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Article
Assessment of High Sensitivity C.Reactive Protein

Author: Dr.Faris Abdul Kareem Khazaal M.B.CH.B., CABM ,FRCP Dr.Safaa HassanFadhil M.B.Ch.B,
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 12-17
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: syndrome X or metabolic syndrome is a collection of multiple diseases mainly visceral obesity , hypertriglyceridemia , decrease HDL level, hypertension and elevated fasting blood glucose that lead to accelerated atherosclerosis through multiple mechanisms, one of the most important is increase inflammation of the vessels manifested by elevated high sensitivity C reactive protein (hs-CRP).Objective: The aim of the study was to assess the prevalence of elevatedhs CRP in people with metabolic syndrome and atherosclerosis complication (IHD, Cerebrovascular disease, peripheral vascular disease) and metabolic syndrome without these complication.Patients and methods:;This is a cross sectional study carried out in Diabetic referral center in Baghdad al-rusafa extended from November 2009 to March 2010 for 84 male patients with metabolic syndrome ,aged 40-70 years, clinical features ,anthropometric and biochemical measurement (BP, Waiste circumference, BMI, HDL, LDL, TG, BG, hs CRP) were recorded and metabolic syndrome diagnosis was made according to IDF definitionResults: The 84 patients with metabolic syndrome divided in to two groups the first 35 patients clinically complicated atherosclerotic group were 30 patients high risk 85% and 5 patients low risk 15%. The second 49 patients (clinically uncomplicated atherosclerotic) group were 30 patients high risk 61% and low risk 19 patients 39%, and tabulated with the p.value was (0.014).These results tabulated with the following parameters ,waist circumference (abnormally high p.value was 0.05, normal p.value was 0.49) ,blood pressure (hypertension p.value was 0.05 and normal blood pressure p.value was 0.58),age(middle age p.value was 0.007 and elderly age p.value was 0.29) and BMI(less than 25g/kg p.value was 0.39 and more than or equal to 25 g/kg p.value was 0.08).Conclusion: The values of hs-CRP are high in most patients with metabolic syndrome but are higher in patients with atherosclerotic complications than those without .specially elevated in those with hypertension ,middle age group, increasing waist/hip ratio with significant p.value,and in high BMI but with insignificant p.value.Key words : (HS-CRP metabolic)

Keywords

HS-CRP metabolic


Article
The value of highly specific C-reactive protein HS-CRP in migraine headache
قيمة البروتين سي التفاعلي HS-CRP المحدد للغاية في صداع الشقيقة

Author: Hussein Khalil حسين خليل
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2018 Volume: 14 Issue: 26 Pages: 1-5
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

AbstractBackground: Migraine is a well known neurologic disease, ordinarily portrayed by intermittent assaults of incapacitating headache and manifestations of autonomic nervous system disturbances. In about 33% patients, headache attacks are joined by transient “focal neurologic aura manifestations”. Migraine is a neurovascular disease accompanied by cranial vascular contractile dysfunction, neurogenic inflammation and cortical spreading depression. Brain tissue activation results in the production of peptides by the perivascular trigeminal areas which lead to an inflammatory response with dilation of extraparenchymal blood vessels. Inflammatory vasculopathy accompany repeated assaults of migraine attacks. A number of studies showed the elevation of certain inflammatory markers in association with migraine such as adhesion molecules, interleukins and C-reactive protein (CRP).Aim of the study: To evaluate the role of HS-CRP in patients with migrainePatients and methods:Current cased control study included 100 patients with migraine headache and 100 apparently healthy subjects. Variables included in the present study are: age, gender and the level of highly specific C-reactive protein (HS-CRP). The study was conducted at the neurology unit, Al-Dewaniyah teaching hospital, Al-dewaniyah province, Iraq. The study started on January 2018 and ended at June 2018.Results: Current study included 100 migraine patients with a mean age of 31.46 ±5.75 years and 100 control subjects with a mean age of 30.55 ±5.54 years and there was no significant difference in mean age between the two groups (P=0.255). Patients group included 23 men (23%) and 77 women (77%) whereas, control group included 24 men (24%) and 76 women (76%); no significant difference was encountered between the two groups with respect to gender (P=0.868). The level of Hs CRP in terms of median and inter-quartile range (IQR) in patients group was significantly higher than that of control group, 4.6 (4.9) versus 1.5 (2) µg/dl (P<0.001). There was no significant difference in the level of Hs CRP between men and women in patients group, 5.3 (5.7) versus 4.6 (4.8) µg/dl (P=0.680), as shown in figure 2. There was no significant correlation between age and level of Hs CRP in patients group (r = -0.056, P =0.581).Conclusion: The present study showed that Hs CRP is significantly higher in patients with migraine headache and this may explain the inflammatory role in the pathogenesis and prognosis of migraine headache.

