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Article
Assessment of Endogenous Erythropoietin Level in Sera Patients with Acute Ischemic Stroke

Authors: Suhayr Aesa Al-Qaysi --- Afaf K. Shweekh --- Zinah Abbass Ali
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 1 Pages: 132-138
Publisher: Babylon University جامعة بابل

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Abstract

A stroke is the loss of brain function due to a disturbance in the blood supply to the brain. Ischemic type is the most common type of stroke in older adults, caused by either blockage of a blood vessel via thrombosis or arterial embolism, or by cerebral hypoperfusion. Erythropoietin (EPO) is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. This study aimed to explore the EPO level in serum of ischemic stroke patients during the acute phase. This study was included 40 subjects, 20 patients with acute ischemic stroke and 20 apparently healthy persons act as a control group. Five milliliters of blood were collected in plane tube without anticoagulants for measuring EPO level in sera of patients and control by ELISA technique. In comparison with the control group, the patients with acute ischemic stroke showed a significant increase in EPO level (P ˂ 0.002). our data revealed that increase circulating endogenous EPO as a response to hypoxia and thereby increase oxygen supply by inducing erythropoiesis and/or other stimulatory factors that contribute the ischemic tolerance.


Article
Role of serum erythropoietin level in patients with absolute erythrocytosis

Authors: Salem R. Hamodi سالم حمودي --- Hamed D. Habeeb حامد حبيب
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2014 Volume: 10 Issue: 18 Pages: 107-111
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

PRV is a myeloproliferative disorder with an acquired genetic mutation involvingthe stem cell. Erythropoietin (Epo) is a hemopoietic growth factor which providessome guidance to the diagnosis of PRV.The study was done to evaluate the diagnostic significance of erythropoietin levelin PRV and its role in pre and post treated PRVpatients.The study includes (47)patients diagnosed as PRV including (31) males and (16) females with age range (20-77 years). The criteria for diagnosis of polycythemia is PCV > 52% and/ or Hb ≥18.5gm/dl for male and PCV >48%and/ or Hb ≥16.5 gm/dl for female.The investigationswhich were done for all new patients including CBC, blood films and serum Epo, inaddition to the BM examination for new indicated cases of PRV. Follow up of oldPRV (31) patients were done by PCV and serum Epo. We found thatthe mean Epowas 9.82mIU/ml. There was no statistical significant correlation between Epo meanand mean of other parameters.There was a statistical significance between pre andpost treated cases regarding mean PCV and Epo. The acceptible EPO cutoff level todefine PRV of (4.9) with sensitivity (71.4), specificity (86.7) and(p<0.001). So, weconclude that the serum Epo level was a simple reliable test for diagnosis of PRV witha cutoff value of (4.9) andthere was a significant difference between treated anduntreated cases of PRV regarding PCV and Epo.

ارتفاع الكریات الحمر الحقیقي ھواضطراب التكاثر في نقیي العظم بسبب طفرة جینیة مكتسبة في الخلایاالجذعیة. ان مستوى الارثروبویتین یعطي مؤشرا عن نوع المرض وعن الفحوصات المختبریة اللازمة لتاكیدسبب المرض. تھدف الدراسة لبیان اھمیة مستوى الارثروبویتین في تشخیص ارتفاع الكریات الحمر الحقیقيبالاضافة الى معرفة الفرق في مستوى الارثروبویتین قبل وبعد العلاج .تم تقییم ( 47 ) مریضا مصابا بارتفاع77 ) سنة. - الكریات الحمر الحقیقي، تضمنت الدراسة ( 31 ) ذكرا و ( 16 ) انثى تراوحت اعمارھم بین ( 20المستوى المعتمد لكریات الحمر المظغوطة ھو اكثر او یساوي 52 % او نسبة الھیموغلوبین اكثر من 18.5غمدل للذكور واكثر او یساوي 48 % و اكثر من 16.5 غمدل. تم اجراء الفحوصات التالیة لكل المرضى:فحص الدم الكامل بواسطة الجھاز الاتوماتیكي ،فلم الدم وقیاس مستوى الارثروبویتین في الدم .تم فحص نخاعالعظم لبعض الحالات التي تستدعي ذلك . اظھرت الدراسة ان متوسط الارثروبویتین 9.82 . لیكن ھناك ارتباطذات دلالة إحصائیة بین متوسط الارثروبویتین ومتوسط العلامات العامة والسریریة. تبین وجود علاقة احصائیةمھمة بالنسبة لمستوى الكریات الحمر المظغوطة ومستوى الارثروبویتین قبل وبعد العلاج. ان مستوى.(p < الارثروبویتین المحدد للتشخیص ھو ( 4.9 ) مع حساسیة ( 71.4 %)،والنوعیة ( 86.7 %) و ( 0.001نستنتج من الدراسة :ان نسبة الارثروبویتین في الدم تعتبر عاملا مھما وفحصا بسیطا لتحدید العامل المسببلارتفاع نسبة الكریات الحمر المظغوطة وان ھناك اختلاف احصائي واضح بین الحالات المعالجة وغیر المعالجةبالنسبة لمعدل الكریات الحمر المظغوطة والارثروبویتین .


