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THE EFFECTS OF 4̄,4 ̄̄ -(4,5,6,7-TETRAHYDRO- [1,2,3-] SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL) BIS(BENZENE-1,3- DIOL) ON FERTILITY, REPRODUCTIVE HORMONES AND OVARIAN HISTOLOGICAL CHANGES IN FEMALE RATS TREATED WITH DIPYRONE.
تأثیر مركب SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL) BIS(BENZENE-1,3- DIOL) ) على الخصوبة والھرمونات الإنجابیة والتغییرات النسیجیة المبیضیة مقارنة مع اناث الجرذان المعالجة بالدایبایرون

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Abstract

The current study aimed to evaluate the effects of [ 4’,4” -(4,5,6,7-tetrahydro-[1,2,3-] selenadiazolo[4,5e] pyridine-4,6-diyl) bis(benzene-1,3-diol)] (T) on femalefertility and reproductive hormones, in addition histopathological examination of ovariesin comparison with the effects of Metamizole or Dipyrone (Di). Four groups of maturefemale rats each group consist of ten healthy female rats. Three groups received T and /orDi dissolved in drinking water 2mL (DW), the forth group received 2 mL of (DW) for 20days before mating and ten days after mating. The results indicated that there was asignificant increase in the number of births of (T) group (13.70±3.34) compared to DWgroup (9.7±1.06). Also, significant decline in T&Di group to (6.91±0.32), with nopregnancies reported in Di treated group. The pregnancy percentage was in T&Di groupbasically decline to 40% compare with T and DW groups 100%. Follicle stimulatingHormone (FSH) level showed a significant elevation (p<0.05) in T group (5.19mIU/mL157Bas.J.Vet.Res.Vol.18, No.1, 2019.±0.72), and T&Di (5.12 mIU/mL ±0.78) compared with DW (1.61mIU/mL±0.52), and Di(1.46 mIU/mL ±0.60) groups. LH concentration of T (1.88 mIU/mL ±0.48), and T&Di(1.67 mIU/mL ±0.41) groups LH values than in DW (1.75 mIU/mL ±0.67). Only in Digroup (0.88 mIU/mL ±0.48) LH value reduced significantly (p<0.05) than in other testgroups. T group (17.22 mIU/mL ±4.50) progesterone level; also T&Di groupprogesterone level (10.11 mIU/mL ±2.05) statistically important increase, while Di groupthere is essentially decreased (p<0.05) to (2.69 mIU/mL±0.89) compare to DW (6.31mIU/mL ±1.41). Histopathological results showed that ovarian section of Di groupdisclosed large cystic corpus luteum CC.L, absence of Graafian Follicles and follicles atdifferent stages of development. T group section showed normal Graafian follicles anddifferent follicles in developmental stages, as well as there were several persistencecorpus luteum. Ovary of T&Di female rats relieves improvement of some Graafianfollicles, Cystic corpus luteum (CC.L). Furthermore, there was some of clear C.L. It canbe concluded that T compound had a Good effect on the level of reproductive hormonesand increase fertility in female rats. While Di long term treatment had bad effects onfemale fertility, by affecting reproductive hormones levels and pathological change ofovaries

