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Article
Spermatozoal creatine kinase (CK) concentration as an indication of idiopathic obese subfertile males with normozoospermia
مستوى إنزيم الكرياتين كاينيز في الحيامين الطبيعية يعتبر مؤشر لمرضى البدانة في حالات العقم الدكوري الغير المفسر

Author: Ahmed S. Al-Hilli. Med MSc. Ph .D¹, Noorhan Shakir Mhao; MBCHB, DOG, FICOG² , Najah R. Haddi;MBCHB ,M.Sc, MD ,Ph. D, FACP,FCCP ³
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2012 Volume: 15 Issue: 1 Pages: 196-203
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objective: To determine the mean of spermatozoal creatine kinase (CK) concentration in idiopathic obese subfertile males with normozoospermia and healthy normal fertile control group. And to compare spermatozoal CK concentration between idiopathic obese normozoosperpmic subfertiles and healthy normal fertile volunteers (control group). Design: A prospective study.Setting: Maternity and Childhood Hospital, Najaf province, during period from April 2006 to January 2007.Patients and Methods: The present study determined the mean of spermatozoal CK concentration in 47 idiopathic obese male subfertiles with normozoospermia ,their ages ranging between 25-45 years ,and sperm count million ml, motility% , morphology %, vitality% are registered as normozoospermia according to WHO criteria. Fifteen apparently healthy normal fertile were regarded as control group. Traditional semen analyses and sperm parameters were assisted by same examiner. CK concentrations were measured using CK kit after the sperm enzyme was extracted within triton –X. The results of spermatozoal CK concentration was determined and compared between both groups.Result(s): There was a statistically significant differences (P<0.05) in active sperm motility % and sperm immotility % in comparison to sperm mean CK concentration in both groups. And sperm mean CK concentration was significantly higher in idiopathic obese male subfertiles with normozoospermia in comparison to control group.Conclusion(s): Elevated levels of spermatozoal CK concentration in idiopathic normozoospermic obese subfertile males may suggest an indication of sperm oxidative stress status which could play a role in idiopathic normozoospermic obese subfertility and fecundity that warrants more detail studies. Recommendation(s): creatine kinase concentration could be use an indication of sperm oxidative stress in idiopathic obese subfertile males with normozoospermia

الخلاصة: لقد اهتمت الدراسات المتقدمة في مجال التناسلية والعقم إلى اللجوء في تشخيص الخلل الوظيفي للحيمن من خلال استحداث فحوص متطورة لغرض التنبوء والتشخيص والعلاج.لقد أشارت الدراسات الحديثة إلى وجود علاقة وثيقة بين البدانة والعقم بشكل عام والعقم الدكوري الغير المفسر بشكل خاص مع وجود تفاسير عديدة لهده العلاقة. تشير نتائج هده الدراسة إلى إن ارتفاع مستوى أنزيم الكرياتين كاينيز في الحيامين الطبيعية يعتبر مؤشر لمرضى البدانة في حالات العقم الدكوري الغير المفسر مما يتسبب في احتمالية قلة الإخصاب.


Article
Creatine Kinase Activity and Malondialdehyde in the Seminal Plasma of Normospermic Infertile Males

Author: Ghassan T. Alani * MBChB, MSc, PhD د. غسان ثابت العاني
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2009 Volume: 51 Issue: 3 Pages: 336-340
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:Background: Normospermia might be a major problem to the doctor and the infertile couple because the male seminal sample has an accepted seminal parameters during the routine seminal examination and the female partner will be claimed for the infertility and she will suffered from coasty, painful, time consuming, non indicated investigations and treatments. Our purpose was to measure sperm creatine phosphokinase (CK) activity, which reflects cytoplasmic retention in immature spermatozoa and malondialdehyde in the seminal plasma which is a marker of oxidative stress in normospermic infertile males' seminal samples.Patient and methods: Nine infertile men with aberrantly normal standard seminal analysis parameters where included in this study and fifteen fertile men samples where used as control. The seminal kinase and seminal malondialdehyde were calculated in addition to the standard seminal analysis. Results: significant higher levels of creatine kinase and malondialdehyde in the normospermic infertile samples (p=0.0001; p=0.006 respectively) and also significant positive correlation between the seminal creatine kinase and seminal malondialdehyde (p=0.001; r=0.613). These markers did not correlate with the percentage of mid piece abnormalities in the studied samples.Conclusion: The seminal plasma creatine kinase and seminal malondialdehyde might be accepted methods to differentiate infertile samples from healthy despite the presence of accepted ranges of standard seminal analysis.Keywords: Normospermia, Oxidative stress, Creatine Kinase.