نبذة مختصرةخلفية: الصداع النصفي هو مرض عصبي معروف ، وعادة ما يصور من قبل اعتداءات متقطعة من الصداع والعجز ومظاهر اضطرابات الجهاز العصبي اللاإرادي. في حوالي 33 ٪ من المرضى ، ينضم إلى نوبات الصداع "مظاهر هالة عصبية بؤرية" عابرة. الصداع النصفي هو مرض وعائي عصبي مصحوب بخلل وظيفي في الأوعية الدموية في الجمجمة ، والتهاب عصبي وانتشار قشري. يؤدي تنشيط أنسجة المخ إلى إنتاج الببتيدات من المناطق الثلاثية المحيطة بالأوعية الدموية التي تؤدي إلى استجابة التهابية مع تمدد الأوعية الدموية خارج الحالب. اعتلال وعائي التهابي يصاحب الاعتداءات المتكررة على نوبات الصداع النصفي. أظهر عدد من الدراسات ارتفاع بعض علامات الالتهاب المرتبطة بالصداع النصفي مثل جزيئات الالتصاق ، الانترلوكينات والبروتين التفاعلي C (CRP).الهدف من الدراسة: تقييم دور HS-CRP في المرضى الذين يعانون من الصداع النصفيالمرضى والطرق: شملت دراسة المكافحة الحالية 100 مريض يعانون من الصداع النصفي و 100 موضوع صحي على ما يبدو. المتغيرات المدرجة في هذه الدراسة هي: العمر والجنس ومستوى البروتين سي التفاعلي محددة للغاية (HS-CRP). أجريت الدراسة في وحدة الأمراض العصبية ، مستشفى الديوانية التعليمي ، محافظة الديوانية ، العراق. بدأت الدراسة في يناير 2018 وانتهت في يونيو 2018.النتائج: شملت الدراسة الحالية 100 مريض يعانون من الصداع النصفي مع متوسط ​​عمر 31.46 ± 5.75 سنة و 100 شخص خاضع للمراقبة مع متوسط ​​عمر 30.55 ± 5.54 سنة ولم يكن هناك فرق كبير في متوسط ​​العمر بين المجموعتين (P = 0.255). شملت مجموعة المرضى 23 رجلاً (23٪) و 77 امرأة (77٪) ، بينما شملت المجموعة الضابطة 24 رجلاً (24٪) و 76 امرأة (76٪) ؛ تمت مصادفة أي فرق كبير بين المجموعتين فيما يتعلق بنوع الجنس (P = 0.868). كان مستوى Hs CRP من حيث المدى المتوسط ​​والرباعي (IQR) في مجموعة المرضى أعلى بكثير من مستوى المجموعة الضابطة ، 4.6 (4.9) مقابل 1.5 (2) ميكروغرام / دل (P <0.001). لم يكن هناك اختلاف كبير في مستوى HP CRP بين الرجال والنساء في مجموعة المرضى ، 5.3 (5.7) مقابل 4.6 (4.8) ميكروغرام / دل (P = 0.680) ، كما هو مبين في الشكل 2. لم يكن هناك ارتباط كبير بين العمر ومستوى Hs CRP في مجموعة المرضى (ص = -0.056 ، P = 0.581).الخلاصة: أظهرت الدراسة الحالية أن Hs CRP أعلى بكثير في المرضى الذين يعانون من الصداع النصفي وهذا قد يفسر الدور الالتهابي في التسبب والتشخيص من الصداع النصفي.

