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Article
Assessment of anticardiolipin and antiphosphatidylserine antibodies in women with recurrent abortion

Author: Ahmed J. AL-Husaynee احمد جاسم الحسيني
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2008 Volume: 34 Issue: 1 Pages: 54-57
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To assess the prevalence of anticardiolipin (ACL) and antiphosphatidylserine (APS) antibodies in women with repeated abortion in Mosul region.
Methods: Women with history of three or more recurrent spontaneous abortions in their first trimester were studied, for ACL and APS antibodies in their sera by enzyme linked immunosorbent (ELISA). Fifty normal pregnant women during the first trimester were included as a control. Chi –squared test was utilized for evaluation.
Results: One hundred –sixty women were tested. ACL and APS were detected in 45/160 (28%) & 22/160 (13.7%) respectively. These antibodies were negative in all control group.
Conclusion: Positivisty of ACL antibodies among women with recurrent spontaneous abortion is a common finding in Mosul region. The use of low dose aspirin plus heparin in management of such women had successful result.

الهدف: معرفة مدى وجود مضاد الكارديوليبين (ACL) ومضاد الفوسفاتيدايل سيرين (APS) لدى النساء اللاتي لديهن إجهاضات متكررة في منطقة الموصل.طرائق البحث: شملت الدراسة النساء الحوامل في الثلث الاول من الحمل ممن لديهن تاريخ ثلاثة اجهاضات تلقائية أو أكثر بإجراء فحوص للتحري عن وجود اجسام مضادة لكل من ACL ، APS في مصل الدم بطريقة ELISA كما شملت الدراسة مجموعة سيطرة من (50) امرأة طبيعية الحمل وفي الثلث الاول من الحمل أيضا قيمت النتائج بحساب مربع كاي (X 2) . النتائج: شمل الفحص 160 امرأة . وجد ACL ، APS لدى 45 (28%) و 22 (13,7%) على التوالي ، ولم نجد أي نتيجة ايجابية لأي الفحصين للجسمين المضادين ACL ، APS لدى النساء في مجموعة السيطرة.الاستنتاج: ان ايجابية فحص ACL لدى النساء اللواتي لديهن تاريخ اجهاضات تلقائية متكررة كثيرة الحدوث في منطقة الموصل. وان استعمال الاسبيرين بجرعات يومية صغيرة مع الهيبارين في تدبير هذه الحالات يعطي نتائج طبية.


Article
Role of mesoprostol in the management of first trimester incomplete abortion
دور الميزوبروستول في معالجة الإجهاض الناقص في الأثلوث الأول

Authors: Sabat A. M. Barawi --- Dlovan Jamal Saeed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2012 Volume: 16 Issue: 2 Pages: 133-138
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objectives: Surgical treatment has been a traditional way of treatment of incomplete abortion. Expectant management and medical treatment can reduce costs and complications generated by surgery. Current study was designed to determine the success rate of treatment of incomplete abortion by mesoprostol thus avoiding surgical intervention. Moreover, factors which can impair efficacy of the treatment were investigated.Method: The sample size included 100 patients with first trimester incomplete abortion attending Maternity Teaching Hospital in Erbil city/ Kurdistan Region / North of Iraq between October, 1st 2009 and March, 1st 2010 being assigned to receive 400 µg mesoprostol orally. A week later the patients were specifically examined to verify that complete abortion had been occurred. A second dose was administered if complete abortion was not yet achieved, provided that the patient was hemo-dynamically stable and notably no substantial bleeding or infection been noticed.Results: The success rate of the treatment was 62% and 93% after first and second dose respectively. The difference in response to the treatment was related to the difference in endometrial thickness and gestational age. No any serious complication was reported.Conclusion: Mesoprostol administered orally is an effective method in treating first trimester incomplete abortion.


