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Article
New Animal Model of Induced Acute Hepatic Injury by Acetaminophen and Vitamin D3 Protective Effect

Author: Malath Azeez Al‑Saady
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2018 Volume: 15 Issue: 1 Pages: 28-31
Publisher: Babylon University جامعة بابل

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Abstract

Background: Drug-induced liver injury is of great interest especially drugs that broadly used like acetaminophen. Objective: To assess newmodel of acetaminophen-induced acute hepatic injury and Vitamin D3 effectiveness. Materials and Methods: Eighteen male rabbits allocatedinto three groups six rabbits for each. Group 1 receives acetaminophen to induce acute hepatic injury and Group 2 receive single injection ofVitamin D3 before induction of hepatic injury, and group 3 was control. After 24 h from three-spaced injection of acetaminophen sample ofblood taken to measure serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, and albumin.Results: Successful model of acetaminophen-induced hepatic injury achieved by significant elevation (P ≤ 0.05) of ALT and AST of Group1 and 2 compared with control. No significance variation observed (P ≥ 0.05) between treatment Group 1 and 2 in liver function enzymeslevel. Conclusion: A new easy model of acetaminophen-induced acute hepatic injury effectively obtained. Although no statistical signifi cantVitamin D3 lower the levels of ALT and AST.


Article
Iron and vitamin D3 levels in infants admitted with chest infection: A hospital-based study

Authors: Nevine Jasim Mohammad --- Sherwan Rahman Sulaiman
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2020 Volume: 24 Issue: 1 Pages: 37-45
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Acute lower respiratory tract infection is one of the major causes of mortality and morbidity in children under five years of age, with many etiologies suggested to be among its predisposing risk factors. Research has suggested that iron and vitamin D deficiencies may contribute to the vulnerability of acute respiratory infection among young children. This study aimed to assess the correlation between iron and vitamin D3 levels with acute lower respiratory tract infection. Methods: The present study is a hospital-based case-control study conducted over a period of six months at Rapareen Teaching Hospital for Pediatrics in Erbil, Iraq. A total of 100 infants, 50 cases with and 50 controls without chest infection, aged four months to one year, attending the outpatient department, participated in the study. Results: A statistically significant correlation was detected between vitamin D level and acute lower respiratory tract infection (P = 0.029). Combined iron and vitamin D deficiency in cases compared to the control group was statistically significant (P = 0.004). Iron level alone and presence of anemia between cases and control were statistically not significant (P = 0.197 and P = 0.216, respectively).Conclusion: The study shows a significant correlation between vitamin D deficiency with increased susceptibility to acute lower respiratory tract infection. It was also found that combined deficiencies of Hb with vitamin D and iron with vitamin D significantly correlated with susceptibility to acute lower respiratory tract infection. It is concluded that treating these deficiencies may decrease the liability of this type of infection in infants.

Keywords

Iron --- Vitamin D3 --- Chest infection


Article
Relationship between vitamin D3 level and rheumatoid arthritis patients attending Rizgary Teaching Hospital in Erbil city
العلاقة بين مستوى فيتامين د 3 ومرضى التهاب المفاصل الروماتويدي الذين يرتادون مستشفى رزكاري التعليمي في مدينة أربيل

Authors: Shwan K. Media --- Banaz Abdulsattar Hamad
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 2 Pages: 1736-1742
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. Vitamin D3 plays an important role in bone metabolism and may also have immunomodulatory effects. This study was designed to estimate the prevalence of vitamin D3 deficiency in patients with rheumatoid arthritis as compared to healthy controls and to analyze the association between vitamin D3 with disease activity.Methods: This case-control study included 50 consecutive rheumatoid arthritis patients, who fulfilled EULAR-ACR-2010 and ACR 1987 criteria for Rheumatoid Arthritis, and 50 age matched controls. Their mean age and standard deviation (SD) was 46.42±10.86 years. They were not on vitamin D3 supplements. They were selected from the Rheumatology and Medical Rehabilitation Department of Rizgary Teaching Hospital in Erbil City. The activity of disease was assessed by disease activity score and clinical disease activity index parameters. The vitamin D3 was measured for all patients and controls.Results: A total of 100 participants were enrolled in the study. The vast majority of them were female, and 70% of cases had deficient vitamin D3 levels, while 46% of control group suffered from vitamin D3 deficiency (P <0.05). There was a non-significant statistical relationship between vitamin D3 levels and duration of disease, disease activity score and clinical disease activity index.Conclusion: Level of vitamin D3 was low among cases compared to controls and it was statistically significant. Vitamin D3 was not correlated with the disease activity.

