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Article
High sensitivity C-Reactive Protein is a Significant Predictor for Hypertension and Obesity in Iraqi Postmenopausal Women

Author: Waleed Kh. Hussein * MBChB , MSc د. وليد كامل حسين
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 328-331
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary: Background: several new inflammatory markers have emerged as strong predictors of cardiovascular disease in healthy and non-healthy subjects, one of these markers is hs-CRP, which has been proposed as independent risk factor for cardiovascular disease, and it is positively associated with body weight. Little is known, however, about the utility of hs-CRP and other biomarkers in obese hypertensive Iraqi post menopausal women.The aim of study is to examine the hypothesis that there is a relation between obesity, hypertension and a chronic low-grade inflammatory status (represented by high hs-CRP).Patients and Methods: A total number of 99 postmenopausal women classified into obese hypertensive group (case) and non obese non hypertensive group(control). For these groups, measurement of zinc, calcium, phosphorus, lipid profile, High sensitivity C–Reactive Protein, body mass index and waist circumference were done.Results: The (Mean ± SD) of hs-CRP in the cases and controls were (5.74 ± 2.1) mg/land (2.1 ± 0.8) mg/l respectively, (P < 0.001).Calcium, phosphorus, zinc and triglycerides showed no statistical significance between the groups (Pvalue >0,05) while body mass index , waist circumference ,HDL ,LDL ,and total were statistically significant (Pvalue <0,05). Conclusion: There is an elevated serum level of hs-CRP in hypertensive and obese subjects in comparison with low levels in control group (non obese non hypertensive) which suggest a role of hs-CRP in developing hypertension and obesity.Keywords: high sensitivity C-Reactive protein, hypertension, obesity, postmenopause.


Article
Measurements of serum high sensitivity C-reactive protein, and procalcitonin levels in type1 and 2 Diabetes complicated with diabetic foot syndrome
قياسات C-reactive protein عالي الحساسية ، ومستويات البروكالسيتونين في داء السكري من النوع 1 و 2 المصحوبة بالمضاعفات بسبب متلازمة القدم السكرية

Authors: Zhian M.I. Dezayee --- Marwan S.M. Al-Nimer
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 3 Pages: 1869-1877
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: There is evidence that the procalcitonin levels are usually correlated with the high sensitivity C-reactive protein levels in inflammatory conditions. Therefore, this study aimed to assess the simultaneous changes of the procalcitonin and hs-CRP levels in the diabetic foot syndrome complicated type 1 and 2 diabetes.Method: This observational study was carried in the Center of Diabetes Mellitus in Erbil, Iraq from 1st January to the 30th September 2015. A total number of 170 participants were enrolled in this study. They grouped into Group I (healthy subjects, n=30), Group II (type 1 diabetes with diabetic foot syndrome, n=70) and Group III (type 2 diabetes with diabetic foot syndrome, n=70). The anthropometric measurements, blood pressure, fasting serum glucose and lipid profile, and the inflammatory markers included high sensitivity C-reactive protein and procalcitonin were determined.Results: Group III patients had a significant longer duration and score of diabetic foot syndrome, higher anthropometric measurements, higher blood pressure and fasting lipid profile levels compared with Group II. Serum procalcitonin and high sensitivity C-reactive protein levels were significantly higher in diabetic patients compared with Group I subjects. The serum levels of procalcitonin and high sensitivity C-reactive protein of Group III patients (1.11±0.47 ng/ml; 12.48±2.57 mg/L) were significantly higher than corresponding values of Group II patients (0.334±0.094 ng/ml; 5.73±0.89 mg/L). A non-significant correlation between procalcitonin with high sensitivity C-reactive protein in Group II and III was observed.Conclusion: We conclude that the simultaneous measurements of high sensitivity C-reactive protein and procalcitonin as inflammatory biomarkers are not necessary because the correlation was not significant.