Article
Oral Misoprostol Versus Vaginal Surgical Evacuation of First Trimester Incomplete Abortion; A comparative Study

Authors: Falah Abdul Hade Muhi1 --- Haitham F. Hamzha
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2015 Volume: 8 Issue: 1 Pages: 2167-2171
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Vaginal surgical evacuation of retained products of conception was the main stay of treatment for a long time for patients with first trimester incomplete abortion. Misoprostol as a thermo stable prostaglandin E1 analogue has been previously tested in the management of incomplete miscarriage in different regimens and setting. Overall results indicate efficacy, effectiveness and acceptability in most of these studies.Objectives: To assess the effectiveness and acceptability of using oral misoprostol for management of first trimester spontaneous incomplete abortion as an alternative to direct vaginal surgical evacuation.Methods: This is a comparative study performed on 84 patients with first trimester incomplete abortion between 6 -12 weeks of gestation requesting medical management .They were divided into two groups; group (1) received misoprostol tablet 200 μg [misotac ,SIGMA] two tablets every 4 h for a maximum of four doses while group (2) underwent surgical vaginal evacuation directly under general anesthesia.Results: In 100% of cases , misoprostol was successful in 79% (p= 0.0006). The overall satisfaction was slightly higher in the surgical group but almost equal percentage of both groups mentioned that they will recommend the method to a friend. No serious side effects or complications were reported in misoprostol group. The incidence of excessive post-abortive bleeding was more in the misoprostol group than the surgical evacuation group (p=0.336). Also endometrial thickness using ultrasonography was significantly thicker in the misoprostol group than group (2) [p=0.0071].Conclusion: Although vaginal surgical evacuation is more effective than misoprostol in solving the problem still medical treatment is effective and acceptable especially when surgical management is not available or risky or patients refuse to do surgical management.


Article
Thyroid Role in Threatened Abortion

Author: Thura jaafar kadhum
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2009 Volume: 2 no.8, 9 Issue: 5 Pages: 568-575
Publisher: Kerbala University جامعة كربلاء

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Abstract


Background: Mild impairment of thyroid function may contribute to disturbed reproductive function.
Objective: To evaluate the role of thyroid hormones in maintaining early pregnancy and their association with the outcome of the threatened abortion.
Materials and methods: The study was carried out in Maternity and pediatric Teaching Hospital in Al-Najaf during period between 1st April to 1st September 2008. The study included 80 pregnant women divided into two groups 50 women with threatened abortion and 30 women with normal pregnancy of comparable age, parity, gestational age and body mass index (BMI). Both groups were subjected to clinical examination, obstetric ultrasound examination and were investigated for hemoglobin, total thyroxine (TT4), total tri-iodothyronine (TT3) and thyroid stimulating hormone (TSH). The group of threatened abortion women divided into two groups where 31 women had a positive outcome (continuation of pregnancy to the third trimester) and 19 women had a negative outcome (pregnancy ended with spontaneous abortion).
Results: There was a significant difference in the level of TT3 and TSH between the control group and the women with threatened abortion (lower TT3 and higher TSH in threatened abortion women) with no significant difference in TT4 between the two groups while TT3and TT4 levels were significantly reduced in the women with negative outcome as compared with the women with a positive outcome while the TSH level was significantly increased in the women with negative outcome. Conclusion: reduced levels of thyroid hormones in early pregnancy may contribute to some cases of spontaneous abortion.
Key words: thyroid hormones, pregnancy, abortion.


Article
Human Cytomegalovirus Up-regulates Nuclear Factor-κB in Women with Spontaneous Abortion

Author: Asmaa’ Baqer Al-Obaidi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 484-487
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Human cytomegalovirus (HCMV) infection during pregnancy causing serious problems through induction of viral genes that enhance the expression of different cellular factors ending in failure of pregnancy.Patients and Methods: Paraffin embedded sections of curate samples were obtained from 34 women had spontaneous abortion, and 5 women had elective termination of pregnancy (as control), and then subjected for immunohistochemistry analysis to detect human cytomegalovirus (HCMV) early protein, and in situ hybridization technique to detect nuclear factor-κB (NF- κB) mRNA.Results: Only nine out of 34 women with spontaneous abortion were positive for HCMV early protein, with a significantly higher expression of NF-κB in HCMV positive cases as compared with HCMV negative and the control group (p = 0.001).Conclusion: This study strengthen the possibility that HCMV infection may play an important role in the pathology of pregnancy loss on multidirectional bases include inducing the expression of the transcriptional factor; NF-κB.