Article
Serum Erythropoietin Concentration In Normal And Preeclamptic Pregnancies

Authors: Athba A. kadhim عذبه عبد كاظم --- Lilyan W. Sersam لليان وديع سرسم
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 2 Pages: 43-49
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Preeclampsia is a multisystem disease and a threat to the well-being of both the mother and her newborn; it contributes significantly to the causes of maternal and perinatal morbidity and mortality. An increase in maternal plasma of erythropoietin in women with preeclampsia may be of placental origion and a reflection of an underlying placental hypoxic condition. Aims: To compare serum erythropoietin concentrations among patients with and without preeclampsia and to investigate the association between serum erythropoietin levels and preeclampsia.Methods: This case-control study involved one hundred pregnant women in their third trimester of singleton pregnancy with gestational age (28-40wk). Fifty patients were with preeclampsia (study group) and fifty patients were with normal healthy pregnancies (control group). For both groups maternal blood samples were collected for Erythropoietin concentration measured by ELISA method. Statistical analysis was performed to compare maternal serum erythropoietin levels in preeclamptic women and normal heathy pregnant women, and to evaluate the association between serum erythropoietin and preeclampsia. Results: Mean erythropoietin level for the preeclamptic group was (41.66±26.76) ranging from 10.716-159.121(mIU/ml) with a median of 36.101 mIU/ml, while for the control group, the mean value was (28.71±14.38) ranging from 6.482-65.228 (mIU/ml) with a median of 26.741 mIU/ml. Erythropoietin levels were significantly (P=0.003) higher among preeclamptic patients compared with controls.Conclusion: Women with preeclampsia have significantly higher levels of serum erythropoietin compared to normal healthy pregnancy.


Article
Effect of Dialysis on Erythropoietin and some Hematological Parameters in Patients with Chronic Renal Failure
تأثير غسيل الكلى على الإريثروبويتين وبعض المعلمات الدموية في المرضى الذين يعانون من الفشل الكلوي المزمن

Authors: Mohamad Salih Jaff --- Jamal M. Aziz --- Zhian Sh. Hayder
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2009 Volume: 13 Issue: 2 Pages: 14-21
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: A prospective study was carried out for estimation the concentration of the erythropoietin hormone and its effects on some hematological parameters in chronic renal failure patients despite medical treatment. The object of the study was to evaluate the available evidences which support the relationship between anemia and adverse outcomes in chronic renal failure patients, to estimate the erythropoietin concentration of plasma in chronic renal failure patients and to examine the relationship between the anemia and erythropoietin concentration in patients with chronic kidney disease.Methods: One hundred and eleven (111) patients with CRF on dialysis in the Dialysis and Kidney Disease Center in Hawler Teaching Hospital and (40) control groups were studied. Haematological parameters: were performed by conventional manual methods. The quantitative measurement of erythropoietin concentration in serum was done by using the Erythropoietin ELISA kit (IBL Immuno Biological Laboratories Hamburg Erythropoietin Kit, German).Results: Hemoglobin, red blood cells, packed cell volume, and mean corpuscular hemoglobin were significantly decreased (P<0.001) in all age groups of Chronic renal failure patients, while, erythrocyte sedimentation rate and mean corpuscular volume (MCV) were increased significantly (P<0.001). Total white blood cells were decreased significantly (P<0.01) at the ages (40-60, >60) years groups, while not significantly decreased at the ages (<20, 20-40) years. Plasma erythropoietin was decreased significantly at the level (P<0.001) in chronic renal failure patients.Conclusions: Anemia is a common and often an early complication of chronic renal diseases and decreased renal production of erythropoietin is the major cause of anemia in these patients.