تھدف الدراسة الحالیة لتقییم تأثیرات مركب)(T[4̄,4 ̄̄ -(4,5,6,7-TETRAHYDRO- [1,2,3-] SELENADIAZOLO [4,5E] PYRIDINE-4,6-DIYL)BIS(BENZENE-1,3-DIOL)]على خصوبة الاناث وھرمونات التكاثر، بالإضافة الى التغییرات النسیجیة المرضیة في المبایض بالمقارنةمع تاثیرات المیتامیزول او الدایبایرون) .(Diاربع مجامیع من اناث الجرذان الناضجة وكل مجموعة تضم عشرمناناث الجرذان الصحیة. ثلاثة مجامیع أعطیت مركب ) (Tمع/ او ) (Diمذاب في ٢مل من ماء الشرب،المجموعةالرابعة أعطیت ٢مل من ماء الشرب لمدة ٢٠یوم قبل التزاوج وعشرة أیام بعد الجماع. النتائج تدل على ان ھناكزیادة معنویة في عدد الموالید في مجموعة ) (13.70±3.34) (Tمقارنة مع مجموعة ماء الشرب ).(9.7±1.06كذلك انخفاض معنوي في مجموعة T&Diالى ) ، (6.91±0.32مع عدم تسجیل حالات حمل في مجموعة المعالجةب .Diالنسبة المئویة للحمل في مجموعة %٤٠ T&Diمقارنة مع مجموعتي Tو .%١٠٠ DWمستوى ھرمونمحفز الجریب ) (FSHاظھر ارتفاع معنوي في مجموعتي ) (5.19 mIU/mL ±0.72) (Tو 5.12 ) T&Di.(1.46 mIU/mL ±0.60) Di ( و1.61mIU/mL±0.52)DW ( مقارنة مع مجموعتيmIU/mL ±0.78تركیزھرمون اللیوتین LHفي مجموعتي ،(1.88 mIU/mL ±0.48)Tو (1.67 mIU/mL ±0.41) T&Diعن تركیز LHفي مجموعة .


Article
Histopathological evaluation of the 4̄,4̄̄ -(4,5,6,7-Tetrahydro- [1,2,3-] Selenadiazolo [4,5 E] Pyridine-4,6-Diyl) Bis(Benzene-1,3-Diol) on female rats in comparison with Dipyrone.
ﺗﻘﯿﯿﻢ اﻟﺘﺎﺛﯿﺮ اﻟﮭﺴﺘﻮﺑﺎﺛﻮﻟﻮﺟﻲ ﻟﻠﻤﺮﻛﺐ 4̄,4̄̄ -(4,5,6,7-Tetrahydro- [1,2,3-] Selenadiazolo [4,5 E] Pyridine- 4,6-Diyl) Bis(Benzene-1,3-Diol) اﻧﺎث اﻟﺠﺮذان ﺑﺎﻟﻤﻘﺎرﻧﮫ ﻣﻊ اﻟﺪﯾﺒﺎرون.

Author: Nadheerah F. Neamah *1, Abdul-Razzak Naaeem Khudair 2, Shaker A.N.Al-Jadaan1
Journal: basrah journal of science البصرة للعلوم ISSN: 18140343 Year: 2019 Volume: 37 Issue: 1 Pages: 141-152
Publisher: Basrah University جامعة البصرة

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Abstract

Selenium (Se) is one of the vital nutritional components with main biological roles. It acts as a prosthetic group in many enzymes like glutathione peroxidase enzyme and thioredoxin reductase enzyme. The aim of the present study to investigate the histological effects of 4̄,4̄̄ -(4,5,6,7-Tetrahydro- [1,2,3-] Selenadiazolo [4,5 E] Pyridine-4,6-Diyl) Bis(Benzene-1,3-Diol)(T) compare with Dipyrone (Di) on kidney, liver and stomach. Healthy female rats divided into four groups received 50mg/kg BW of T (T group), Di (Di group), both T and Di (T&Di) dissolved in 2 ml of distilled water(DW), the forth group control received 2 mL of (DW) for 30 days. The samples of liver, kidney and stomach were fixed in 10%formalin, and the histological sections and staining were prepared in the pharmacy college central lab for histopathological examination. The results indicated that Di group showed disarrangement of hepatic architecture and sinusoids narrowed of the liver. Section of the kidneys reveal shrinkage in glomerular content and misshaped of cuboidal lining epithelial. Stomach sections showed destruction of gastric pits and increased number of fundic glands. T group liver sections incomplete disappearance of hepatocyte radiation. Renal Section of T treated group rat’s disappearance of Bowman’s capsule; stomach Sections showed complete disappearance of epithelial cells of the gastric pit. T&Di group sections exhibit disappearance of hepatocytes normal radiation architecture phenomena, also there is some hemorrhages. Renal histological sections showed absences of walls of cuboidal lining epithelium with enlarged nuclei. It can be concluded that T compound has low destructive effects on the test organs compare with Di and control group. Administrations of both treatments have no benefit effects.