Keywords

HCMV --- NF-κB --- abortion


Article
Serum Anti-Cardiolipin Antibodies among Women with Recurrent Abortions in Diyala Province

Authors: Abdul-Razak shafiq Hasan --- Abbas A. Al-Duliami --- Rafah O. A-Zubiadi
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2010 Volume: 6 Issue: 3 Pages: 91-101
Publisher: Diyala University جامعة ديالى

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Background: Anticardiolipin antibodies (ACL) are heterogenous group of autoantibodies directed against negatively charged phospholipid and phospholipid binding proteins. They gained much attention due to their association with pregnancy failure, particularly recurrent fetal loss.Objectives:To investigate the relevance of positive ACL antibodies with recurrent abortion among women in Diyala province and to explore the effect of certain co-factors.Materials and methods:The study groups include, 45 pregnant women with previous history of recurrent abortion (mean age 29.3 ± 6.7) years; 60 pregnant women without previous abortion (mean age 28 ± 6.1) years; 50 non-pregnant women with history of recurrent abortion (mean age 29.7 ± 6) years and 60 non-pregnant women without history of previous abortion (mean age 31.5 ± 7.2) years. Required information were collected by personal interview. Detection of ACL-IgM and ACL-IgG were done using ELISA technique.Results:The results showed that the seropositivity of ACL-IgM among pregnant women with recurrent abortion and without abortion was 30% and 3.3% respectively. While the seropositivity of ACL-IgM among non-pregnant women with previous abortion and those without abortion was 20% and 0% respectively. The ACL-IgG among non-pregnant women without previous abortion and those with previous abortion was 0% and 35% respectively.Conclusion:Anticardiolipin antibodies may play as a cause of recurrent spontaneous abortion among women in Diyala province.


Article
The ASSOCIATION BETWEEN ABO BLOOD GROUP AND SPONTANEOUS ABORTION
الترابط بين فصائل الدم والإجهاض التلقائي

Author: Khalid Gata Washeel Al-Fartosi خالد كاطع وشيل الفرطوسي
Journal: basrah journal of science البصرة للعلوم ISSN: 18140343 Year: 2008 Volume: 26 Issue: 1B english Pages: 1-10
Publisher: Basrah University جامعة البصرة

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A study had been carried out to determine the association between ABO bloodgroup and spontaneous abortion. One hundred two couples from Al-Nassiriyah City(Iraq),sustained repeated abortion had been investigated for the ABO blood groups tofind the frequency of ABO blood group phenotypes .In husbands group, the maximumnumber of individuals had blood group B. In wife group, blood group A was thehighest among all individuals. In mixed group 204 individuals had been tested and outof these, again blood group A shows the highest number of individuals. Blood groupA was higher in individuals and mixed groups as compared with normal group in thisstudy. This study came to a conclusion that there is a clear increase in number ofindividuals for blood group A in-patients with repeated abortion, and this factor mayneed to consider in future investigations