Keywords

Hs CRP --- Migraine --- Headache


Article
HYPERTENSION AND OBESITY IN RELATION TO HIGH SENSITIVITYC-REACTIVE PROTEIN AND LIPID PROFILE IN IRAQI PATIENTS

Authors: Baydaa Ahmed Abed --- Esam Noori Salman Al-Kirwi
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2009 Volume: 12 Issue: 4 Pages: 145-150
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Abstract
Introduction:
High sensitive C-reactive protein (hs-CRP) is one of new inflammatory markers which has been
proposed as independent risk factor for cardiovascular disease, and it is positively associated with
body weight. Little is known, however, about the utility of (hs-CRP) and other biomarkers in obese
hypertensive Iraqi patients.
Objectives:
To examine the hypothesis that there is a relation between obesity, hypertension and a chronic
low-grade inflammatory status (represented by high hs-CRP).
Patients and Method:
A total number of 99 patients stratified according to hypertension and obesity into two groups:
1. Obese hypertensive: Body mass index (BMI > 30 kg/m2 and blood pressure (BP) >140/90 mmHg
± history of taking anti hypertensive medications), n = 65, Age = (56.02 ± 4.379) years,
BMI = (35.68 ± 4.78) kg/m².
2. Over weight normotensive: (BMI > 25 kg/m² and < 30 kg/m2, BP < 140/90 mmHg), n = 34,
Age = (56.44 ± 3.17) years, BMI = (26.06 ± 3.05) kg/m².
Assessment of (hs-CRP) and lipid profile (total serum cholesterol (s.chol), serum triglyceride
(s.TG), low density lipoprotein (LDL), and high density lipoprotein (HDL) was done.
Results:
The (Mean ± SD) of (hs-CRP) in the patients and controls were (5.74 ±2.15) mg/l and
(2.14 ± 0.85) mg/1 respectively, (P < 0.001). The (Mean ± SD) of cholesterol for cases and control
were (215.17 ± 33.3) mg/dl and (197.81 ± 27.3) mg/dl respectively, (P < 0.05). For HDL were (51.31 ±
7.45) mg/dl and (54.63 ± 5.091) mg/dl respectively, (P < 0.05). For LDL were (136.9 ± 32.87) mg/dl and
(117.81 ± 24.73) mg/dl respectively, (P < 0.005). For BMI were (35.68 ± 4.78) kg/m2 and
(26.06 ± 3.05) kg/m2 respectively, (P < 0.001).
Conclusions:
There is an elevation of serum level of (hs-CRP) in hypertensive obese subject in comparison with low
levels in control group

عدة واسمات التهابية جديدة قد ظهرت كمنبه قوي حول امراض القلب والاوعية الدموية في الاشخاص الاصحاء وغير الأصحاء. إحدى هذه الواسمات هو البروتين التفاعلي نوع C العالي الحساسية ( hs-CRP) والذي يعتبر عامل خطورة مستقل لامراض القلب والاوعية الدموية ويتعلق ايجابياً مع وزن الجسم. ولكن المعلومات حول استخدام هذا البروتين وشاكلة الدهون في المرضى العراقيين الذين يعانون من السمنة وارتفاع الضغط هي معلومات قليلة.


Article
Evaluation of serum anti-Cardiolipin antibody, hs-CRP and IL-6 levels in chronic periodontitis as possible risk factors for cardiovascular diseases

Author: Batool H. Al-Ghurabei بتول الغرابي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2012 Volume: 24 Issue: special issue 2 Pages: 161-165
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: It has long been established that there is an association between cardiovascular disease andperiodontitis. Evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents viainduced systemic inflammatory mediators’ production and increase in serum levels of autoantibodies such as anticardiolipinantibody. The aim of the present study was to determine the presence of anti-cardiolipin antibody(ACLA)-IgG and -IgM, and to investigate the systemic levels of inflammatory markers of cardiovascular diseases likehigh sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) in patients with chronic periodontitisin (CP) as wellas to examine the relationships between these mediators and clinical periodontal parameters.Subjects and Methods: Blood samples were collected from 45 patients with CP (20 with sever periodontitis and 25with moderate periodontitis) and from 30 healthy age matched individuals served as controls. Clinical periodontalparameters used in this study were plaque index, gingival index, probing pocket depth, clinical attachment leveland bleeding on probing. The levels of serum ACLA-IgG, ACLA-IgM, hs-CRP and IL-6 were determined using enzymelinkedimmunosorbent assays.Results: The current results revealed that serum levels of ACLA-IgG, hs-CRP and IL-6 were significantly higher inpatients group as compared to healthy control group (p<0.05, p<0.001), whereas the serum level ACLA-IgM was notobserved any significant differences between two groups (p>0.05). Concerning the comparison between twopatient groups, sever CP group showed significant elevation in serum levels of ACLA-IgG, hs-CRP and IL-6 (p<0.05,p<0.001), while there is no differences in serum level of ACLA-IgM when compared to moderate CP patients group(p>0.05). Furthermore, in regards to the correlation between serum ACLA-IgG, ACLA-IgM, hs-CRP and IL-6, andclinical periodontal parameters, IL-6 level was showed significant positive correlation with clinical attachment level,whereas hs-CRP was showed significant positive correlation with each of probing pocket depth, clinical attachmentlevel and bleeding on probing. Moreover; linear positive correlation was noticed between ACLA-IgG and clinicalattachment level. Conversely, ACLA-IgM level did not show any correlation with clinical parameters of periodontitis(p>0.05).Conclusion: Elevation in prothrombotic autoantibodies, ACLA-IgG and inflammatory mediators (hs-CRP and IL-6)factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk forcardiovascular events