Article
The correlation between serum high sensitivity C-reactive protein and leptin in reproductive age overweight/obese women in Erbil city
العلاقة بين مصل البروتين سي التفاعلي عالي الحساسية واللبتين لدى النساء ذوات الوزن الزائد / البدينات في سن الإنجاب في مدينة أربيل

Author: Showan D. Hussain
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 3 Pages: 167-174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objectives: Leptin could be a key regulator of C-reactive protein (CRP) levels, which serve as a marker of systemic inflammation. Both leptin and CRP are predictors of cardiovascular disease (CVD). This study, attempted to characterize the association between inflammatory marker hs-CRP and serum leptin in overweight/obese women in reproductive age in comparison with normal body mass index women (BMI) as a control group. Methods: Eighty reproductive age women were divided into two groups: first group of 50 overweight / obese women; with mean age 27.7 years and BMI mean (31.4 Kg/m2). The second group of 30 age-matched women with mean age 28.8 years and BMI mean (22.5 Kg/m2) which served as control group. Any subject with other diseases or on medication that might affect the study was excluded. Fasting blood samples for both groups were collected and serum hs-CRP, leptin, lipid profile and glucose were measured Results: In the overweight / obese group hs-CRP concentrations were significantly associated with BMI and leptin (r =0.3, r =0.284, with p <0.05) respectively. This association remained significant, even after adjusting BMI, for each one unit increase in serum leptin the serum hs-CRP escalated by a mean of 0.05 (mg/L). Serum Leptin notably has a more significant role than BMI in explaining changes of serum hs-CRP since its standardized coefficient was higher (ß =0.384 with p=0.001) versus (ß =0.266 with p=0.016) for BMI in overweight and obese women. Conclusion: Leptin is a stronger predictor of hs-CRP than BMI in overweight and obese women in reproductive age.


Article
Assessment of Myeloperoxidase enzyme activity and high sensitivity C-reactive protein as an Inflammatory markers in Ischemic Heart Disease: A prospective & Follow up Study

Authors: Thabit Nouman --- Abd Al-'Hameed Al-Queseer --- Sarah Isam Attallah
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2015 Volume: 28 Issue: 2 Pages: 94-100
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The diagnostic work-up of patients with ischemic heart disease in the cardiac care unit (CCU) is a challenging task. So taken together, high sensitivity C-reactive protein and Myeloperoxidase enzyme activity may be complementary and explore different fields: hs-CRP is a marker of disease activity and vascular inflammation, and is useful for long-term risk stratification while MPO is a marker of plaque instability and neutrophil activation and may be associated with short-term stratification, in particular in patients with troponin negative levels.Objective: To evaluate the activity of myeloperoxidase enzyme and hs-CRP in ischemic heart disease patients in the routine setting of CCU, its value after treatment, and it's interaction with the other inflammatory biomarker hs-CRP.Patients and Methods: Ten patients with angina pectoris and twenty eight patients with acute myocardial infarction recruited from Diayla Teaching Hospital. Demographic data, anthropometric measurement and blood samples were obtained from patients for determination of myeloperoxidase enzyme activity, and high sensitivity C-reactive protein.Results: The results showed that Serum myeloperoxidase enzyme activity on admission was higher than corresponding value after treatment in AMI (62.5±44.6vs 42.0 ±44.5µU/ml).hs-C-reactive protein level is significantly high in all patients, in these with Angina pectoris have significantly higher than corresponding patients with acute myocardial infarction which amounted 19.1±2.5 µU/ml).Conclusion: The activity of myeloperoxidase enzyme is partly enhanced by treatment and there are independent interrelationships between inflammatory biomarkers hs-CRP and MPO.