Keywords

Rheumatoid arthritis --- Vitamin D3 --- DAS28 --- CDAI


Article
Antioxidant effect of vitamin D3 and its relation to salivary proteins and oral health

Authors: Faehaa Azher Al-Mashhadane --- Asmaa Y Thanoon
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2020 Volume: 20 Issue: 1 Pages: 114-124
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To investigate the antioxidant effects of vitamin D3 on oral health and to evaluate its effect on total salivary proteins in saliva. Materials and Methods: Forty patients were classified into two groups: Group 1: (20) chronic gingivitis patients, did not receive vitamin D3 (control group), Group 2: (20) chronic gingivitis patients (treatment group), received Vitamin D3 1000IU capsule. Scaling and polishing have been carried out for each volunteer to reach the base line for plaque index, gingival index, oral hygiene index and calculus index. In the next day, these indices were measured for all participants, then measured after 3 weeks then after 6 weeks from treatment. At the same visits, five milliliters of unstimulated saliva were collected for measurement of total salivary proteins and total antioxidant capacity. Results: there were significant reduction in oral health indices in 21st and 42nd days of the study which mean good response to treatment and improvement in gingival health. Conclusion: Vitamin D3 can be a good adjuvant in periodontal therapy


Article
Serum Vitamin D3 Level in a Sample of Healthy Students in Baghdad College of Medicine

Author: Khudair Z Al-Bedri
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 3 Pages: 429-435
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Vitamin D has an important biologic activity including cellular proliferation, differentiation, immune system modulation and muscle strengthening. Vitamin D is considered as essential environmental factor in the etiology of T-cell mediated auto immune disease.OBJECTIVE: To estimate the level of vitamin D3 in a sample of healthy students in Baghdad College of Medicine and correlation of the various variables to the levels of vitamin D3.SUBJECTS AND METHODS: A cross–sectional study was conducted on 90 healthy Iraqi Students in Baghdad College of Medicine, from 1st March 2014 to 30th October 2014. Subjects had history of chronic illness, smoking, alcohol consumption, pregnancy, post-menopause and chronic use of medication was excluded from the study. Subjects were evaluated for age, gender, body mass index, dietary habit, walking exercise and graduate level of students (undergraduate or postgraduate). Venous blood samples were obtained from all subjects to estimate serum level of 25 hydroxy vitamin D3 using enzyme –linked immunosorbent assay (ELISA).RESULTS: The frequency of female was more than males (63.3% versus 36.7%) with mean age of 32.24±9.59 years. Mean serum vitamin D3 level was 18.33± 8.8 ng/ml. There was significant higher level of vitamin D3 in the undergraduate student than postgraduate (22.29 ng/ml versus 15.93 ng/ml) with p value = 0.001. Subjects who consume vegetables rich diet had higher serum of vitamin D3 than those who consume more meat and balanced diet (27.467, 16.975 ng/ml and 15.971 ng/ml) with p value <0.001. Subjects who used to exercise and perform daily exercise > 30 minutes per day have higher level of vitamin D3 than subjects who exercised ≤ 30 minutes, and subject without exercise (29.27 ng/ml, 22.91 ng/ml and 16.34 ng/ml respectively) with p value < 0.00. Obese students have vitamin D3 level higher than over weight and normal weight students (25.85, 20.12 and 16.17 ng/ml respectively) with p value < 0.00. Gender did not exhibit statistical difference (male 18.42 ng/ml and female 18.28 ng/ml). CONCLUSION: Most studied subjects had mild to moderate vitamin D inadequacy. Subjects who consume more vegetable, perform brisk daily walking exercise, undergraduate and overweight have higher mean level of vitamin D3 while the gender have no effect on mean level of vitamin D3.


