research centers


Search results: Found 5

Listing 1 - 5 of 5
Sort by

Article
The Effect of Garlic Powder on Enterobius vermicularis infection

Authors: Ahmed Fu'ad AL-BAYATI * Sabah Abbas AL-NAJAR**M.Sc. د. احمد فؤاد البياتي --- sabah Abbas AL-NAJAR
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2005 Volume: 47 Issue: 2 Pages: 165-167
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Summary:Background: Enterobius vermicularis causes infection in different age groups , but specially in small ages . It is well known that parasitic infection in most middle eastern countries is common among them is Entrobius vermicularis , in which 11% is in school- children & 14% in pre-school children . In Iraq several studies on the prevalence of Enterobiasis in different age groups & from different areas were reported.Aim of study: This study was conducted to look for the therapeutic efficacy of garlic powder against Enterobiasis and the recurrence of this infection in many individuals to be compared with the drugs of choice that is a single dose, 100 mg of mebendazole tablets.Patients <6 Methods: One hundred and sixty patients were included in this study mostly were children, suffering from the clinical manifestation of Enterobiasis and confirmed by scotch tape slide method for identification. Those patients are divided into 2 groups: -1-firstgroup including 80 patients treated by garlic capsule 400 mg2-Second group included 80 patients treated by mebendazole tablets lOOmg.Results: We found that the highest incidence of Enterobiasis was in females 56.9% than males 43.1 % simultaneously age group 6 to 10 years showed the highest rate of infection. Our results showed that the typical dose of garlic capsule to eradicate Enterobius vermicularis 100% is one capsule twice-daily for three consecutive days. All patients and control group were followed up to 6 months and it has been noticed that patients who received garlic therapy had no recurrence, except three patients as compared with twenty-five patients of control group. Conclusion: Our study had proved the therapeutic efficacy of garlic powder against Enterobiasis and we recommended it to be used instead of mebendazole.Keyword: Entrobius vermicularis, mebendazole


Article
Clinical findings and management of intracranial Hydatid cyst in north of Iraq
النتائج السريرية ومعالجة كيس الهيدريد داخل الجمجمة في شمال العراق

Author: Emad Kh. Hammood
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2013 Volume: 17 Issue: 2 Pages: 471-476
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

Loading...
Loading...
Abstract

Background and objective: Where Hydatid cyst of E. granulosus reaches 1 cm in diameter, its wall will differentiated into a thick outer laminated and thin germinal epithelium from which occasionally, daughter cysts could appear within the Hydatid. Aim: management of the Hydatid cyst is performed surgically by separating the two layers of the cyst keeping the inner layer intact during removal process to prevent the generation of daughter cysts at the same site in the future.Methods: We conducted the study using hematology coulter counter to analyze whole blood samples of rats after exposure to welding fumes. We investigated the effect of wielding fume exposure on some hematological parameters such as the red blood corpuscles (RBCs), white blood cells (WBCs) and platelet parameters. Fourteen male albino rats were randomly assigned to control or wielding fume inhalation.Results: Total removal of the cyst was done in thirty cases using neurosurgical microscope to separate the cyst wall. Two patients had multiple intracranial Hydatid cysts. The commonest location was in the parietal lobe (21 cases). Recurrence was seen in two cases as a result of rapture of the cyst during the first surgery, in other two cases secondary infestation was seen after 1st operation 9-12 months.Conclusion: Infection acquired in early life and symptoms usually appear later. (mebendazole) is used as prophylaxis. Pathologically there is no calcification of all cysts. radiologically pressure effect is not associated with edema. Big size lead to shift of the brain to the opposite side


Article
Preparation and Evaluation of Liquid and Solid Self-Microemulsifying Drug Delivery System of Mebendazole
تحضير وتقييم نظام لايصال الدواء على شكل سائل وصلب ذاتي الاستحلاب الى المبيندازول

Author: Ahmed A. Hussein احمد عباس حسين
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2014 Volume: 23 Issue: 1 Pages: 89-100
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