Article
Study of the Correlation between high sensitivity C reactive protein and Each of Malondialdehyde , Lipid profile, and Atherogenic Index inPatients with Ischemic Heart Diseases(IHD) in Thi-Qar Governorate
دراسة علاقة بروتين سي الفعال عالي الحساسية وكل من المالون داي الديهايد، نمط الدهون، وعامل التصلب في مرضى امراض القلب الاسكيمية في محافظة ذي قار

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Abstract

Objective: Ischemic heart disease (IHD) is estimated to be leading cause of mortality in the world and in high-income countries. The present study was designed to determine and compare the levels of (hsCRP, MDA, lipid profile, and atherogenic index)in patients with (IHD) and healthy individuals and asses the titer of hsCRP among different types of IHD to predict its role in the risk stratifications of Ischemic Heart Disease and healthy individuals. Material and Methods:Serum high sensitivity C reactive protein ,lipid profile ,malondialdehyde, and atherogenic index levels were measured in 100 patients Ischemic Heart Disease and 70 supposedhealthy subjects .Results:The levels of serum high sensitivity C reactive protein , malondialdehyde, biochemical markers of lipid profile (serum TCH,TG,LDL,VLDL)and atherogenic index (AI) were revealed significant increase in patients with coronary artery disease as compared to control group whereas the levels (HDL) showed a significant decrease in coronary heart disease patients in comparison to control subjects(P ≤ 0.01).This study was also revealed the correlation between the concentrations of the measured parameters and hsCRP.This study revealed significant in hsCRPin patients with (IHD). Conclusion:This study revealed significant inhsCRPin patients with (IHD).Lipid peroxidation and oxidative stress is more prominent in patients with (IHD) comparison to healthy individuals ,and this is mostly the leading cause of atherosclerotic processes and resultant complication of coronary occlusion . this lipid peroxidation reflected by (hsCRP, MDA, LDL, and atherogenic index ) were obvious in this study .

الهدف: مرض القلب الاسكيمي قدر ليكون السبب الرئيسي للوفيات في العالم وفي البلدان ذات الدخل المرتفع .وقد تم تصميم هذه الدراسة(الدراسة الحالية) لتحديد ومقارنة مستويات بروتين سي الفعال عالي الحساسية ،مالون داي الديهايد ،نمط الدهون ،وعامل التصلب لمرضى امراض القلب الاسكيمية والاشخاص الاصحاء .وتقويم معيار بروتين سي الفعال عالي الحساسية بين انواع مختلفة من امراض القلب الاسكيمية للتنبؤ بدورها في مطابقات خطر مرض القلب الاسكيمي والاشخاص الاصحاء. الموادوطرق العمل :تم قياس بروتين سي الفعال عالي الحساسية في مصل الدم ونمط الدهون ومالون داي الدبهايد وعامل التصلب في (100) مريض من مرضى امراض القلب الاسكيمية و(70)شخصاً مفترض انهم اصحاء. النتائج:تناولت مستويات بروتين سي الفعال عالي الحساسية ومالون داي الديهايدوعلامات الكيموحيويةمن نمط الدهون (الكولسترول، الترايكليسيرايد، والبروتينات الدهنية واطئة الكثافة ، والبروتينات الدهنية واطئة الكثافة جداً)في مصل الدم وعامل التصلب زيادة كبيرة في المرضى الذين يعانون من مرض الشريان التاجي مقارنة مع مجموعة السيطرة. بينما اظهرت مستويات البروتينات الدهنية عالية الكثافة انخفاض ملحوظ في مرضى القلب التاجي مقارنة مع مجموعة السيطرة ((P ≤ 0.01وقد تناولت هذه الدراسة ايضاً العلاقة بين تراكيز كل من المعايير المقاسة وبروتين سي الفعال عالي الحساسية، هذه الدراسة تناولت الاهمية لبروتين سي الفعال عالي الحساسية في المرضى الذين يعانون من امراض القلب الاسكيمية. الاستنتاجات : تناولت هذه الدراسة الاهمية لبروتين سي الفعال عالي الحساسية في المرضى المصابين بامراض القلب الاسكيمية . الاكسدة الفوقية للدهون وفرط الاكسدة هو الاكثر بروزاً مقارنة في مرضى القلب الاسكيمية الى الاشخاص الاصحاء وهذا هو في الغالب السبب الرئيسي لعمليات تصلب الشرايين والناتجة من مضاعفات انسداد الشريان التاجي. هذه الاكسدة الفوقية للدهون التي يعكسها بروتين سي الفعال عالي الحساسية ومالون داي الديهايد والبروتينات الدهنية واطئة الكثافة وعامل التصلب واوضحت الدراسة الحالية تناسبها طردياً


