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Article
Identification histopathological characterizations of mercuric chloride toxicity in albino male mice

Author: Enwar Abdalkarim Abdalhussin
Journal: Journal of Education for Pure Science مجلة التربية للعلوم الصرفة ISSN: 20736592 Year: 2017 Volume: 7 Issue: 3 Pages: 216-224
Publisher: Thi-Qar University جامعة ذي قار

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Abstract

AbstractMercury compounds have been known as one of most heavy metals which cause adverse effect forboth human and animal. Nevertheless, several studies have been documented poison effect ofmercury in different aspects, but so far there are few reports related histopathlogical changes are notenough clear according dose-dependent. Therefore, our study focused on histopathlogicalexamination of kidney and lung tissues which were treated with two different dose of mercuricchloride to elucidate level of toxicity. Thirty male mice have been equally divided in to three groups.First group was treated with distilled water as control and other two groups were given two differentdoses of mercuric chloride; 1mgk.g and 4 mgk.g respectively. All animals have been administratedby intra-peritoneal injection for 60 consecutive days. At the end of experimental; all mice weresacrificed and eviscerated the target organs (kidney and lung) to prepare for histological processingsteps. Histopathlogical results have revealed that severity of low dose mercuric chlorideadministration was minor effect than high dose given in both kidney and lung. That was showingmoderate renal structures damages and pulmonary parenchyma destruction. Consequently, theseresults indicated that toxic activity of mercuric chloride was according to dose-dependent.Subsequently, the moderate damages have been occurred in renal and lung tissues due to long termexposure.


Article
Eruca sativa and Raphanus sativus Oils Enhance Hepatic and Renal Tissues Regeneration in White Mice

Authors: Amel Mustafa Kamil --- Ala'a Hassan Mirza --- Yasamin Thamer Kadoori --- Shaymaa Jamal Ahmad
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2018 Volume: 29 Issue: 4 Pages: 27-37
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Regeneration is a process of tissue repairing in the body, and according to this process the cells of the body are divided into three types; labile, stable and permanent cells. The aims of this study are to evaluate the ability of two herbal seed oils [Eruca sativa and Raphanus sativus] to enhance regeneration and repair in the liver and kidney in the irradiated mice. And to investigate which herbal oil is more effective. Four groups of mice were used in this study. The first three groups were exposed to radiation while the fourth was used as a control. After irradiation the first and second groups were treated with local Eruca sativa and Raphanussativus oils respectively. While the third group used as a control. Then histopathological investigation was done. Results: Histopathological examination in irradiated groups exhibited that both seed oils could induce regeneration in both hepatic and renal tissues but the activity of Raphanus sativus oil was more effective than Eruca sativa especially in renal tissue. Meanwhile, poor regeneration process appeared in the third group [control].In conclusion, both local herbal oils had ability to enhance regeneration in the examined tissues but R. sativus seed oil exerted more activity than E. sativa seed oil.

التجديد هي من العمليات الاصلاحية التي تحدث في أنسجة الجسم, واعتمادا على هذه العملية تنقسم خلايا الجسم الى ثلاثة أنواع: الخلايا القلقة والخلايا المستقرة والخلايا الثابتة. تهدف الدراسة الى تقييم قابلية زيت بذور الجرجير وزيت بذور الفجل في تحفيز عملية التجديد والترميم في الخلايا الكبدية والخلايا الكلوية. والتعرف على اي الزيتين يمتلك كفاءة اكبر من الثاني في تحفيز هذه العملية. طريقة العمل: أستخدمت في هذه الدراسة أربعة مجاميع من الفئران؛ المجاميع الثلاثة الاولى عرضت للاشعاع , في حين المجموعة الرابعة لم تعرض للاشعاع وأستعملت سيطرة للمجاميع الثلاثة الاولى. عوملت المجموعة الاولى بزيت الجرجير وعوملت المجموعة الثانية بزيت الفجل, ثم جمعت العينات النسيجية لغرض الفحص النسيجي حيث اظهر الاخيران كلا الزيتين لديهما القابلية في تحفيز عملية التجديد في نسيجي الكبد والكلية. ولكن اظهر زيت بذور الفجل كفاءة أعلى في تحفيز هذة العملية. نستنتج من هذه الدراسة إن زيتي كلا النبتتين لهما تأثير فعال في عملية الترميم والتجديد التي تحدث في الكلية والكبد ولكن كفاءة زيت الفجل أكبر..

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