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Article
P53 Expression in Gastric Dysplasia and carcinoma in Erbil City

Authors: Gayllan Qadir Ali كيلان قادر --- Bayan. A.Al-Badri بيان البدري
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 / 24108057 Year: 2011 Volume: 53 Issue: 2 Pages: 190-193
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Alteration in the expression of p53 tumor-suppressor protein is an event that occurs frequently in human cancer, but the practical implications of this phenomenon are yet to be fully exploited.
Objectives: to determine the value of p53 expression as a marker of tumor aggressiveness and the relationship between p53 over expression and clinico-pathologic variables in gastric adenocarcinoma.
Material & Methods: The expression of p53 was studied immunohisto-chemically in 10 cases with gastric dysplasia and 85 cases with gastric adenocarcinomas using formalin fixed, paraffin-embedded tissue samples. D07 a monoclonal antibody to p53 protein was used for the immunehistochemical analysis. The correlation between p53 expression in gastric dysplasia, gastric adenocarcinoma and clinicopathologic variables were analyzed.
Results: P53 positivity was found in 48.2% of gastric carcinoma cases, and 40% of gastric dysplasia. There was a significant correlation between the rate of p53 over expression and tumor grade (p = 0.015), and also with carcinomas associated with lymph node involvement (p = 0034). There was no significant association between p53 protein expression and histological type (p = 0.171). The association between p53 protein expression and the depth of tumour invasion was found to be statistically insignificant.
Conclusion: The results obtained suggest that P53 protein expression is a useful biomarker for the assessment of gastric adenocarcinoma aggressiveness. The preoperative assessment of p53 expression in gastric carcinomas can be helpful in identifying patients with higher grades and more advanced tumors. P53 immunoreactivity can predict lymph node status in patients with gastric carcinoma.


Article
Primary Gastric Lymphoma in North of Iraq (A Study of 34 cases in the surgical departments of Erbil and Mousl hospitals).

Author: Abdulqadir M.Zangana
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2007 Volume: 6 Issue: 4 Pages: 294-302
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Primary Gastric Lymphoma is an uncommon malignancy among gastric malignancies. Histology of the Primary Gastric Lymphoma is varied and the extranodal marginal zone B-cells lymphoma is especially significant on account of its potential remission with antibiotic therapy.OBJECTIVE:To study the incidence, staging, clinical presentation, histological and management of Primary Gastric Lymphoma in the North of Iraq.PATIENTS AND METHODS:From January 1988 to February 2005, A total number of 534 patients operated as gastric tumors, 34 (4%) diagnosed as Primary Gastric Lymphoma. at the surgical departments of Erbil and Mousl teaching hospitals.RESULTS:Out of 34 Primary Gastric Lymphoma,24 cases (70.5%) were located in the distal part of the stomach the most common cell type was B-cell type non-Hodgkin's lymphoma,.Surgery was the main method of treatment and followed by chemotherapy and radiotherapy. Helicobacter pylori were isolated from all 34 Patients.All patients received antibiotics for eradication for H. Pylori infection for 4-6 weeks.Long-term remission were induced in the low-grade MALT lymphomas in 73% of cases by the successful eradication of the H. pylori infection Operative mortality rates was12 %CONCLUSION:surgical intervention was confined to stage I&II while patients with stage III surgery was indicated mostly for complications like bleeding and perforationMucosa-associated lymphoid tissue tumor (MALT) had a better prognosis because it tends to be localized with a long survival period.