Article
A comparison of Erythropoietin hormone level at male diabetic patients with and without nephropathy
مقارنة مستوى هرمون الارثروبيوتين لدى مرضى السكري من الرجال المصابين وغير المصابين باعتلال الكلى السكري

Authors: Esraa Mahdi Abdulhadi Zahid --- Saher Muhmood Jwad AL-Jammali
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2013 Volume: 3 Issue: 3 Pages: 1-9
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objective: It aims to estimate the level of Erythropoietin hormone at the serum of diabetic patient males with and without nephropathy. Methodology: the present study was carried out in the center of Diabetes mellitus and Endocrinology in AL-Sader medical city for the period from October-2012 until March-2013. The number of collected samples 73 urine and blood samples from the diabetic patients were divided in to two groups with and without nephropathy according the albumin and creatinine ratio in urine. The statistical analysis, by using ( statistical package for social sciences) SPSS and t-test. The least significant difference was calculated at the level P<0.05. Results: the results were obtained, there were a significant increase (P<0.05) in the ratio of albumin to creatinine ratio in urine and the concentrations of glycosylated hemoglobin and urea, while the Erythropoietin and hemoglobin concentrations were revealed a significant decrease (P<0.05) at the patients with diabetic nephropathy when compared with patients in the other group. In related with other parameters which included : iron ions, total iron binding capacity, ferritin and red blood corpuscles count were not showed any significant change during the present study. Conclusion: the diabetes mellitus was affected on the kidney's physiological functions that led to a decrease in the Erythropoietin level at the serum of patients which caused an early anemia. Recommendation: study the change in the cytokine level at the blood of diabetic patients to know the relation between there concentrations and diabetic nephropathy progression

الهدف:تقدير مستوى هرمون الارثروبيوتين في المصل لدى مرضى داء السكري من الرجال المصابين وغير المصابين باعتلال الكلى السكري. المنهجية: اجريت الدراسة الحالية في مركز السكري والغدد الصم التابع لمدينة الصدر الطبية للفترة من تشرين الاول-2012 الى اذار-2013 . وكان عدد العينات التي جمعت (73) عينة ادرار ودم من مرضى السكري, الذين قسموا الى مصابين وغير مصابين باعتلال كلوي اعتمادا على نسبة الالبومين الى الكرياتنين في الادرار. وكان التحليل الاحصائي المستخدم SPSS واختبار-t . واستخرج اقل فرق معنوي (L.S.D) عند مستوى احتمال ((P<0.05 . النتائج: بينت النتائج وجود ارتفاع معنوي (P<0.05) في نسبة الالبومين الى الكرياتنين في الادرار وكذلك تركيزي الهيموغلوبين المسكر واليوريا, في حين اظهر تركيزي الارثروبيوتين و الهيموغلوبين انخفاضا معنويا لدى مرضى اعتلال الكلى السكري عند مقارنتهم بمرضى المجموعة الاخرى.وفي ما يتعلق بالمعايير الاخرى والتي شملت تركيز ايون الحديد والسعة الكليةلارتباط الحديد والفرتين واعداد كريات الدم الحمر لم تظهر اي تغير معنوي يذكر. الاستنتاجات: ان داء السكري الذي اثر على الوظائف الفسلجية للكلية الامر الذي ادى الى انخفاض مستوى هرمون الارثروبيوتين والذي تسبب في ظهور فقرالدم المبكر لدى مرضى اعتلال الكلى السكري. التوصيات: دراسة التغيرات الحاصة في مستوى السايتوكينات في دم مرضى السكري لمعرفة العلاقة بين تركيزها و تقدم اعتلال الكلى السكري.


