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Article
Frequency of early postoperative complications of breast cancer following modified radical mastectomy
المضاعفات المبكرة بعد استئصال الثدي والابط لمعالجة سرطان الثدي

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Abstract

Background: Breast cancer is a common cancer in female and many surgical options are undergone for its treatment. Modified radical mastectomy with axillary clearance is one of the common options with certain early and late postoperative complications. We conducted a retrospective study to evaluate the pattern of early postoperative complications of established breast cancer women.Patients and methods: A total of one hundred and fifty patients were seen in AL-Fayhaa General Hospital between the period of November 2008 and June 2014, entered the study and those were analyzed in terms of general patient data in respect to age as well as analysis of early postoperative complications regarding seroma, lymphedema, wound infection, parasthesia, hematoma, hemorrhage, flap necrosis and muscle paralysis.Results: Age factor was analyzed in a study cases which showed a highest case frequency in the age group of 36 -40 years old as compared to a lowest figure in the group of less than 25 years old. Early postoperative complications were seroma, lymphedema, wound infection, parasthesia, hematoma, hemorrhage, flap necrosis and muscle paralysis with their frequencies of 56, 37, 17, 18, 2, 0 , 8, 3 and 3 of total number respectively.Conclusion: Early postoperative detection of breast cancer related surgical complications is essential through appropriate postoperative care.


Article
Investigation of Microsatellite Instability BAT 25 and BAT 26 in Breast Cancer Patients by Conventional PCR

Authors: Jabbar Salman Hasan --- Basim Mohammed Hanon --- Ahmed Hasan Mohammed
Journal: Journal of Education for Pure Science مجلة التربية للعلوم الصرفة ISSN: 20736592 Year: 2017 Volume: 7 Issue: 3 Pages: 161-170
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Abstract:Background: Breast cancer is the most common cancer among women worldwide, comprising 23%of the 1.1 million female cancers that newly diagnosed each year.Aims: Investigate the existence of microsatellite instability (MSI) in breast cancer of patients.Settings and Design: Fifty female patients with invasive ductal breast carcinoma (IDC) collected.Inclusion criteria of subjects include female patients with diagnostic feature of breast cancer and agerange 26-42 years old untreated with chemotherapy or hormonal therapy.Methods and Material: DNA had be extracted from frozen tissue samples of breast cancer. Thisprotocol done according to the kit manufacture’s manual of QIAamp DNA Mini kit from Qiagen –USA. All samples tested for MSI bysingleplex PCR reactions using two microsatellite markers BAT25 and BAT 26.PCR achieved in a final volume of 50 μl and after thermal cycles, gel visualizationperformed.Statistical analysis used: The significance of differences in proportions was analysed by the Fisher’sexact testwith SPSS version 20 and P values equal or less than 0.001 considered statisticallysignificant.Results: PCR demonstrating microsatellite instability in 13 (26%) of the 50 breast cancer sample.Eight (16%) of 50 breast cancer sample were BAT 25 positive with a PCR product size of 124 bp,while 5 (10%) of 50 breast cancer sample were BAT 26 positive with a PCR product size 121bp.Conclusions: The result suggest strong evidence that microsatellite instability (MSI) at the BAT 25and BAT 26 and have involved in the pathogenesis of the great majority of breast cancers.


Article
Steroid Hormones, Immunoglobulins and Some Biochemical Parameters Changes in Patients with Breast Cancer
اضطراب في التغييراتِ الهورمونيةِ وبَعْض الدوال الكيموحيوية في مرضى سرطان الثدي

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Abstract

Background: Breast cancer is one of the diseases that a woman may have to face during her lifetime. Hormones play a role in breast cancer spread, determining the association between plasma hormones and breast cancer risk may provide insight into the etiology of breast cancer. Objective: To evaluate the use of sex steroid hormone levels with some biochemical parameters as a serum tumor marker in patients with breast cancer. Materials and Methods: Two groups of subjects were included, 50 patients with histologically confirmed diagnosis of Breast Cancer (group I) and 40 healthy female (group II) the age range was (35-70) years were collected from Rizgary hospital and Nanakaly hospital, in Erbil city, Iraq. During the period from May 2015 till November 2015. The measured biochemical parameters included: the level of estrogen, progesterone, prolactin, estradiol, testosterone hormones, some immunoglobulins (IgG, IgA and IgM), also ferritin, sodium and calcium ions levels have been measured in the study. Results: The results demonstrated significantly high values of steroid hormones (p<0.001, p<0.01, p<0.002, p<0.05, p<0.05 (estrogen, progesterone, prolactin, estradiol, testosterone) and significantly high values in immunoglobulins IgA, IgG, IgM in breast cancer in comparison with control group. There were also high values of sera ferritin, sodium, and calcium in women breast cancer in comparison with control group.Conclusion: An elevation of serum steroid hormone, immunoglobulins (IgA, IgG, IgM), Na, and Ca levels in cases of carcinoma breast in our study is signifies, and its importance as a marker of the disease. A serial measurement of these steroid hormones and with some biochemical parameters will have a prognostic significance and help treatment decisions.

خلفية الدراسة: يعد سرطان الثدي واحد من الأمراض التي تهدد حياة المرأة و تُواجهَها أثناء حياتها. الهرمونات تلعب دورا حاسما في تطوير سرطان الثدي، وتحديد العلاقة بين الهرمونات البلازما وخطر الاصابة بسرطان الثدي يمكن أن توفر نظرة ثاقبة على المسببات لسرطان الثدي.الهدف من الدراسة: لتقييم استخدام مستوى الهرمونات الستيرويدية وبعض الدوال الكيموحيوية كمؤشر لورمِ المصل في المرضى الذين يعانون من سرطان الثدي. المرضى والطرائق : أدرجت مجموعتان, 50 امرأة من النساء المصابات بسرطان الثدي (المجموعة الأولى) و 40 امرأة من النساء السليمات (المجموعة الثانية) من الفئة العمرية ذاتها (35-70) سنة. اذ شملت القياسات البيوكيميائية قياس: مستوى كل من هرمون الاستروجين والبروجسترون، البرولاكتين، استراديول، وهرمونات التستوستيرون، وبعض الغلوبولينات المناعية (IgA، IgG و IgM)، وأيضا تم قياس مستويات الفيريتين، البروتين الكلي، الصوديوم و الكالسيوم. النتائج: أظهرت النتائج قيم عالية وذات دلالة احصائية للهرمونات الستيرويدية (P <0.001 ، P <0.01 ، P < 0.002، P <0.05، P <0.05 (الاستروجين والبروجسترون، البرولاكتين، استراديول، التستوستيرون) وكذلك للغلوبولينات المناعية (IgA، IgG و IgM)، في مرضى سرطان الثدي بالمقارنة مع مجموعة الضابطة، كما سجل ارتفاع في مستوى الفيريتين, الصوديوم والكالسيوم في مصول النساء المصابات بسرطان الثدي بالمقارنة مع مجموعة الضابطة ، ولوحظ وجود انخفاض في البروتين الكلي وكانت النتيجة ذات دلالة احصائية . الاستنتاجات: ارتفاع فى مستوى الهرمونات الستيرويدية و الغلوبولينات المناعية (IgA، IgG و IgM) وكذلك مستويا ت Na, Ca. في حالاتِ سرطان الثدي تُبيّنُ أهميتَها كمؤشر للمرضِ و أن القياسات المتسلسلة لهذه الهرمونات الستيرويدية وببَعْض الدوال الكيموحيوية سَيكونُ لهاأهمية تنبؤية وقرارات معالجةِ مساعدةِ.

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