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Article
Serum Fetuin-A, A New Potential Biomarker For Diagnosis Of IHD In Menopausal Women.
استخدام فيتوين ا (Fetuin-A) كمؤشر حيوي لتشخيص مرض القلب الأقفاري لدى النساء في سن اليأس.

Authors: Safaa Ali Khudhair --- Arshad N. AL-Dejaly --- Mohammed Emad
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2013 Volume: 3 Issue: 3 Pages: 119-123
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: The role of inflammation in atherogenesis would suggest, a great deal of work looking for inflammatory markers that are risk factors for IHD. The most extensively examined markers are fibrinogen, C-reactive protein, IL-6, homocysteine, and fetuin-A.Aim of the study: The present study is focusing on role of biomarker fetuin-A in the diagnosis of IHD in menopausal female.Method: This study involved 76 menopause women suffering from IHD (42 patients with AMI and 34 with angina) and 20 healthy menopause women as control. Patients were divided into subgroups according to the presence of DM and hypertension. Serum Fetuin-A level is estimated in each group. Results: There is significant reduction in serum fetuin-A levels in menopausal women with IHD. Diabetes mellitus and hypertension associated with significant decrease in serum fetuin-A levels in menopausal women with IHD.Conclusion: Serum fetuin-A can be used as biomarker for diagnosis of angina and AMI in menopausal women. Both DM and hypertension have detrimental effect on serum fetuin-A levels.

المقدمة: دراسة المؤشرات الحيوية ومساراتها الكيميائية سمح بتطور العديد من الاستراتيجيات الجديدة في تشخيص النساء المصابات بمرض القلب الأقفاري في سن اليأس. احد هذه المؤشرات الحيوية هو .(Fetuin-A)هدف الدراسة: دراسة اهمية المؤشر الحيوي (Fetuin-A) في تشخيص مرض القلب الأقفاري لدى النساء في سن اليأس.منهجية العمل: شملت الدراسة 76 من النساء المصابات بمرض القلب الأقفاري بالإضافة الى 20 من النساء الاصحاء. تم تقسيم المريضات الى عدة مجاميع بناءً على وجود مرض السكري و ارتفاع ضغط ألدم ثم تم قياس مستوى (Fetuin-A) في الدم لدى كافة النساء.ألنتائج: اظهرت الدراسة انخفاض معنوي في مستوى (Fetuin-A) في الدم لدى النساء المصابات بمرض القلب الأقفاري.الاستنتاج: يمكن استخدام (Fetuin-A) كمؤشر حيوي لتشخيص المصابات بمرض القلب الأقفاري.التوصيات: دراسة المؤشر الحيوي (Fetuin-A) في تشخيص مرض القلب الأقفاري لدى الرجال و النساء و في اعمار مختلفة

Keywords

Fetuin-A --- IHD --- DM --- menopause


Article
Orthostatic Hypotension Predicts The Early Morbidity And Mortality In Patients With Ischemic Heart Disease In Coronary Care Unit

Author: dr. Safaa Ali Khudhair د. صفاء علي خضير
Journal: Thi-Qar Medical Journal مجلة ذي قار الطبية ISSN: 19929218 Year: 2009 Volume: 3 Issue: 1 Pages: 33-39
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

ABSTRACTBackground: The mechanism by which the orthostatic hypotension and cardiac autonomic neuropathy increase cardiovascular morbidity and mortality remain to be settled. Some studies found exercise intolerance in patients with cardiac autonomic neuropathy with a reduced response in heart rate and blood pressure and decreased cardiac output during exercise. An association between cardiac autonomic neuropathy and QT prolongation has been shown.Objective: To asses the role of the orthostatic hypotension in the development of the early cardiovascular complications in the patients of the coronary care unit.Patients and method: In this a prospective observational follow up study, (50) patients with ischemic heart diseases were included. Blood pressure was measured with the standard mercury sphygmomanometer, the measurement in supine position was taken after at least 15 minutes of rest and the measurement in standing position was taken at the third minutes of standing, the orthostatic hypotension is said to be present when there was a sustained drop in systolic (≥ 20 mmHg) or diastolic (≥ 10 mmHg) blood pressure at the third minute of standing up.Results: Out of twenty two patients with orthostatic hypotension fifteen patients developed cardiovascular complications and out of twenty eight patients without orthostatic hypotension five patients developed cardiovascular complications, this association is statistically significant Conclusion: Orthostatic hypotension can be used as a prognostic marker for the development of early adverse outcomes in patients with acute coronary syndrome, thus it can be useful tool to screen the high risk patients in the coronary care unit.