Article
Consideration of Liver Function test with Erythropoietin Hormone Levels in Iraqi Patients Diagnosed with Lymphoid and Myeloid Leukemia

Authors: Nour Sh, Rezaieg --- Muthanna M. Awad
Journal: Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية ISSN: 20786123 Year: 2018 Volume: 11 Issue: 1 Pages: 36-41
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The study was carried out to measure the erythropoietin hormone level and a number of the hematological variables (redblood cells, platelets, monocytes and lymphocytes) and biochemical variables (erythropoietin, alkaline phosphatase, alaninetransaminase and aspartate transaminase) for two types of leukemia (lymphoid leukemia and myeloid leukemia). EnzymeLinked Immune Sorbent Assay (ELISA) was used to detect level of erythropoietin in patients with lymphoid and myeloid,leukemia and control group , liver enzymes activity were measured including alkaline phosphatase (ALP) alanine transaminase(ALT) and aspartate transaminase (AST). Also estimated some hematological variables were estimated: red blood cells,platelets, lymphocytes and monocytes, as well as, ABO blood groups in all studied groups. The statistical analysis showedsignificant (P< 0.05) increase in the level of erythropoietin, liver enzymes, lymphocytes and monocytes number in patientswith lymphoid and myeloid leukemia when compared with the control group. While, there was a decrease (P< 0.05) in redblood cells count and platelets count in the patients groups compared with the healthy group. Also, the results from statisticalanalysis revealed that there was a strong correlation between ABO blood groups and leukemia.

Keywords

Erythropoietin --- Leukemia --- ALP --- ALT --- AST --- RBC.


Article
Association of Erythropoietin, Adiponectin and Leptin levels with Anemia in uremic diabetic patients (Under hemodialysis):

Authors: Tahrir E. Al-Kadium --- Munaf S. Daoud --- Salim M. Al-Rubaâe
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 4 Pages: 432-437
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: End stage renal disease in patients with diabetes mellitus has been called a medical catastrophe of worldwide dimensions .It was recognized that anemia is a complication of diabetes, particularly in patients with diabetic kidney diseases. The purpose of the present study is to determine whether erythropoietin, adiponectin, and leptin levels correlate with anemia in uremic diabetic patients (under hemodialysis).
Patients and Methods: The studied groups were comprised of (30) diabetic patients(9 patients with type1 and 21 type2 diabetes) with renal failure (group2) who had been under hemodialysis compared with (30) healthy controls (group1). Blood film was obtained in addition to blood tests include fasting serum glucose (FSG), glycosylated hemoglobin (A1c), insulin, urea, creatinine, uric acid, estimated glomerular filtration rate (eGFR), serum erythropoietin (EPO), Adiponectin (ADPN),and leptin.Results: It was found that uremic diabetic patients in group2(G2) had higher FSG, A1c, insulin and higher levels of urea, creatinine, uric acid and lower levels of eGFR when compared to healthy controls (P <0.05). Anemia was confirmed in the diabetic patients by Hemoglobin (Hb) and hematocrit (Hct) that were lower than healthy control (group1) (G1) (P<0.05).EPO, ADPN levels were increased in uremic diabetic patients as compared to control subjects (P <0.05). While, leptin levels were higher in type2 diabetes when compared to type1 diabetes and control subjects (group1) (P <0.05). There were positive significant correlations between (FSG and A1c), (Hb and Hct), (EPO and leptin), (EPO and Hct), (ADPN and urea). In addition there were significant negative correlations between (FSG and EPO), (A1c and leptin), (ADPN and leptin).Creatinine was negatively associated with Hb and Hct. ADPN was negatively associated with Hb in uremic diabetics.Conclusions: Anemia is a common accompaniment to diabetes, particularly in those with renal failure or under hemodialysis .Adipocytokines like leptin and adiponectin may involved with anemia in these patients. Leptin in the present study was positively associated with EPO levels (the hormone that stimulates red blood cells production in the bone marrow). ADPN was negatively associated with Hb. These elevated levels of ADPN may antagonize EPO and leptin to increase the hemopoiesis rate and Hb levels in uremic diabetic patients in addition to other factors involved with diabetes.