Article
Anti-inflammatory effect of vitamin D3 on chronic gingivitis

Authors: Faehaa Azher Al-Mashhadane --- Asmaa Y Thanoon
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2020 Volume: 20 Issue: 1 Pages: 73-82
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To investigate the effects of vitamin D3 on chronic gingivitis and to evaluate its effect on Tumor necrosis factor-α and Interleukin-6 in their saliva. Material and Method: Forty patients were classified into two groups: - group 1: (20) chronic gingivitis patients, did not receive any medication (control group), group 2: (20) chronic gingivitis patients (treatment group), received Vitamin D3 1000IU capsule/ day. Scaling and polishing have been carried out for each volunteer to reach the base line for gingival index, oral hygiene index and calculus index. Then these indices were measured for all patients on the next day, after 3 weeks and after 6 weeks in both groups. Five milliliters of unstimulated saliva were collected for measurement of human salivary Tumor necrosis factor-α and Interleukin-6 by ELISA Kits. Results: significant differences were observed between treatment and control groups throughout study days with significant reduction in oral health indices in 21st and 42nd days of treatment group. Comparisons between the salivary parameters showed significant decreases in Tumor necrosis factor-α and Interleukin-6 levels throughout 1st, 21st and 42nd day in treatment group, while in control group no significant differences were observed for IL-6 but significant increase in levels of TNF α was detected. Conclusion: Vitamin D3 has beneficial effect during treatment of chronic gingivitis


Article
Effect of injected with gibberllic acid ga3 and addition of vitamin d3 to the diet on some productive parameters of aged laying hens
تأثير الحقن بحامض الجبرليك GA3 واضافة فيتامين D3 الى العليقة في بعض الصفات الإنتاجية للدجاج البياض المتقدم بالعمرالانتاجي

Authors: Hala Ah. Ali هالة عبد الحميد موسى علي --- Dhia. K. Ibrahim ضياء خليل ابراهيم --- Waleed M. Razuki وليد محمد رزوقي
Journal: ANBAR JOURNAL OF AGRICULTURAL SCIENCES مجلة الأنبار للعلوم الزراعية ISSN: PISSN: 19927479 / EISSN: 26176211 Year: 2010 Volume: 8 لمؤتمر - عدد خاص - الجزء الا Issue: 4 Pages: 57-71
Publisher: University of Anbar جامعة الانبار

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Abstract

This experiment was conducted to examine the effects of injected gibberellic acid GA3 in subcutaneous of hens neck and supplemental vitamin D3 to control basal diet on productive performance and egg shell thickness ,relative weight of egg shell of aged laying hens. Two hundred and seventy Lohmann Brown laying hens at 73 weeks of age were randomly assigned to three treatments groups. Each treatment consist of three replicates (30 hens / replicate). The treatments were : T1 control were injected subcutaneous with 0.2 ml / kg of body weight of ethanol: sesame oil solution, T2 and T3 were injected subcutaneous with 0.2 ml / kg of body weight of ethanol: sesame oil solution which contained 400 µg GA3/ kg of body weight /week during 8 weeks (treatment period) and allowed without injection for 4 weeks (recovery period). During the treatment and recovery periods all the hens of treatments were fed the control basal diets, only T3 supplemented with 500 IU vitamin D3 / kg diet during the treatment period (8 weeks). The results showed a significant improvement in egg production (H.D%), egg mass and feed conversion ratio, whereas, feed intake and egg weight were decreased significantly for hens in T2 and T3 compared with those in T1 during both periods of experiment (treatment and recovery period). Hens that received T2 or T3 tended to increased the relative weights of eggshell and shell thickness compared with hens received T1during the period of treatment and recovery.We can concluded that gibberellic acid GA3 injection alone or with VD3 supplementation to diets improve some of productive parameters especially the relative weights of eggshell and shell thickness of aged laying hens.

