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Article
Vascular Endothelial Growth Factor as Predictive Marker for Hypertension in Iraqi Adults Patients

Authors: Huda Jaber Waheed --- Huda Abdul Ridha Hadi --- Mostafa Abdulfatah Shafek
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2016 Volume: 15 Issue: 2 Pages: 56-59
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Vascular endothelial growth factor (VEGF) is considered the most potent angiogenic growth factor for the stimulation of collateral vessel growth in peripheral and myocardial ischemia and other coronary heart disease. Aim: The aim of the present study was first to assess the levels of VEGF in adult subjects with hypertension, second to find any correlation between VEGF and other studied biochemical markers. Patients & Methods: Thirty four adults with hypertension (age mean 34.55 ± 3.79 year) from outpatients of Al-yarmook Teaching Hospitals in Baghdad were selected randomly from March to April 2015. For comparison, (30) normotensive subjects which were matching to patients in age and BMI. VEGF levels were measured. Results: Biochemical parameters include FBG, HDL, and cholesterol, TG, HbA1c and PCV. Anthropometric measurements were also recorded. VEGF significantly higher (p ˂ 0.05) in patients group when compared to healthy group, as well as, significant elevation also shown in FPS, HDL and HbA1c, while TG, cholesterol, Creatinine and PCV not affected. Conclusion: VEGF can be used as diagnostic marker for the hypertension in adult patients.

Keywords

Hypertension --- VEGF


Article
Effect of hypertension on diabetic peripheral neuropathy

Author: Ihsan M. Ajeena
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 2 Pages: 160-165
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:
Back ground: Two groups of diabetic patients ((the first include 20 patients
complaining from diabetes mellitus alone, and the second include patients that
complain from both hypertension and diabetes mellitus)) were included in this
study. These patients were chosen((from a large number of patients, with a proved
diagnosis, that are referred to the neurophysiology unit from the department of
medicine)) to be of the same age group and gender, so that any of these two factors
can no longer be a source of any possible error in the results.
Patients & methods: The electrophysiological tests that were done to all of our
patients include: sensory latency and sensory amplitude for the ulnar and sural
nerves, also the distal motor latency, motor conduction velocity and motor
amplitude for both ulnar and common peroneal nerves.
Results: The results show that the second patient group is affected more by the
peripheral neuropathy and their neuropathy was widely spread and its underlying
cause is the worse.
Conclusions: results indicate that hypertensive disease increase the deterioration of
the peripheral nerve function in diabetic patients.


Article
The Effect of Methyl dopa on serum lipid profile in rat

Author: Laith Mohammed Abbass AL-Hussueni ليث محمد عباس
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2007 Volume: 3 Issue: 4 Pages: 85-92
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Evidence liking hypertension and dyslipidemia are very important in deciding which antihypertensive drug is going to be describe to hypertensive patient who had or at risk to had dyslipidemia. Antihypertensive drugs which have neutral effect or preferably beneficial effect on lipid profile are the first choice in those patients. Drugs with harmful effect on serum lipid profile may add another problem to the patient and increase the risk of complications. Purpose: This study is carried on to evaluate the effect of methyl dopa on serum lipid profile. Methods: Twenty rats enrolled in the experiment given atherogenic diet for twelve weeks then randomly divided into two groups, first group received 33 mg /Kg /day P. O Methyl dopa dissolved in 2 ml distilled water given by nasogastric tube twice daily and serve as central group. The treatment continues with atherogenic diet for another twelve weeks. The serum lipid profile namely triglyceride, total cholesterol, LDL-cholesterol (low density lipoprotein cholesterol) HDL-cholesterol (high density lipoprotein cholesterol) and HDL-cholesterol / total cholesterol ratio were estimated before and after the treatment. The statistical analysis was done using ANOVA with level of significance P<0.05. Result: Methyl dopa was found to have no effect on serum triglyceride level and on total cholesterol serum level but it causes significant decrease in LDL-cholesterol serum level and significant increase in HDL- cholesterol serum level in comparison to control group. Conclusion: Methyl dopa has beneficial effect on serum lipid profile as it causes decrease in LDL-cholesterol level which is the atherogenic portion of cholesterol and causes increase in HDL-cholesterol level which is the protective portion of cholesterol. This effect justify it's use in patients who have or at risk to have dyslipidemia.