Article
SERUM CREATINE KINASE AND ITS ISOENZYME CK-MB IN THE PREDICTION OF TUBAL ECTOPIC PREGNANCY

Author: Hala A Abdullateef هاله عبد القادر عبد اللطيف
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2013 Volume: 11 Issue: 2 Pages: 170-175
Publisher: Al-Nahrain University جامعة النهرين

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Background:Ectopic pregnancy is a major cause of maternal morbidity and mortality. Creatine kinase is an enzyme that its increase reflects tissue injury and could be useful in the diagnosis of tubal pregnancy.Objectives:To evaluate the diagnostic value of total creatine kinase in women with ectopic pregnancy, tubal rupture ectopic pregnancy, spontaneous abortion, and normal pregnancy and to investigate the possible discriminatory ability of creatine kinase-MB for diagnosis of tubal rupture ectopic pregnancy.Methods:Forty women with ectopic pregnancy, 17 with intrauterine abortion and 24 women with normal gestation were studied. The diagnosis of ectopic pregnancy was based on clinical assessment and transvaginal ultrasonography. Serum human chorionic gonadotropin levels were measured by enzyme linked immuno-sorbent assay. Total serum creatine kinase and creatine kinase-MB values were determined by spectrophotometrical analysis.Results:Creatine kinase and creatine kinase-MB levels were significantly higher in tubal ectopic pregnancy compared with both intrauterine abortions and normal gestations. When using creatine kinase-MB of 4.55 IU/ml as a cut-off value for the diagnosis of tubal ectopic pregnancy from control groups, sensitivity 81.64%, specificity 84.3%, positive predictive value 88.5% and negative predictive value 71.4%. Creatine kinase level in the ruptured ectopic pregnancy group was significantly higher than in the unruptured ectopic pregnancy, and normal pregnancy. When using creatine kinase of 29.43 IU/ml as a cut-off value for the diagnosis of ruptured ectopic pregnancy from unruptured groups, sensitivity 92%, specificity 100%, positive predictive value 100%, negative predictive value 96% and efficiency 97.4%.Conclusions:Women with ectopic had a significantly higher levels of creatine kinase-MB compared with women with normal pregnancy or intrauterine abortion and it has a high discriminatory ability for diagnosis of tubal rupture ectopic pregnancy.Keywords:Ectopic pregnancy, creatine kinase-MB


Article
Correlation between Visfatin and Creatine Kinase Levels with Periodontal Health Status of Patients with Coronary Atherosclerosis and Chronic Periodontitis

Authors: Basma R. Omer بسمة عمر --- Maha Sh. Mahmood مها محمود
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 3 Pages: 121-125
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Visfatin is a novel adipokine that mainly secreted by visceral adipose tissue, had an important role ininflammation and immune system. Creatine Kinase (CK) which is an enzyme that is involved in energy metabolism,found in large amounts in myocardium, brain and skeletal tissues.This study is carried out To evaluate the periodontal health status of the study groups (chronic periodontitis andchronic periodontitis with coronary atherosclerosis) and control groups, to measure the salivary levels of visfatin andCreatine Kinase in these groups and compare between them, and to determine the correlations between salivaryvisfatin and Creatine Kinase levels with the periodontal parameters in the three groups.Materials and Methods: eighty participants, males and females were recruited in this study with age ranged from (30-60) years, they were divided into three groups: the first study group was the Chronic periodontitis group (n=30), thesecond study group was chronic periodontitis and coronary atherosclerosis (n=30) and the control group(n=20)which was healthy systemically with healthy periodontium. Periodontal health status was determined by measuringplaque index(PLI),gingival index (GI), probing pocket depth(PPD), bleeding on probing (BOP) and clinicalattachment level (CAL),salivary samples were taken from each participants, salivary visfatin levels were determinedby enzyme-linked immune-sorbent assay(ELISA) while the activity of salivary Creatine Kinase was determinedspectrometrically by using the International Federation of the Clinical Chemistry (IFCC) method on Hitachi 911Automatic analyzer.Results: The results of the study showed that the mean values of PLI, GI, visfatin, Creatine Kinase and the percentagesof sites according to PPD scores, CAL scores, BOP were higher in the second study group with chronic periodontitisand coronary atherosclerosis than in the other groups with highly significant differences between the groups at(P≤0.01). Also by using Pearson Correlation Coefficient, salivary visfatin levels were correlated positively with allclinical periodontal parameters with a strong and positive correlation between salivary visfatin levels and CAL scoresand PPD scores. Salivary Creatine Kinase levels were correlated positively with all clinical periodontal parameters witha strong and positive correlation between its levels and mean values of GI and percentages of BOP.Conclusion: The present study showed that salivary visfatin can be used as a marker for the development ofcoronary atherosclerosis and its levels are associated with the degree of periodontal destruction and showed thatCreatine Kinase may be used as a marker for coronary atherosclerosis and chronic periodontitis.