تخصصت هذه الدراسة لبحث العلاقة بين فصائل الدم والإجهاض التلقائي. اشتملت الدراسة على102 عينة من الازواج المشخص لديهم حالات الإجهاض المتكرر من مدينة الناصرية / العراق وملاحظةكانت هي الأعلى في تكرار الحالات B تكرار فصائل الدم لديهم . اظهرت النتائج ان المجموعة الدمويةكانت هي الأعلى لدى النساء (الزوجات) . اظهرت A المدروسة من الازواج , بينما المجموعة الدمويةكانت هي الأعلى ايضا في المجموعة المختلطة التي تشتمل على الازواج A النتائج كذلك ان الفصيلة الدمويةهي الاعلى لدى الافراد والمجموعة المختطلة عند مقارنتها مع المجموعة A والزوجات. ان الفصيلة الدموية. A الطبيعية. الدراسة الحالية استنتجت زيادة واضحة في عدد حالالت الإجهاض لحاملي الفصيلة الدموية

Keywords

Blood group --- Abortion


Article
THE CLINICAL EVALUATION OF THE EFFECT OF XYLAZINE IN PREGNANT BUFFALOEs AND CATTLE
التقييم السريري لتأثيرالزايلازين على الحوامل في الجاموس والابقار

Author: M. J. Eesa محمد جواد عيسي
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2007 Volume: 6 Issue: 2 Pages: 37-41
Publisher: Basrah University جامعة البصرة

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Abstract

The object of this study was to investigate the effect of xylazine administration at dose of (0.05 mg/kg BW) intravenously in late pregnancy of buffaloes and cattle. Under xylazine as sedation and analgesia, accompanied with local anesthesia, rumenatomy were implemented on three hundred seventy two buffaloes and sixty four cattle. Eighty two and thirty five of these buffaloes and cattle were in late pregnancy respectively. The results of this study revealed that xylazine did not effect the buffaloes in late stage of pregnancy, but it cause abortion in late pregnancy in cattle at a percentage of 3.65%. Also there was individual variation of response to xylazine in both buffaloes and cattle. The latter appeared to be more sensitive to xylazine than buffaloes

ان اهداف هذة الدراسة هو معرفة تأثير حقن الزايلازين بالوريد وبجرعة(0,05ملغم/كغم ) من وزن الجسم في المرحلة الاخيرة من الحمل للجاموس والابقار.حيث تم تحت تأثير الزايلازين كمسكن ومسدر وبمساعده المخدر الموضعي,اجراء عمليه فتح الكرش 372 من الجاموس و64 من الابقار,وكانت 82و35 من الجاموس والابقار على التوالي في المراحل الاخيرةمن الحمل. بينت نتائج الدراسة ان الزايلازين لم يحدث تاثير على الحمل في الجاموس ولكن سجلت حالتين للأجهاض وبنسبه3,65% في الابقار.وكذلك فأن هنالك اختلافات واضحه للاستجابة للزايلازين في كلا من الجاموس والابقار و تبين بأن الاخيرة اكثر حساسيه للزايلازين من الجاموس

Keywords

Intravenous --- Abortion --- Xylazine


Article
INDUCTION OF ABORTION IN IRAQI GOATS USING BROMOCRIPTINE
استحداث الاجهاض في الماعز العراقي باستخدام البروموكربتين

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Twenty pregnant goats at gestation period ranged from 100 – 130 days were used in this study and divided in to four groups according to duration of gestation period. G (A) = 100 – 110 days, G (B) = 111 – 120 days, G (C) = 121 – 130 days. All of the goats were injected with a single dose of 2.5 mg / kg B.W. Bromocriptine I.M. The fourth group also 5 goats G (D) = 120 – 130 days were used as control & given 2 ml distal water I.M. Results showed that 80% of G (A) aborted after 5.12 ± 1.74 days, 60% of G (B) aborted after 4.92 ± 1.15 days and 60% of G (C) aborted after 4.97 ± 1.15 days of injection. In addition all the aborted goats showed complications represented by retention of fetal membranes and subsequent uterine infection compared to controls which showed neither abortion nor complications.

