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Biological evaluation of alveolar bone remodeling in methylprednisolone treated –rats during orthodontic tooth movement

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Abstract

Background: Bone remodeling and metabolism associated with orthodontic tooth movement are regulated by alarge number of local and systemic factors. The widespread useof therapeutic corticosteroids (GCs) today raiseconcerns with regard to their effects on mineralized tissue metabolism. This study aimed to investigate the effect ofMethylprednisolone treatment on alveolar bone remodeling during orthodontic tooth movement.Materials and Methods: A twenty-six 12-weeks old male Wistar albino rats were divided into 2 groups; control group (n= 13) without any drug administration during the study and steroidal group (n = 13) which received 5 mg/kg/day ofmethylprednisolone for 3 weeks. A split- mouth design was used performing orthodontic tooth movement on theupper right 1st molar by applying 20 g of mesial force using superelastic closed-coil spring attached to the incisors for21 days while the upper left side served as the non-appliance side. Orthodontic tooth movement was evaluated onweekly basis using digital caliber. The rats were sacrificed after 3 weeks and alveolar bone remodeling process wasevaluated by counting the number of osteoblast and osteoclast cells at the compression and tension sites at thecoronal and apical levels of the mesiobuccal root of upper 1st molar in both appliance and non-appliance sidesusing digital microscope at 400~ magnification. At day of sacrifice serum measurements for alkaline phosphatase(ALP) and acid phosphatase (ACP) activity were carried out.Results: Showed that in the steroid group there was significantly greater amount of orthodontic tooth movement,greater reduction of bone formation and an increase in bone resorption with the presence of orthodonticappliance, increase in serum ACP activity and reduction of serum ALP activity as compared with the controlgroup,(P . 0.05).Conclusion: The Methylprednisolone therapy in low-medium doses elicits a noticeable change in the bone turnoverrate during orthodontic tooth movement


Article
Evaluation of the Effectiveness of Two Methods Using Methylprednisolone on Post Operative Sequelae Following Lower Third Molar Surgery

Author: *Ibrahim S. Gataa, BDS , FICMS
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 2 Pages: 257-266
Publisher: University of Kufa جامعة الكوفة

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Abstract

The surgical extraction of lower wisdom tooth like any surgical procedure is usually associated with postoperative sequelae (pain, swelling and trismus).Different drugs and surgical techniques were used to decrease these inflammatory responses. Steroids have been used commonly for this purposes particularly methylprednisolone (MP). The aim of this study was evaluating the efficacy of preoperative systemic and local administration of MP (10 mg) on the post operative sequelae following surgical removal of lower third molar. Patients included in the study were (60) divided into 3 groups each group consist from (20) persons. The first group was the control one while the second group received (10mg) of MP orally and the third group injected with (10mg) of MP locally around the site of surgery one hour preoperatively. The postoperative sequelae were assessed on the 2nd,5th, and 7th days following the operation. The result showed significant reduction in pain and oedema with the use of systemic MP and there was no effect on trismus. The local injection of (10mg) of MP was significantly affecting the oedema formation on the 5th, and 7th days. The administration of oral methylprednisolone (10mg) played a good role in reducing pain and oedema following lower third molar surgery. The method used was simple, applicable and easily accepted by the patients.

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