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Article
Hypothyroidism in Adults Early Clinical Presentation in Relation to Age

Authors: Karim O. Al-Naffii --- Hassan A. A. Nasseralah --- Kadhum A. Al-Hillali --- Akram F. M. Ali
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2008 Volume: 2 no.4, 5 Issue: 3 Pages: 352-356
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: Hypothyroidism in adults is not a rare disease but has non –specific clinicalpresentation which may delay its diagnosis.Objective: the aim of the study is to identify the presenting symptoms of hypothyroidism,their frequency & their relation to age.Patients & Method : All adult patients > over 18 years of age who attended the consultationclinic, in Al-Hussein Teaching Hospital / Karbala, from January 2002 to December 2007showing clinical features suggestive of hypothyroidism were sent for T3, T4 & TSH.Results: Sixty eight patients were found to have hypothyroidism, 52 females & 16 males(F/M ratio 4.7:1). Seventy percent of the group are less than 55 yr of age, their mean age is42.3 yr. Malaise & arthralgia were the main complaints especially in those aged 55year &over (69% & 25%) respectively while skin changes were the main early physical signs inthose less than 55yr of age (26%).Discussion: Hypothyroidism is a disease which may present in a nonspecific clinical picturesuch as malaise or fatigability especially in elderly or skin changes in young age group or asmenstrual irregularities in young females.Conclusion: High index of suspicion is the main initial tool for diagnosis of hypothyroidism& should be considered in any elderly patient with unexplained malaise or fatigability or inyoung females with unexplained menstrual irregularities. To look for other physicalsymptoms & signs in those patients which may mandate sending them for thyroid functiontest or at least only TSH level.


Article
Demographic and Clinical Presentations of Pediatric Hydrocephalus in Medical City

Authors: Mahjoob N. Al Naddawi --- Numan Nafie Hameed --- ,Amal A. Rasheed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 139-144
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Hydrocephalus is distension of the ventricular system of the brain related to inadequate passage of cerebrospinal fluid from its points of production within the ventricular system to its points of absorption into the systemic circulation.OBJECTIVE:To study the demographic and clinical presentations of pediatric hydrocephalus in medical city complex , Baghdad.PATIENTS AND METHODS:This is a prospective study ,which was carried out on 100 children with a mean age+- standard deviation ( 24.3 +/- 16.06 )months and median 16 months, who were admitted to Children Welfare Teaching Hospital & neurosurgical department ( Surgical Specialties Hospital) / Medical City complex, Baghdad in the period from April first 2009 to October first 2009. A specially designed questionnaires were used to aid the investigators in performing a family interview. General and neurological examinations, and investigations including neuroimaging studies were done.RESULTS:Of 100 patients,(62%)were males and (38%) were females, with male to female ratio of 1.6:1. Family history of congenital anomaly was positive in (26%) of patients, while hydrocephalus was positive in (14%). Seventy-Two percent of patients had congenital hydrocephalus. Eighty–Seven percent of patients were full term. Fifty-Seven percent of patients were products of NVD ,while (43%) were products of CS,(2%) of them were emergency CS& (41%) were elective. The macrocephaly was diagnosed or noted at birth in (32%)of patients. The study showed that U/S finding of hydrocephalus was positive in (49%).CONCLUSION:The majority of the patients had congenital hydrocephalus, but there was delay in the diagnosis of macrocephaly. Prenatal ultrasound diagnosis yield was low in this study. Family history of hydrocephalus and other neural tube defect was important to be elicited


Article
Breast cancer: selected cytokines in the clinical presentation

Journal: Muthanna Medical Journal مجلة المثنى الطبية ISSN: 2226146x Year: 2014 Volume: 1 Issue: 1 Pages: 1-8
Publisher: Al-Muthanna University جامعة المثنى

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Abstract

Breast cancer is among the most commonly diagnosed cancer types in women worldwide and is the second leading cause of cancer-related disease in the USA. Recent data have suggested that many cytokines may be essential roles in the pathogenesis of breast cancer. The goal of this paper is to examine the major cytokines involved in breast cancer immunotherapy and discuss their basic biology and clinical presentation. IL-1, IL-6, IL-8, IL-10, and TNF-α in patients with breast cancer (n = 63) and healthy individuals as control (n = 68). We found that there were higher levels of IL-6, IL-8, IL-10 and TNF-α in patients with breast cancer compared to healthy controls (P<0.05). We conclude that the significance of selected cytokines is potential clinical Keywords: Breast Cancer; Cytokine; Clinical markers; Immunotherapy


Article
CLINICAL CHARACTERISTIC AND IN –PATIENTS MORTALITY AMONG 100 PATIENTS WITH HEART FAILURE ADMITTED TO IBN SEENA CENTRAL HOSPITAL, MUKALLA, HADHRAMOUT- YEMEN
الخصائص السريرية والوفيات في المستشفى بين مائة مريض بفشل القلب ادخلوا مستشفى ابن سيناء المركزي – المكلا / حضرموت خلال الفترة من اكتوبر2007 إلى يوليو 2008.