Article
Serum Interleukine 35 in Iraqi female patients with newly diagnosed of rheumatoid arthriti
مصل الانترليوكين – 35 في النساء العراقيات المصابات بمرض التهاب المفاصل الروماتويدي

Author: Anwar F. Al-Tai انوار فاروق مسلم
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2014 Volume: 56 Issue: 3 Pages: 322-324
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Rheumatoid arthritis (RA) characterized by local and systemic effects of inflammation has a wide range of biochemical markers implicated directly or indirectly to its pathogenesis. Objective: To evaluate interlukine 35 (IL-35) in Iraqi females with newly diagnosed RA and to assess its contribution in the disease process. Patients and method: Serum of (55 Females) of newly diagnosed RA and 23 healthy Females were used to estimate their interlukine levels. Results: Females of RA showed a significant increase in the levels of interleukine 35(IL-35) and in the levels of High Sensitivity C-Reactive Protein (hs CRP). While there were no significant changes in the level of alkaline phosphatase (ALP) and calcium (Ca). The correlation between IL-35 and each of hs CRP, ALP and Ca (-ve) were non-significant (r = -0.066, -0.04271 and -0.103) respectively. Conclusion : This is the first study to show the elevation of serum levels of IL-35 in Iraqi female patients with newly diagnosed RA which indicates that IL- 35 may be a good biomarker for early RA. Key Words: Rheumatoid arthritis (RA), Interleukin 35 (IL-35), High sensitivity C- reactive protein (hs CRP), Calcium (Ca), alkaline phosphatase (ALP).

الخلفية: يتصف التهاب المفاصل الروماتويدي بنتائج التهابات موضعية وعامة والتي تمتلك مساحة واسعة لقياسات الكيمياء الحياتية والتي تؤثر بصورة مباشرة او غير مباشرة على تكوين المرض.الهدف من الدراسة: لتقييم الانترليوكين 35 ودوره الفعال للكشف المبكر عن التهاب المفاصل.الاشخاص وطريقة العمل: تم أخذ (55) امرأة مشخصة حديثاً بالتهاب المفاصل الروماتويدي و(23) انثى كمجموعة ضبط لدراسة الانترليوكين (35) والبروتين الفعال من النوع الحساس.النتائج: وجدت زيادة ملحوظة في مستوى الانترليوكين (35) والبروتين الفعال عند النساء المصابات بالتهاب المفاصل الروماتويدي وكذلك لم يلاحظ اي تغيير في مستوى الفوسفات القاعدية والكالسيوم عند تلك النساء المصابات. كما وجدت علاقة سالبة ملحوظة بين الانترليوكين (35) مع (البروتين الفعال، الفوسفات القاعدية والكالسيوم).الاستنتاجات: تظهر هذه الدراسة ارتفاع مستويات الانترليوكين (35) في مصل دم النساء العراقيات المصابات بالتهاب المفاصل الروماتويدي المشخص حديثاً وبذلك يمكن اعتبار قياس تركيز الانترليوكين (35) في الدم كمؤشر حيوي للكشف المبكر عن التهاب المفاصل الروماتويدي.الكلمات المفتاحية: التهاب المفاصل الروماتويدي، الانترليوكين35، الروتين الفعال الحساس من النوع سين، الكالسيوم Ca، أنزيم الفوسفوتيز القلوي ATP.

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