اجريت هذه التجربة بهدف التعرف على تأثير الحقن بحامض الجبرليك (GA3) تحت جلد الرقبة واضافة فيتامين D3 الى العليقة في الاداء الانتاجي والوزن النسبي وسمك القشرة لبيض الدجاج البياض المتقدم بالعمر الانتاجي. استخدم في التجربة 270 دجاجة بياضة سلالة لوهمان البني بعمر 73 اسبوع وزعت عشوائياً على 3 معاملات. قسمت كل معاملة الى 3 مكررات (30 دجاجة/مكرر). وكانت المعاملات كالاتي: T1 السيطرة والتي حقنت تحت جلد الرقبة 0.2 مل/كغم من وزن الجسم من مخلوط زيت السمسم : ايثانول ، T2 و T3 فقد تم حقنها 0.2 مل من مخلوط زيت السمسم : ايثانول/ كغم من وزن الجسم مع اضافة 400 مايكروغرام من حامض الجبرليك (GA3)/كغم من وزن الجسم وكانت هذه المعاملات تجرى مرة في الاسبوع ولمدة 8 اسابيع (مدة المعاملة) ثم تركت بدون حقن لمدة 4 اسابيع (مدة الاسترجاع). غذيت طيور جميع المعاملات خلال مدتي المعاملة والاسترجاع على عليقة السيطرة،عدا المعاملة T3 فقد غذيت على عليقة السيطرة مع اضافة 500 وحدة دولية من فيتامين D3/كغم علف خلال مدة المعاملة (8 اسابيع) دون مدة الاسترجاع وكانت العليقة تحتوي على 2800 كيلوسعرة طاقة ممثلة/كغم علف ،15.1% بروتين خام. اظهرت النتائج حصول تحسن معنوي في بعض مدد المعاملة والاسترجاع في متوسط انتاج البيض (%H.D) ، كتلة البيض ومعامل التحويل الغذائي في المعاملات T2 و T3 مقارنة بمعاملة السيطرة (T1)، بينما انخفض وزن البيض معنوياً لطيور معاملتي T2 (الحقن بحامض الجبرليك) و T3(الحقن بحامض الجبرليك مع اضافة فيتامين D3الى العليقة) مقارنة بطيور معاملة السيطرة T1 خلال مدتي التجربة (المعاملة والاسترجاع).كما لوحظ حصول تحسن معنوي في الوزن النسبي وسمك القشرة في طيور المعاملة T2 وT3 مقارنة بالمعاملة T1 خلال مدتي المعاملة والاسترجاع. يمكن الاستنتاج بان حقن حامض الجبرليك بتركيز 400 مايكروغرام لوحده اومع اضافة فيتامين D3 ادى الى حصول بعض التحسن في بعض الصفات الانتاجية والوزن النسبي وسمك القشرة للدجاج البياض المتقدم بالعمر الانتاجي .


Article
Evaluation of vitamin-D3 Concentration in Patients with Thalassemia in Baghdad City
تقييم نقصان تركيز فيتامين D3 لدى مرضى الثلاسيميا في مدينة بغداد

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Abstract

Background:Thalassemia is inherited blood disorders characterized by abnormal hemoglobin production.Objective:To evaluate decreasing in vitamin-D3 concentration in patients with thalassemia among healthy men in Baghdad city.Patients and Methods: In this study containing 99 thalassemia patients from Baghdad city (68 female and 31 male patients) and (31 healthy males and 10 healthy women) as a control group collected from Al-Kadhymia hospital. Their age ranged (15-40) years old which are compatible to age of study group. Serum samples taken from the patients to determined vitamin-D concentration by using Enzyme Linked Immuno Sorbent Assay (ELISA) technique, during the period 1st April 2016 to 28th January 2017.Results:The study revealed highly significant (P<0.01) low of vitamin-D3 concentration in patients with thalassemia (89.9% decrease vit-D3 compared with 10.1% control group vit-D3 concentration).Conclusion:The decreasing in vitamin-D3 concentration associated with thalassemia patients was due to less exposure to sun light that affected the vitamin metabolism in their bodies.

