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Correlation of HER-2 Status with Estrogen, Progesterone Receptors and Histological Grading in 122 Invasive Breast Carcinomas
ارتباط حالة HER-2 مع هرمون الاستروجين ، مستقبلات البروجسترون والدرجات النسيجية في 122 سرطان الثدى الغازي

Author: Salah A. Ali
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2009 Volume: 13 Issue: 2 Pages: 1-7
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Many laboratory & clinical studies have suggested that there are important inverse relationships between expression of HER-2 oncoprotein and hormonal receptors(ER,PR),the prognosis & treatment are also greatly depend on hormonal receptor of neoplastic cells to define these relationships using standard immunohistochemistry for HER-2,ER and PR studies were performed in addition to routine histopahtological grading of carcinoma of the breast.Methods: Between January 2006 and December 2008 at histopathology lab of Rezgary hospital & private lab, (122) women who were operated on for diagnostic excisional biopsies of the breast cancers to allow analysis of routinely resected tissue. Quantitative expression of HER-2,ER and PR was measured on the resected samples of the breast cancers with cutoff points HER-2,ER and PR positivity were 10.6%,5.5%,5% respectively in addition to routine study of histopathology for grading of cancers according to Nottingham modified Bloom & Richardson criteria.Results: Immunohistochemical analysis for ER, PR, and HER-2 were performed. ER and PR expression were decreased significantly in HER-2 positive tumors compared with HER- 2 negative tumors (ER,15.57%,vs 41.8% vs. and PR, 13.11% vs. 37.70%;). Even among HER-2+ tumors, the rate of ER or PR expression in high-grade tumors was significantly decreased compared with intermediate grade tumors. HER-2 was positive in 73.3% of grade 2 and 66.6% of grade 3 ductal carcinomas and 6.89 in grade 1 ductal carcinomas. HER-2 expression essentially in grades 2 and 3 ductal carcinomas, very few cases in grade 1 and correlated inversely with ER or PR expression. Although ER or PR expression is decreased in HER-2+ tumors, a substantial proportion of them still express ER or PR.Conclusions: The results of this study are consistent with the indication of inverse relationships between HER-2 and ER,PR increased ER and PR levels in low grade neoplastic tissue ,the low grade neoplasms responding to hormonal therapy while high grade responding to hormonal therapy while high grage responding to herceptin

Keywords

HER-2 --- ER --- PR --- breast cancers


Article
Knowledge, awareness and practices about breast and cervical cancer in a group of women in Erbil city-Iraq

Author: Lina G. Husamaldien , Ali S. Dauod
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2016 Volume: 2 Issue: 2 Pages: 54-66
Publisher: Tikrit University جامعة تكريت

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Abstract


Article
Immunohistochemical Targeting of p110β Isoform of phosphatidylinositol 3-kinase co-associated with Cyclin-Dependent Kinase 1 in a Group of Tissues from Iraqi Patients with Breast Cancer

Author: Mohammed A.M. Al-Qurtas *
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2017 Volume: 13 Issue: 2 Pages: 136-146
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: While two-thirds of breast cancers express hormone receptors for either estrogen (ER) and/or progesterone (PR) , genetically altered PI3K pathway was found in more than 70% of ER-positive breast cancers.An aberrant activity of cyclin-dependent kinase 1 (CDK1) in a wide variety of human cancers has selectively constituted an attractive pharmacological targets in MYC-dependent human breast cancer cells.Aim of the study: Role of p110-beta as well as and CDK 1 in the pathogenesis of subset of breast cancers and contribution in their carcinogenesis. Type of the study: is a retrospective studyMethods: This retrospective research enrolled 70 paraffin embedded breast tissue blocks which were retrieved from archives of the period 2011 till 2017 at major hospitals and private histopathological laboratories as well as Forensic Medicine Institute in Baghdad. They comprised 30 breast cancers, 25 benign breast tumors and 15 apparently normal breast autopsies. Two 4 mm - thick sections were specified on positively charged slides for monoclonal primary p110 as well as and CDK 2 antibodies using immune-enzymatic antigen detection system for immunohistochemistry (IHC) techniques.Results: Seventeen out of 30 (56.7%) of the total breast cancer cases in this study showed positive immunohistochemistry reaction(IHC) for detection of P110- beta gene expression in these tissues. In the benign group, 6 out of 25 cases (24%) revealed positive IHC signals. None of control group presented positive signals. The differences begroup tween the percentages of P110-beta in breast cancers and each of control group and benign breast tumors group are statistically very highly significant (P value = < 0.0001). The expression of CDK1 was detected in 53.3% (16 out of 30) of breast cancers tissues and in 44% (11 out of 25) benign breast tumors, whereas none of control group of tissues showed CDK1- expression.Conclusions: The present data indicate that p110-beta as well as and CDK 1 could have a role in the pathogenesis of subset of breast cancers and contribution in their carcinogenesis.

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