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Article
Assessment of Endometrial Thickness in Postmenopausal Women with and without Hypertension

Author: Nada Salih Amen
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 1 Pages: 39-44
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT :BACKGROUND:Hypertension in postmenopausal women is a risk factor for endometrial hyperplasia.OBJECTIVE:To examine whether the endometrium of hypertensive postmenopausal women is thicker than thatof non hypertensive postmenopausal women, to determine whether this thickening is directlyrelated to the antihypertensive drugs and whether is associated with abnormal pathology.METHODS:A Case control study of Forty five hypertensive asymptomatic postmenopausal women wasconducted in Al Yarmouk Teaching Hospital, (22) were treated with B- blockers combinationmedication and (23) were treated with other medications. They were compared with each and with(25) non hypertensive women. All women were interviewed; blood tests were performed andendometrial thickness in antero-posterior diameter was measured by vaginal ultrasonography.Endometrial sampling had been taken for those with increased endometrial thickness more than5mm.RESULTS:24.44% of hypertensive women and 4.00% of non hypertensive women had an endometrialthickness more than 5mm. There was no statistically significant difference between those whotreated with medication including B- blocker and those who were treated with other medication.The histological findings were mainly of endometrial hyperplasia for those with thickenedendometrium.CONCLUSION:Hypertension may have a role in endometrial thickness. We were unable to substantiate anassociation between the type of treatment administered and the increase in endometrial thickness.Those with increased endometrial thickness more than 5mm, the histological findings were mainlyof endometrial hyperplasia


Article
P53 Expression in Endometrial Hyperplasia and Endometrial Carcinoma
التعبير P53 في فرط تنسج بطانة الرحم وسرطان بطانة الرحم

Authors: Rivan Hermiz Isaac --- Nadya Y. Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 2 Pages: 28-34
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Mutations of the P53 tumor suppressor gene and altera-tions in its protein expression often occur in a variety of human malignant tumors, including endometrial carcinoma, but the practical implications of this phenomenon are yet to be fully exploited. This study was designed to evaluate P53 protein expression in normal, hyper-plastic and malignant endometrium by immunohistochemical study and to correlate P53 expression in endometrial carcinoma with other clinic-pathological prognostic parameters (age, histologic type, tumor grade, cervical & myometrial invasion, and tumor stage).Methods: The studied samples included 100 formalin fixed, paraffin embedded endo-metrial tissue specimens which were divided to the following diagnostic categories: - Pro-liferative endometrium (n=10); secretory endometrium (n=10); simple hyperplasia (n=10); complex hyperplasia without atypia (n=20); atypical complex hyperplasia (n=10) and endo-metrial carcinoma (n=40).Results: None of the normal endometrium, simple hyperplasia and complex hyperplasia without atypia showed P53 immunostaining, while 20% of atypical complex hyperplasia and 32.5% of endometrial carcinoma showed immunoreactivity for P53. In endometrial car-cinoma, significant correlation was observed between P53 expression and age at diagno-sis, histological grade,FIGO stage, myometrial invasion & cervical invasion ; but not with the histological type .Conclusions: The results indicated the validity & simplicity of the application of immuno-histochemistry in determining the status of P53 overexpresion which is strongly associated with endometrial carcinoma aggressiveness and high malignant potential.


Article
Role of SOX4 gene in the progression of endometrial hyperplasia to endometrial adenocarcinoma

Author: Mahdi Saber Al-Deresawi 1 , Abdul Hussein Moyet AlFaisal 2 , Salim Rasheed Al- obaidi 3
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 2 Pages: 82-90
Publisher: Baghdad University جامعة بغداد

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Abstract

The objective of this study was to investigate the role of SOX4 gene in progression of endometrial hyperplasia to endometrial adenocarcinoma .A total of 41 Iraqi patients with abnormal uterine bleeding followed by hysterectomy. Histological findings recorded 36 cases with endometrial hyperplasia and 5 endometrium adenocarcenoma. Cases collected during the period from February 2017 to October 2017. Curettage techniques were used to obtain a ten samples as healthy control group. All cases were obtained from Al-Zahra Teaching Hospital in Wasit Province . Endometrial hyperplasia subjects distributed according to age, the highest percentage ranged (40-50)years recorded (58.33%). To evaluate the SOX4 gene expression, total RNAs were extracted with TRIzol from each sample then directly converted to cDNA. RT-PCR technique was used to estimate the SOX4 gene expression and (GAPDH gene used as a reference gene). The results revealed that there was a highly significant increase (p<0.01) in SOX4 gene expression in endometrium adenocarcenoma (9.24±0.52) followed by endometrial hyperplasia (6.14±0.17) when compared to the healthy control group (1±0.00).In conclusion, endometrial hyperplasia can be a precursor of endometrium adenocarcenoma when the SOX4 gene expression elevated gradually.

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