استهدفت هذه الدراسة معرفة تأثير دواء مثيل دوبا المستخدم في علاج ارتفاع ضغط الدم على مستوى الدهون في مصل الدم لدى الجرذان بسبب وجود ارتباط وثيق بين ارتفاع ضغط الدم وبين ارتفاع مستوى الدهون وبالتالي يتحتم علينا اختيار دواء لا يؤدي إلى زيادة الاضطراب في مستوى الدهون. عشرون جرذاً استخدمت في التجربة أعطيت غذاء عالي الكولسترول لمدة اثنا عشر أسبوعاً ومن ثم قسمت إلى مجموعتين الأولى: أُعطيت (33) ملغرام/ كغم/ اليوم من دواء مثيل دوبا عن طريق الفم مرتين في اليوم. والمجموعة الثانية: أعطيت ماء مقطر واعتبرت مجموعة سيطرة. العلاج استمر لمدة اثنا عشر أسبوع مع الغذاء عالي الكولسترول أيضاً. مستوى الدهون في مصل الدم تم قياسه قبل وبعد البدء بالعلاج وكانت النتائج كالأتي: لم يكن لدواء مثيل دوبا تأثير على الكلسيريدات الثلاثية ولا على ولا على الكولسترول الكلي لكنه سبب نقصان ملحوظ في مستوى الكولسترول واطئ الكثافة وسبب زيادة في مستوى الكولسترول عالي الكثافة بالمقارنة مع مجموعة السيطرة الأمر الذي يظهر فائدة كبيرة في استخدام هذا الدواء للمرضى الذين يعانون من ارتفاع ضغط مع اضطراب مستوى الدهون لديهم.


Article
HYPERTENSION IN CHILDREN WITH NEPHROTIC SYNDROME

Author: FARiS M. FRANKUL
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 1 Pages: 5-8
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Hypertension occurs in some patients with primary nephritic syndrome it may be mediated by changes in vasopressin activities or intravascular volume.Aim of study: is to find out how many patients with idiopathic nephritic syndrome hare hypertension. Subj. & Methods: The study included 50 children (29 males and 21 females) with age ranger between1-13 years. Sixteen patients (32%) were with initial attack of nephritic syndrome, while thirty four patients (68%) presented with relapse.Results: Nine (18%) patients had hypertension, eight (16%) patients were relapse cases, and one (2%>) patient was with initial attack. Hypertension was found in four (8%) patients with steroid resistant neurotic syndrome, three (6%) patients with steroid sensitive nephritic syndrome in relapse state and two (4%) patients with steroid dependent nephritic syndrome. Abnormal renal function was found in four patients (8%), two (4%) with hypertension and two (4%) without hypertension.It is concluded the necessity of the follow up and periodical measurement of blood pressure of nephritic patients to allow early recognition and management of hypertension.Conclusion: the necessity of the follow up & periodical measurement of blood pressure of nephroticpatients to allow early recognition & management of hypertension.


Article
Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Compliance and Knowledge of Hypertensive Patients atients atients Attending ttending ttending Shorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk Governorate Shorsh Hospital in Kirkuk GovernorateShorsh Hospital in Kirkuk Governorate Shorsh

Authors: Layla Hassan Mohmed --- Haitham Issa Al – Banna
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 145-150
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT: BACKGROUND: Medical non-compliance has been identified as a major public health problem in the treatment of Hypertension. OBJECTIVE: To identify factors related to non-Compliance with the treatment of patients with Hypertension.PATIENTS AND METHODS: A total number of (400) hypertensive patient was enrolled to assess compliance rate at Shorsh General Hospital from July 21/2006 to July 21/2007, using a structured questionnaire. RESULT: The study revealed a low compliance rate among hypertensive patients, Males were less compliant (65.6%) than females (46%). Smokers (61.7%) more than non-smokers (50.6%),non-regular follow-up (76.7%) more than regular, primary and secondary education (68.5%) more than illiterate and high education, more than one medication (66.9%)than single medication. Poverty was the main cause of non-compliance (38.1) while absence of drugs and medical staff are the least to cause non-compliance (2.7%). CONCLUSION: Compliance rate in general is low in our study. Compliance rate is more in female, no family history, single drug medication, non-smokers, no other chronic diseases, more than 10 years of hypertension. Patient’s knowledge about their disease is insufficient because there are no health educational programs


Article
Leptin Effect in the Development of Obesity –Related Hypertension in Postmenopausal Women