Article
Serum Interleukin-8 and Hs-C Reactive Protein Determination in Iraqi Multiple Sclerosis Patients: Case Control Study

Author: Khawla A. A. AL-Sammariey
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 153-155
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease caused by a complex disorder that cluster many common diseases in children and adults, leading to chronic inflammatory disease of the central nervous system with morphological hallmarks of inflammation, demylination, axonal loss and gliosis .Factors responsible for MS and its progression are still not fully understood, but it has been suggested that both environmental determinants and genetic susceptibility are involved.OBJECTIVE :The aim of this study is to evaluate the role of inflammatory markers ;hs-CRP and IL-8 in pathogenesis of MS and to see the correlation between them.PATIENTS AND METHODS: Twenty one MS Patients (7male,14 female) attending the MS Clinic at Baghdad teaching hospital, their ages range between( 20-32) years (15) age- and sex- matched healthy control participated in the study. Investigations included serum measurements of high sensitive C-reactive protein (hs- CRP) and interleukin-8 in patients and control groups.RESULTS: The result of the present study showed significant increase in both CRP(p<0.001 ) and IL-8 (p< 0.001 ) in the serum of MS patients compared to control.CONCLUSION: There is evidence that neuroinflammatory process due to elevation of CRP and IL-8 has an important role in MS .


Article
Elevated Levels of IL- 6 in serum of SLE patients correlated with High- sensitivity CRP and ESR.
قياس مستويات المحرك الخلوي IL-6 في مصل المرضى المصابين بداء الذئب الاحمراري وعلاقته ب CRP,ESR

Author: Saad Shaheen Hammadi**, Munther Hussain*** ايمان طارق علي ,عواطف حميد محيسن*,سعد شاهين حمادي** ,منذر الحسين***
Journal: basrah journal of science البصرة للعلوم ISSN: 18140343 Year: 2014 Volume: 32 Issue: 2B micro conf Pages: 112-136
Publisher: Basrah University جامعة البصرة

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Abstract

Systemic Lupus erythematosus (SLE) is an autoimmune disease more prominent in women characterized by wide variety of auto antibodies production, some of which are pathogenic, immune complex deposition and various clinical systemic manifestation that effect various organ. The aim of this study is to investigate the correlation between IL-6, high sensitivity CRP, ESR and organ involvement in SLE patients and to assess if IL-6 could be related to disease activity and to organ involvement. Total of 50 patients with SLE(48female.2Male) and 30 healthy control were studied. SLE patients were divided into two groups 42 patients had active disease and 8 had inactive disease at p= 0.000. The mean level of IL-6 in SLE patients and healthy control groups was (541.1; 5.31 pg/ml) respectively, the difference was statistically significant at (p=0.000).There was positive correlation between serum IL-6 and SLEDAI (r= 0.422**, p= 0.002).Associations of IL-6 levels in patients with active and inactive disease in different organs were high significant at p= 0.000, The mean levels of IL-6 in patients with Lupus nephritis was (936.270pg/ml) the difference was higher significantly than other organs (p=0.000). The mean levels of hs CRP for SLE patients was (6.08 mg/l) and the difference was statistically significant (p= 0.000) than healthy control groups, There was strong positive correlation between IL-6 and hs CRP in serum of SLE patients (r= 0.969**, p= 0.000). But the difference was not significant between hs CRP and ESR (r= 0.249, p = 0.08), The mean levels of hs CRP in SLE patients was (8.844 mg/l) significantly higher in patients with lupus nephritis than other organs p= 0.000.