The aim of present study was to develop solid and liquid self-microemulsifying drug delivery system of poorly water soluble drug mebendazole using Aerosil 200 as solid carrier. Microemulsions are clear, stable, isotropic liquid mixtures of oil, water and surfactant, frequently in combination with a co-surfactant having droplet size range usually in the range of 20-250 nm. Oleic acid, tween 80 and polypropylene glycol were selected as oil, surfactant and co-surfactant respectively and for preparation of stable SMEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant (1:1, 2:1 and 3:1), oil and water. In brief S/ CoS mix means surfactant to co-surfactant and oil were mixed at ratio of 1:9, 2:8, 3:7, 4:6, 5:5, 6:4, 7:3, 8:2 and 9:1 manner. To the resultant mixtures, water was added drop wise till the first sign of turbidity in order to identify the end point and after equilibrium; if the system became clear then the water addition was continued. Prepared optimised formula of microemulsion was evaluated for SEM, particle size analysis, polydispersity index, phase separation, viscosity determination, zeta potential, in- vitro dissolution study and in- vivo studies. The optimized microemulsion was converted into solid form by Spray Drying technique by using Aerosil 200 as solid carrier. Prepared SMEDDS was characterized for same parameters as that of microemulsion. Solid SMEDDS of mebendazole prepared using Aerosil 200 by spray drying technique showed good drug content uniformity. After reconstitution it formed microemulsion with micrometric range. In-vitro drug release and in-vivo plasma drug concentration of microemulsion and SMEDDS was much higher than that of marketed praparation. Hence lipid based drug delivery system may efficiently formulate microemulsion and it can be solidified easily by spray drying technique which enhances dissolution rate and thus concomitantly bioavailability. In conclusion ,self micro emulsifying drug delivery system has become promising tool to overcome shortcomings associated with conventional delivery.

الهدف من الدراسه المقدمة هو تطوير نظام صلب وسائل ذاتي الاستحلاب للعقار القليل الذوبانية المبيندازول بأستخدام الايروزيل كناقل. المستحلب المايكروي شفاف ومستقر ومزيج موحد من الزيت والماء والسيرفكتانت وغالبا مايستخدم مع كوسيرفكتانت له حجم قطره يتراوح من 20-250 نانوميتر. الاوليك اسد ,التوين 80 والبروبلين كلايكول يستخدمون كزيت وسيرفكتانت وكوسيرفكتانت بالتعاقب وتم تعيين المستحلب المايكروي باستخدام مخطط ثلاثي الحالة يحتوي نسب مختلفه من السيرفكتانت والكوسيرفكتانت.للمزيج الناتج يضاف الماء تدريجيا لحين اول منطقه من التعكر لكي تعيين نقطة النهاية بعد التوازن اذا اصبح النظام واضح يستمر بعد ذلك اضافة الماء. الصيغه الامثل المحضرة من المستحلب المايكروي قييم لمسح المجهر الالكتروني, حجم الجزيئه, مؤشر التشتت المتعدد , حالة الانفصال، وقيمة اللزوجة، زيتا المحتملة، في دراسة حل التجارب المختبرية والدراسات المجراة. المستحلب المايكروي الامثل تم تحويله الى صلب بواسطة بخاخ تقنية التجفيف باستخدام الايروسيل 200 كناقل صلب. المستحلب المايكروي الصلب يقييم لنفس العوامل للمستحلب المايكروي السائل. المستحلب المايكروي الصلب للمبيناديزول المحضر باستخدام ايروسيل 200 يظهر محتوى جيد للمحتوى.بعد اعادة الذوبانيه المسحلب المايكروي تكون بالمدى المايكروي. معدل تحرير العقار داخل وخارج الجسم للمستحلب المايكروي اعلى من المحضر تجاريا. بالتالي وجد ان نظام العقار المستند للدهون يمكن ان يكون مؤثر كمستحلب مايكروي ويمكن ان يتصلب بسهولة بواسطة تقنية تجفيف الرذاذ والذي يزيد من معدل تحرر العقار ولذلك تزداد التوافر البايولوجي. النظام الذاتي المستحلب للعقار اصبح كتقنيه واعده لتجاوز الانظمه التقليديه.


Article
In Vitro and In Vivo Tests of the Cidal Effects of Certain Agents for Hydatid Protoscolices

Author: Dhilal Mahdi Al-Muathen
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2016 Volume: 19 Issue: 4 Pages: 139-142
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Cysts from the liver of hydatidosis infected sheep were obtained from a local abattoir, live protoscolices were prepared by using of Kreb's Ringer solution plus Hydatid Cyst Fluid (4:1) and exposed to selected protoscolicidal agents (Mebendazole 5%, Cetrimide 0.15%, and Formaline 2%) in vitro, survival times of protoscolices in the presence of chemicals was used as a criterion of protoscolicidal agents activity by using eosin stain. After treatment it was concluded that all the treated protoscolices of the study were completely killed with Mebendazole 5% and Cetrimide 0.15% at 5 minutes of exposure, while Formaline 2% did not cause complete killing even at 15 min of exposure. furthermore the results of in vivo part of this study showed that all the treated scolices in vitro part were completely killed and did not cause hydatidosis up to 90 days post infection in laboratory albino mice.