Article
The Ankle- Brachial Pressure Index AS A Predictor of Coronary Artery Disease Severity

Author: Hilal B. Al Saffar* MBChB, FRCP, FACC د. هلال بهجت الصفار
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 254-258
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Atherosclerosis is a diffuse disease process, being present in one vascular bed predicts its presence in the others. Ankle –brachial pressure index (ABI) is a non invasive test proved to be sensitive and specific in detecting and assessing the severity of peripheral arterial disease.Patients and Methods: One hundred fifty patients (150) were enrolled in this study, from January - June 2007; all were referred to the Iraqi Centre for Heart Diseases (I.C.H.D.) for further evaluation, with request for further assessment of CAD or lower extremity peripheral arterial disease. Clinical data and physical examination were performed; ABI was calculated by measurement of systolic pressure on both ankles over both dorsalis pedis and posterior tibial arteries and on both arms over the brachial arteries by using a Doppler stethoscope. The Ankle –Brachial Pressure Index (ABI) calculation was made by taking the lowest value for the ankle pressure and the highest value for the brachial pressure. The normal value for the ABI range from (1-1.4), a cutoff value of < 0.90 was used to identify low ABI. All patients underwent diagnostic coronary angiography and quantitative coronary angiography (QCA) was used to identify the lesion length and severity of stenosis. The severity of CAD was quantified by GENSINI score, the number of diseased vessels and the number of significant lesions. Results: The mean Ankle-Brachial Pressure index (ABI) for the sample was 0.908±0.31 (range 0-1.53), the mean GENSINI score was 44.02±40 (range 0-148), GENSINI score was zero in 30 (20%) patients, 40 (26%) were having no diseased vessel, 41(27%) having single, and 43 (28.7%) double and 26 (17%) triple vessel disease. ABI was inversely related to the extent of CAD assessed by GENSINI (p-value 0.015), number of diseased vessels (p-value 0.009), and number of significant lesions (p-value 0.021). ABI < 0.9 was recorded in 51 patients (34%) and a low ABI was an independent factor for a higher GENSINI scores (p-value 0.043) and a higher number of diseased vessels (p-value 0.0001). Patients who were referred with PAD were found to have significantly lower ABI than the rest of the sample (p=0.0001), and a coexisted CAD was detected in 15 out of 20 (75%) patients.Conclusions: ABI was a useful bedside clinical test that predicts the severity of the CAD in patients who are already suffering from or suspected to have ischemic heart disease.Keywords: IHD, Ankle-Brachial Pressure index, GENSINI score


Article
The Role of Circulating Immune Complexes in the Pathogenesis of the Ischemic Heart Disease

Author: Suha AL-Fakhar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 4 Pages: 406-410
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Circulating immune complexes (CICs) were found to have an effect on the pathogenesis and prognosis of ischemic heart disease (IHD).METHODS:A total of 24 patients, 13 as a patient group with IHD (10 males and 3 females), and 11 healthy control group (6males and 5 females), for all the level of CICs was detected by platelets aggregation test (1).RESULTS:The results showed that all patients with IHD had positive platelets test, while only 4control group had a positive results.CONCLUSION:This study showed that there was significant raise in the level of CICs in the IHD and it might play a role in it’s development.