Article
Study the Spermatozoal Lipid Peroxidation and Creatine Kinase Activity on Sperm Parameters after Use of Simvastatin in Infertile Male Patients
دراسة تأثير مضادات الاكسدة بإستخدام عقارsimvastatin على فعالية اكسدة الشحوم و مستوىcreatine kinase في صفات السائل المنوي لمرضى العقم الذكري

Authors: Ahmed S. Al-Hilli --- Foud Shareef Dleikh --- Samia M. H. Al-Shahawani --- Najah R. Al-Mousaw
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2013 Volume: 10 Issue: 3 Pages: 735-749
Publisher: Babylon University جامعة بابل

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Abstract

The present study was carried out on a total of 55 patient with primary male factor infertility in Maternity and Childhood Teaching Hospital and Cancer Research Center, Kufa Medical College in Najaf Province between April 2005 - June 2006. The distribution of 55 patients in group I was classified into 8 subgroups according to the pathological cause of infertility and 35 normal proven fertility volunteer men served as a control group. All patient group was given simvastatin (simlo) tablets lpca, lpca laboratories Ltd Mubai: India at dose 20 mg twice per day for a period of 3 months. Spermatozoal malondialdehyde and creatine kinase (CK) were assessed before and after termination of treatment period. The present results showed a statistically significant decrease (p<0.05) in malondialdehyde MDA level and creatine kinase CK activity. Data also pointed out that there was a positive relation between spermatozoal MDA level and CK activity in most Simvastatin treated sperm pathological subgroups. This study might suggest and adopt an evidence of the action of simvastatin in lowering lipid peroxidation as MDA level and CK activity as an indicator of sperm parameters improvement due to antioxidant properties in patients with spermatozoal oxidative stress.

اجريت هذه الدراسة على (55) مريضاً من الذكور ممن يعانون من العقم الاولي الابتدائي في وحدة علاج العقم في مستشفى النجف للولادة والاطفال وللفترة من نيسان 2005 الى حزيران 2006 وقد صنف هؤلاء المرضى الى ثمانية مجاميع ثانوية طبقاً للسبب المرضي للعقم وقد تم مقارنتهم مع (35) شخصاً طبيعياً كمجموعة ضابطة . تم اعطاء هذه المجاميع عقار (Simvastatin) وبجرعة (20 ملغم) مرتين في اليوم ولفترة 3 أشهر . بينت هذه الدراسة وجود انخفاض معنوي في مستويات (Creatine Kinase & Malondialdehyde) في السائل المنوي للمرضى المعالجين بالعلاج المذكور مبينة دوره كمادة مانعة للأكسدة في تحسين صفات السائل المنوي في مرضى العقم الذي يعانون من ارتفاع في مستويات مضادات الاكسدة.


Article
Effect of Very Early Atorvastatin Initiation for Acute Myocardial Infarction on Creatine Kinase release

Authors: Adnan A. Al.adeem عدنان العديم --- Lewai S. Abdulaziz لؤي عبد العزيز --- Faris Abdul Kareem فارس عبد الكريم
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2010 Volume: 6 Issue: 1 Pages: 79-84
Publisher: Baghdad University جامعة بغداد