Keywords

gastric lymphoma --- primary


Article
Gastric Cancer Staging Comparism and Role of EUS

Authors: Aqeel Shakir Mahmmod --- Talib A.Majid --- Waseem Mohammed Shakir
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 1 Pages: 36-40
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:The tumor stage of gastric cancer in the preoperative period must be evaluated to choose the type of therapy so the preoperative imaging diagnosis is the basis for a tumor–stage –adapted therapy of each patient .OBJECTIVE:Is to compare between the preoperative staging of gastric cancer which includes the ultrasound scan, CT scan and EUS findings and the postoperative staging which include the histopathological finding and to assess the efficacy of EUS in determining the tumor and lymph node stage of tumor.PATIENT AND METHODS:Prospective study of 32 patients with gastric cancer admitted to the surgical word in the gastroenterology and hepatology teaching hospital, medical city, Baghdad over the period from Nov. 2005 to Nov. 2007 who underwent gastric resection , all the cases were proved to be gastric cancer by endoscopic biopsy or by histopathological examination of the gastric specimen after operative resection, and all the cases radiologically investigated in the preoperative period by abdominal ultrasound, endoluminal ultrasound and abdominal CT scan.RESULTS:Show that there is increase in the staging in 18 (56.25%) cases and same staging in 8 (25%) cases and decrease staging in 6 (18.75%)cases.CONCLUSION:Endoluminal ultrasound is most accurate preoperative investigation to determine staging of gastric malignancy. Ultrasound and CT scan although it is important in the assessment but they downstage the tumor in about half of cases. So we recommend that EUS is done for all patients with gastric cancer for accurate planning for surgery


Article
STUDY THE EFFECT OF ETHANOLIC EXTRACT OF ( MATRICARIA RECUTITA AND GLYCYRRHRZA GLABRA) COMPARED WITH CIMETIDINEE IN TREATING GASTRIC ULCERATION IN RABBITS INDUCED BY ASPIRIN
تأثير المستخلص الكحولي لأزهار نبات البابونج وعرق السوس Matricaria recutita and Glycyrrhrza glabra مقارنة بالسمتدين في معالجة قرحة المعدة المستحدثة بالأسبرين في الأرانب

Author: Huda K.Khasaf, HassanT. ,Abdulrhazzak N.Khudeir هدى كامل خصاف , حسن طعمة عبد الرزاق نعيم خضير
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2012 Volume: 11 Issue: 2 Pages: 135-144
Publisher: Basrah University جامعة البصرة

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Abstract

This study aimed to evaluate the effect of the drenching ethanolic extract of Chamomile and licorice at a dose of (100 mg/kg and 250 mg/kg ) respectively in treating gastric ulcer induced by aspirin in rabbits. The study included the effect of drenching the ethanolic extract of both plants on the gastric ulcer index ,gastric juice pH, and volume of gastric fluid as well as curative ratio. Results revealed that treatment with cemitidine and Chamomile or licorice or their combination was associated with significant(p<0.05) increase in pH values compared to the respective value of the untreated (positive) group. Chamomile or licorice was superior to that of cimetidinee and to combiation of the extracts. Groups treated with cemitidine and drenching of Chamomile or Licorice were associated with significant (p<0.05) reduction in the volume of gastric juice compared to positive and control groups, a group treated with a combination of extracts caused significant (p<0.05) reduction in gastric juice volume compared to positive group. A curative ratio of gastric ulcer was better in groups given chamomile or licorice over those given cemitidine or combination of chamomile and licorice. Furthermore, chamomile was superior over licorice in its curative ratios of gastric ulcer.In view of above results we can conclude that a drenching ethanolic extract of Chamomile and licorice in the doses used in this study caused increased gastric ulcer healing compared with treatment by 200mg/kg of cimetidinee in treatment gastric induced by Aspirin in rabbits.


Article
Association of Helicobacter Pylori Infection and Gastric Cancer

Author: Shurooq A. Lafta, Abdul Hussein M. ALFaisal
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 1 Pages: 1-9
Publisher: Baghdad University جامعة بغداد

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Abstract

Helicobacter pylori (H. pylori) is the most important etiologic factor for gastric cancer. It is one of the most common human pathogens, which colonizes in the mucus layer of the gastric epithelium in more than 50% of the population. The study include 78 samples of gastric cancer in addition to 42 blood samples. The results from 78 gastric cancer samples showed that gastric cancer can occur red at any age, but it increases in older ages and the incidence of H. pylori infected positive gastric cancer (HIP-GC) is higher than of H. pylori infected negative gastric cancer (HIN-GC). Male is the predominant in both groups and female affected by H. pylori more than male and the intestinal type was the predominant type.