اﻟﺴﯿﻠﯿﻨﻮم ھﻮ اﺣﺪ اﻟﻌﻨﺎﺻﺮ اﻟﻐﺬاﺋﯿﺔ اﻟﺤﯿﻮﯾﺔ اﻟﺬي ﻟﮫ ادوار ﺑﺎﯾﻠﻮﺟﯿﺔ ﻣﮭﻤﺔ, ﺣﯿﺚ ﯾﻌﻤﻞ ﻛﻤﺠﻤﻮﻋﺔ ﺻﻨﺎﻋﯿﺔ ﻓﻲ اﻟﻌﺪﯾﺪ ﻣﻦ اﻻﻧﺰﯾﻤﺎت ﻣﺜﻞ اﻧﺰﯾﻢ ﻛﻠﻮﺗﺎﺛﯿﻮن ﺑﯿﺮوﻛﺴﯿﺪﯾﺰ واﻧﺰﯾﻢ ﺛﯿﻮروﻛﺴﯿﻦ اﻟﻤﺨﺘﺰل. اﻟﮭﺪف ﻣﻦ ھﺬه اﻟﺪراﺳﺔ ھﻮ اﺳﺘﻜﺸﺎف اﻵﺛﺎر اﻟﻨﺴﯿﺠﯿﺔ ﻟﻤﺮﻛﺐ 4̄,4̄̄ -(4,5,6,7-Tetrahydro- [1,2,3-] Selenadiazolo [4,5 E] Pyridine-4,6-Diyl) Bis(Benzene-1,3-Diol)(T) ﻣﻘﺎرﻧﺔ ﻣﻊ ﺗﺎﺛﯿﺮ اﻟﺪﯾﺒﺎﯾﺮون ﻋﻠﻰ اﻟﻜﻠﻰ واﻟﻜﺒﺪ واﻟﻤﻌﺪة. ﻗﺴﻤﺖ اﻧﺎث اﻟﺠﺮذان اﻟﻰ ارﺑﻊ ﻣﺠﺎﻣﯿﻊ ﺗﻠﻘﺖ ﻛﻞ ﻣﺠﻤﻮﻋﺔ 50 ﻣﻠﻐﻢ/ﻛﻐﻢ وزن اﻟﺠﺴﻢ ﻣﻦ اﻟﻤﺮﻛﺒﺎن T )ﻣﺠﻤﻮﻋﺔ T (, اﻟﺪﯾﺒﺎﯾﺮون )ﻣﺠﻤﻮﻋﺔ Di(, واﻻﺛﻨﺎن Tوﻛﺬﻟﻚ Di )ﻣﺠﻤﻮﻋﺔ Di&T( ﻣﺬاب ب 2 ﻣﻞ ﻣﻦ اﻟﻤﺎء اﻟﻤﻘﻄﺮ , اﻣﺎ ﻣﺠﻤﻮﻋﺔ اﻟﺘﺤﻜﻢ DWاﻋﻄﯿﺖ 2ﻣﻞ ﻣﻦ اﻟﻤﺎء اﻟﻤﻘﻄﺮ ﻟﻤﺪة 30 ﯾﻮﻣﺎ. ﺛﺒﺘﺖ ﻋﯿﻨﺎت اﻟﻜﺒﺪ واﻟﻜﻠﻰ واﻟﻤﻌﺪة ﺑﻤﺎدة اﻟﻔﻮرﻣﺎﻟﯿﻦ وﺗﻢ ﻋﻤﻞ اﻟﻤﻘﺎطﻊ اﻟﻨﺴﯿﺠﯿﺔ واﻟﺘﺼﺒﯿﻎ ﻓﻲ اﻟﻤﺨﺘﺒﺮ اﻟﻤﺮﻛﺰي