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Abstract

Background : It has been suggested that pre-treatment with a statin agent prior to myocardial infarction limits myocardial creatine kinase release, and thus may act to limit myocardial infarct size in humans.Objective : To examine the effect of very early statin initiation for acute myocardial infarction (AMI), to the extent of myonecrosis as manifested by peak serum creatine kinase levels.Methods : Patients with AMI admitted to Al-Kindy teaching hospital cardiac care unit from 1st February 2007 to 28th February 2008, who fulfilled the inclusion criteria cited in the present study, were randomly assigned into two study groups. The statin group patients have received a single oral dose of 40 mg atorvastatin at time of admission and repeated for the next days until discharge, patients not receiving statin were considered as controls, blood samples were obtained on admission and every 8 h for another three consecutive samples to identify peak creatine kinase levels.Results : Patients who had statin therapy initiated immediately after hospital admission have similar peak creatine kinase concentrations as compared to those not receiving statin therapy ( P= 0.332).Conclusion : statin initiation in AMI patients fails to show any observable effect on creatine kinase release, the need of an extended period for the statin agent to achieve the predictable outcome may suggest the necessity of statin pretreatment in patients at high risk for AMI.


Article
The Effect of Atenolol on CK-MB Levels in Hypertensive Patients

Author: Inaam A. Amin انعام احمد امين
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2009 Volume: 18 Issue: 1 Pages: 61-64
Publisher: Baghdad University جامعة بغداد

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Abstract

Atenolol is one of beta-adrenergic receptor blocking agent. It is widely used for the treatment of hypertension as a selective antihypertensive drug. But long term usage of atenolol may cause one of the cardiovascular diseases like myocardial infarction. To prove the relationship between atenolol and cardiovascular disease, measurement of creatinekinase-MB as a diagnostic indicator in early and long term usage of this drug by hypertensive patients is recommended. A comparative study was conducted in Al-Yarmouk Teaching Hospital–Emergency Department- on 30 hypertensive patients using atenolol. They were divided into (2) groups A and B according to the duration of the drug usage. Group A- (15) patients with a mean age (56+6) years. They used atenolol for a period of (1-5) years. Group B- also (15) patients with mean age (60+6) years. They used atenolol for (6-20) years. Both groups were with nearly the same number of males and females. All subjects of the study groups were screened to exclude evidence of hyper or hypothyroidism, diabetes and chronic renal failure. Venous blood samples were taken in first 8 hours after onset symptoms of cardiac attack from each patients and the levels of creatine kinase-MB were estimated and compared between the (2) groups. There is a significant correlation between levels of serum creatine kinase-MB of group A and group B (P<0.05). Atenolol causes increased level of serum CK-MB and this increase was directly proportional to the duration of the drug usage. CK-MB is one of cardiac markers that released from heart muscle when it is damaged as a result of myocardial infraction. So, atenolol has a significant correlation with development of myocardial diseases.

التينورمين هو واحد من مجموعة الأدوية التي تعمل على غلق مستقبلات بيتا، وهو يستخدم بشكل واسع في معالجة ارتفاع ضغط الدم ولهذا فإن هذا العقار قد يصنف كدواء اختياري لتقليل ارتفاع ضغط الدم ولكن استخدام هذا العقار على مدى طويل قد يسبب حدوث واحد من امراض الجهاز القلبي الوعائي. ولإثبات العلاقة بين عقار التينورمين وأمراض الجهاز القلبي الوعائي بواسطة قياس أنزيم الكرياتين كاينيس م ب ككاشف تحليلي على المدى القصير والبعيد لاستخدام هذا العقار لدى مرضى ارتفاع ضغط الدم، ولهذا أجريت دراسة مقارنة حالات في مستشفى اليرموك التعليمي- قسم الطوارئ- على (٣٠) مريضاً يعانون من ارتفاع ضغط الدم ويستعملون تينورمين كعلاج وتم تقسيم هؤلاء المرضى إلى مجموعتين (أ وب) وفقاً إلى طول فترة استعمالهم لعقار التينورمين. المجموعة (أ) وتتألف من (١٥) مريضاً، معدل أعمارهم (٥٦+٦) سنة واستعملوا التينورمين لفترة زمنية تراوحت بين (١-٥) سنة والمجموعة (ب) وتتألف أيضاً من (١٥) مريضاً، معدل أعمارهم (٦٠+٦) سنة استعملوا التينورمين لمدة تراوحت بين (٦-٢٠) سنة. كلا المجموعتين تقريباً تضم نفس العدد من كلا الجنسين، وكل المرضى المشمولين بهذه الدراسة غير مصابين بأمراض الغدة الدرقية ولا بداء السكري أو عجز الكلية المزمن. تم أخذ عينات من دم كل مريض خلال الساعات الثمانية الأولى بعد ظهور أعراض الأزمة القلبية لقياس مستوى أنزيم الكرياتين كاينيس م ب وتمت مقارنة النتائج بين المجموعتين. كان معدل الأنزيم كرياتين كاينيس م ب في مصول دم المجموعة (ب) مقارنةً بالمجموعة (أ) عالية وبمعنوية واضحة ٠٫٠٥ P< . ومن خلال النتائج التي تم الحصول عليها تبين أن عقار التينورمين يؤدي إلى ارتفاع وزيادة مستوى الأنزيم كرياتين كاينيس م ب وهذه الزيادة تتناسب طردياً مع طول الفترة الزمنية لاستعمال التينورمين وبما أن هذا الأنزيم مؤشر حيوي خاص لأمراض الجهاز القلبي الوعائي، لذا فإن عقار التينورمين له علاقة معنوية بحدوث أمراض الجهاز القلبي الوعائي وخصوصاً احتشاء العضلة القلبية.