Article
Circulating Human IL-10 - Secreting Regulatory B Cells in Acute and Chronic Ischemic Heart Disease

Author: Zaman I. AL-Kaabi 1, Nidhal A. Mohammad 2, Atheer B. AL-Ansari 3
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2015 Volume: 14 Issue: 1 Pages: 63-69
Publisher: Baghdad University جامعة بغداد

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Abstract

Abstract: Ischemic heart disease (IHD) is a leading cause of death worldwide. Suppression of immune system after the resolution of infection or inflammation is an important process that limits immune-mediated pathogenesis, therefore, in this study for the first time in Iraq we highlights the importance of IL-10 secreting regulatory B cells (B10/Br1/BREG) in ischemic heart disease immunoregulation. Peripheral blood lymphocytes were isolated from 83 patients with ischemic heart disease, then IL-10 secreting regulatory B cells were detected by using double staining immunocytochemistry (DS-ICC) with both CD19 and IL-10 monoclonal antibodies. Results showed the decreased number and mean percentage of BREG in the peripheral blood of both acute and chronic ischemic heart disease in general when compared with controls, but these cells recorded higher number and mean percentage in acute than chronic ischemic heart disease, and there was a significant difference in the mean percentage of BREG cells among the patient's groups. In conclusion, IL-10 secreting regulatory B cells play an important but limited role in ischemic heart disease immunoregulation due to their lower numbers, and further studies must be done for future directions correlated with how to manipulate these cells in immunoregulation with more advanced pathways.

Keywords

IL-10 --- B cell --- CIH --- DS-ICC --- IHD.


Article
Distal left Main Coronany Stem Lesion Managed by Intervententional Crush Technique

Authors: Majid Abdul Muhsin --- Alaa Abdulhussein Allawi --- Ali Hashim Hussein
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 1 Pages: 62-64
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Intervententional Crush might end high rates of restenosis. OBJECTIVE: Studying immediate and late outcome of crush technique in distal left main stem lesion intervention.PATIENTS AND METHOD:(40) patient had crush technique intervention method for management of LMS lesions,(15) patients done as primary PCI method, while( 25) patients as elective management.RESULTS:A total of 40 patients with distal left main stem lesion included in our study, their age range between 45-75 years with a mean±SD of 59±4.5 years,25 were male,15 female.One patient died in one year follow up because of noncompliance for medication.One patient had ISR treated by drug eluted balloon. Two patients lost follow up after 2 months. 25 patients(62.5%)had more than one significant lesion,9 patients (22.5%) had low ejection fraction at time of intervention, functional MR were reported in 5 (12.5%) of patients.All ischemic chest pain disappeared after interventional procedure. CONCLUSION: LMS crush technique is favorable alternative method for the management of LMS especially in patients unable to do CABG.


Article
Association between Resisten Gene Polymorphism (420C/G) and Lipid profile in Ischemic Heart Diseases

Authors: Asraa Ali Kadhum --- Majid Kadhum Hussain --- Riyadh. Dh. Al-zubaidi
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2018 Volume: 11 Issue: 1 Pages: 3937-3942
Publisher: Kerbala University جامعة كربلاء

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background: (resistin is considered as a pro-inflammatory molecule and plays a role in the inflammatory response that lead to atherosclerosis)Aim: To evaluate the risk of resisten gene polymorphism (420C/G) in the development of Ischemic Heart Disease. To verify the relationship of the investigated SNPs with the metabolic changes related to (IHD), in particular, serum lipid profile.Methods: A case control study was performed at which 150 patients with IHD and 150 healthy individuals. Genotyping for SNP 420C>G in the resistin gene was performed by the polymerase chain reaction –restriction fragment length polymorphism method. Lipid profile were measured.Results: The genotype and allele frequencies of resistIn gene polymorphism in IHD and control persons were examined under the co-dominant, dominant and recessive models with the use of multi nominal logistic regression analysis. Neither genotype distribution nor the minor allele frequency showed significant changes among the comparison of the of IHD patients with the control group. The frequency of the G allele of 420(CG) polymorphism was significantly higher in ischemic heart diseases (IHD). There are significant increases in the level of LDL, triglyceride, VLDL, BMI and a significant decrease in the level of cholesterol in the group of patients with the GG+CG genotypes when they were compared with those of the CC genotype. It shows significant differences in BMI, Age, Cholesterol, LDL, and HDL in the group of IHD, and no significant difference was seen in VLDL and sex.Conclusion: The −420C>G SNP of resistin gene is not associated with ischemic heart disease in the population of Kerbala and Najaf. The G allele is seemed to increase serum lipid concentrations so it could be considered as an atherosclerotic parameter.