ﻓﻲ ﻛﻠﯿﺔ اﻟﺼﯿﺪﻟﺔ . اظﮭﺮت اﻟﻨﺘﺎﺋﺞ ان ﻣﺠﻤﻮﻋﺔ Di اظﮭﺮت ﻋﺪم اﻧﺘﻈﺎم ﺑﻨﯿﺔ اﻟﻜﺒﺪ , اﻣﺎ ﻣﻘﺎطﻊ اﻟﻜﻠﻰ ﺗﻈﮭﺮ ﺗﺸﻮه اﻟﻤﺤﺘﻮى اﻟﻜﺒﯿﺒﻲ واﻟﺒﻄﺎﻧﺔ اﻟﻈﺎھﺮﯾﺔ ,ﻣﻘﺎطﻊ اﻟﻤﻌﺪة اﺷﺎرت اﻟﻰ ﺗﺤﻄﻢ ﻓﻲ ﺣﻔﺮ اﻟﻤﻌﺪة وزﯾﺎدة ﻏﺪد ﻓﻮﻧﯿﻚ. اﻣﺎ ﻣﺠﻤﻮﻋﺔ T اظﮭﺮت ﻣﻘﺎطﻊ اﻟﻜﺒﺪ اﺧﺘﻔﺎء ﻏﯿﺮ ﻛﺎﻣﻞ ﻟﻠﺸﻌﺎع اﻟﻜﺒﺪي, ﻣﻘﺎطﻊ اﻟﻜﻠﻰ ﻟﻤﺠﻤﻮﻋﺔ اﻟﺠﺮذان T اظﮭﺮت اﺧﺘﻔﺎء ﻛﺒﺴﻮﻟﺔ ﺑﻮﻣﺎن , واﺷﺎرت ﻣﻘﺎطﻊ اﻟﻤﻌﺪة اﺧﺘﻔﺎء ﺗﺎم ﻟﻠﺨﻼﯾﺎ اﻟﻈﮭﺎرﯾﺔ ﻣﻦ ﺣﻔﺮ اﻟﻤﻌﺪة. ﺗﻈﮭﺮ ﻣﺠﻤﻮﻋﺔDi&T اﺧﺘﻔﺎء اﻟﺒﻨﺎء اﻻﺷﻌﺎﻋﻲ اﻟﻄﺒﯿﻌﻲ ﻟﺨﻼﯾﺎ اﻟﻜﺒﺪ ﻣﻊ وﺟﻮد ﻧﺰﯾﻒ, واظﮭﺮت اﻟﻤﻘﺎطﻊ اﻟﻨﺴﯿﺠﯿﺔ اﻟﻜﻠﻮﯾﺔ ﻏﯿﺎب ﺟﺪران ﺑﻄﺎﻧﺔ اﻟﻈﮭﺎرة اﻟﻤﻜﻌﺒﺔ ﻣﻊ ﺗﻮﺳﻊ ﺑﺎﻟﻨﻮﯾﺎت. ﯾﻤﻜﻦ اﻻﺳﺘﻨﺘﺎج ان ﻣﺠﻤﻮﻋﺔ T ﻟﺪﯾﮭﺎ اﺿﺮار ﺗﺪﻣﯿﺮﯾﺔ ﻣﻨﺨﻔﻀﺔ ﻣﻘﺎرﻧﺔ ﻣﻊ اﻟﻤﺠﻤﻮﻋﺔ Di وﻣﺠﻤﻮﻋﺔ اﻟﺘﺤﻜﻢ DW . اﻣﺎ اﻋﻄﺎء اﻻدوﯾﺔ T ﻣﻊ Di ﻟﯿﺲ ﻟﮫ ﺗﺎﺛﯿﺮات ﻣﻔﯿﺪة.

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