داء الذئب الاحمراري (SLE) هو أحد أمراض المناعة الذاتية أكثر وضوحا في النساء ويتميز بانتاج تشكيلة واسعة من الأجسام المضادة ، وترسيب المعقدات المناعيه ومختلف الاعراض جهازية السريرية التي تؤثر على اعضاء مختلفه من الجسم . هدف الدراسة هو البحث عن العلاقة بين كل من المحرك الخلوي IL-6-، ومعدل الترسيب( (ESR hs-CRPو وعلاقتهم بالاعضاء المشمولة في المرضى المصابين ، وتقييم ما إذا IL-6- يمكن أن يكون ذي علاقة بشدة المرض(SLEDAI) ومشاركة الأعضاء. وقد تناولت الدراسة 50 مريضا مصابا بداء الذئب الاحمراري( SLE )(48اناثا, 2 ذكورا)ا و 30من الاصحاء, حيث تم تقسيم هؤلاء المرضى إلى مجموعتين كان 42 مريضا ينتمون الى المجموعة الشديده(النشطه)و 8 مرضى الى المجموعة الساكنه( غير نشط )عند (P = )0.004. كان متوسط مستوى تركيزIL-6)) في مرضى داء الذئب و الاصحاء (541.19، 5.319 بيكوغرام / مل) على التوالي، وكانت الفروق ذات دلالة إحصائية عند (P = 0.000) عندما كان P <0.05. تحققت الدراسه من وجود علاقة إيجابية طرديه بين كل من المصل (IL-6) وSLEDAI (r = 0.422 **، P = 0.002) وكان مستوى متوسط (IL-6) في المرضى الذين يعانون من التهاب الكلية هو(936.27بيكوغرام / مل)حيث كان الفرق أعلى بكثير من الأجهزة الأخرى (P = 0.000).بينما كانت تراكيز مستويات البروتين التفاعلي ((hs-CRP لمرضى الذئبة الحمراء هي (6.0879 ملجم / لتر) وكان الفارق معنويا (P = 0.000) عن الاصحاء، حيث تحققت الدراسه من وجود ارتباطا طرديا قويا بين(IL-6) و hs-CRP في مصل الدم لمرض ىداء الذئبة (r = 0.969 **، P = 0.000). ولكن الفرق لم يكن كبيرا بين hs-CRP وESR (r = 0.249، P = 0.08)، حيث كان متوسط مستويات البروتين التفاعلي( CRP) لدى مرضى الذئبة الذين يعانون من التهاب الكلية هو (8.844 ملغم / لتر) أعلى بكثير في المرضى الذئبة من الأجهزة الأخرى P = 0.000

Keywords

SLE --- IL-6 --- hs CRP --- ESR.


Article
Detection of Serum Hs CRP and C3 Complement Levels Following Immunization with Measles Containing Vaccine in Iraqi Young Adults

Authors: Ismail Ibrahim Latif --- Salwa S. Abdul –Wahid --- Arwa Mujahid Abdullah --- Zena Jassim Mohammed
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2014 Volume: 7 Issue: 1 Pages: 50-56
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Measles remains a major cause of worldwide childhood mortality, and has been targeted by the WHO for global eradication following the eradication of poliomyelitis. Despite the implementation of mass school catch-up campaigns for measles, an outbreak of measles occurred mostly affecting the adult population.Objectives: To measurement of Highly Sensitive C Reactive Protein (Hs CRP) and C3 Complement levels in adult volunteers after vaccination with live attenuated measles containing vaccine, and to compare the results with that following vaccination. Subjects and methods: A sero-surveys for serum Hs CRP and C3 complement levels was conducted among [190] healthy young adults aged 18-25 years, randomly selected, and to compare after a national campaign with measles containing vaccine. Hs CRP and C3 complement were detected in volunteer’s sera prior to, 1, and 4 weeks after vaccination, measured by Enzyme Linked Immunosorbent Assay and Single Radial Immunodiffusion Assay respectively. Results: There was a significant differences (p ≤ 0.05) in the concentration of serum Hs CRP and C3 complement at week one following vaccination with measles containing vaccine, and returned to normal after four weeks. Conclusions: Raising Highly Sensitive C Reactive Protein and Complement C 3 Levels in the sera of adult volunteers after measles containing virus vaccine administration could play a role in increasing innate immune response against measles virus infection and may explain some mechanisms of immune response associated with measles infection.


Article
IMPACT OF SERUM AMYLOID A IN EARLY DETECTION OF ENDOTHELIAL ENGARY BY PERCUTANEOUS CORONARY INTERVENTION
مستوى (Amyloid A) في مصل الدم في التشخيص المبكر لتلف الشرايين القلبية عند مرضى التداخل القسطاري (PCI)