الخلاصةاستخدم في هذا البحث 20 معزة حامل وقسمت اعتمادا على طول فترة الحمل الى أربعة مجاميع متساوية، إذ كانت فترة الحمل في المجموعة (A) 100-110 يوما ً وفي المجموعة (B) 111-120 يوما ً وفي المجموعة (C) 121-130 يوما ً اعتمادا على تاريخ التسفيد. وقد حقنت جميع المعزات بجرعة واحدة من البروموكربتين 2.5 ملغم/كغم بالعضل. وقد استخدمت 5 معزات اخرى حوامل (D) 120-130 يوما ً كسيطرة بعد حقنها بــ2ملل ماء مقطر بالعضل.لقد أظهرت النتائج حدوث إجهاض في 80% من المجموعة A بعد 5.12±1.74 يوما ً من الحقن وإجهاض 60% من المجموعة B بعد 4.92±1.15 يوما ً من الحقن وإجهاض 60% من المجموعة C بعد 4.97±1.50 يوما ً من الحقن، إضافة لذلك فان جميع المعزات المجهضة قد عانت من مضاعفات تمثلت باحتباس الاغشية الجنينية ومن ثم التهابات رحمية بالمقارنة مع مجموعة السيطرة التي لم يحدث فيها مضاعفات بعد الولادة الطبيعية.

Keywords

Abortion --- Goats --- Fetal membrane


Article
Efficacy of Intravaginal Misoprostol in Different Media for First and Second Trimester Termination of Pregnancy

Authors: Najah Shaker Yassen --- Lava Chazi Faithullah
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 3 Pages: 315-320
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Medical abortion becomes the 1st choice for early 1st and 2nd trimester termination of pregnancy in many countries although dilatation and evacuation is commonly used in USA ,Medical abortion has been more patchy in its introduction in England and Walse and there continuous to be significant variation in its provision across health authorities .Medical method are often favored because they appear more physiological ,like a miscarriage and avoid the need for uterine instrumentation and also share the advantages of low rate of complication and failure.OBJECTIVE:To evaluate the effect of different media ( acetic acid , normal saline or dry)on the efficacy of intravaginal misoprostol used for induction of first and second trimester abortion.PATIENTS AND METHOD:During the 12 months of the study period, 90 pregnant women seeking termination of early pregnancy loss up to 24 weeks, as an indication for induction of abortion, their mean age were 27.7±5.5 years, and mean weight 72.3±3.9 kg.The first 30 pregnant patients received intravaginal 400μg misoprostol moistened with 2 ml of 5% acetic acid for 4hours interval up to 5 doses for 24 hours ,if the participant failed to achieve abortion the same regimen repeat for the next 24 hours, including 8 primiparous and 22 multiparous. Next 30 patients received intravaginal 400μg misoprostol moistened in 2ml of normal saline for 4 hours interval up to 5 doses for 24 hours ,if abortion failed then the trial repeated once again , including 15 primiparous and 15 multiparous. The last 30 patients received dry intravaginal 400μg misoprostol , 4hours intervals up to 5 doses for 24 hours. if abortion failed the same regimen repeat for the next 24 hours, including 10 primiparous and 20 multiparous.RESULT:All patients aborted within 48 hour. Significantly shorter induction –abortion interval for the moistened misoprostol tablet in acetic acid ( mean 8.3 ±2.2 hours), P value (0.000) ,than induction- abortion interval for moistened misoprostol tablet in normal saline (mean 19.5±7.7 hours) , and dry misoprostol tablet (mean23.1± 8.8hours) .The number of doses required to achieve response for moistened misoprostol in acetic acid was significantly less(mean 1.5±0.5), P value (0.000),than that required for moistened misoprostol in normal saline( mean 3.1±0.8),and for the dry misoprostol tablet (mean 3.7±0.8). The side effects being of no statistical significant.CONCLUSION:Acidic medium enhance the effect of misoprostol administered for induction of abortion. Moistening intra vaginal misoprostol may affect the pharmacokinetics of the drug to achieve a constant plasma profile.

Keywords

abortion --- misopristol --- vaginal ph

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