Author: Waleed Kh. Hussein
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 155-157
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Obesity in humans causes hypertension, myocardial hypertrophy and coronary atherosclerosis, and increased cardiovascular morbidity and mortality that is thought to be related to sympathetic overactivity. Leptin is an adipocyte-derived hormone that acts in the hypothalamus to regulate appetite, energy expenditure and sympathetic nervous system outflow. One of the major mechanisms leading to the development of obesity-induced hypertension appears to be leptin-mediated sympatho-activation.OBJECTIVE:This study is done to evaluate the contribution of leptin in the development of obesity related hypertension in post menopausal women.SUBJECTS AND METHODS:A total number of 64 subjects (post menopausal women) included in the study were divided into obese hypertensive group (n= 38 )and non obese non hypertensive group (n=26) , age(57+4.5year) and (56+2.7year) respectively(mean+SD).Obese hypertensive group defined as (BMI ≥ 30 kg/m2 and blood pressure ≥ 140/90 mmHg with or without history of taking anti hypertensive medications)and Non-obese non hypertensive group defined as (BMI < 30 kg/m2- blood pressure < 140/90 mmHg).In the present study leptin had been measured.RESULTS:Leptin level is higher in obese hypertensive group than in non obese non hypertensive group and it was 29.2+4 and 15.2+2.1(mean+SD) respectively and this difference is statistically significant with p value < 0.001.CONCLUSION :leptin may play a role in the development of obesity- related hypertension and may be an independent predictor of hypertension

Keywords

leptin --- obesity --- hypertension


Article
Effect of hawthorn extract on blood pressure and lipid profile in patients with stage I hypertension: A placebo-controlled, double-blind randomized trial

Author: Ali Ismail A. Al-Gareeb
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 52-57
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Aims: To investigate the possible effects of hawthorn extract on blood pressure & blood lipid profile in patients with stage I hypertension. Patients and Methods: This 12 week randomized, double -blind, placebo controlled study was conducted on newly diagnosed patients with stage I hypertension (n=60). Patients were selected from outpatient clinic in Al-Yarmuk Teaching Hospital, Baghdad and were divided into two groups each comprising of 30 patients, they were given hawthorn extract capsule 450 mg (Willmar Schwabe Pharmaceuticals) twice daily and identical placebo capsule respectively. Systolic and diastolic blood pressure was recorded and fasting lipid profile was done initially and at the end of 4th, 8th and 12th week of treatment. Both of hawthorn and placebo treated group were given diet and exercise plan. Results: After 12 weeks the hawthorn treated group had a significant reduction in both of systolic and diastolic blood pressure (p<0.01), serum total cholesterol (p<0.001) and low density lipoprotein (p<0.001), while the placebo treated group had a non-significant decrease in their blood pressure (p>0.05), serum total cholesterol and low density lipoprotein (p>0.05). High density lipoprotein was significantly increased in patients treated with hawthorn (3.01 mg/dl, 8.13% P= <0.05) compared with placebo group (1.06 mg/dl, 2.8 % P= > 0.05) but there was no significant difference in triglyceride detected between two groups. Conclusions: The study suggests that hawthorn does have an effective antihypertensive ability, as well as lipid lowering effects.


Article
LIPID PROFILE CHANGES IN PREGNANCY INDUCED HYPERTENSION

Authors: Lamia M Al Naama --- Muhsin Al Sabbak --- Weam Al-Mahfooz
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2005 Volume: 11 Issue: 1 Pages: 50-59
Publisher: Basrah University جامعة البصرة

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Abstract

We tested the hypothesis that the plasma lipid and lipoproteins concentrations are increased markedly in women with pregnancy induced hypertension (PIH) relative to women with uncomplicated pregnancy and that these lipids decrease postpartum and to clarify the relation of lipid profile changes with the severity of pregnancy induced hypertension.This study is a prospective, case-control study conducted at Basrah Maternity and Child Hospital extended through a period of 12 months from the first of August 2000 till the first of August 2001.Pre-labor venous blood samples were collected for 90 women with pregnancy-induced hypertension and 110 women with normal uncomplicated pregnancy with an age range (16-40) years and gestational age range (34-42) weeks after 12 hours fasting. Venous blood samples were also collected from only 30 women with PIH and 30 women with normal uncomplicated pregnancy after 24-48 hours postpartum. Serum was analyzed for concentrations of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C).Pre-labor serum (TG), (TC), (LDL-C) and (VLDL-C) were increased in women with PIH relative to uncomplicated pregnancies respectively P value (<0.001). (HDL-C) concentration does not differ between studied groups (P = 0.1). Concentrations of all lipids decreased significantly (P value <0.001) in both groups within the first 24-48 hours postpartum. However the levels of these lipids remained higher in women with PIH but were statistically not significant. Serum triglyceride and VLDL concentrations but not total cholesterol, HDL-C and LDL-C were significantly higher in severe PIH group in comparison with mild PIH. There was no correlation between the age, parity and the lipid profiles changes in both groups. There was a positive correlation between each of the (TG), (TC), (LDL-C) and (VLDL-C). (HDL-C) does not correlate significantly with other different types of lipid. In conclusion, plasma lipids and lipoproteins but not HDL-C are increased in PIH relative to normal pregnancy and hypertriglyceridemia found in severely PIH may contribute to endothelial dysfunction in PIH.