Authors: DHIA J. AL-TIMIMI ضياء التميمي --- ARAM J. MIRZA أرام ميرزا --- CHRO S M. ZANGANA جرو زنكنة
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2016 Volume: 10 Issue: 1 Pages: 1-9
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background: Evidence of elevated serum levels of inflammatory and restenosis markers afterpercutaneous coronary intervention (PCI), including balloon angioplasty and stenting has been reported in various population. The utility of serum amyloid A in early diagnosis of endothelial cell damage of coronary arteries by cardiac ballooning and stenting still uncertain.The aim of the present study was to determine the validity of serum amyloid A in early diagnosis of endothelial cell damage of coronary arteries by cardiac ballooning and stenting.Methods Serum amyloid A and high sensitive c-reactive protein (Hs-CRP) was determined in a sample of 137 patients attended diagnostic cardiac angiography unite at Sulaimaniyah Center of Heart disease,68 cases were previously diagnosed with coronary artery lesions, underwent coronary ballooning and stenting, and 69 patients with chest pain underwentdiagnostic angiography, free of coronary artery lesion participated in this study. The alteration in serum amyloid A and Hs-CRP levels was estimated before and after 4 hours from procedure.Results: The comparison between cases and controls showed that the 2 groups did not differ significantly with respect to age, gender, ethnicity, hypertension, diabetes mellitus and smoking.The pre- and post-operative mean values of Hs-CRP were similar in cases and controls. The post-operative cases exhibited significantly higher serum amyloid A levels than controls and the difference was statistically significant (p=0.001).The usefulness of serum amyloid as a screening test for endothelial injury was assessed by calculating its validity with regard to cut-off point of Hs-CRP. The post-operative cases with Hs-CRP > 3 mg/l had a higher prevalence 54.0% of amyloid A compared with those of Hs-CRP <3 mg/l. ( 46.0%, p=0.001).Conclusions: It is evident from this study that post-operative cases underwent coronary ballooning and stenting had high serum amyloid Aproteinlevels. It thus indicates the needs for determining serum amyloid A in patients at risk of early coronary endothelial injury.

المقدمة والاهداف: ارتفاع مستوǽات مؤشرات الالتهاب وأعادة التضییȘ Ǽعد التداخل القسطارȑ) PCI (ȞالǼالون والشǽȞǼة اصǼحت مؤشرات مدونة في مجتمعات مختلفة. استخدام مستوȐ) A Amyloid (في مصل الدم في التشخǽص المȞǼر لتلف الخلاǽا المǼطنة للشرایین القلبǽة Ǽسبب الǼالون و الشǽȞǼة غیر مؤȞدة لحد الان.طرق الǺحث: حددت مستوȐ) A Amyloid (و(CRP-Hs (في نموذج من ١٣٧ مرȄض زارو وحدة تلوȄن الشرایین القلبǽة التشخǽصي في مرȞز السلǽمانǽة لأمراض القلب ٦٨ منهم تم تشخǽصهم قبل ذلك Ǽمرض الشرایین القلبǽة وخضعوا للتداخل القسطارȑ بواسطة الǼالون والشǽȞǼة و٦٩ منهم عانوا آلام في الصدر وخضعوا لتلوȄن الشرایین القلبǽة ولكن لم Ȟǽن لدیهم أمراض الشرایین القلبǽة شارȞوا في هذه الدراسة. تم قǽاس التغییر في مستوȐ مصل الدم لكل من (A Amyloid(و(CRP-Hs (قبل وǼعد أرȃعة ساعات من العملǽة.خذا بنظر الاعتǼار Ȟل من العمر، الجنس، العرق، ً النتائج: بینت المقارنة انه لا یوجد اختلاف ملحوȍ بین المجموعتین أارتفاع ضغط الدم، مرض السȞر والتدخین. معدل القǽمة لـ(CRP-Hs (قبل وǼعد العمیلة Ȟان متشابها بین المجموعتین.مرضى الشرایین القلبǽة Ǽعد العملǽة أظهروا مستوȐ أعلى للـ(A Amyloid (من اللذین لǽس لدیهم مرض الشرایین القلبǽةً (001.0=P .(تم تقیǽم فائدة فحص الدم للـ(A Amyloid (Ȟفحص مسحي لتلف ً وȞان الاختلاف ملحوظا احصائǽا الخلاǽا المǼطنة للشرایین القلبǽة بواسطة حساب صلاحǽة الفحص مع الاخذ بنظر الاعتǼار نقطة حد الفصل لـ(-Hs CRP .(مرضى الشرایین القلبǽة Ǽعد العملǽة مع مستوȐ) CRP-Hs (أكثر من (L/mg 3 (Ȟانت لدیهم نسǼة انتشار (3 mg/L) من اقل) Hs-CRP) Ȑمستو لدیهم اللذین مع مقارنة) Amyloid A) Ȑمستو من) 54.0%) اعلى .(P=0.001 ,46.0%) الاستنتاج: شوهدت في هذه الدراسة أن مرضى الشرایین القلبǽة الذین خضعوا للǼالون والشǽȞǼة Ȟان لدیهم ارتفاع مستوȐ البروتین (A Amyloid (في مصل الدم Ǽعد عملǽة التداخل القسطارȑ ،ولذلك تحدید مستوȐ الـ(A Amyloid (أصǼح مشروطا في المرضى الذین لدیهم نسǼة خطورة عالǽة لجرح الخلاǽا المǼطنة للشرایین القلبǽة المȞǼر.


