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The prevalence of Von-¬¬¬Willebrand disease in menorrhagia and post partum hemorrhage
تقييم أنتشار مرض فون ويلبراند في النساء ذوات الحيض الشديد والنساء المصابات بالنزف ما بعد الولادة

Author: Ali Mohamed Murad د.علي محمد مراد
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2009 Volume: 22 Issue: 1 Pages: 24-29
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: To estimate the prevalence of Von-Willebrand disease in women with menorrhagia and post partum hemorrhage. Patients & method: It is a cross sectional study done in the department of obstetrics and gynecology in Al Yarmouk teaching hospital from 1st of October 2004 to 30th of October 2005.Ninety nine women participated in this study. Thirty nine women with menorrhagia,30 women with post partum hemorrhage and 30 women as control. Blood sample from each case was drawn for von Willebrand factor antigen (vWf-Ag), factor 8(fvIIIc), prothrombin time (P.T.), activated partial thromboplastine time (APTT),bleeding time, C.B.P, renal function test and liver function test. Laboratory results for menorrhagia and post partum hemorrhage patients were compared with those of control group to estimate the prevalence of von Willebrand disease.Results: Von-Willebrand disease was found in five(12.8%), four (13.3%)and zero(0.0%)from women with menorrhagia, post partum hemorrhage and control groups respectively.Conclusion: The measurement of the laboratory investigations for Von- Willebrand factor should be incorporated into the diagnostic evaluation of patients referred to gynecological clinic with menorrhagia or post partum hemorrhage of certain criteria, otherwise; it may lead to hemorrhagic complications associated with surgical intervention in patients with Von- Willebrand disease.Key wards: Von-Willebrand disease, menorrhagia, post partum hemorrhage.

الملخص:الخلفية:دراسة مستقبلية اجريت في قسم النسائية والتوليد في مستشفى اليرموك التعليمي من الاول من تشرين الأول 2004 ولغاية الثلاثين من شهر تشرين الأول 2005. الهدف: هو تقييم نسبة مرض فون ويلبراند في النساء المصابات بالحيض الشديد والمصابات بالنزف ما بعد الولادة .طريقة العمل : تتضمن الدراسة(99) مريضة . (39) مريضة مصابة بالحيض الشديد و (30) مريضة مصابة بالنزف ما بعد الولادة و(30)حالة اعتيادية لا تعاني من الحيض الشديد او النزف ما بعد الولادة وارسل نموذج من الدم لكل حالة لاجراء الفحوصات لنسبة عامل فون ويلبراند المستضد ونسبة عامل الثمانية المستضد ، وقت النزف ، دراسة التخثر وفحص الدم الكامل وفحص وظائف الكلى والكبد . وقد قارنت نتائج المختبر للمرضى المصابات بالحيض الشديد والمرضى المصابات بالنزف مابعد الولادة مع الحالة الاعتيادية لمعرفة نسبة مرض فون ويلبراند.الاستنتاج:اثبتت الدراسة ان نسبة 12.8% من النساء المصابات بالحيض الشديد ونسبة 13.3%من النساء اللواتي يعانين من نزف بعد الولادة مصابات بمرض فون ويلبراند .نستنتج من هذه الدراسة ان اجراء التحاليل المختبرية يجب ان يشمل قياس عامل مرض فون ويلبراند للمرضى المحالين الى قسم النسائية المصابات بنزف الحيض الشديد والمرضى المصابات بنزف ما بعد الولادة للتاكد من وجود مرض فون ويلبراند والذي يجنبها اجراء تداخلات جراحية غير لازمة .