Article
STUDY THE EFFECT OF PROANTHOCYANIDIN AND RANITIDINE ON HAEMATOLOGY AND BIOCHEMICAL PARAMETERS IN ADULT FEMALE RABBITS WITH GASTRIC ULCERATION INDUCED BY INDOMETHACIN
دراسة تأثير بروانثوسياندين و الرانتدين على المعايير الدمويه والكيموحيويه في اناث الارانب البالغة المستحدثه القرحه بواسطه الاندوميثاسين

Author: Abrar S. Abdul -Razak* Muna H. AL-Saeed** Eman A. AL-Masoudi
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2016 Volume: 15 Issue: 1 Pages: 132-160
Publisher: Basrah University جامعة البصرة

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Abstract

The study was conducted in Collage of Veterinary Medicine Basrah University,to evaluate the effect of proanthocyanidin and ranitidin on gastric ulcer, haematological and biochemical parameters changes by using female rabbits with acute gastric lesions induced by indomethacin.The study done on (30)adult female rabbits, their weight ranged between (1500-2000.0mg); divided into five groups, each group consist of six rabbits as the following: Group1:- healthy (negative control group) administrated normal saline (0.9 of normal saline) for 10 days; Group 2:-given indomethacin 75mgkg B.W. for two days(positive control group); Group 3:- at first given indomethacin 75mgkg B.W. for two days, then treated with proanthocyanidin(PA) 100mgkg B.W. for 10 days; Group 4, initially given indomethacin 75mgkg for two days, then treated with proanthocyanidin(PA) 200mgkg for 10 days; Group 5, given indomethacin 75mgkg for two days, then treated with ranitidin 50mgkg for10 days.The results showed that proanthocyanidin(PA) and ranitidin caused significant reduction (P≤0.05) in gastric volume, ulcer area, serum MDA, gastric tissue MDA while significant increase (P≤0.05) in mucin and gastric pH. It also revealed significant decrease (P≤0.05) in glucose concentration in rabbits treated with proanthocyanidin compared to positive control group while showedno-significant change in glucose concentration in rabbits treated with ranitidine compared with positive control group. It also, showed significant increase (P≤0.05) in Red Blood Cell(RBC),Hemoglobin(Hb) andMean Corpuscle hemoglobin concentration(MCHC) in rabbit treated with proanthocyanidin or ranitidin, while there was significant decrease (P≤0.05) in Mean Corpuscle Volume(MCV) in rabbits treated with proanthocyanidin in dose of 100mgkgand ranitidine in a dose of 50mg/kg with non-significant change of MCV in female rabbits with gastric ulceration treated with proanthocyanidin at dose 200 compared with positive control group.It showed non-significant changes in White Blood Cell (WBC) of female rabbits with gastric ulceration treated with proanthocyanidin compared with positive and negative control groups, while the results showed significant decrease (P≤0.05) in WBC of female rabbits with gastric ulceration treated with ranitidine group compared with positive and negative control groups and the other groups. The study revealed significant decrease (P≤0.05) in total cholesterol, triglyceride, Low Density Lipoprotein(LDL) and very Low Density Lipoprotein(VLDL) of female rabbits with gastric ulceration treated with proanthocyanidin and ranitidine group compared with positive control group while it showed significant increase (P≤0.05) in High Density Lipoprotein (HDL) in rabbits treated with proanthocyanidin and ranitidine group compared with positive control group. It is concluded that proanthocyanidin extract of the grape seeds(Vitis vinifera)displayed good antiulcer activity, hypoglycemia effect, amelioration of heamatological parameters and improve dyslipidemia corroborating the folk use of Vitis vinifera preparations, and contributing for its pharmacological validation.


Article
The correlation between KRAS mutations and H. pylori in gastric cancer patients

Author: Shorouq Abdul Jabar1 , Abdul Hussein M. ALFaisal 2
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2017 Volume: 16 Issue: 3 Pages: 82-93
Publisher: Baghdad University جامعة بغداد