جمعت الرؤيسات الأولية للأكياس العدرية من الخ ا رفالمصابين بطفيلي المشوكة الحبيبية Echinococcus granulosus من المجازر المحلية. و حضرت في الزجاجبأستخدام وسط محلول كريبس رينكر + سائل الكيس العدري4:1 ( لغرض معاملتها بمواد قاتلة للرؤيسات الأولية هي ()الميبيندازول 5%, السترمايد 5145 %, الفورمالين 2%(. وقد أستخدم وقت البقاء للرؤيسات الأولية بوجود الموادالكيميائية المستخدمة كوسيلة لمعرفة فعالية هذه الموادبأستخدام صبغة الأيوسين. و قد أستنتج في هذه الد ا رسة أنكل من الميبندازول 5% و السسترمايد 5145 % هو مادةقاتلة جيدة للرؤيسات الأولية خلال فترة تعرض 5 دقائق,أضافة الى ذلك فأن الفورمالين 2% قد سبب قتل كاملللرؤيسات الأولية في 41 دقيقة. كما و أظهرت الد ا رسة داخلالجسم الحي ان كل الرؤيسات المعاملة بالمواد القاتلة لهاالمستعملة في الجزء المختبري قد قتلت بصورة كاملة و لمتسبب أحداث أصابة بالأكياس المائية حتى بعد تسعين يوممن أحداث الأصابة في الفئ ا رن المختبرية.


Article
DESTRUCTION OF EXPIRED DRUGS TO ADDRESS ENVIRONMENT-FRIENDLY
اتلاف الادوية المنتهية الصلاحية (المستحلبات) بشكل صديق للبيئة

Loading...
Loading...
Abstract

The method of incineration was chosen to treat the most commonly used antimicrobial agents in Iraq (Triclabendazol, Oxfendazol, Mebendazole), which are antibiotics for children. The moisture content and chemical oxygen demand (COD) were examined and the results were (93.34, 94.88, 92.97)%, (52000, 33200, and 64000) mg/ L. The temperature was determined as a variable in the burning process (600, 500, 400)° C for the purpose of calculating the loss of ignition LOI and determining the ideal temperature. The results of the models (Triclabendazol, Oxfendazol, Mebendazole) (94.92, 93.12, 58.81% and 88.87), (62.61, 44.08%, 98.75, 84.98 and 55.086)% respectively. When mixing the three models in equal proportions, the percentage of loss was 92.87%. The analysis of the active aggregates using FTIR device was determined. A diagram of each dryer model was determined before burning and re-examination at each degree after burning. It was observed that the peaks of the model fingerprint and the active aggregates were dissolved and the materials were fully decomposed to carbon at a temperature of 600°C.

اختيرت طريقة الحرق لمعالجة مخلفات دوائية (مستحلبات) شائعة الاستخدام في العراق وهي (Triclabendazol, Oxfendazol, Mebendazole) وهي مضادات حيوية للالتهابات خاصة بالاطفال، اجري فحص محتوى الرطوبة والمتطلب الكيمياوي للاوكسجينChemical Oxygen Demand COD وكانت النتائج (92.97، 94.88، 93.34)% و (64000، 33200، 52000)% ملغم/لتر، وحددت درجة الحرارة كعامل متغيير في عملية الحرق (400، 500، 600)م لغرض حساب نسبة الفقدان Loss of Ignition LOI وتحديد درجة الحرارة المثالية وكانت النتائج للنماذج (Triclabendazol, Oxfendazol, Mebendazole) (58.81، 93.12، 94.92)% و (44.08، 62.61، 88.87)% و (55.086، 84.98، 98.75)% على التوالي وعند خلط النماذج الثلاثة بنسب متساوية كانت نسبة الفقدان (92,87)%ن واعتمد فحص المجاميع الفعالة باستخدام جهاز FTIR حيث حدد مخطط لكل نموذج مجفف قبل الحرق وأعادة الفحص عند كل درجة بعد الحرق ولوحظ أختفاء القمم التي تدل على بصمة النموذج والمجاميع الفعالة و تتحلل المواد بشكل كامل الى كاربون عند درجة حرارة 600م.

Listing 1 - 5 of 5
Sort by
Narrow your search

Resource type

article (5)


Language

English (4)

Arabic (1)


Year
From To Submit

2018 (1)

2016 (1)

2014 (1)

2013 (1)

2005 (1)