Article
Levels of Some Proinflammatory Cytokines in Obese Women with Polycystic Ovary Syndrome after Metformin Therapy
مستويات بعض السيتوكينات قبيل الالتهاب في النساء البدينات المصابات بمتلازمة المبيض المتعدد الأكياس بعد العلاج بالمتفورين.

Author: Yaser Abbas Ateia, Eman Mahdi Saleh, Thikra N. Abdullah, Zynab Al Musawee.
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2013 Volume: 9 Issue: 2 Pages: 45-48
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Polycystic ovary syndrome is a heterogeneous disorder and its etiology appears to be complex and multifactorial; characterized by hyperandrogenism, chronic anovulation and infertility. It’s associated with evidence of low-grade chronic inflammation, as indicated by the presence of elevated levels of high sensitive C- reactive protein levels, interleukin-6 and tumor necrosis factor-α. The source of excess circulating tumor necrosis factor-α in obese Polycystic ovary syndrome patient is likely to be the adipose tissues while in lean women increased visceral adiposity has been proposed as a source of excess tumor necrosis factor-α.Objectives: to evaluate the levels of high sensitive C- reactive protein, tumor necrosis factor-α and interleukin-6 in patients with polycystic ovary syndrome before and after treatment with metformin; with emphasis on their relationship with the improvement in ovulation rate and body mass index in Iraqi women.Methods: 69 Iraqi females with PCOS, with mean age of 25.8±4.4 years, body mass index 31.14±2.23 kg/m2 and insulin resistant equal to 3.15±0.25. Additionally, 30 healthy fertile women BMI= 26.87±3.1 kg/m2 and mean age 23.4±2.8 years), the patients were treated with metformin 1500 mg/day for 3 months. Blood samples were obtained in the morning subsequent to an overnight fasting at baseline and at the end of the 12 weeks period of treatment, the samples were analyzed for plasma glucose level estimated by enzymatic colorimetric kit, while serum insulin , TNF-α, IL-6 , hs-CRP, Progesterone and sex hormone binding globulin . Results: BMI values were significantly increased at baseline value in patients (P<0.05) compared with healthy controls, then significantly decreased (12.9%) after treatment compared with baseline values, HOMA-IR index were significantly elevated in patients group at baseline compared with control, and significantly decreased by 17.4% after treatment. Regarding the influence of metformin on inflammatory markers, the present study demonstrated significant elevation of baseline levels (P<0.05) of TNF-α, hs-CRP and IL-6 compared with controls, and the baseline levels significantly decreased after treatment by 16%, 38% and 37% respectively. Meanwhile, sex hormone binding globulin levels were significantly decreased in PCOS patients compared with healthy controls, and significantly increased after treatment by 16.6%, also progesterone levels decline at baseline compared with control group, and it was increased significantly after treatment by 24%.Conclusions: The study detects an increased level of inflammatory cytokines, SHBG and decrease level of progesterone in Iraqi females with PCOS, and metformin therapy improves serum levels of the inflammatory cytokines associated with increased ovulation rate.