Article
The Correlation between Lactate Dehydrogenase, Creatine Kinase and Total thiol Levels in Sera of Patients with &#946;-Thalassemia

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Abstract Lactate dehydrogenase (LDH), creatine kinase (CK) activities and total thiol levels had been measured in serum samples for 30 β-Thalassemia patients, aged 7-35 years who had been treated at Thalassemia center in the Babylon Maternity and children Hospital for the period between April 2008 to July 2008, compared with 30 healthy controls aged 7-35 years. The purpose of this study was to investigate the activity of these enzymes and the levels of total thiol in β-Thalassemia patients as indicators of the relationship between these parameters and complication of Thalassemia. There was a significant increase of LDH, no significant decrease of CK activity. There was no statistical significant difference between patients and controls as regards to total thiol levels.

الخلاصة تم دراسة كل من اللاكتيت ديهايدروجينيزLDH و الكرياتين كاينيزCK والثايول الكلي لمرضى البيتا ثلاسيميا (30 مريض) تتراوح اعمارهم بين 7-35 سنة ومقارنة النتائج بمجموعة الاصحاء(30 شخص) اعمارهم 7-35 سنة . وقد استنتج من البحث ان هناك ارتفاعا معنويا في قيم اللاكتيت ديهايدروجينيز وانخفاضا غير معنويا في قيم الكرياتين كاينيز في حين لوحظ انخفاضا معنويا في قيم الثايول الكلي لدى المرضى مقارنة بالأصحاء. ويمكن الاعتماد على العلاقة بين المتغيرات الثلاثة LDH, CK, total thiol لدراسة تطور الحالة المرضية.


Article
Troponin I and Creatine Kinase (MB) as Biochemical Markers in Acute Myocardial Infarction

Author: Salman A Ahmed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 82-86
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Ischemic heart disease is the leading cause of death among adults. Broad based studies that include allED patients who received an ECG for the evaluation of chest pain syndromes found that 5% of thesepatients were ultimately diagnosed with acute myocardial infarction (AMI) and an additional 10% hadnon-AMI acute coronary syndromes (ACS). Thus, 85% of patients have non-ACS causes for theirsymptoms.OBJECTIVE:To study the relation between the level of cardiac troponin I and creatine kinase (MB) in AcuteMyocardial infarction.SUBJECT AND METHOD:The present study was designed to investigate changes in serum cardiac biomarkers in patients withacute myocardial infarction. The present study consists of 61 patients who were admitted to the hospitalwith acute myocardial infarction. Serum levels of cardiac troponin I (cTnI) and creatine kinase (MB)were determined on day 1 (within24 hours) and the 3rd day after acute myocardial infarction. Serumcardiac biomarkers were compared between day 1 of acute myocardial infarction and the 3rd day afterthe acute myocardial infarction with healthy subjects (control group). All measurements were takenthrough September 2009 to April 2010 in department of medical and molecular biotechnology/Biotechnology Research Center/ Al-Nahrain university and Ibn Al-Nafees Hospital Department ofClinical Chemistry and Coronary Care Unit. Cardiac troponin I (cTnI) and CK-MB were measured byusing microtitre plate ELISA method, absorbance is measured spectrophotometrically at 450 nm.Levels of serum cTnI and CK-MB for smoker patients who suffered from MI and otherdiseases(diabetes mellitus, and hypertension) (group 4) higher than levels for patients who complainedfrom MI in addition to other diseases(group2), group 2 higher than levels for smoker patients whosuffered from MI (group 3) and group 3 higher than levels for patients who complained from only MI(group 1).RESULTS:Results showed significant (p<0.01) decreases observed for the levels of cTnI in group 4 with group 1and group 2 with group 1, and significant (p<0.05) decreases in group 4 with group 3. Significant(p<0.05) decreases were observed for the levels of CK-MB in group 4 with group 1.CONCLUSION:Myocardial infarction patients with diabetes mellitus , hypertension and smoking suffer increase levelsof cTnI and CK-MB. This proved that cardiac risk factors increase risk for heart injury. However, suchresults must be considered during the evaluation of the results of cardiac biomarker in patients of MI .