Keywords

LIPID --- PREGNANCY --- HYPERTENSION


Article
STUDYTHE EFFECT_ OF THE ANTIHYPERTENSIVE DRUG (TENORMIN) ON SOME BLOOD CHARACTERISTICS AND ON THE ACTIVITY OF ISOLATED LEUKOCYTES MEASURED BY CHEMILUMINESCENCE
دراسة تاثير المعالجة بالعقار المثبط لارتفاع ضغط الدم ((تينورمين)) في بعض الصفات الدموية وفي نشاط الكريات الدموية البيضاء المعزولة مقاسا بطريقة التالق الكيمياوي

Author: Abdul — Razak N. Khudayer عبد الرزاق نعيم خضير
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2006 Volume: 5 Issue: 2 Pages: 57-65
Publisher: Basrah University جامعة البصرة

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tenormin (atenolol) orally daily for more than three years. The other This study had beendone on thirty blood samples drown from thirty men between 40-60 years of age half of themsuffering from hypertension and taking 100mg fifteen men were healthy and did not takingany drug and regarded as control. Those blood samples were subjected to study somehematological parameters such as hemoglobin percentage and total erythrocyticr andleukocytic counts. Also isolation of leukocytes was done from both hypertensive patient andcontrol and study their activity by chemiluminescence method.v Result showed that prolonged treatment by tenormin of 100 mg orally daily resulted insignificant decrease (P < 0.0l)in total erythrocytic and leucocytic counts as well as the samesignificant decrease in hemoglobin percentage as compared with controls , it also resulted insignificant inhibition of activity of isolated leukocytes as measured by chemiluminescencetechnique which resulted from their weak reaction with the luminescence material(lucigenin)mixed with it in the measuring chemiluminescence apparatus which is an indicationof reduced immunological ability of those leukocytes in addition to their decreased number.


Article
STUDYTHE EFFECT_ OF THE ANTIHYPERTENSIVE DRUG (TENORMIN) ON SOME BLOOD CHARACTERISTICS AND ON THE ACTIVITY OF ISOLATED LEUKOCYTES MEASURED BY CHEMILUMINESCENCE
دراسة تاثير المعالجة بالعقار المثبط لارتفاع ضغط الدم ((تينورمين)) في بعض الصفات الدموية وفي نشاط الكريات الدموية البيضاء المعزولة مقاسا بطريقة التالق الكيمياوي

Author: Abdul — Razak N. Khudayer عبد الرزاق نعيم خضير
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2006 Volume: 5 Issue: 2 Pages: 57-65
Publisher: Basrah University جامعة البصرة

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Abstract

tenormin (atenolol) orally daily for more than three years. The other This study had beendone on thirty blood samples drown from thirty men between 40-60 years of age half of themsuffering from hypertension and taking 100mg fifteen men were healthy and did not takingany drug and regarded as control. Those blood samples were subjected to study somehematological parameters such as hemoglobin percentage and total erythrocyticr andleukocytic counts. Also isolation of leukocytes was done from both hypertensive patient andcontrol and study their activity by chemiluminescence method.v Result showed that prolonged treatment by tenormin of 100 mg orally daily resulted insignificant decrease (P < 0.0l)in total erythrocytic and leucocytic counts as well as the samesignificant decrease in hemoglobin percentage as compared with controls , it also resulted insignificant inhibition of activity of isolated leukocytes as measured by chemiluminescencetechnique which resulted from their weak reaction with the luminescence material(lucigenin)mixed with it in the measuring chemiluminescence apparatus which is an indicationof reduced immunological ability of those leukocytes in addition to their decreased number.

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