Article
Congenital von Willebrand factor deficiency in single Iraqi teaching hospital: A descriptive study

Authors: Obeida Amir Abid --- Lubna Foad Hussain
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2016 Volume: 5 Issue: 2 Pages: 154-156
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: Von Willebrand disease (vWD) is a common, inherited hemorrhagic disorder caused by adeficiency or dysfunction of the protein von Willebrand factor (vWF).OBJECTIVES: The aim of this study is to assess the diagnosis and treatment of vWD in a single Iraqi teachinghospital.PATIENTS AND METHODS: This descriptive study was conducted on 778 patients with bleeding tendency,107 patients were diagnosed to have vWD, and from the first of October 2013 to the first of August 2015.The diagnosis of the disease was made by a wide spectrum of characteristics including family history, clinicalmanifestations, and laboratory tests.RESULTS: The common manifestations of the disease at the time of the diagnosis were epistaxis (39.2%), gumbleeding (24.2%), and menorrhagia (23.4%) in female patients. The age of patients at time of presentation wasbetween 1 and 10 years. Family history was positive in most patients. Hepatitis C was rare in the patients aftercryoprecipitate administration.CONCLUSIONS: It is a common inherited hemorrhagic disease in Iraq, mostly presented as minor bleedinginvolving mainly mucocutaneous regions which appears at an early childhood with positive family history in mostcases.


Article
10.THE ROLE OF COLLAGEN BINDING ASSAY IN CLASSIFICATION OF VON WILLEBRAND DISEASE

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Abstract

Background: von Willebrand disease (VWD) is the most common, genetically, hereditary and clinically heterogeneous bleeding disorder caused by qualitative or quantitative defects in von Willebrand factor (VWF) that leads to imperfect VWF interaction between platelets and injured blood vessel wall which deteriorate primary hemostasis.Objective: To assess the role of collagen binding assay in the classification of VMD.Methods: A cross sectional study was conducted on 52 suspected known patients with VWD with no consideration to their age or gender who attended the National Center of Hematology. They were submitted to von Willebrand factor antigen (VWF:Ag), factor VIII (FVIII), ristocetin co factor assay (VWF:RCo), ristocetin induced platelet aggregation (RIPA), and collagen binding assay (VWF:CB) at the same center.Results: The patients mean age was 14.42 ±1.64 years, median 10 years, and range of 1-40 years. More than half of cases below 10 years with M:F ratio 1:1.26. Two out of 9 cases of subtype I was diagnosed as subtype II, 4 out of 7 cases of subtype II sub classified as subtype2M and the rest 3 cases sub classified as 2A, 11 out of 36 of subtype III diagnosed as 8 cases for subtype I, and 3 cases for subtype II.Conclusion: VWF:CB assay is an important and effective supplementary test, in addition to three test panel FVIII, VWF:Ag, VWF:RCo, and multimere analysis, for sub classification of VWD. VWF:CB assay has a role in reclassified VWD patients with highly variable clinical presentation and laboratory values. Type III VWD is most frequent diagnosed type among symptomatic patients due to high consanguinity rate which detected earlier with severe bleeding tendency.Keywords: Von Willebrand disease, collagen binding assay, VWF:RCo. Citation: Suha K. Jabbar, Subh S. Al-Mudallal, Zeyad A. Shabeeb, Yusra G. Al-Obaidy, Hind S. Al-Mamoori. The role of collagen binding assay in classification of von Willebrand disease. Iraqi JMS. 2017; Vol. 15(2): 175-180. doi: 10.22578/IJMS.15.2.10


Article
von Willebrand Disease: The Diagnosis and Management of This Bleeding Disorder

Author: Basim A. Abd, Nawrass J. Al‑Salihi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2020 Volume: 17 Issue: 2 Pages: 122-125
Publisher: Babylon University جامعة بابل

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Abstract

von Willebrand disease (vWD) is one of the most common bleeding disorders, first described by Erik von Willebrand in the Aland Islands.It occurs as a result of decreased or abnormal von Willebrand factor (vWF), a factor that is needed in the process of blood coagulation;acting like a “glue” helping platelets to stick together and form the blood clot. The principal function of vWF is binding with other clottingfactors (especially Factor VIII) that are also necessary in the clotting process. There are two main forms of this disease: the inherited and theacquired forms; each one’s pathophysiology depends on the qualitative or the quantitative defects in vWF. The diagnosis of vWD dependson several factors: measurement of vWD antigen, vWF activity assay, the activity of Factor VIII, and some other additional tests. Themanagement of this disease includes replacement therapy, nonreplacement therapy, and some other kinds of managements that include theuse of fibrinolytics and topical agents.

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