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Article
Evaluation of Lung diffusing capacity for Carbonmonoxide (DLco) in healthy adolescents

Author: AMJAD F. AHMAD
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2006 Volume: 6 Issue: 1 Pages: 15-24
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

In pulmonary function tests (PFT), the selection of prediction equation for lung diffusing capacity for carbonmonoxide (DLco), remains a problem. If a single equation is selected and used by all laboratories, the variation in percent predicted values would be large enough to cause numerous diagnostic errors. The present study involved 36 healthy adolescents (20 boys and 16 girls aged 13-19 years) with body height (157-170 cm) and body weight (38-63 Kg). Normal values were reported for lung volumes, ventilation and diffusing capacity using spirographic, helium dilution and carbon monoxide single-breath techniques. Values observed in the present study were comparable to Asians studies but lower than those of Westerns. All pulmonary function parameters were significantly higher in boys, mainly due to larger lung volume, in addition to differences in the level of physical activity and social patterns of life. Regardless to sex, indices of lung volume and diffusion increased with age, body height, and surface area, however, best correlation was observed with body height. Gender specific prediction equations were generated for lung diffusing capacity. Lung diffusion corrected for volume (DLco/VA) seemed independent to sex or body size. In conclusion, it is not appropriate to rely on prediction equations derived from western populations who had higher levels of normality for DLco. Furthermore, height was the best single predictor for lung diffusion in adolescence age group.

Keywords

PFT --- DLco --- prediction equations --- adolescence


Article
Evaluation of the Lung Diffusing Capacity for Carbonmonoxide (Dlco) in Healthy Male Teenagers in Relation To Physical Activity
تقييم كفاءة الرئتين لانتشار اول اوكسيد الكاربون في عينة من الاصحاء البالغين وعلاقتها بالنشاط الرياضي

Author: Amjad F. Ahmad د. امجد فوزي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 3 Pages: 215-219
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Intensive research work has been conducted on lung function changes during exercise, however, little is known about the influence of physical activity on the resting lung function especially in younger age group. The present study involved (25) healthy male teenagers (13-19 years) with body height(170±5.9 cm) and body weight(63±10.23 Kg).Lung volumes(VC and TLC), ventilation(FEV1% and MMEF25-75%) and diffusion parameters (DLco and DLco/VA) were measured by computerized spirographic , helium dilution and carbonmonoxide single-breath techniques.All tested lung function parameters except, lung diffusion per unit lung volume (DLco/VA), had increased significantly with higher level of daily physical activity. The observed increase in the resting lung diffusion seemed to be related to the increase in lung volume brought about by higher physical activity rather than to changes in lung diffusing capacity per unit of lung volume (DLco/VA). The effect of cigarette smoking habit on lung diffusing capacity was evaluated. In conclusion, physical activity has a definite beneficial effect on resting lung diffusion, an effect which seemed unopposed by mild cigarette smokingKey words: PFT, DLco, adolescence, physical activity.

الملخص:مع أن هناك دراسات كثيرة تناولت التغيرات الحاصله في وظائف الرئة إثناء اجراء التمارين الرياضية ,الا انه لا تزال هناك فجوه واضحة في دراسة تأثير التمارين، متمثلة بالنشاط الجسمي اليومي، على وظائف الرئه عند الراحه ,لاجله شملت الدراسة الحالية (25) متطوعا من المراهقين الذكور الأصحاء(13-19 سنه) بطول(170± 5.9سم) و بوزن(63±10.23 كغم) حيث تم قياس وظائف الرئة (حجم الرئة , تهويه الرئة إضافة الى كفاءة الرئة على انتشار غاز أول اوكسيد الكربونDLco))) وذلك باستخدام برامج الحاسوب الخاصة بوظائف الرئة وبواسطة استخدام غاز الهليوم و غاز اول اوكسيد الكربون.لوحظ بأن هناك زيادة مهمة إحصائيا في جميع وظائف الرئة ألمقاسه (عدا قابلية انتشار غاز أول اوكسيد الكربون بالنسبة الى حجم الرئه DLco/VA ) وذلك تبعا لزيادة النشاط الجسمي اليومي . وقد أعزيت الزيادة في قابلية الرئة على انتشار غاز اول اوكسيد الكربونDLco)) الى الزيادة المصاحبة في حجم الرئة جراء ممارسة الرياضة في حين لم تلعب قابلية انتشار غاز اول اوكسيد الكربون بالنسبة الى حجم الرئه DLco/VA) ) دورا مهما في هذه الزيادة . أظهرت نتائج البحث العلاقة الايجابية بين النشاط الجسمي و وظائف الرئة عند الراحة اضافة الى استمرار التأثير الايجابي للنشاط الجسمي على وظائف الرئه ولكن بدرجة اقل في حالة التدخين البسيط

Keywords

PFT --- DLco --- adolescence --- physical activity.


Article
The Effect of Postural Changes on Spirometric Indices of Upper Airway Obstruction

Authors: Ali Mansoor Al-Ameri --- Ahmad Jumah Mhows --- Mudhaffar Sami Khazaál,
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2013 Volume: 6 Issue: 2 Pages: 1608-1614
Publisher: Kerbala University جامعة كربلاء

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Abstract

the spirometric diagnosis of upper airway obstruction is an important non-invasivetechnique that was validated for the diagnosis of such lesions relying on severalindices that were derived from the flow volume loops of patients.Objectives: Is to find out if postural changes have an effect on spirometric indices of airwayobstruction in healthy subjects and if so, does this merit performing the test in supineposture?Subjects and methods: This study conducted in the department of physiology and medicalphysics/ Kerbala medical college, in which 17 males aged from 18-19 years (18.53 ± 0.51),had BMI of (22.95 ± 2.11 Kg/M2 ), heights of (1.75 ± 0.14 meters) and weights of (70.32 ±6.34 Kgs) were enrolled. The following spirometric data were measured in two different bodypositions (erect versus supine): Forced vital capacity (FVC), Forced inspiratory flow at 50%of vital capacity (FIF50%), Forced expiratory flow at 50% of vital capacity (FEF50%), Forcedexpiratory volume in first second (FEV1), Forced expiratory volume in first 0.5 second (FEV0.5), Peak inspiratory flow (PIF) and Peak expiratory flow (PEF). From these data, thefollowing indices of upper airway obstruction were derived: (FEV1/ FEV0.5, FEV1/ PEF,FEF50%/ FIF50%, and PEF/PIF). These indices were compared with each other in respect totwo body positions.Results:1- All the measured inspiratory and expiratory flow rates were significantly lower in supineposition (p < 0.05).2- Of the four measured indices of upper airway obstruction, only the FEV1/PEF ratioincreased significantly (p < 0.05) by about 27% upon reclining.

Keywords

PFT --- UAO --- FVL --- Body posture --- and OSAS.

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