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Abstract

Helicobacter pylori (H. pylori) is the most important etiologic factor for gastric cancer ,it is one of the most common human pathogens, which colonizes in the mucus layer of the gastric epithelium in more than 50% of the population. It is the only bacterium that classified as a class I carcinogen by the WHO .The clinical outcomes of H. pylori infection is determine by host genetic predisposition, bacterial virulence factors, and environmental factors. H. pylori can induce chronic inflammation and oxidative stress that provides a permissive environment to DNA damage, this damage can lead to genetic instability and eventually, neoplastic transformation. KRAS is one of the most frequently mutated oncogenes in human cancers, in particular in pancreatic, colorectal and lung cancers. However, oncogenic mutations of KRAS are infrequent in gastric cancer. Point mutations of the KRAS are found predominantly in adenocarcinomas. Codons 12 and 13 are the most frequently detected mutation “hot spots”, they make the protein resistant to GTP hydrolysis by GTPases, thereby leading to constitutive KRAS activity. The results revealed that no mutations in codons 12 or13 detected in all patient groups, but the sequencing analysis detected other mutations in exon 2. These mutations were found in 7 /20 (35%) patients of HIP-GC group, 5/16(31.25%) patients of HIN-GC group and 4/15(26.7%) patients of the ulcer group.


Article
β-Catenin Protein and Its Association with Helicobacter Pylori as A Possible Marker for Gastric Cancer

Authors: Mustafa K. Al-Bayaty --- Salma A. Abass --- Mohammed F. Al-Marjani
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 3 Pages: 43-49
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Gastric cancer is still the main health threat being the third leading cause of deaths from cancers in the world, the major risk behind this disease is that it remains asymptomatic in the early stages and in (97 %) cases it metastasizes to other organs. Gastric cancer is a multifactorial disease with Helicobacter pylori (H. pylori) being the major risk factor, however, patients with gastritis, especially atrophic gastritis and gastric ulcer have been shown to be at an increased risk for developing gastric cancer. In this research, serum β-catenin, carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) were measured in patients diagnosed with gastric cancer, gastric ulcer and gastritis and also in healthy volunteers. Infection with Helicobacter pylori (H. pylori) was diagnosed by histological test, rapid urease test (RUT) and by serological tests which included IgG and IgA antibodies. The results showed that there was a large significant increase in the levels of serum β-catenin in patients with gastric cancer compared to the control group as well as to the gastritis and gastric ulcer patients. A significant increase was also seen in gastric ulcer and gastritis patients when compared to the control group. In addition, a significant increase was seen in β-catenin serum levels in patients with gastric cancer and gastric ulcer infected with H. pylori compared to the uninfected gastric cancer and gastric ulcer patients. A non-significant change was observed in the levels of CEA and CA 19-9 in all the patients compared to the control group. The results of this study suggest that β-catenin can serve as a potential biomarker for the diagnosis of gastric cancer and that H. pylori has a significant effect on the levels of this protein.


Article
STUDY THE EFFECT OF ISOLATED ALKALOID FROM HALOXYLON SALICORNICUM PLANT ON SOME HEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN GASTRIC ULCERATION RABBITS INDUCED BY INDOMETHACIN .
دراسة تأثير القلويد المعزول من نبات الشنان على بعض المعايير الدموية والبايوكيميائية في الارانب المصابة بالقرحة المعدية المستحدثة بواسطة الاندوميثاسين

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Abstract

This study was undertaken to isolate alkaloids from Haloxylon Salicornicum plant to show the curative effect after short-term daily orall administration for 10 days (300 mg/Kg B.W.) on gastric ulcer,hematological parameters and some biochemical parameters in gastric ulceration rabbits induced by indomethacin.Moreover,some qualitative chemical analysis,thin layer chromatography,UVspectroscopy and FTIR spectroscopy were used to identify alkaloid compound .Rabbits were divided randomly into three groups,6 rabbits in each.Group one received 3 ml normal saline orally (control group).Group two was treated with indomethacin (75 mg/Kg B.W.) (gastric ulceration group).Third group gastric ulceration rabbits post-treated with isolated alkaloid (300 mg/Kg B.W.).The results of the present study indicated that isolated alkaloid has Rf= 0.86,high significant decreased (p≤0.001) in RBC,Hb,PCVand mucin,(P ≤ 0.01) in MCHC and PH,no significant difference (P ≥ 0.05) in MCH in gastric ulceration rabbits compared with control group and observed high significant increased (p≤0.001) in MCV, MDA and gastric juce volume,WBCcount appeared high significant increased (P≤0.01).While, observed high significant increased(P≤ 0.001) in Hb,PCVand mucin,(P≤ 0.01) in RBC,MCHC and pH.Significant increased(P≤0.05) in MCH after treated with isolated alkaloid and high significantly decrease (P ≤ 0.001)in MCV,gastric juce volume and MDA

