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2011 Volume: 20 Issue: 1 Pages: 57-65
Publisher: Baghdad University جامعة بغداد

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Abstract

In this study, a bioadhesive dosage form of eoconazole nitrate for vaginal delivery was designed using a combination of bioadhesive polymers: Carbopol 941 p and sodium carboxymethylcellulose or methylcellulose in different ratios. The bioadhesive strength was evaluated by measuring the force required to detach the tablet from sheep vaginal mucosal membrane. It was found that the bioadhesive force was directly proportional to Carbopol 941 p content in the different formulae. The formulae were tested for their swelling behavior using agar gel plate method. The results showed that formulae containing a combination of Carbopol 941 p and sodium carboxymethylcellulose had greater swelling index than those containing a combination of Carbopol 941 p and methylcellulose. In vitro drug release study showed that the release of eoconazole nitrate from Formulae containing sodiumcarboxymethylcellulose was faster than its release from those containing methylcellulose.Thedissolution profiles of the formula containing Carbopol 941 p alone and those conaining various combinations of Carbopol 941 p and methylcellulose could be considered similar since their calculated similarity factor values were >50. Formula F3 composed of CP/NaCMC in a ratio 1:1 showed moderate swelling, good bioadhesion and retardation of drug release. Thus, it may be considered a good candidate for vaginal bioadhesive dosage forms.

في هذه الدراسة تم تصميم شكل دوائي لنترات الايكونازول ملتصق بالانسجة الحيوية للاستخدام المهبلي. بجمع كل منالكاربوبول مع كاربوكسي مثيل سليلوز الصوديوم أو المثيل سليلوز (باعتبارها بوليمرات لاصقة بالانسجة الحيوية)بنسب مختلفةلتصييغ الحبوب المهبلية. تم تقييم القوة الألتصاق من خلال قياس القوة المطلوبة لفصل الحبة عن الغشاء المخاطي المهبلي للنعاج,فتبين ان قوة الالتصاق كانت متناسبة طرديا مع محتوى الكاربوبول في الصيغ . تمت دراسة قابلية الانتفاخ للصيغ المصنعةباستخدام صحون الاكار. وقد اظهرت النتائج أن الصيغ المحتوية على خليط من الكاربوبول و كاربوكسي مثيل سليلوز الصوديومأكثرأنتفاخا من تللك المحتوية على خليط الكاربوبول والمثيل سليلوز. دراسة تحرر العقار أظهرت أن تحررالعقار من الصيغ المحتويةعلى كاربوكسي مثيل السليلوز الصوديوم كان اسرع من تحرره من تلك الصيغ المحتوية على مثيل السليلوز. كانت قيم عاملالتشابه المحسوبة للصيغة المحتوية على الكاربوبول فقط والصيغ المحتوية على خليط منه والمثيل سليلوز أعلى من ٥۰ وبالتالي يمكنتحرراجيدا للدواء و انتفاخا معتدلا وخاصية التصاق جيدة لذلك يمكن ( F اعتبار نمط ذوبان هذة الصيغ متشابها .أظهرت الصيغة ( 3اعتبارها مرشحا جيدا لتطوير شكل دوائي مهبلي قابل للالتصاق.

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