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Article
The prevalence and antimicrobial sensitivity of Esbl Escherichia Coli. in clinical isolates

Author: Zaid I. Al-Attar .M.B.Ch.B. M.S.c. (pharmacology)*
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2014 Volume: 10 Issue: 2 Pages: 96-99
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The antimicrobial resistance is one of the most serious and expanding health problems world -wide in the last decades. The esbl escherichia coli. (extended – spectrum beta-lactamase e.coli) represents an important aspect of it .Objectives: To get an overview on the esbl e.coli prevalence profile in general. Also to assess the antibiotic sensitivity of esbl e. coli trying to specify the most effective antibiotics in combating this micro-organism.Methods: this study tries to focus on this problem in Iraq which through a prospective study approach by taking 35 clinical samples from various sources (urine, blood, abscess, eye ,vagina ,stool and others),and after confirming the presence of e.coli, the presence of esbl e.coli and antibiotic sensitivity are confirmed by the use of Kirby - bauer method.Results: results showed that esbl e.coli constitutes 80% of the cases, while the results of antibiotic sensitivity were as follows: ampicillin 3.3% , ampicillin/sulbactam 20% , amoxi/clav 0%pipracillin/tazobactam 89.7% meropenem 96.7% ,imipenem 96.9% ,cefotaxime 0% ,ceftriaxone 11.8%,ceftazidime 16.1%,cefipime 14.3% ,cefazolin 16.1% cefoxitin 64.7%, aztreonam 14.3%,gentamycin 50% ,tobramycin 64.3%, amikacin 94.3%,ciprofloxacin 58.8% ,levofloxacin,64.5%nitrofurantoin,79.2%,trimethprimesulphamethoxazole 29.6% .Conclusion: the problem of esbl e.coli is expanding and there is a continuous demand for frequent monitoring of the new trends on antimicrobial resistance in different parts of the world in addition to trying to develop new antimicrobials to combat the new highly resistant strains .moreover there is a continuous need to educate the medical and the paramedical staff abot the risk of unjustified and improper prescription and use of antimicrobials.Key words: escherichia coli, extended-spectrum beta-lactamase, kirby-bauer method, muller hinton agar


Article
Assessment of the antibacterial activity of macroalgae Cladophora crispata extract against extended spectrum beta-lactamase producing Escherichia coli isolated from diarrheic children

Author: Uday Abdul-Reda Hussein
Journal: JOURNAL OF THI-QAR SCIENCE مجلة علوم ذي قار ISSN: 19918690 Year: 2017 Volume: 6 Issue: 3 Pages: 3-11
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

Background: Diarrhea is a major cause of morbidity and mortality in children under 5 years old in developing countries.Objective: This study designed to investigate the occurrence of extended spectrum beta-lactamase producing Escherichia coli (E. coli ) as etiological infectious agents of diarrhea in children, assessment of their susceptibility/resistance to antibiotics, and to evaluate the antibacterial activity of the macroalgae Cladophora crispata extract towards these bacteria .Materials and Methods: 150 diarrheic stool samples were collected from children less than 5 years and cultured. The isolated bacteria were subjected to various identification and biochemical tests. Then all the isolated bacteria (E. coli ) were subjected to ESBL-producing screening by double-disc synergy test, the antibacterial activity of algal extract and antibiotic susceptibility test against tested bacteria were determined by using agar well diffusion and disc diffusion methods respectively . Results: Out of total 150 samples, only 18 isolates revealed the presence of extended spectrum β-lactamase producing E. coli, which showed highly susceptibility to gentamicin and amikacin, Cladophora crispata extract revealed a strong antibacterial activity against ESBL-producing E. coli. Conclusion: Cladophora crispata extract showed a strong antibacterial activity against ESBL-producing E. coli which can be exploited as source of antibacterial drugs to control and treatment diarrheal infection caused by these bacteria.

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