أجريت هذه الدراسة لعزل القلويدات من نبات الشنان لمعرفة التأثير العلاجي بعد الاعطاء قصير المدى (10 ايام ) للقلويد المعزول بجرعة يومية (300 ملغم / كغم ) فمويا على قرحة المعدة حيث تم قياس معايير الدم وبعض المعايير البايوكيميائية في الارانب المصابة بالقرحة المعدية المستحدثة بواسطة الاندوميثاسين ( indomethacin ) بالاضافة لاجراء بعض الكشوفات الكيميائية النوعية كما استخدمت كروموتوغرافيا الطبقة الرقيقة ومطيافية الاشعة فوق البنفسجية ومطيافية الاشعة تحت الحمراء لتشخيص القلويد المعزول .تم تقسيم الارانب عشوائيا الى ثلاثة مجموعات (6 لكل مجموعة ) ,المجموعة الاولى هي مجموعة السيطرة جرعت 3 مل من المحلول الملحي الفسيولوجي , المجموعة الثانية المصابة بالقرحة المستحدثة بواسطة indomethacin (75 ملغم / كغم )والمجموعة الثالثة المصابة بالقرحة المعالجة بالقلويد المعزول (300 ملغم / كغم ) . اوضحت نتائج الدراسة ان للقلويد المعزول معدل سريان (Rf=0.86 ) كما اوضحت نتائج الدراسة حصول انخفاض عالي المعنوية (p≤0.001) في عد RBCومستوى Hb,PCV ,pHوmucin وبفرق عالي المعنوية ( p ≤ 0.01 )في مستوى PHو MCHCوعدم حدوث فرق معنوي في مستوى MCH في المجموعة المصابة بالقرحة المعدية مقارنة بمجموعة السيطرة كما لوحظ ارتفاع عالي المعنوية (p≤0.001) في مستوى MCV وMAD وحجم سائل المعدة وبفرق عالي المعنوية ( P≤ 0.01) في عد WBC في المجموعة المصابة بالقرحة المعدية مقارنة بمجموعة السيطرة وبعد المعاملة بالقلويد المعزول لوحظ ارتفاع عالي المعنوية( P≤ 0.01) في عد RBC و نسبة MCHCوpH وبفارق عالي المعنوية ( P≤ 0.001 ) في مستوى PCV, Hb و mucin وانخفاض عالي المعنوية ( P≤ 0.001) في حجم سائل المعدة ومستوى MDA وانخفاض معنوي ( p≤0.05) في عد WBC وارتفاع معنوي(P≤0.05 )في مستوى MCH مقارنة بالمجموعة المصابة بالقرحة المعدية وتدل نتائج الدراسة الى امكانية استخدام القلويد المعزول من نبات الشنان كعلاج للقرحة المعدية وبشكل فعال .


Article
Epidermal Growth Factor Receptor (egfr) Immunohistochemical Expression in Gastric Carcinoma

Author: Salim R.Al-Obaidie , Ali F.Hashim, Farah F.Hassan
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2016 Volume: 15 Issue: 3 Pages: 379-384
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND : Gastric cancer is the the fourth most common cancer and the second leading cause of cancer-related deaths. Gastric cancer is a major cause of cancer morbidity and mortality worldwide.OBJECTIVE:To estimate the immunohistochemical expression of epidermal growth factor receptor(EGFR) in the gastric cancer in relation to other parameters like grade and stage.METHODS: Formaline fixed ,paraffin-embedded blocks from 51 patients (29 male and 22 female) with gastric carcinoma were included in this study. Ten biopsies of normal gastric tissue were selected as a control group. Envision (DAKO) technique was applied to study the immunohistochem- ical expression of EGFR in paraffin embedded sections of gastric cancer. RESULTS: Positive immunohistochemical expression of EGFR was seen in 41.2% of cases as both membranous and cytoplasmic brown staining while there was negative staining in the normal control group (p<0.05). EGFR immunoexpression was correlated with the histological type( more in the intestinal variant than the diffuse type) (p<0.0.5).CONCLUSION: These findings provides further evidence for the role of EGFR in the tumorgenensis of gastric cancer. However, EGFR could not be well correlated with stage of tumor and hence may be poor prognostic parameters of the state of malignancy.

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