Article
Thyroid Function in patients with Ischemic Heart Diseases
تاثير وظائف الغدة الدرقية على امراض القلب الاقفارية

Author: Maha Arshed Hamdi Mageed مها ارشد حمدي مجيد
Journal: Tikrit Journal of Pure Science مجلة تكريت للعلوم الصرفة ISSN: 18131662 Year: 2018 Volume: 23 Issue: 6 Pages: 74-78
Publisher: Tikrit University جامعة تكريت

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Abstract

The effects of thyroid hormones on the cardiovascular system are the most clinically useful and sensitive signs of thyroid dysfunction. Regarding pathophysiology, thyroid dysfunction has essential cardiovascular consequences in myocardial contractility, peripheral hemodynamics, and heart rate. The aim: To study the association of serum TSH, T4, and T3 levels on ischemic heart diseases. Patients & methods a cross sectional study was conducted in Sallah Alddin general hospital in Tikrit city – Iraq , from 1st January to 30th of June 2017. Fifty patients (34 male & 16 female ) have joined this study age (mean 58.6 ± 15.2 years), all suffering from ischemic heart diseases (myocardial infarction, angina, & congestive heart failure) & admitted to the Coronary cure unite in the hospital. Also, 50 control healthy subjects were participated in the present study, (30 males and 20 female subjects). Results anthropometric measurements for both males and females (age, weight, height BMI) show no significant differences between patients and the control, while, the BMI for female group exhibits a significant difference. Female and male lipid profile results indicate good significant differences between patients and control except for LDL result for female. Moreover, there are no significant differences for LDL and VLDL in male patients. The TSH, T3, T4, and troponin levels in both male and female patients show significant differences between them and the control groups except T3 level show no significant differences.

يركز البحث على دراسة تأثير هورمونات الغدة الدرقية على جهاز القلب والاوعية الدموية في المرضى المصابين بأمراض القلب الاقفارية, الهدف: دراسة العلاقة بين مستوى هورمونات الغدة الدرقية في الدم وامراض القلب الاقفارية.العينات وطريقة العمل: تمت الدراسة في مستشفى صلاح الدين العام للفترة من الاول من كانون الثاني الى الثلاثين من حزيران سنة 2017م. شملت الدراسة خمسون مريضا (34 ذكر و 16 انثى) جميعهم يعانون من امراض القلب الاقفارية, اما المجموعة القياسية شملت خمسون شخصا من الاصحاء (30 ذكر و20 انثى),النتائج: معامل كتلة الجسم اظهر فرقا معنويأ في مجموعة النساء فقط, اما نتائج مستويات الدهون بالدم جميعها اظهرت فروقا معنوية بين المرضى والاصحاء ما عدا كولسترول واطئ الكثافة لم يظهرفرقا معنويافي مجموعة النساء ,وكولسترول واطئ الكثافة و كولسترول واطئ الكثافة جدا لم يظهرا فروقا معنويه في مجموعة الرجال. اما بالنسبة لبروتين التروبونين وهورمونات الغدة الدرقية فجميعهم اظهروا فروقا معنوية بين المرضى والاصحاء ما عدا هورمون ترايايودوثايرونين لم يظهر فرقا معنويأ

Keywords

Thyroid gland --- IHD patients --- lipid profile --- TSH --- T3 --- T4 --- Troponin


Article
A new insight in the role of serum albumin and albumin binding capacity for cobalt and copper in ischemic heart disease
رؤية جديدة لدور قدرة الزلال في المصل والزلال في مصل الكوبالت والنحاس في أمراض القلب الإقفارية