خلفية الدراسة: مرض الثلاسيميا هو فشل دموي وراثي يتصف بانتاج الهيموغلوبين الغير طبيعي.اهداف الدراسة: هدفت هذه الدراسة الى تقيم نقصان فيتامين دي 3 بين المرضى المصابين بالثلاسيميا مع الاشخاص الاصحاء في مدينة بغداد .المرضى والطرائق : تضمنت هذه الدراسة 99 مصاب بالثلاسيميا من مدينة بغداد (68 إناث و 31 ذكور ) و(31 رجال اصحاء و10 نساء اصحاء) كمجموعة سيطرة جمعت من مستشفى الكاضمية . تراوحت أعمارهم بين (15-40) سنة‚ حيث كانت متوافقة مع عمر مجموعة الدراسة. أخذت عينات المصل من الأشخاص المصابين لتعين تركيز فيتامين (دي3) باستخدام تقنية مقايسة الأنظيم المرتبط الممتز المناعيه خلال الفترة من الأول من شهر نيسان 2016 ولغاية 28 من شهر كانون الثاني 2017.النتائج: أظهرت هذه الدراسة زيادة معنوية عند قيمة أحتماليه (P<0.01 ). لوحظ انخفاض تركيز فيتامين دي3 عند الأشخاص المصابين بالثلاسيميا 89.9% مقارنة مع عينات السيطرة 10.1% .الاستنتاجات : الانخفاض بتركيز فيتامين دي3 عند مرضى الثلاسيميا كانت تعزى الى قلة التعرض لضوء الشمس والذي يؤثر على عملية ايض فيتامين دي3 في اجسام المرضى.


Article
Effect of Vitamin D3 Supplement on Biochemical Markers and Blood Pressure Reading in Hypertensive patients as A secondary Prevention
تأثير تناول فيتامين د3 على بعض القراءات البايوكيميائية وقراءات ضغط الدم واستخدامه كعلاج ثانوي في المرضى الذين يعانون من ارتفاع ضغط الدم

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Abstract

Hypertension is the most significant risk factors for cardiovascular morbidity and mortality. It has two classes according to causes of the high blood pressure (Primary and Secondary). This study was intended to evaluate the potential benefit of vitamin D3 supplementation as a secondary preventive therapy for hypertensive patients. It is a prospective randomized controlled study was carried out on 40 patients visiting the Imam Al-Hussein medical city / Karbala and conducted from Sep 2016 to May 2017. The patients were allocated into group1; include 20 hypertensive patients presented with vitamin D deficiency assigned to receive conventional therapy for hypertension with vitamin D3 (100000 IU) orally every 2 weeks for 8 weeks, and group 2; include 20 hypertensive patients presented with vitamin D deficiency assigned to receive anti hypertension therapy only. Ethical committee approval and written consent of patients were obtained. Results revealed that the effect of vitamin D3 supplementation on both angiotensin II level and endogenous vitamin D levels were significantly clear regardless of age group, gender, BMI, duration of disease, and smoking status, except for systolic and diastolic blood pressure, TC, and LDL-c was affected particularly by age group and the duration of disease.

ارتفاع ضغط الدم هو واحد من أهم عوامل الخطورة لامراض القلب والأوعية الدموية والوفيات. كما يمكن ان يقسم الى قسمين وفقا لأسباب ارتفاع ضغط الدم (الابتدائي والثانوي) هذه الدراسة احتمالية عشوائية تهدف إلى تقييم الفائدة المحتملة من مكملات فيتامين D3 كعلاج وقائي ثانوي لمرضى ارتفاع ضغط الدم. تم إجراء الدراسة على 40 مريضا خلال زيارتهم مدينة الإمام الحسين (ع) الطبية / كربلاء لأخذ العلاج من سبتمبر 2016 إلى مايو 2017. تم الحصول على موافقة اللجنة الأخلاقية وموافقة خطية من المرضى وتم تقسيم المرضى الى مجموعتين الاولى المجموعة التي تتناول فيتامين D3مع علاج الضغط المقرر والمجموعة الثانيةالتي تتناول علاج الضغط فقط لمدة شهرين من العلاج للمجموعتين. كما اوضحت النتائج ان التاثير الايجابي للفيتامين على تعديل مستوى الانجيوتنسين وفيتامين د بالجسم لايتعلق بالخصائص الديموغرافية للمريض لكلا المجموعتين بما يخص العمر ونوع الجنس ووزن الجسم ومدة المرض والتدخين عدا بعض التاثير للعمر و مدة المرض على قياس ضغط الدم ومستوى الكولستيرول بعد العلاج بالفيتامين.


Article
Effects of vitamin D supplementation on red cell indices and cytokines in patients with thalassemia: An open-label randomized clinical trial
آثار مكملات فيتامين (D) على مؤشرات الخلايا الحمراء ومستويات السيتوكينات في المرضى الذين يعانون من ثلاسيميا بيتا الرئيسية; تجربة سريرية عشوائية ذات علامة مفتوحة.