الأهداف : متلازمة المبيض المتعدد الأكياس هي مرض غير متجانس ومسبباته معقدة ومتعددة ويتميز بزيادة مستوى الأندروجين في الدم وعدم التبويض المزمن والعقم. وتصاحبه دلائل درجات منخفضة من الألتهابات المزمنة كما يبدو من ارتفاع مستويات TNf-αو IL-6وhs-crp. إن منشأ زيادة مستوى إل TNf-α في البدينات المصابات بمتلازمة المبيض متعددة الأكياس هو عل الأرجح النسيج ألدهني، بينما في النحيفات فأن الدهون في منطقة البطن قد اقترحت كمنشأ لزيادته. الدراسة الحالية صممت لتخمين مستويات TNf- α و IL-6وhs-crp. .في المصابات بمتلازمة المبيض المتعدد الأكياس قبل وبعد العلاج بالمتفورمين مع التشديد على علاقته بتحسين التبويض ومؤشر كتلة الجسم .طرق البحث:69 مصابة بمتلازمة المبيض المتعدد الأكياس وبمعدل عمر 25.8±4.4 سنة ومؤشر كتلة الجسم 31.14± 2.23ومؤشر مقاومة الأنسولين 3.15±0.25 علاوة على ذلك 30 أمرأة وبمعدل عمر23.4±2.8 سنة ومؤشر كتلة الجسم26.87±3.1 اعتبرت كمجموعة ضابطة.المريضات تم علاجهن بالمتفورمين بجرعة 1500 ملغم يوميا ولمدة 3 اشهر. تؤخذ نماذج الدم حبات بعد صيام منذ الليلة الفائتة ويعتبر هذا هو خط البداية , وكذلك يؤخذ نموذج الدم في نهاية فترة الدراسة , ويتم قياس كل من مستوى السكر والأنسولين واال TNf-α IL-6وhs-crp والبروجستيرون وSHBG.النتائج : قيمة مؤشر كتلة الجسم للمريضات في بداية الدراسة ظهرت اكبر من المجموعة الضابطة ثم انخفضت بنسبة 12.9% بعد العلاج مقارنة مع مؤشر كتله الجسم للمريضات ,إما مؤشر مقاومة الأنسولين فأنه يرتفع بصورة معبرة في مجموعة المريضات مقارنة مع المجموعة الضابطة ثم ينخفض بنسبة 17.4% بعد العلاج وبالأخذ بنظر الاعتبار تأثير المتفورمين على مستوى علامات الاألتهابات أظهرت الدراسة ارتفاعها عند مستوى خط البداية بالنسبة ل TNf- αو IL-6 و hs-crp عند المريضات مقارنة مع المجموعة الضابطة, وينخفض عن مستوى خط البداية بالنسبة للمريضات بعد العلاج بنسبة16%,38%,37% بالتتابع, في حين آن SHBG.يقل بنسبة 16,6%وكذلك والبروجستيرون عند المريضات مقارنة مع المجموعة الضابطة ويزداد بصورة معبرة بنسبة24%.الاستنتاج: الدراسة حددت زيادة في مستوى السيتوكينات الالتهابية وانخفاض في مستوى آل SHBG. والبروجستيرون لدى النساء العراقيات. وعقار المتفورين يحسن مستوى السيتوكينات الالتهابية وزيادة مستوى ال SHBG.والبروجستيرون مصاحبة مع زيادة التبويض .


Article
Evaluation of Some Pro-inflammatory and Anti-inflammatory Factors in Patients with Acromegaly

Author: Refif Sabih Al-Shawk
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 3 Pages: 71-76
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Inflammation is an important risk factor in disorders such as cardiovascular, metabolic syndrome, diabetes mellitus and insulin resistance and there is a controversy about the role of pro and anti-inflammatory factors in acromegaly and their relationships with each other. Evidence showed that IL-10 level is associated with insulin resistance.Objectives: To investigate the association of GH with IL-10, TNF-α and hs-CRP in patients with active acromegaly and the association of IR with IL-10, TNF-α and hs-CRP.Methods: The study was conducted on thirty Iraqi acromegalic patients (age 35-57 years) attending the endocrine clinic of National Diabetes Center of Mustansiriyah University and were diagnosed with active acromegaly. For the purpose of comparison, 28 apparently healthy control subjects age matched to the patients were included in this study. Serum was obtained from all subjects for the determination of the GH , hs-CRP,IL-10 and TNF-α levels which was measured by Enzyme Linked Immunosorbent Assay (ELISA) in both study groups.Results: The results in this study revealed that mean levels of serum TNF-α, hs-CRP levels were significantly decreased in active acromegaly as compared with control group and this significantly correlated with GH, while IL-10 and IR were significantly increased in active acromegalic patients when compared with control group and IL-10 showed no significant correlation with GH, but significantly correlated with IR in patients group.Conclusion: There were significant negative correlations between TNF-α and hs-CRP levels with GH in patients with active acromegaly, while IL-10 is nonsignificantly correlated with GH. A positive correlation of both TNF-α and IL-10 was observed with IR in patients with acromegaly. TNF-α and IL-10 can play a role in IR in patients with acromegaly and might be involved in the inflammatorynetwork of acromegalic patients.

Keywords

GH --- hs-CRP --- IR --- TNF-α --- IL-10 --- active acromegaly

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