Author: Sanaa G. Hama AL- Mandalawi
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 1 Pages: 79-84
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: In the presence of ischemia, albumin, undergoes changes resulting in the formation of ischemia modified albumin .Increased serum concentration of ischemia modified albumin that was measured by albumin cobalt binding assay have been found in patients with myocardial ischemia. The purpose of this study was to investigate the relationship between serum albumin concentration and ischemia modified albumin concentration.Methods: Eighteen patients with stable angina and fifteen who didn’t have any evidence of coronary artery disease , were taken as control subjects, both groups underwent treadimall exercise stress test ,about 15 minuets after treadimall test blood samples were drawn from all the subjects, brought to laboratory to measure the serum ischemia modified albumin concentration and serum albumin concentration.Results: The study showed a significant difference in ischemia modified albumin between study groups, while no significant difference in serum albumin between both groups. There is a largest Receiver Operating Characteristics(ROC) area for ratio of serum albumin cobalt binding to serum albumin than serum albumin cobalt binding capacity alone.There is a weak positive linear correlation for both cupper and cobalt binding capacity among control subject ,where there is a weak negative linear correlation for both markers among cases with ischemic heart disease (IHD).Conclusion: The quantification of the role of serum albumin in combination with albumin cobalt binding capacity is expected to differentiate between ischemic heart disease patient and normal subject to larger extent.


Article
Prevalence of Pericardial Effusion in Patients on Maintenance Hemodialysis in The Iraqi Dialysis Center

Author: Ali Jasim M. AL-Sultani,
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2016 Volume: 24 Issue: 7 Pages: 1888-1897
Publisher: Babylon University جامعة بابل

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Abstract

Background: Patients with end stage renal disease (ESRD) on regular hemodialysis (HD) are presented in significant percentage with pericardial effusion that was associated with significant morbidity and little mortality.Aim: This study concern to estimate the prevalence of uremic pericardial effusion (UPE) amoung patients on regular hemodialysis and its possible associated factors. Patients and Methods :In this cross section study, the data was conducted at the Iraqi Dialysis Center of Baghdad Teaching Hospital in Medical City, mainly assessed by echocardiography to 100 patients on regular hemodialysis included in this study attending our hospital for hemodialysis as part of thier long term treatment. Results: The prevalence of UPE was 23% among HD patients and the result was significant with P<0.001, mainly associated with aging, those with hypertention (HTN), diabetes mellitus (DM) ,ischaemic heart disease (IHD) , hypoalbuminaemia, anaemia and inadequate HD , but the prevalence interstingly was low in patients with heptitis C virus infection.Conclusion: the prevalence of UPE was higher than previous study that show dialysis-associated pericardial effusion account to 8-12% of patients on hemodialysis

الخلفية ان مرضى عجز الكلى المزمن كثيرا ما يعانون من انصباب التامور الذي كثيرا ما يعرضهم الى درجة ملحوضة من المرض وبعض الاحيان يهدد حياتهم.الهدف دراستنا تركز على تخمين مدى الانتشار بالانصباب التاموري لدى مرضى الفشل الكلوي الذين يجرون غسيل الكلى الدموي ومعرفة الاسباب المرتبطة بالاصابة.الطرائقفي هذه الدراسة تم جمع البيانات في المركز العراقي لغسل الكلى في مستشفى بغداد التعليمي في مدينة الطب ل 100 مريض ياتون للمستشفى لاجراء الغسل الكلوي الروتيني لهم وتم التشخيص عن طريق اجراء فحص الايكو.النتائجاظهرت الدراسة ان معدل الانتشار بانصباب التامور كانت 23 % بين مرضى الغسل الكلوي الدموي حيث كان نسبة الاصابة عالية مع التقدم بالعمر,الاصابة بارتفاع ضغط الدم او السكري ,انخفاض نسبة الالبومين بالدم ,فقر الدم ,امراض تصلب الشرايين والمرضى الذين لايخضعون لجلسات غسل كافية (مرتان اسبوعيا),بينما ينخفض المعدل بالنسبة للمرضى المصابين بالتهاب الكبد الفايروسي نوع سي.الاستنتاجتم الاستنتاج من هذه الدراسة انها اثبتت تاثير بعض العوامل في حدوث الاصابة بانصباب التامور لدى المرضى الذين يعانون من الفشل الكلوي المزمن وبالخصوص تقدم عمر المرضى , الاصابة بارتفاع ضغط الدم او السكري ,انخفاض نسبة الالبومين بالدم,فقر الدم ,امراض تصلب الشرايين والمرضى الذين لايخضعون لجلسات غسل كافية (مرتان اسبوعيا) , بينما ينخفض المعدل بالنسبة للمرضى المصابين بالتهاب الكبد الفايروسي نوع سي.

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