Article
Erythropoietin level in acute leukemia
مستوى الإريثروبويتين في سرطان الدم الحاد

Author: Seenaa Badr Mohammed سيناء بدر محمد
Journal: Iraqi National Journal Of Chemistry المجلة العراقية الوطنية لعلوم الكيمياء ISSN: 22236686 Year: 2015 Volume: 15 Issue: 2 Pages: 140-148
Publisher: Babylon University جامعة بابل

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Abstract

AbstractBackground: Acute leukemia is a proliferation of immature bone marrow-derived cells (blasts) that may also involve peripheral blood or solid organs. Erythropoietin, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production also has other range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis,and inducing proliferation of smooth muscle fibers.Objective: to evaluate serum level of erythropoietin in patients with acute leukemia. Research design and methods: In this case-control study, serum level of erythropoietin measured in 22 patients with Acute leukemia and 22 apparently healthy subjects using ELISA. Statistical analysis was performed using SPSS 17.0 . Results: There was a significant increment in level of erythropoietin in patients with acute leukemia compared to apparently healthy subjects (P < 0.001) independently to other parameters.Conclusion: Erythropoietin concentrations may predict adverse outcomes, and their measurement may facilitate risk estimation in leukaemic patients.

الخلاصةالخلفية : سرطان الدم الحاد هو انتشار الخلايا المشتقة من نخاع العظم غير الناضجة التي قد يشتمل أيضا على الدم المحيطي أو الاعضاء الصلبة. الإرثروبويتين ، هو هرمون بروتين سكري والذي يسيطر على انتاج الكريات الحمر وعمليات اخرى بما في ذلك تضيق الأوعية وارتفاع ضغط الدم ، وتنشيط الأوعية الدموية ، و يحفز انتشار ألياف العضلات الملساء .الهدف من الدراسة: لتقييم مستوى الإرثروبويتين في المصل من المرضى الذين يعانون من سرطان الدم الحاد .طريقةالعمل: في هذه الدراسة تم قياس الإرثروبويتين في 22مريض الذين يعانون من سرطان الدم الحاد و 22 شخصا على ما يبدو اصحاء باستخدام تقنية الاليزا . تم إجراء التحليل الإحصائي باستخدام SPSS 17.0. النتائج : كان هناك زيادة كبيرة في مستوى إرثروبويتين في المرضى الذين يعانون من سرطان الدم الحاد مقارنة مع الأصحاء (P < 0.001) .الاستنتاج : تركيزات إريثروبويتين قد يتوقع نتائج سلبية ، وقياسها قد يسهل تقدير المخاطر في المرضى.


Article
The Role of The Serum Calcium on Erythropoietin Responsiveness in Anaemic Haemodialysis Chronic Renal Failure Patients and The Effect of Dialysis Frequency and Duration

Author: Aljefery Mohammed Hashim
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2012 Volume: 20 Issue: 4 Pages: 1270-1280
Publisher: Babylon University جامعة بابل

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Abstract

In this study we examine the effect of the serum calcium level (in mmol/dl) on the rHuEPO ) EPREX) in 100 patients of different age group (20-65 years mean 42.5)of both sexes (35 female and 65 male) in haemodialysis program .We examine the responsiveness of anaemic CRF patients in HD program to the rHuEPO by the level of the PCV and compare the differences in the results according to the changes of the level of the serum calcium which may be fluctuated from patients to patients according to the different causes and from our result we can conclude that: the serum calcium level which examine in all patients in the study has a direct effect on erythropoietin treatment to anaemic HD CRF patients (p<0.05) and for this reason the calcium play a vital role in the anaemia management in this group of patients.


Article
EVALUATION OF THE EFFECT OF ORAL VERSUS INTRAVENOUS IRON TREATMENTS ON ANEMIA IN PATIENTS WITH CHRONIC KIDNEY DISEASES
تقييم ومقارنة تأثيرِ الحديدِ الوريدي ِمع الفموي على فقرِ الدم في المرضى المصابين بقصور الكليةِ المُزمنِ