Authors: Raz Muhammed HamaSalih راز محمد حمه صالح --- Marwan S.M. Al-Nimer مروان صالح النمر
Journal: Al-Mustansiriyah Journal for Pharmaceutical Sciences مجلة المستنصرية للعلوم الصيدلانية ISSN: 18150993 Year: 2019 Volume: 19 Issue: 4 Pages: 170-179
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background and aimDeficiency of vitamin D is known as a health problem all over the world and a recognized clinical complication of beta thalassemia patients. Vitamin D acts as a hormone at the nuclear receptor rendering it a beneficial medication for a number of diseases. It is believed that vitamin Dis important in the modulation of the inflammation system by regulating the formation of inflammatory cytokines and immune cells. This study aimed to investigate the effect of vitamin D supplementation on the red cell indices and cytokines levels in patients with beta thalassemia major, in an open label randomized clinical trial.Patients and Methods: this study performed an open-label randomized clinical trial in patients with beta thalassemia major. Forty-six patients completed the eight weeks clinical trial and were allocated to administer oral vitamin D3 supplement of 100,000 IU every two weeks as an add-on treatment. During the study, hematological indices, serum iron, ferritin, vitamin D, calcium and inflammatory markers (interleukin-6, interleukin-2 and interleukin-10) were evaluated before (at baseline) and after vitamin D supplementation for 8 weeks.Results: Vitamin D3 supplements significantly decreases interleukin-6 levels and elevates the serum levels of anti-inflammatory cytokines IL-2 and IL-10, it also significantly reduced serum ferritin level, but it did not alter the hematological indices.Conclusion: Our results suggest that administration of vitamin D has a potential anti-inflammatory role in beta thalassemia patients and reduces serum ferritin levels, which may reduce the burdens of iron overload in thalassemia patients.

خلفية:يعرف نقص فيتامين (D) بأنه مشكلة صحية في جميع أنحاء العالم ومضاعفات سريرية معترف بها لمرضى الثلاسيميا بيتا. يعمل فيتامين (D) كهرمون في المستقبل النووي مما يجعله دواء مفيد لعدد من الأمراض. ويعتقد أن فيتامين (D) مهم في تعديل نظام الالتهابات من خلال تنظيم تشكيل السيتوكينات الالتهابية والخلايا المناعية.الهدف: تهدف هذه الدراسة إلى دراسة آثار مكملات فيتامين (D) على مؤشرات الخلايا الحمراء ومستويات السيتوكينات في المرضى الذين يعانون من ثلاسيميا بيتا الرئيسية، في تجربة سريرية عشوائية ذات علامة مفتوحة.الإعداد: مركز الثلاسيميا ، دليل الصحة ، المستشفى العام فی السليمانية، إقليم كوردستان - العراق.الطريقة:أجرينا تجربة سريرية عشوائية مفتوحة التسمية علی المرضى الذين يعانون من ثلاسيميا بيتا الرئيسية. أكمل ستة وأربعون مريضا التجربة السریریة (الكلينيكية) التي استمرت ثمانية أسابيع وتم تخصيصها لإعطاء مكملات فيتامين D3عن طريق الفم والتي تبلغ 100000 وحدة دولية IU كل أسبوعين كعلاج إضافي. خلال الدراسة، تم تقييم مؤشرات الدم، الحديد في الدم، فيريتين، فيتامين D ، الكالسيوم وعلامات الالتهابات (إنترلوكين -6، إنترلوكين -2 وإنترلوكين -10) قبل (في الأساس) وبعد مكملات فيتامين (D) لمدة ثمانیة أسابيع.النتائج: مكملات فيتامين D3 تقلل بشكل كبير مستويات إنترلوكين -6 وترفع مستويات مصل السيتوكينات المضادة للالتهابات IL-2 و IL-10 ، كما أنه يقلل بشكل كبير من مستوى فيريتين المصل، لكنه لم يغير مؤشرات الدم.خاتمة:تشير نتائجنا إلى أن تناول فيتامين (D) له دور محتمل مضاد للالتهابات في مرضى الثلاسيميا بيتا ويقلل من مستويات فيريتين المصل، مما قد يقلل من أعباء الحديد الزائدة في مرضى الثلاسيميا.

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