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Role of SOX4 gene in the progression of endometrial hyperplasia to endometrial adenocarcinoma

Author: Mahdi Saber Al-Deresawi 1 , Abdul Hussein Moyet AlFaisal 2 , Salim Rasheed Al- obaidi 3
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 2 Pages: 82-90
Publisher: Baghdad University جامعة بغداد


The objective of this study was to investigate the role of SOX4 gene in progression of endometrial hyperplasia to endometrial adenocarcinoma .A total of 41 Iraqi patients with abnormal uterine bleeding followed by hysterectomy. Histological findings recorded 36 cases with endometrial hyperplasia and 5 endometrium adenocarcenoma. Cases collected during the period from February 2017 to October 2017. Curettage techniques were used to obtain a ten samples as healthy control group. All cases were obtained from Al-Zahra Teaching Hospital in Wasit Province . Endometrial hyperplasia subjects distributed according to age, the highest percentage ranged (40-50)years recorded (58.33%). To evaluate the SOX4 gene expression, total RNAs were extracted with TRIzol from each sample then directly converted to cDNA. RT-PCR technique was used to estimate the SOX4 gene expression and (GAPDH gene used as a reference gene). The results revealed that there was a highly significant increase (p<0.01) in SOX4 gene expression in endometrium adenocarcenoma (9.24±0.52) followed by endometrial hyperplasia (6.14±0.17) when compared to the healthy control group (1±0.00).In conclusion, endometrial hyperplasia can be a precursor of endometrium adenocarcenoma when the SOX4 gene expression elevated gradually.

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