Article
Determination of Some Biochemical Marker Levels in Serum of Patients with Congestive Heart Failure, Angina Pectorisand Myocardial Infarction
تحديد مستوى بعض المؤشرات الكيموحيوية في مصل مرضى عجز القلب الاحتقاني والذبحة الصدرية والجلطة القلبية

Author: Maysoon M.N.M. Saleem
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2012 Volume: 30 Issue: 6 Pages: 939-949
Publisher: University of Technology الجامعة التكنولوجية

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Abstract

The study enrolled a total of 33 patients with congestive heart failure,angina pectoris and myocardial infarction for evaluation of the activity of enzymes, creatine kinase, and aspartate transaminase, concentrations of calcium, cholesterol, and triglyceride and they were compared with 16 normal healthy human. .This study involved three groups of patients a first one consisted of 9 patients with congestive heart failure. Second group of 9 patients with angina pectoris with chest pain. Third group consisted of 15 patients with myocardial infarction. They were obtained from Ibn-Al-Bay tar hospital and Ibn-Al-Nafess for cardiac care unit of Baghdad. They were investigated for enzymes activity and concentration of calcium, cholesterol,and triglyceride. There was very highly significant increase in the activities of creatine kinase, aspartate transaminase (P< 0.001) with different heart diseases when compared with normal healthy subjects. The result demonstrated a statistically significant decrease in the concentration of calcium (P< 0.001) and significant increase in concentration of Cholesterol and triglyceride when compared with normal healthy subjects with different heart diseases (P< 0.001).

شملت الدراسة 33 عينة من امصال المرضى المصابين بأمراض احتقان القلب والذبحة الصدرية والجلطة القلبية وتم تقدير فعالية انزيمات الكرياتين كاينيزواسبارتيتترانسامينبز وتراكيز الكالسيوم والكوليسترول والشحوم الثلاثية لهؤلاء المرضى وتمت مقارنتهم مع 16 عينة منالأشخاصالاصحاء. تضمنت الدراسة ثلاث مجاميع من المرضى المصابين بأمراض القلب ، شملت المجموعة الاولى تسعة اشخاص من المرض ى المصابين بأمراض احتقان القلب ، المجموعة الثانية المرضى المصابين بأمراض الذبحة الصدرية وكان عددهم تسعة والمجموعة الثالثة كانت لخمسة عشر عينة من المرضى المصابين بأمراض الجلطة القلبية . تم جمع العينات للمرضى الراقدين في مستشفى ابن البيطار ومستشفى ابن النفيس / وحدة العناية الم ركزة لأمراض القلب في بغداد وتم تقدير فعاليةالانزيمات كرياتين ك اينيزوالاسبارتيتترانس امينيز لهذه العينات وتراكيز الكالسيوم والكولسترول والشحوم الثلاثية . بينت النتائج ارتفاعفي P< احصائي ملحوظ لفعالية انزيمات الكريانينكاينيزوالاسبارتيتترانسامينيز 0.001 كلحالاتامراض القلب المختلفة عند مقارنتها بالأشخاص الاصحاء، كما اوضحتوارتفاع في تراكيز P< النتائجوجود نقصان معنويملحوظفيمستوى الكالسيوم 0.001عند مقارنتها بالأشخاص الاصحاء لكل حالات P< الكولسترول والشحوم الثلاثية 0.001امراض القلب

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