Author: Ahmed Ali Bahaj احمد علي باحاج
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2010 Volume: 8 Issue: 3 Pages: 60-68
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: The rate of heart failure in Hadhramout is steadily increasing.Objective: To determine the clinical characteristic and the predictors of in –hospital mortality of heart failure patients.Method: The first 100 consecutive patients with heart failure admitted to Ibn Seena central hospital in Mukalla for whom clinical history, physical examination and the basic investigations( including hemogram, blood sugar, chest X-Ray. Renal function test, serum cholesterol, electrocardiogram and echocardiogram) were performed during the period from October 2007 to June 2008.Results: In this study, we found male were more affected than female (65% versus 35%). The mean age of the patients was 57 ±12.1 years for males and 59 ±12.2 years for females. The most common underlying causes in all the patients were IHD in 52% followed by AHT 25%. IHD was more in males and AHT was more in females, while valvular heart diseases was the cause of HF in only 7%. The most common associated co-morbidities were renal dysfunction, anemia, dyslipidemia, diabetes mellitus and stroke in 43%, 41%, 35%, 25% and12% respectively. Patients of heart failure with impaired left ventricular function were 67.8%. And it was more in males than in females (52.7% &15.1%). The most common presenting symptoms was dyspnea of different classes in all of the patients and the most common sign was cardiomegaly in 89% of the patients followed by pulmonary crackles in 82%. And the most common arrhythmia were ventricular ectopic in 28% and atrial fibrillation in 21%. During the admission period 9 out of 100 patients died. The most common underlying causes were IHD, AHT and DCM and the most common co-morbidities of death were elder age of the patients, male sex, anemia, renal failure, DM, Stroke, impaired systolic ventricular function, and class IV NYHA dyspnea. Conclusion: This study revealed that HF is common in our community and it is recommended that early detection and management of the underlying etiology and associated co-morbidities could reduce the morbidity and mortality of HFKey words: Heart failure, clinical presentation, predictors, outcome. Mukalla, Yemen

خلفية الدراسة: ازداد معدل حالات مرضى فشل القلب في حضرموت التي يتم إدخالها إلى مستشفى ابن سيناء المركزي بالمكلا / حضرموت باضطراد . هدف الدراسة: تهدف هذه الدراسة إلى تحديد الخصائص الإكلينيكية للمرضى وتحديد أسباب توقع الوفيات بينهم .طريقة الدراسة: وقد شملت هذه الدراسة مائة مريض بفشل القلب ممن تم إدخالهم للمستشفى حلال الفترة من أكتوبر 2007 م إلى يوليو 2008 ممن تم معرفة التاريخ المرضي لهم وتم فحصهم سريرياً وأجريت لهم الفحوصات الضرورية والتي شملت فحص الهيموجلوبين والسكر والكولسترول ووظيفة الكلى والأشعة السينية للصدر وتخطيط القلب والأيكو . ولم تشمل الدراسة المرضى الذين لم تعمل أو تكتمل لهم الفحوصات بسبب الوفاة أو التحويل إلى مستشفى آخر أو أي أسباب أخرى.النتائج: وأظهرت الدراسة ارتفاع معدل المصابين بهبوط القلب بين الذكور أكثر من النساء بنسبة 65% إلى 35% وكان متوسط العمر للذكور ا57 ± 12.1 سنة بينما كان 59 ± 12.2 سنة وكان أهم أسباب هبوط القلب الذبحة القلبية في 52% متبوعا بارتفاع ضغط الدم في 25% وكان الذبحة القلبية الأكثر بين الذكور وارتفاع ضغط الدم الأكثر بين النساء.بينما كانت أمراض الصمامات القلبية هي السبب في 7% . كانت أهم أنواع المراضة المصاحبة لفشل القلب اختلال الكلى ، فقر الدم، السكري، اختلال الكولسترول والصدمة الدماغية في 43%، 41%، 35%، 25% و12%. وكان المرضى المصابين بالضعف الانقباضي للبطين الأيسر للقلب الأكثر في الذكور من النساء (52.7% مقابل 15.1%) . وكانت صعوبة التنفس أكثر الأعراض بنسبة 100% وكانت أكثر العلامات تضخم عضلة القلب في 89% تليها وجود الخشخشة الرئوية في 82% . حلال فترة الدراسة توفي 9 من 100 مريض أثناء وجودهم في المستشفى وكان أكثر الأسباب المؤدية للوفاة هي كبر السن، الذكورة ، فقر الدم، اضطراب الكلى، ضعف الوظيفة الانقباضية للقلب ووجود صعوبة في التنفس من الدرجة الرابعة بمقياس جمعية القلب في نيويورك.الاستنتاج: خلصت الدراسة إلى أن حالات هبوط القلب في مجتمعنا في ازدياد وان الاكتشاف المبكر للأسباب المؤدية إلى فشل القلب واستخدام العلاج المناسب للأمراض المسببة والمصاحبة يمكن أن يساعد في التقليل من معدلات المراضة والوفيات. مفتاح الكلمات: فشل القلب ، التقديم السريري التوقع والمخرجات في المكلا- حضرموت - اليمن