Author: Arif Sami Malik عارف سامي مالك
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2010 Volume: 8 Issue: 4 Pages: 47-52
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Correction of anemia as a result of renal failure improves cardiovascular function and also provides significant cognitive and emotional benefits.The most appropriate route for iron supplementation has not been determined for patients with chronic renal failure who are not y et on dialysis.Objective:It is to compare the efficacy and tolerability of oral and intravenouse iron as an adjuvant therapy for erythropoieten treated anemic patients with chronic kidney disease in predialysis state.Methods:Forty five anemic patients with chronic kidney disease where prospectively randomized to receive an oral (ferrous sulfate 200 mg three time dialy ), or intravenous (300 mg iron dextran/ monthly) iron treatment, the duration of treatment was six months.Erythropoietin (rHuEpo) was simultaneously commenced and the dose adjusted according to pre-established protocol.Results:There were no significant differences in baseline patients characteristics between the two groups. four patients suffered possibleallergic reaction to iron dextran. Hemoglobin response in the end of study was similar in two groups, but serum ferritin was significantly higher in the intravenous group.the Starting dose of rHuEpo temporarily discontinued in the patients on oral iron and the patients receiving iron dextran rHuEpo was increased after 3 months , final doses on EPO were (33.5) and (41.6) units /Kg/week respectively in the oral and intravenous group. Although gastrointestinal symptoms were more commonly reported in patients taking oral iron.Conclusions: In pre-dialysis patients; the efficacy of monthly 300 mg iron dextran administerd intravenously is not superior in regard to haemoglobin response and EPO dose as compared with daily oral dose of 300 mg of ferrous sulfate or equivalent. Key words: Chronic renal failure,Erythropoietin, Dialysis, Ferritin , Iron dextran

خلفية الدراسة: يُحسّنُ تصحيحُ فقر الدم عند المرضى المصابين با لفشلَ الكلويَ الوظيفةً القلبية الوعائيةَ ويُزوّدُ منافعَ إدراكيةَ وعاطفيةَ هامّةَ أيضاً. الطريق الأكثر ملائمة للعلاج بالحديد متباين ومختلف عليه للمرضى المصابين بالفشلِ الكلويِ المُزمنِ الذين لم تجرى تهم عملية الديلزه هدف الدراسة: تهدف هذه الدراسه تقيييم ومقارنة نأثير الحديد عن طريق الفم والحديد دكستران الوريدي على فقر الدم عند المرضى المصابين بقصور الكلى المزمن.طرق الدراسة: خمسة وأربعون مريضاً مصاباً بفقر الدم نتيجة إصابتهم بعجز الكليةِ المُزمنَِ مستقبلياً يتلقوا (كبريت حديدوز 200 مللي غرام فموي ثلاث مرات يوميا، أَو وريدي (دكستران الحديد 300مللي غرام/ شهرياً)، مدّة المعالجةِ كَانتْ ستّة شهور..(ارثروبويتين rHuEpo )شُرِعَ بشكل آني والجرعةَ عدّلتْ طبقاً للنظامِ المُؤَسَّسِ.النتائـج: لاتوجد هناك اختلافات هامّةَ في خصائصِ مرضى الخطّ الأساسِ بين المجموعتين . أربعة مرضى عَانوا ردّ الفعل الحسّاس المحتمل للحديد دكستران. نتيجة اّلهيموغلوبينِ في النهاية مِنْ الدراسةِ كَانتْ متماثلة في المجموعتين، لكن فرتين المصل أعلى ً في المجموعةِ الوريديةِ. أوقفتْ الجرعةُ البادِئةُ لـrHuEpo بشكل مؤقت في المرضى على الحديد الفموي أما الذين يأخذون دكستران الحديد الوريدي فأن عقار ألأرثروبوينين زِيد بعد 3 شهورِ، أو كَانتْ (33.5) و(41.6) وحدات / كيلوغرام / أسبوع على التوالي في المجموعةِ الفموية والوريديةِ. بالرغم من أن الأعراضِ المعويةِ كَانتْ مُخْبَرة عَنْها عموماً أكثر في المرضى التي تَأْخذُ حديداً عن طريق الفم.الاستنتاج:في المرضى المصابين بالقصور الكلوي قَبْلَ غسلَ الكلية؛ ً 300 مللي غرام حديدِ دكستران بشكل وريدي لَيستْ متفوّقةَ فيما يتعلق بالاستجابة في زيادة الهيموغلوبينِ واحتياج جرعةِ ألأرثروبوييتين أو كما هو مُقارن بالجرعةِ اليوميةِالفمويهِ 300 مللي غرام مِنْ كبريتِ الحديدوز أَو المكافئِ.

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