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Bronchial wash miR-21 as a potential biomarker for non-small cell lung cancer

Authors: Hussain Abady Aljebori --- Ban A. Abdulmajeed --- Adnan Aljubori
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2015 Volume: 4 Issue: 1 Pages: 39-60
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Background: Lung cancer is one of the major health problems all over the world. Most ofcases are discovered at advanced stages because of late appearance of symptoms and the lackof efficient and effective methods for early diagnosis and screening of high risk groups. ThemicroRNA-21(miR-21) was stably present and reliably measurable in all samples of bronchialwash whether positive or negative (control) for lung cancer.Objectives: to evaluate the expressions of the miRNA-21 as a minimally invasive diagnosticbiomarker for non-small cell lung cancer (NSCLC).Results: Relative quantification of miR-21 gene showed overexpression in samples positivefor NSCLC (non-small cell lung cancer) and ROC study yielding 85% sensitivity and 98%specificity in distinguishing NSCLC patients from controls with p-value < 0.05.Conclusion: altered expressions of the miR-21 in samples of bronchial wash may provide apotential biomarker for detection of non-small cell lung cancer.

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