Article
Epidemiological and Clinical Features of Hydatid Cyst Disease in Babylon Province, During the years 2010-2015

Authors: Aulla Abbas Fadhil --- Hasan Alwan Baiee
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2018 Volume: 26 Issue: 2 Pages: 185-199
Publisher: Babylon University جامعة بابل

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Abstract

Background:-Hydatid disease is a chronic parasitic disease highly endemic in Iraq, it has serious health and economic consequences.Objectives:-To identify epidemiologic features in (person, place, and time) module of hydatid cyst disease and describing its clinical features among patients admitted to public hospitals for surgery.Methodology:-This cross sectional study was conducted by reviewing the clinical records of 208 hydatid cyst patients who were admitted to eight public hospitals in Babylon province during 6 years period (2010-2015), the records of all patients of hydatid disease were studied single handy by the researcher, incomplete, duplicated records and non surgically operated patients were excluded from this study. The period of the study extended from February 2016 through June 2016, the following independent variables were studied; such as socio-demographic data, clinical presentation of the disease and the organs involved and other characteristics of cyst.Results:-This study revealed that the average and the standard deviation of patients age were (34.13±16.17), females were significantly more infected than males (p>0.05), liver was the most infected organ (82.2%),more than two thirds of cases(70.2%) had a single cyst. The disease was predominantly present among rural dwellers(55.8%).About 15% of cases had cysts more than (10cm) in diameter. The predominant presentation of the disease was abdominal pain(52.4%) followed by abdominal mass.This study revealed that this disease was predominated in people with low socioeconomic status. Conclusion:-Hydatid cyst disease is an endemic disease in Babylon province, it was more common in females, low socioeconomic status groups, rural dwellers; liver is the most commonly infected organ. A strategic plan should be put to eliminate this disease in our society.

خلفية البحث: داء الأكياس العداريه هو من الأمراض الطفيلية المزمنة المستوطنة لحد الآن في العراق,له عواقب صحية واقتصادية خطيرة.الأهداف: للتعرف على السمات الوبائية لمرض الأكياس العداريه في النمط الوبائي (الشخص، المكان، والزمان) ووصف معالمه السريرية بين المرضى الذين يتم إدخالهم إلى المستشفيات العامة لإجراء العمليات الجراحية لغرض رفع الكيس.طريقة البحث: أجريت هذه الدراسة المقطعية من خلال مراجعة السجلات السريرية ل(208 (مريض بداء الأكياس العداريه الداخلين في ثمان مستشفيات عامه في محافظة بابل خلال فترة 6 سنوات (2010-2015)، وتمت دراسة سجلات جميع مرضى الأكياس العداريه بشكل مفرد بأيدي الباحث, وقد استبعدت السجلات الناقصة والمكررة والمرضى الذين لم يتم علاجهم جراحيا من الدراسة، هذا وقد امتدت فترة الدراسة من شباط 2016 حتى نهاية حزيران 2016, هذا وتمت دراسة المتغيرات المستقلة التالية: مثل البيانات الاجتماعية الديموغرافية والأعراض السريرية للمرض والعضو المصاب وغيرها من خصائص ومميزات الكيس.النتائج: كشفت هذه الدراسة أن متوسط العمر و الانحراف المعياري للمرضى كان سن (34.13 ± 16.17)، وقد كانت إصابة الإناث أكثر من الذكور بفارق معنوي و إحصائي ملحوظ0.05) >p)، وكان الكبد العضو الأكثر إصابة بنسبة (82.2٪)، وقد كان أكثر من ثلثي الحالات (70.2٪) لديهم كيس منفرد. كما كان هذا المرض منتشراً في الغالب بين سكان الريف بنسبة (55.8٪) مقارنة بسكان المدينة. وكان حوالي( 15٪) من الحالات لديهم أكياس قطرها يزيد عن(10سم). وكان العارض السريري السائد للمرض هو ألم البطن بنسبة (52.4٪) ويليه ورم البطن. كشفت هذه الدراسة أن هذا المرض هو مرض منتشر بشكل كبير بين الناس ذوي الوضع الاجتماعي والاقتصادي المنخفض.الاستنتاج: داء الأكياس العداريه هو مرض متوطن في محافظة بابل، أكثر شيوعا في الإناث، و بين مجاميع الناس ذوي الأحوال الاقتصادية والاجتماعية المنخفضة، وأكثر انتشاراً بين سكان الريف مقارنة بسكان المدينة، وان الكبد عادة هو العضو الأكثر عرضة للإصابة. يجب وضع خطه استراتيجيه للقضاء على هذا المرض في مجتمعنا.

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